Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Name	AC	CK
Acetaminophen (Tylenol) Toxicity	282	789
Cardiac Mortality	11	280
Cardiovascular Diseases	13	272
Myocardial Infarction	6	230
Liver Damage: Drug-Induced	116	228
Gastric Ulcer	55	197
Coronary Artery Disease	8	170
Drug-Induced Toxicity	8	166
Oxidative Stress	72	150
Inflammation	43	148
Aspirin-Induced Toxicity	36	135
Prenatal Chemical Exposures	22	119
Dysmenorrhea	9	100
Hearing Loss	6	98
Chemically-Induced Liver Damage	46	92
Fever	3	92
NSAID-induced toxicity	9	88
Osteoarthritis: Knee	7	80
Drug-Induced Toxicity: Indomethacin	28	71
Heart Failure	3	71
Kidney Damage: Drug-Induced	28	70
Abortion: Spontaneous	2	60
Children: Drug-Induced Toxicity	1	60
Miscarriage	2	60
Drug-Induced Toxicity: Gastrointestinal	8	53
Attention Deficit Disorder with Hyperactivity	6	52
Febrile Seizures	2	52
Cardiac Arrest	1	50
Mortality: All-Cause	2	50
Helicobacter Pylori Infection	4	48
Autism Spectrum Disorders	7	44
Duodenal Ulcer	3	42
Hypertension	3	40
Rheumatoid Arthritis	6	37
Chronic Pain	4	34
Gastroduodenal Ulcer	3	32
Stroke	4	32
C-Reactive Protein	2	30
Common Cold	1	30
Diabetes Mellitus: Type 2	2	30
Diabetes: Cardiovascular Illness	2	30
Heart Attack	2	30
Osteoarthritis	7	30
Rhinovirus Infection	1	30
Ibuprofen Toxicity	10	28
Kidney Damage	3	24
Lipid Peroxidation	11	24
Kidney Failure	3	23
Gastric Ulcers	2	22
Hypersensitivity	3	22
Pain	2	22
Ulcerative Colitis	5	22
Gastrointestinal Hemorrhage	3	21
Thrombosis	2	21
Aspirin-Exacerbated Respiratory Disease (AERD)	1	20
Brain Edema	2	20
Cerebral Aneurysm	2	20
Cerebral Ischemia	2	20
Chronic Kidney Disease (CKD)	1	20
Congestive Heart Failure	1	20
Coronary Stenting	2	20
Dementia	2	20
Depression	2	20
Dyspepsia	1	20
Elderly: Age Specific Diseases	1	20
Fasciitis: Necrotizing	1	20
Hypertension: Pulmonary	1	20
Osteoporosis	1	20
Premature Birth	1	20
Preterm Infants: Patent Ductus Arteriosus (PDA)	1	20
Prostate Cancer	1	20
Renal Colic	1	20
Skin Infections	1	20
Subarachnoid hemorrhage	2	20
Thromboembolism	1	20
Tinnitus	6	18
Cognitive Decline/Dysfunction	3	14
Arthritis	3	13
Brain Inflammation	3	13
Enteropathy	3	13
Neurodevelopmental Disorders	3	13
Cancer Mortality	2	12
Cold and Flu: Infants & Children	2	12
Anemia: Hemolytic	1	10
Athletic Performance	1	10
Attention Deficit Hyperactivity Disorder	1	10
Bipolar Disorder	1	10
Blood Transfusion	1	10
Brain Hemorrhage: Cerebral	1	10
Brain Injury: Traumatic	1	10
Brain Ischemia	1	10
Cancers: All	1	10
Carpal Tunnel Syndrome	1	10
Childhood Chronic Lung Diseases	1	10
Chronic Pelvic Pain Syndrome	1	10
Cirrhosis	1	10
Clostridium Infections	1	10
Colorectal Cancer	1	10
Diarrhea	1	10
Diverticular Disease	1	10
Diverticular Disease: Bleeding	1	10
Encephalitis	1	10
Gastrointestinal Diseases	1	10
Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient)	1	10
Glucosephosphate Dehydrogenase Deficiency	1	10
Headache: Migraine	1	10
Hemodialysis	1	10
Hepatitis	1	10
Hypoxia	1	10
Infant Mortality	1	10
Intracranial Hemmorhage	1	10
Intraocular Hemorrhage	1	10
Kidney Failure: Chronic	1	10
Left Ventricular Dysfunction	1	10
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	10
