Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Name	AC	CK
Acetaminophen (Tylenol) Toxicity	415	1348
Prenatal Chemical Exposures	60	394
Liver Damage: Drug-Induced	155	299
Cardiac Mortality	11	280
Cardiovascular Diseases	13	272
Myocardial Infarction	6	230
Gastric Ulcer	58	203
Oxidative Stress	97	198
Coronary Artery Disease	8	170
Drug-Induced Toxicity	8	166
Inflammation	47	156
Asthma	15	149
Aspirin-Induced Toxicity	38	139
Dysmenorrhea	9	100
Hearing Loss	6	98
Chemically-Induced Liver Damage	47	96
Attention Deficit Disorder with Hyperactivity	12	94
Fever	3	92
Kidney Damage: Drug-Induced	39	91
NSAID-induced toxicity	10	90
Osteoarthritis: Knee	7	80
Drug-Induced Toxicity: Indomethacin	28	71
Heart Failure	3	71
Ibuprofen Toxicity	16	70
Abortion: Spontaneous	2	60
Children: Drug-Induced Toxicity	1	60
Miscarriage	2	60
Hypertension	5	57
Drug-Induced Toxicity: Gastrointestinal	8	53
Febrile Seizures	2	52
Cardiac Arrest	1	50
Helicobacter Pylori Infection	5	50
Mortality: All-Cause	2	50
Rheumatoid Arthritis	7	47
Autism Spectrum Disorders	9	46
Duodenal Ulcer	3	42
Chronic Pain	4	34
Lipid Peroxidation	16	33
Gastroduodenal Ulcer	3	32
Stroke	4	32
C-Reactive Protein	2	30
Common Cold	1	30
Diabetes Mellitus: Type 2	2	30
Diabetes: Cardiovascular Illness	2	30
Heart Attack	2	30
Osteoarthritis	7	30
Rhinovirus Infection	1	30
Wheezing: Infants	3	30
Neurodevelopmental Disorders	7	26
Kidney Damage	4	25
Kidney Failure	3	23
Gastric Ulcers	2	22
Hypersensitivity	3	22
Pain	2	22
Ulcerative Colitis	5	22
Gastrointestinal Hemorrhage	3	21
Thrombosis	2	21
Alcohol Toxicity	6	20
Aspirin-Exacerbated Respiratory Disease (AERD)	1	20
Atopic Dermatitis	2	20
Brain Edema	2	20
Cerebral Aneurysm	2	20
Cerebral Ischemia	2	20
Chronic Kidney Disease (CKD)	1	20
Congestive Heart Failure	1	20
Coronary Stenting	2	20
Dementia	2	20
Depression	2	20
Dyspepsia	1	20
Elderly: Age Specific Diseases	1	20
Fasciitis: Necrotizing	1	20
Hypertension: Pulmonary	1	20
Low Back Pain	2	20
Osteoporosis	1	20
Premature Birth	1	20
Preterm Infants: Patent Ductus Arteriosus (PDA)	1	20
Prostate Cancer	1	20
Renal Colic	1	20
Skin Infections	1	20
Subarachnoid hemorrhage	2	20
Thromboembolism	1	20
Liver Damage	7	19
Infertility: Male	6	18
Tinnitus	6	18
Cognitive Decline/Dysfunction	4	16
Arthritis	4	15
Brain Inflammation	4	15
Male Reproductive Development Abnormalities	2	14
Enteropathy	3	13
Antibiotic Toxicity	2	12
Cancer Mortality	2	12
Cold and Flu: Infants & Children	2	12
DNA damage	7	11
Anemia: Hemolytic	1	10
Athletic Performance	1	10
Attention Deficit Hyperactivity Disorder	1	10
Bipolar Disorder	1	10
Blood Transfusion	1	10
Brain Hemorrhage: Cerebral	1	10
Brain Injury: Traumatic	1	10
Brain Ischemia	1	10
Cancers: All	1	10
Carpal Tunnel Syndrome	1	10
Childhood Chronic Lung Diseases	1	10
Chronic Pelvic Pain Syndrome	1	10
Cirrhosis	1	10
Clostridium Infections	1	10
Colorectal Cancer	1	10
Diarrhea	1	10
Diverticular Disease	1	10
Diverticular Disease: Bleeding	1	10
Encephalitis	1	10
Gastrointestinal Diseases	1	10
Glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient)	1	10
Glucosephosphate Dehydrogenase Deficiency	1	10
Headache: Migraine	1	10
Hemodialysis	1	10
Hepatitis	1	10
Hypoxia	1	10
Infant Mortality	1	10
Infants: Low Birth Weight	1	10
Intracranial Hemmorhage	1	10
Intraocular Hemorrhage	1	10
Kidney Failure: Chronic	1	10
