Saccharin

Views 2221
Download the GMI DOC on this Topic

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
20 Diseases Researched for Saccharin
NameACCKFocus
Obesity314Locked
Dysbiosis313Locked
Diabetes Mellitus: Type 2212Locked
Diabetes Mellitus: Type 2: Prevention110Locked
Insulin Resistance110Locked
Metabolic Syndrome X110Locked
Urinary Tract Cancer110Locked
DNA damage33Locked
Antibiotic Toxicity 12Locked
Appetite Disorders12Locked
Bacterial Infections: Resistance/Biofilm Formation12Locked
Circadian Dysregulation12Locked
Infection: Antibiotic Resistant12Locked
Overweight 12Locked
Prediabetes12Locked
Aging11Locked
Atherosclerosis11Locked
Colon Cancer11Locked
Hyperinsulinism11Locked
Metabolic Diseases11Locked
2 Adverse Pharmacological Actions Researched for Saccharin
NameACCKFocus
Hepatotoxic12Locked
Gastrotoxic11Locked
Related Topics

Saccharin is a Sub of the following Topic

View the Evidence:
20 Abstracts with Saccharin Research

[+]

Artificial sweetener consumption is associated with urinary tract tumors. Jul 01, 2008

Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Diseases : Urinary Tract Cancer
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Artificial sweeteners induce glucose intolerance by altering the gut microbiota.Sep 16, 2014

Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Article Published Date : Sep 16, 2014
Study Type : Animal Study, Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention, Dysbiosis, Insulin Resistance, Metabolic Syndrome X
Problem Substances : Artificial Sweeteners, Artificially Sweetened Beverages, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

Results suggest that long-term intakes of aspartame, saccharin, or diet soda may increase AT deposition and risk of incident obesity.Jul 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Obes (Lond). 2023 Jul 13. Epub 2023 Jul 13. PMID: 37443272
Article Published Date : Jul 12, 2023
Study Type : Human Study
Additional Links
Diseases : Obesity
Problem Substances : Aspartame, Saccharin
[+]

Saccharin, sucralose, and acesulfame-potassium were present in 65% of participants' milk samples.Dec 31, 2014

Pubmed Data : J Toxicol Environ Health A. 2015 ;78(16):1029-32. Epub 2015 Aug 12. PMID: 26267522
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sucralose (aka Splenda)
[+]

Aspartame and saccharin led to overexpression of the key oncogene (h-Ras) and the downregulation of the tumor suppressor gene (P27) in all treated rats.May 31, 2015

Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):247-55. Epub 2015 May 26. PMID: 26015492
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Additional Keywords : Gene Expression, Tumor Suppressor Genes
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Intense sweetness can surpass cocaine reward in the animal model. Jan 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2007 ;2(8):e698. Epub 2007 Aug 1. PMID: 17668074
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Problem Substances : Saccharin
[+]

Non-caloric artificial sweeteners can disturb the circadian sleep-wake cycle and cause behavioural inactivity in mice.Mar 25, 2016

Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909
Article Published Date : Mar 25, 2016
Study Type : Animal Study
Additional Links
Diseases : Circadian Dysregulation
Problem Substances : Artificial Sweeteners, Saccharin
[+]

Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Microbes. 2023 ;15(1):2157698. PMID: 36524841
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Diseases : Antibiotic Toxicity , Bacterial Infections: Resistance/Biofilm Formation, Infection: Antibiotic Resistant
Additional Keywords : Antibiotic Resistance, Infection: Antibiotic Resistant
Problem Substances : Acesulfame potassium , Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

Non-nutritive sweetened beverages impair therapeutic benefits of metformin in prediabetic diet-induced obese mice.May 24, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 May 25 ;15(11). Epub 2023 May 25. PMID: 37299435
Article Published Date : May 24, 2023
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 2, Obesity, Prediabetes
Additional Keywords : Metformin
Problem Substances : High Fructose Corn Syrup, Saccharin
[+]

Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(7):e0199080. Epub 2018 Jul 5. PMID: 29975731
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis
Additional Keywords : Microbiota
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sucralose (aka Splenda)
[+]

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.Oct 18, 2012

Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Article Published Date : Oct 18, 2012
Study Type : Animal Study
Additional Links
Diseases : Appetite Disorders, Obesity, Overweight
Problem Substances : Aspartame, Saccharin
[+]

This study describes the fate of artificial sweeteners, including the fraction found in SPM and in sludge, in addition to the aqueous portion of wastewater in WWTPs.Dec 01, 2014

Pubmed Data : Environ Sci Technol. 2014 Dec 2 ;48(23):13668-74. Epub 2014 Nov 14. PMID: 25365516
Article Published Date : Dec 01, 2014
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollutant
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

two-week supplementation of a low carbohydrate diet with sucralose, saccharin or acesulfame-K up-regulated intestinal SGLT1 expression levels to Sep 17, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Article Published Date : Sep 17, 2007
Study Type : Animal Study
Additional Links
Additional Keywords : Cephalic Phase Effect
Problem Substances : Acesulfame potassium , Saccharin, Sucralose (aka Splenda)
[+]