Low Immune Function: Natural Killer Cells	1	10
Lymphoma	1	10
Macular Degeneration	1	10
Mastalgia	1	10
Menstrual Cramps	1	10
Migraine Disorders	1	10
Obesity	1	10
Preterm Infant Care	1	10
Viral Infections	1	10
Vitamin B Deficiency	1	10
Alcohol Toxicity	4	9
Lipopolysaccharide-Induced Toxicity	5	8
Wound Healing	4	8
Infertility: Male	4	7
Anemia	1	6
Dysbiosis	2	6
Gastrointestinal Inflammation	3	6
Infertility: Female	2	6
Influenza	1	6
Influenza: Mortality	1	6
Kidney Damage: Chemically-Induced	3	6
Liver Damage	4	6
Nephritis	2	6
Renal tubulointerstitial fibrosis	2	6
Testicular Injury: Chemical/Metal Induced	3	6
Hypogonadism	1	5
Testosterone: Too Low	1	5
Alzheimer's Disease	3	4
Asthma	2	4
Colitis	2	4
DNA damage	2	4
Endometriosis	2	4
Endothelial Dysfunction	2	4
Inflammatory Bowel Diseases	2	4
Male Reproductive Development Abnormalities	1	4
Microplastic Toxicity	2	4
Mitochondrial Dysfunction	2	4
Streptococcus infections: Group A	1	4
Vibrio Infections	1	4
Wound Healing: Delayed	2	4
Aphthous Ulcer	1	3
Arrhythmias: Cardiac	1	3
Arthritis: Juvenile Rheumatoid	1	3
Eosinophilic Pneumonia.	1	3
Esophageal Cancer	1	3
Gastritis	1	3
Kidney Tubular Necrosis: Acute	1	3
Liver Failure: Drug Induced	1	3
Meningitis: Aseptic	1	3
Pericarditis	1	3
Pneumonia: Drug-Induced	1	3
Respiratory Diseases	1	3
Toxic Epidermal Necrolysis	1	3
Wegener Granulomatosis	1	3
Acute Myeloid Leukemia: Stem Cell	1	2
Allodynia	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Antibiotic Toxicity	1	2
Atherosclerosis	1	2
Brain: Microglial Activation	1	2
Breast Cancer	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colon Cancer	1	2
Colon Cancer: Prevention	1	2
Coronavirus Infection	2	2
Diabetic Neuropathies	1	2
Fatty Acid Disorders/Imbalances: Arachidonic Acid	1	2
Fetal Origin of Adult Disease	1	2
Fluoride Toxicity	1	2
Glutathione Deficiency	1	2
Heart Attack: Recovery	1	2
Hyperalgesia	1	2
Hyperglycemia	1	2
Hypoglycemia	1	2
IgE-Mediated Hypersensitivity	1	2
Ileitis	1	2
Immune Disorders: Low Immune Function	1	2
Infertility	1	2
Inflammation: Neutrophil-Mediated	1	2
Intestinal Permeability	1	2
Leukemia	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Disease	1	2
Lung Inflammation	1	2
Methanol Toxicity	1	2
Neuropathic Pain	1	2
Parkinson's Disease	1	2
Radiation-Induced Illness: Plutonium	1	2
Reye Syndrome	1	2
Sepsis	1	2
Sexual Behavior	1	2
Spinal Cord Injuries	1	2
Stress	1	2
Surgery: Abdominal	1	2
Uranium Poisoning	1	2
Vitamin E Deficiency	1	2
Amyotrophic Lateral Sclerosis	1	1
Autism	1	1
Cadmium Poisoning	1	1
Campylobacter Infections	1	1
Cancer Stem Cells	1	1
Coronavirus Disease (Covid-19)	1	1
Detoxification: Impaired	1	1
Diabetic Nephropathy	1	1
Drug-Induced Nutrient Depletion: Aspirin	1	1
Endocannabinoid Disorders	1	1
Endometrial Cancer	1	1
Endometrial Neoplasms	1	1
Escherichia coli Infections	1	1
Liver Cancer	1	1
Liver Steatosis	1	1
Melanoma	1	1
Memory Disorders	1	1
Multiple Myeloma	1	1
Neurodegenerative Diseases	1	1
Pleurisy	1	1
Psoriasis	1	1
Sjogren's Syndrome	1	1
Skin Cancer	1	1
Squamous cell carcinoma	1	1
Stroke: Prevention	1	1
Vitamin C Deficiency	1	1