Left Ventricular Dysfunction	1	10
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	10
Lipopolysaccharide-Induced Toxicity	6	10
Low Immune Function: Natural Killer Cells	1	10
Lymphoma	1	10
Macular Degeneration	1	10
Mastalgia	1	10
Menstrual Cramps	1	10
Migraine Disorders	1	10
Obesity	1	10
Preterm Infant Care	1	10
Sperm Quality: Low	1	10
Testicular Injury: Chemical/Metal Induced	5	10
Viral Infections	1	10
Vitamin B Deficiency	1	10
Mitochondrial Dysfunction	6	8
Wound Healing	4	8
Anemia	1	6
Dysbiosis	2	6
Gastrointestinal Inflammation	3	6
Infertility: Female	2	6
Inflammatory Bowel Diseases	3	6
Influenza	1	6
Influenza: Mortality	1	6
Kidney Damage: Chemically-Induced	3	6
Lung Damage	3	6
Nephritis	2	6
Renal tubulointerstitial fibrosis	2	6
Hypogonadism	1	5
Infertility	3	5
Testosterone: Too Low	1	5
Aging	2	4
Alzheimer's Disease	3	4
Colitis	2	4
Endometriosis	2	4
Endothelial Dysfunction	2	4
Microplastic Toxicity	2	4
Streptococcus infections: Group A	1	4
Vibrio Infections	1	4
Wound Healing: Delayed	2	4
Aphthous Ulcer	1	3
Arrhythmias: Cardiac	1	3
Arthritis: Juvenile Rheumatoid	1	3
Eosinophilic Pneumonia.	1	3
Esophageal Cancer	1	3
Gastritis	1	3
Kidney Tubular Necrosis: Acute	1	3
Liver Failure: Drug Induced	1	3
Memory Disorders	2	3
Meningitis: Aseptic	1	3
Pericarditis	1	3
Pneumonia: Drug-Induced	1	3
Respiratory Diseases	1	3
Toxic Epidermal Necrolysis	1	3
Wegener Granulomatosis	1	3
Acute Myeloid Leukemia: Stem Cell	1	2
Allodynia	1	2
Amyotrophic lateral sclerosis (ALS)	1	2
Atherosclerosis	1	2
Brain: Microglial Activation	1	2
Brain: Oxidative Stress	1	2
Breast Cancer	1	2
Cervical Cancer	2	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colon Cancer	1	2
Colon Cancer: Prevention	1	2
Coronavirus Infection	2	2
Crohn's Disease	1	2
Diabetic Neuropathies	1	2
Fatty Acid Disorders/Imbalances: Arachidonic Acid	1	2
Fetal Origin of Adult Disease	1	2
Fluoride Toxicity	1	2
Glutathione Deficiency	1	2
Heart Attack: Recovery	1	2
Hyperalgesia	1	2
Hyperglycemia	1	2
Hypoglycemia	1	2
IgE-Mediated Hypersensitivity	1	2
Ileitis	1	2
Immune Disorders: Low Immune Function	1	2
Inflammation: Neutrophil-Mediated	1	2
Intestinal Permeability	1	2
Leukemia	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Disease	1	2
Low Testosterone	1	2
Lung Inflammation	1	2
Methanol Toxicity	1	2
Neuropathic Pain	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Parkinson's Disease	1	2
Periodontitis	1	2
Radiation-Induced Illness: Plutonium	1	2
Reye Syndrome	1	2
Sepsis	1	2
Sexual Behavior	1	2
Smoking	1	2
Spinal Cord Injuries	1	2
Stress	1	2
Surgery: Abdominal	1	2
Uranium Poisoning	1	2
Vitamin E Deficiency	1	2
Amyotrophic Lateral Sclerosis	1	1
Autism	1	1
Bisphenol Toxicity	1	1
Cadmium Poisoning	1	1
Campylobacter Infections	1	1
Cancer Stem Cells	1	1
Coronavirus Disease (Covid-19)	1	1
Detoxification: Impaired	1	1
Diabetic Nephropathy	1	1
Drug-Induced Nutrient Depletion: Aspirin	1	1
Endocannabinoid Disorders	1	1
Endometrial Cancer	1	1
Endometrial Neoplasms	1	1
Escherichia coli Infections	1	1
Hyperlipidemia	1	1
Liver Cancer	1	1
Liver Failure: Acute	1	1
Liver Steatosis	1	1
Melanoma	1	1
Multiple Myeloma	1	1
Neurodegenerative Diseases	1	1
Pleurisy	1	1
Psoriasis	1	1
Sjogren's Syndrome	1	1
Skin Cancer	1	1
Squamous cell carcinoma	1	1
Stroke: Prevention	1	1
Vitamin C Deficiency	1	1