Aspartame, Acesulfame potassium and Saccharin have potential genotoxicity. Jan 01, 2008

Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Acesulfame potassium , Aspartame, Saccharin
[+]

Long term consumption of artificial sweeteners might accelerate atherosclerosis and aging. May 01, 2011

Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Article Published Date : May 01, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Aging, Atherosclerosis
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Aspartame, Saccharin
[+]

Saccharin consumption may potentially alter the intestinal integrity in humans.Jun 24, 2018

Pubmed Data : Food Funct. 2018 Jun 25. Epub 2018 Jun 25. PMID: 29938270
Article Published Date : Jun 24, 2018
Study Type : In Vitro Study
Additional Links
Problem Substances : Artificial Sweeteners, Saccharin
Adverse Pharmacological Actions : Gastrotoxic
[+]

Sucralose and sodium saccharin seemed to elicit the greatest degree of DNA fragmentation of all the sweeteners tested in all the cell lines used.Dec 31, 2014

Pubmed Data : Drug Chem Toxicol. 2015 ;38(3):318-27. Epub 2014 Oct 15. PMID: 25317478
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Diseases : Colon Cancer, DNA damage
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sodium Cyclamate
[+]

Sucralose, aspartame and saccharin have been shown to disrupt the balance and diversity of gut microbiota.Apr 13, 2016

Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Article Published Date : Apr 13, 2016
Study Type : Bacterial
Additional Links
Diseases : Dysbiosis, Metabolic Diseases
Additional Keywords : Microbiota, Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame, Saccharin, Sucralose (aka Splenda)
[+]

The artificial sweeteners sodium cyclamate, aspartame, acesulfame potassium, and saccharin have insulin-releasing action on pancreatic beta cells. Nov 01, 1998

Pubmed Data : Cell Signal. 1998 Nov;10(10):727-33. PMID: 9884024
Article Published Date : Nov 01, 1998
Study Type : In Vitro Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium , Artificial Sweeteners, Saccharin, Sodium Cyclamate
[+]

Various food additives, preservatives, fungicides and artificial sweeteners have been demonstrated to have the potential to damage DNA in gastrointestinal organs. Aug 26, 2002

Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Article Published Date : Aug 26, 2002
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Biphenyl, Butylated hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), Saccharin, Sodium Cyclamate, Sodium o-phenylphenol, Sucralose (aka Splenda), Thiabendazole

Saccharin Related Articles

Study: Saccharin And Sugar May Be More Addictive Than Cocaine
Written by Sayer Ji, Founder
Sugar and artificial sweeteners are so accessible, affordable and socially sanctioned, that few consider their habitual consumption to be a problem on the scale of say, addiction to cocaine. But if recent research is correct, their addictive potential could be even worse.
How Artificial Sweeteners Induce Diabetes- and Obesity-Related Changes
Written by Sayer Ji, Founder
A groundbreaking new study reveals that non-caloric artificial sweeteners (NAS) drive obesity- and diabetes-related changes in both mice and humans.
Sweet! Dieting Without Deprivation
Written by Sayer Ji, Founder
So, you are looking to lose a few pounds, or keep them off. What better way to accomplish this feat than to eliminate both empty sugar calories and synthetic sweeteners, which studies show can generate excessive cravings for sweets and actually increase weight gain.
4 Artificial Sweeteners Linked to 'Nightmare Bacteria'
Written by Sayer Ji, Founder
Synthetic sweeteners have been linked to a wide range of health problems, with over 80 documented on the GreenMedInfo database, alone. The various mechanisms of their toxicity, however, have not yet been fully elucidated. A new study raises a disturbing possibility that these widely consumed chemicals are driving otherwise 'good bacteria' into developing potentially lethal antibiotic resistance through a gut-mediated process.
3 Popular Sweeteners That Can Destroy Your Health
Written by GreenMedInfo Research Group
That diet soda you're sipping to cut calories? It might be doing more harm than good. Recent research suggests some of the most popular artificial sweeteners could be wreaking havoc on your health - from disrupting your gut bacteria to potentially increasing cancer risk.
6 FDA-Approved Sweeteners Proven Toxic to Human Digestion
Written by GMI Reporter
FDA-approved artificial sweeteners and sport supplements have now been found to be toxic to digestive gut microbes, according to a new paper published in the journal Molecules
Artificial Sweeteners Found More Weight-Promoting Than Sugar
Written by Sayer Ji, Founder
A new study published this month in the journal Appetite revealed that when rats were given the synthetic sweeteners saccharin and aspartame, compared to sucrose (table sugar), they gained more weight even at similar total caloric intake levels

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2025 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.