Name	AC	CK
Cardiotoxic	11	256
Nephrotoxic	3	65
Gastrotoxic	4	62
Ulcerogenic	4	62
Teratogenic	2	60
Immunosuppressive	3	44
Neurotoxic	12	33
Bronchoconstriction	1	20
Hypertensive	1	20
Hepatotoxic	4	16
Carcinogenic	1	10
Hemolytic	1	10
Hemorrhagic	1	10
Cytotoxic	1	5
Immunotoxic	2	4
Inflammatory	1	4
Genotoxic	2	3
Irritant	1	2
Oxidant	1	2
Mutagenic	1	1
Necrotic	1	1
Sulfotransferase inhibitors	1	1

[+]

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Pubmed Data : Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26914515

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

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Pubmed Data : Toxicol Rep. 2015 ;2:677-684. Epub 2015 May 8. PMID: 28962403

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bergamot

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

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Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935

Article Published Date : Jun 24, 2018

Study Type : Animal Study

Additional Links

Substances : Coconut Water

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Inflammation

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Coenzyme Q10 and curcumin administration improves retinal histology by reversing the pathological changes due to chronic methanol and establish a morphologically normal retina.Mar 31, 2012

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Pubmed Data : J Med Assoc Thai. 2012 Apr ;95 Suppl 4:S76-81. PMID: 22696856

Article Published Date : Mar 31, 2012

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10, Curcumin

Diseases : Methanol Toxicity

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Colon targeting of naringin for enhanced cytoprotection against indomethacin-induced colitis.Dec 31, 2019

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Pubmed Data : Drug Des Devel Ther. 2020 ;14:677-696. Epub 2020 Feb 19. PMID: 32109993

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Colitis, Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Indomethacin

[+]

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

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Pubmed Data : Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):69-74. PMID: 31334048

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Diclofenac

[+]

Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin.Jan 05, 2021

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Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.Oct 24, 2019

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Pubmed Data : Biol Trace Elem Res. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654258

Article Published Date : Oct 24, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Selenium

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Diclofenac

[+]

Curcumin may offer potential remedy of gastric antral ulcerations.May 19, 2016

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Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.Nov 18, 2024

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Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031

Article Published Date : Nov 18, 2024

Study Type : Animal Study

Additional Links

Substances : Berberine, Curcumin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Dual anti-platelet therapy might pose a hazard when applied to a patient with undiagnosed and untreated malignant cancer prone to undergo vascular mimicry.Apr 02, 2018

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Pubmed Data : Exp Anim. 2023 Nov 9 ;72(4):513-519. Epub 2023 Jun 19. PMID: 37331803

Article Published Date : Nov 08, 2023

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Gastroprotective

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Aspirin

[+]

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

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Pubmed Data : An Acad Bras Cienc. 2018 Aug ;90(2 suppl 1):2347-2358. Epub 2018 Jun 25. PMID: 29947676

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Chamomile, Cumin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of gastrointestinal toxicity of ibuprofen using surrogate markers in rats: effect of formulation and route of administration.Feb 29, 2000

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Pubmed Data : Clin Exp Rheumatol. 2000 Mar-Apr;18(2):187-92. PMID: 10812490

Article Published Date : Feb 29, 2000

Study Type : Animal Study

Additional Links

Diseases : Intestinal Permeability

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury.Oct 31, 2023

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Pubmed Data : Photochem Photobiol Sci. 2023 Nov ;22(11):2527-2540. Epub 2023 Oct 3. PMID: 37787959

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Pubmed Data : Curr Issues Mol Biol. 2024 Jan 21 ;46(1):923-933. Epub 2024 Jan 21. PMID: 38275673

Article Published Date : Jan 20, 2024

Study Type : Animal Study

Additional Links

Substances : Sinomenine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Exploration of the protective mechanism of naringin in the acetaminophen-induced hepatic injury by metabolomics.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7138194. Epub 2022 Sep 16. PMID: 36160708

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats.Apr 23, 2019

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Pubmed Data : Arch Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020376

Article Published Date : Apr 23, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol.Oct 13, 2021

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Pubmed Data : Biology (Basel). 2021 Oct 14 ;10(10). Epub 2021 Oct 14. PMID: 34681141