Name	AC	CK
Cardiotoxic	11	256
Teratogenic	5	66
Nephrotoxic	3	65
Gastrotoxic	4	62
Ulcerogenic	4	62
Immunosuppressive	3	44
Neurotoxic	14	36
Bronchoconstriction	1	20
Hypertensive	1	20
Hepatotoxic	4	16
Carcinogenic	1	10
Hemolytic	1	10
Hemorrhagic	1	10
Cytotoxic	1	5
Immunotoxic	2	4
Inflammatory	1	4
Genotoxic	2	3
Irritant	1	2
Oxidant	1	2
Embryotoxic	1	1
Mutagenic	1	1
Necrotic	1	1
Sulfotransferase inhibitors	1	1

[+]

Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

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Pubmed Data : Chest. 2009 Nov ;136(5):1316-1323. Epub 2009 Aug 20. PMID: 19696122

Article Published Date : Oct 31, 2009

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671

Article Published Date : Jun 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Cardiovascular Diseases, Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 2

Problem Substances : Aspirin

[+]

In this meta-analysis a positive relation between all-NSAID intake and prostate cancer was observed.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Surg Oncol. 2014 ;12:304. Epub 2014 Oct 5. PMID: 25282624

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Pubmed Data : Prescrire Int. 2007 Feb ;16(87):17. PMID: 17323524

Article Published Date : Feb 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Fasciitis: Necrotizing, Skin Infections

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.Oct 19, 2010

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Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85. PMID: 20946994

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arthritis Rheum. 2012 Nov ;64(11):3511-21. PMID: 22833186

Article Published Date : Oct 31, 2012

Study Type : Meta Analysis

Additional Links

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Additional Keywords : Risk Factors

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Click here to read the entire abstract

Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737

Article Published Date : May 01, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Tylenol

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Click here to read the entire abstract

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis

Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic

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Ameliorating role of hydrogen-rich water against NSAID-induced enteropathy.Apr 30, 2023

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Pubmed Data : Dig Dis Sci. 2023 May ;68(5):1824-1834. Epub 2022 Dec 7. PMID: 36478314

Article Published Date : Apr 30, 2023

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

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Pubmed Data : JAMA Pediatr. 2020 Nov 1 ;174(11):1073-1081. PMID: 32986124

Article Published Date : Oct 31, 2020

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

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Pubmed Data : Phytomedicine. 2003 Jan ;10(1):3-7. PMID: 12622457

Article Published Date : Dec 31, 2002

Study Type : Human Study

Additional Links

Substances : Frankincense

Diseases : Arthritis, Osteoarthritis: Knee

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Boswellia serrata significantly reduced cerebral edema measured by MRI in the study population.Aug 14, 2011

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Pubmed Data : Cancer. 2011 Aug 15 ;117(16):3788-95. Epub 2011 Feb 1. PMID: 21287538

Article Published Date : Aug 14, 2011

Study Type : Human Study

Additional Links

Substances : Frankincense

Diseases : Brain Edema, Cancers: All

Therapeutic Actions : Placebo Effect

Additional Keywords : Medication Reduction, Phytotherapy

Problem Substances : Dexamethasone, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

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Pubmed Data : J Pharm Biomed Anal. 2011 Dec 15 ;56(5):998-1005. Epub 2011 Jul 29. PMID: 21855244

Article Published Date : Dec 14, 2011

Study Type : Human Study

Additional Links

Substances : Frankincense

Diseases : Brain Edema, Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

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Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088

Pubmed Data : J Bodyw Mov Ther. 2021 Jul ;27:705-709. Epub 2021 May 17. PMID: 34391310

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cochrane Database Syst Rev. 2012 ;10:CD008424. Epub 2012 Oct 17. PMID: 23076948

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Ulcerative Colitis

Additional Keywords : Complementary Alternative Medicine, Natural Substance/Drug Synergy, Randomized Controlled Trials As Topic

Problem Substances : Mesalamine, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Problem Substances : Mefenamic acid

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Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

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Fennel extract/vitamin E compares favorably with ibuprofen on the pain intensity in students with primary dysmenorrhea.Aug 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Nurs Midwifery Res. 2013 Sep ;18(5):355-9. PMID: 24403936