Article Published Date : Oct 13, 2021

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Acetaminophen (Tylenol) Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

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Pubmed Data : Front Pharmacol. 2020 ;11:162. Epub 2020 Feb 28. PMID: 32184730

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Folic acid protects against the cardiotoxic effects of celecoxib.Nov 30, 2017

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Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1295-1303. PMID: 28274156

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Folic Acid

Pharmacological Actions : Cardioprotective

Problem Substances : Celecoxib

[+]

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

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Pubmed Data : PLoS One. 2017 ;12(2):e0170900. Epub 2017 Feb 24. PMID: 28234915

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Formula feeding predisposes gut to NSAID-induced small intestinal injury.Dec 31, 2015

Pubmed Data : Saudi J Gastroenterol. 2015 Jan-Feb;21(1):35-42. PMID: 25672237

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bael

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Gastroprotective

Additional Keywords : Plant Extracts

Problem Substances : Aspirin

[+]

Gastro-protective effect of methanol extract of Vernonia amygdalina leaf on aspirin-induced gastric ulcer.Dec 31, 2016

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Pubmed Data : Toxicol Rep. 2017 ;4:625-633. Epub 2017 Nov 13. PMID: 29657922

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Pubmed Data : Am J Chin Med. 2019 Dec 2:1-17. Epub 2019 Dec 2. PMID: 31786947

Article Published Date : Dec 01, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2021

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Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396

Article Published Date : Oct 24, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235

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Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

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Pubmed Data : Neuroscience. 2009 Mar 3;159(1):325-34. Epub 2008 Dec 24. PMID: 19154777

Article Published Date : Mar 03, 2009

Study Type : Animal Study

Additional Links

Diseases : Tinnitus

Problem Substances : Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Pubmed Data : Hindustan Antibiot Bull. 2003 Feb-2004 Nov;45-46(1-4):41-6. PMID: 16281828

Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Jambul can be used as anti-inflammation and antigastric ulcer compound.Dec 31, 2014

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Pubmed Data : Gastroenterol Res Pract. 2015;2015:343642. Epub 2015 Nov 8. PMID: 26633969

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Jambul

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective

Additional Keywords : Plant Extracts

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

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Pubmed Data : Drug Chem Toxicol. 2020 Aug 5:1-13. Epub 2020 Aug 5. PMID: 32757682

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Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):903-909. PMID: 29513960

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Pubmed Data : Nutrients. 2019 Jul 16 ;11(7). Epub 2019 Jul 16. PMID: 31315186

Article Published Date : Jul 15, 2019

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Lactobacillus fermentum, Milk: Fermented

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Indomethacin

[+]

Moringa oleifera leaf extracts shielded kidneys from acetaminophen toxicity through enhancement of the endogenous antioxidant system.Dec 31, 2015

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Pubmed Data : Food Funct. 2022 Sep 2. Epub 2022 Sep 2. PMID: 36052647

Article Published Date : Sep 01, 2022

Study Type : Animal Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression.Dec 31, 2015

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Pubmed Data : Food Nutr Res. 2016 ;60:30849. Epub 2016 Apr 26. PMID: 27121041

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Allodynia, Chronic Pain, Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

Additional Keywords : Superiority of Natural Substances versus Drugs

Problem Substances : Diclofenac

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O. europaea extract can be used to decrease some side effects of indomethacin on intestinal tissue.Dec 31, 2019

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Oral administration of curcumin reduces inflammation in the first six hours after experimentally zymosan-induced arthritis.Oct 31, 2014

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Pubmed Data : Acta Cir Bras. 2014 Nov ;29(11):727-34. PMID: 25424293

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Pubmed Data : Can J Physiol Pharmacol. 2010 Oct ;88(10):1010-6. PMID: 20962901

Article Published Date : Sep 30, 2010

Study Type : Animal Study

Additional Links

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-4 downregulation

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response.Feb 28, 2014

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Piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice.Dec 06, 2012

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Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Study Type : Animal Study

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Substances : Curcumin, Piperine

Diseases : Cognitive Decline/Dysfunction, Oxidative Stress, Stress

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Increased Bioavailability, Natural Substance Synergy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Plantago major had considerable anti-inflammatory and hepatoprotective activities.May 31, 2009

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Pubmed Data : Turk Pediatri Ars. 2016 Jun ;51(2):72-8. Epub 2016 Jun 1. PMID: 27489463