Article Published Date : Aug 31, 2013

Study Type : Human Study

Additional Links

Substances : Fennel

Diseases : Dysmenorrhea

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Mefenamic acid

[+]

Fennel is safe and effective for treating primary dysmenorrhea. Feb 01, 2003

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Pubmed Data : Int J Gynaecol Obstet. 2003 Feb;80(2):153-7. PMID: 12566188

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2014 Dec ;17(12):1361-7. PMID: 25058311

Article Published Date : Nov 30, 2014

Study Type : Human Study

Additional Links

Substances : Rosemaric Acid

Diseases : Osteoarthritis: Knee

Additional Keywords : Phytotherapy

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair.Jun 30, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Additional Keywords : Plant Extracts

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Lactobacillus complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.May 08, 2022

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Pubmed Data : Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Article Published Date : May 08, 2022

Study Type : Human Study

Additional Links

Substances : Enterococcus faecium, Lactobacillus rhamnosus

Diseases : Aspirin-Induced Toxicity

Pharmacological Actions : Gastroprotective

Problem Substances : Aspirin

[+]

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Epigenetics. 2017 ;9:77. Epub 2017 Aug 2. PMID: 28785368

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Pubmed Data : Planta Med. 2015 Nov 19. Epub 2015 Nov 19. PMID: 26584456

Article Published Date : Nov 18, 2015

Study Type : Human Study

Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Feb 28, 2013

Study Type : Human Study

Additional Links

Substances : Fennel

Diseases : Dysmenorrhea, Menstrual Cramps

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Mefenamic acid

[+]

Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug.Feb 28, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Nurs Midwifery Res. 2013 Mar ;18(2):128-32. PMID: 23983742

Article Published Date : Feb 28, 2013

Study Type : Human Study

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation

Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity

Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

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Patients taking aspirin plus ibuprofen have an increased risk of all-cause mortality.Feb 15, 2003

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Pubmed Data : Lancet. 2003 Feb 15;361(9357):573-4. PMID: 12598144

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Pubmed Data : Xenobiotica. 1991 May ;21(5):689-93. PMID: 1949902

Article Published Date : Apr 30, 1991

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Rheumatoid Arthritis

Problem Substances : Acetaminophen, Paracetamol

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Patients with recurrent urticaria and angio-edema show significant improvement when they refrain from using aspirin, benzoates and azo dyes. Jul 01, 1976

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Pubmed Data : Br J Dermatol. 1976 Jul;95(1):19-24. PMID: 952737

Article Published Date : Jul 01, 1976

Study Type : Human Study

Additional Links

Problem Substances : Aspirin , Azo Dyes, Food Colorings, Sodium Benzoate

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People with the heaviest opioid or NSAID use had slightly higher dementia risk than people with little or no use.Jul 31, 2015

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Pubmed Data : J Am Geriatr Soc. 2015 Aug ;63(8):1519-26. PMID: 26289681

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Pubmed Data : Int J Clin Pract. 2004 Sep ;58(9):827-32. PMID: 15529515

Article Published Date : Aug 31, 2004

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Viral Infections

Pharmacological Actions : Antitussive Agents, Antiviral Agents

Additional Keywords : Homeopathic Vs. Conventional Treatment

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2016 12 1 ;45(6):1987-1996. PMID: 27353198

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

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Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

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Pubmed Data : Int J Epidemiol. 2013 Dec ;42(6):1702-13. Epub 2013 Oct 24. PMID: 24163279

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Pubmed Data : Hum Reprod. 2016 Nov ;31(11):2642-2650. Epub 2016 Sep 8. PMID: 27609981

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Male Reproductive Development Abnormalities, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Preoperative use of aspirin plus clopidogrel is associated with an increased risk of infection after coronary artery bypass surgery. Apr 27, 2009

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Pubmed Data : Arch Intern Med. 2009 Apr 27;169(8):788-96. PMID: 19398691

Article Published Date : Apr 27, 2009

Study Type : Human Study

Additional Links

Diseases : Coronary Artery Disease

Problem Substances : Aspirin , Clopidogrel

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[+]

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurotoxicol Teratol. 2024 ;101:107319. Epub 2024 Jan 8. PMID: 38199313

Article Published Date : Dec 31, 2023

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

The results of this study show better improvement in acute LBP treated with LLLT used as additional therapy.Jul 31, 2010

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Pubmed Data : Photomed Laser Surg. 2010 Aug ;28(4):553-60. PMID: 20001318

Article Published Date : Jul 31, 2010

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Pubmed Data : Arch Dis Child Fetal Neonatal Ed. 2010 Sep 27. Epub 2010 Sep 27. PMID: 20876595