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Pubmed Data : Reproduction. 2017 Aug ;154(2):145-152. Epub 2017 May 30. PMID: 28559473

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Sexual Behavior

Problem Substances : Acetaminophen, Paracetamol

[+]

Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol.Dec 31, 2014

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Pubmed Data : J Med Life. 2015 ;8(Spec Iss 4):270-274. PMID: 28316743

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Zataria multiflora

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Processed Aloe vera gel attenuates non-steroidal anti-inflammatory drug-induced small intestinal injuryAug 31, 2019

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Pubmed Data : Food Funct. 2019 Sep 1 ;10(9):6088-6097. Epub 2019 Sep 6. PMID: 31490512

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : Aloe Vera

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective

Problem Substances : Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on aspirin-induced gastric ulcers.Nov 30, 2023

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Pubmed Data : Inflammopharmacology. 2023 Dec ;31(6):3183-3201. Epub 2023 May 15. PMID: 37184667

Article Published Date : Nov 30, 2023

Study Type : Animal Study

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Substances : Aloe Vera, Geranium

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

Problem Substances : Aspirin

[+]

Propolis significantly prevented paracetamol induced renal, hepatic and hematological toxicity.Nov 30, 2018

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Pubmed Data : Nutr Res Pract. 2018 Dec ;12(6):535-540. Epub 2018 Nov 23. PMID: 30515282

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect and mechanism of action of diallyl disulfide against acetaminophen-induced acute hepatotoxicity.Oct 31, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):28-37. Epub 2017 Aug 25. PMID: 28847761

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

[+]

Protective effect of two extracts of quince fruits on gastric ulcer induced by indomethacin.Dec 31, 2016

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Pubmed Data : Int J Prev Med. 2017 ;8:58. Epub 2017 Aug 24. PMID: 28900537

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Quince

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents

Problem Substances : Indomethacin

[+]

Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury.Nov 30, 2022

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Pubmed Data : Pharm Biol. 2022 Dec ;60(1):1095-1105. PMID: 35658820

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Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711

Article Published Date : Sep 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of dried mature Citrus unshiu peel (Chenpi) and hesperidin on aspirin-induced oxidative damage.Feb 28, 2021

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Pubmed Data : Dose Response. 2018 ;16(3):1559325818785087. Epub 2018 Jul 8. PMID: 30013459

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Pubmed Data : BMC Complement Altern Med. 2019 Feb 20 ;19(1):49. Epub 2019 Feb 20. PMID: 30786935

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Barley

Diseases : Gastric Ulcer, Lipid Peroxidation

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Gastroprotective, Glutathione Upregulation

Additional Keywords : Plant Extracts

Problem Substances : Indomethacin

[+]

Protective role of β-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer.Jan 14, 2018

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Pubmed Data : Phytomedicine. 2018 Jan 15 ;39:111-118. Epub 2017 Dec 25. PMID: 29433672

Article Published Date : Jan 14, 2018

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Pubmed Data : Cell Physiol Biochem. 2018 Sep 20 ;49(5):1943-1958. Epub 2018 Sep 20. PMID: 30235447

Article Published Date : Sep 19, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Pycnogenol reduced the toxic effect of indomethacin on the stomach and increased anti-inflammatory activity.Aug 31, 2022

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Pubmed Data : Gen Physiol Biophys. 2022 Sep ;41(5):473-481. PMID: 36222345

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Pycnogenol (Pine Bark)

Diseases : Drug-Induced Toxicity: Indomethacin

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Gastrointestinal Agents, Gastroprotective, Malondialdehyde Down-regulation

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

Problem Substances : Indomethacin

[+]

Quercetin could protect against pantoprazole sodium induced enteropathic damage in a dose dependent manner.Oct 21, 2016

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Pubmed Data : Exp Toxicol Pathol. 2016 Oct 22. Epub 2016 Aug 22. PMID: 27780667

Resveratrol is a potent inhibitor of vascularization in endometriotic lesions.Apr 30, 2013

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Sesamol protects against acetaminophen-induced injury in animals.Jul 01, 2009

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Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Tylenol

Adverse Pharmacological Actions :

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View the Evidence: 649 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Research

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Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Brazilian green propolis prevents cognitive decline into mild cognitive impairment in elderly people living at high altitude.Dec 31, 2017

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer.Sep 22, 2023

Cardioprotective role of royal jelly in the prevention of celecoxib-mediated cardiotoxicity.Mar 17, 2024

Carnosic acid ameliorates indomethacin-induced gastric ulceration.Mar 08, 2023

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Carvacrol exerts anti-inflammatory, anti-oxidative stress and hepatoprotective effects against diclofenac-induced liver injury.Dec 31, 2022

Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.Feb 23, 2016

Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress.Nov 06, 2022

Chrysin possesses a potential protective effect against indomethacin-induced gastric ulcer.Jan 04, 2018

Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.Oct 31, 2017

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Cinnamon oil could be an alternative nutraceutical substitute in APAP overdose poisoning.Feb 28, 2022

Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke.Aug 31, 2013

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

Coenzyme Q10 and curcumin administration improves retinal histology by reversing the pathological changes due to chronic methanol and establish a morphologically normal retina.Mar 31, 2012

Colon targeting of naringin for enhanced cytoprotection against indomethacin-induced colitis.Dec 31, 2019

Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced acute kidney injury.Mar 31, 2019

Combined Lycium babarum polysaccharides and C-phycocyanin increase gastric Bifidobacterium relative abundance and protect against gastric ulcer caused by aspirin.Jan 05, 2021

Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats.Jan 26, 2016

Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.Nov 30, 2010

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

CoQ10 promotes resolution of necrosis and liver regeneration after acetaminophen-induced liver injury.Dec 27, 2021

Curcumin and selenium can hinder the progression and severity of liver injury during acute inflammatory episodes.Oct 24, 2019

Curcumin may offer potential remedy of gastric antral ulcerations.May 19, 2016

Curcumin prevents paracetamol-induced liver mitochondrial alterations.Jan 14, 2016

Curcumin was effective in restoring the histopathological changes induced by acetic acid administration.Dec 31, 2014

Dandelion extracts pretreatment protects against acetaminophen-induced hepatic injury.Nov 23, 2021

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Depletion of gut microbiota with antibiotics led to a higher mortality in mice compared to controls.Jan 08, 2017

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Aug 31, 2015

Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury.Dec 31, 2018

Dietary supplementation of aloe components ameliorates intestinal inflammatory responses in a DSS-induced ulcerative colitis model.Mar 13, 2011

Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration.Jan 06, 2023

Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.Mar 02, 2014

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.Nov 18, 2024

Dual anti-platelet therapy might pose a hazard when applied to a patient with undiagnosed and untreated malignant cancer prone to undergo vascular mimicry.Apr 02, 2018

Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum.Apr 13, 2017

Early-life long-term ibuprofen exposure reduces reproductive capacity involved in spermatogenesis impairment.Nov 15, 2023

Echinacoside alleviates acetaminophen-induced liver injury.Dec 31, 2020

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol.Mar 31, 2019

Effectiveness of the homeopathic preparation Zeel compared with carprofen in dogs with osteoarthritis.Dec 31, 2010

Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion.Jun 30, 1993

Effects of taxifolin on aspirin-induced gastric damage.Nov 08, 2023

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

Eriodictyol may be used to treat acetaminophen-induced hepatotoxicity.Jan 04, 2017

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats.Jul 31, 2018

Evaluation of gastrointestinal toxicity of ibuprofen using surrogate markers in rats: effect of formulation and route of administration.Feb 29, 2000

Evaluation of photobiomodulation therapy (117 and 90s) on pain, regeneration, and epigenetic factors (HDAC 2, DNMT3a) expression following spinal cord injury.Oct 31, 2023

Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis.Aug 31, 2018

Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.Nov 30, 2022

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

Exploration of the protective mechanism of naringin in the acetaminophen-induced hepatic injury by metabolomics.Dec 31, 2021

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats.Apr 23, 2019

Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol.Oct 13, 2021

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

Extracts of M. vulgare and marrubiin display antiulcer activities. Aug 31, 2011

Fermented ginseng was shown to possess hepatoprotective activity against paracetamol (APAP)-induced liver injury.Mar 31, 2015

Fisetin attenuates paracetamol-induced hepatotoxicity by regulating CYP2E1 enzyme.Dec 31, 2022

Fisetin prevents acetaminophen-induced liver injury by promoting autophagy.Dec 31, 2019

Folic acid protects against the cardiotoxic effects of celecoxib.Nov 30, 2017

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

Formula feeding predisposes gut to NSAID-induced small intestinal injury.Dec 31, 2015

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

View the Evidence:
649 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Research