Article Published Date : Sep 27, 2010

Study Type : Human Study

Additional Links

Diseases : Childhood Chronic Lung Diseases, Preterm Infant Care

Problem Substances : Ibuprofen

[+]

The use of rofecoxib, valdecoxib, and indomethacin increases the risk of cardiovascular disease.Nov 01, 2009

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Pubmed Data : Pharmacoepidemiol Drug Saf. 2009 Nov;18(11):1053-63. PMID: 19637402

Pubmed Data : J Orofac Pain. 2012 ;26(2):99-104. PMID: 22558609

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Pubmed Data : J Acupunct Meridian Stud. 2015 Oct ;8(5):229-35. Epub 2014 Nov 29. PMID: 26433799

Article Published Date : Sep 30, 2015

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Pubmed Data : Eur J Clin Invest. 1999 May;29(5):438-44. PMID: 10354201

Article Published Date : May 01, 1999

Study Type : Human Study

Additional Links

Diseases : Aspirin-Induced Toxicity , Hypoxia

Problem Substances : Aspirin

[+]

Use of non-selective NSAIDs was associated with an increased early risk of out-of-hospital cardiac arrest.Dec 25, 2016

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Pubmed Data : Eur Heart J Cardiovasc Pharmacother. 2016 Dec 26. Epub 2016 Dec 26. PMID: 28025218

Article Published Date : Dec 25, 2016

Study Type : Human Study

Additional Links

Diseases : Cardiac Arrest, NSAID-induced toxicity

Additional Keywords : Increased Risk

Problem Substances : Celecoxib, Diclofenac, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Rofecoxib

Adverse Pharmacological Actions : Cardiotoxic

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Pubmed Data : Clin Case Rep. 2024 Apr ;12(4):e8723. Epub 2024 Mar 27. PMID: 38550731

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Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244

Article Published Date : Apr 02, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Salvia miltiorrhiza

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, MicroRNA modulator

Additional Keywords : MicroRNA-485

Problem Substances : Acetaminophen, Paracetamol

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The first documented ibuprofen-Induced toxic epidermal necrolysis in the Middle East and North Africa region.Oct 31, 2023

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Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417

Article Published Date : Jul 31, 2015

Study Type : Animal Study

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Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

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Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

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Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

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Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

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Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178

Article Published Date : Jun 11, 2017

Study Type : Animal Study

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Substances : Bamboo

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

Pubmed Data : Arterioscler Thromb Vasc Biol. 2010 Mar ;30(3):426-35. Epub 2010 Jan 7. PMID: 20056909

A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis.Aug 31, 2018

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Pubmed Data : Can Vet J. 2018 Sep ;59(9):959-966. PMID: 30197438

Article Published Date : Aug 31, 2018

Study Type : Animal Study

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Diseases : Osteoarthritis

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Analgesics

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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A single early-life acetaminophen exposure causes persistent abnormalities in the murine lung.Jul 31, 2025

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Pubmed Data : Am J Respir Cell Mol Biol. 2025 Aug ;73(2):232-250. PMID: 39836061

Article Published Date : Jul 31, 2025

Study Type : Animal Study

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Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage

Problem Substances : Acetaminophen, Paracetamol

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A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Acacia catechu

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

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Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

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Pubmed Data : Pharmacol Biochem Behav. 2018 Dec ;175:146-151. Epub 2018 Oct 22. PMID: 30359628

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Pubmed Data : J Clin Endocrinol Metab. 2022 May 17 ;107(6):1647-1661. PMID: 35147701

Article Published Date : May 16, 2022

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

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Acetaminophen toxicity is substantially reduced by beta-carotene in mice.Dec 31, 1994

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Pubmed Data : Int J Vitam Nutr Res. 1995 ;65(3):175-80. PMID: 8829996

Article Published Date : Dec 31, 1994

Study Type : Animal Study

Additional Links

Substances : beta-Carotene, Carotenoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Acetaminophen toxicity to cultured rat embryos.Dec 31, 1989

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Pubmed Data : Teratog Carcinog Mutagen. 1990 ;10(5):361-71. PMID: 1981948

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Pubmed Data : Lett Appl Microbiol. 2024 Dec 12. Epub 2024 Dec 12. PMID: 39668634

Article Published Date : Dec 11, 2024

Study Type : Animal Study

Additional Links

Substances : Bifidobacterium Longum , Lactococcus lactis

Diseases : Aspirin-Induced Toxicity , Brain Inflammation , Helicobacter Pylori Infection

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective

Problem Substances : Aspirin

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Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury.May 31, 2016

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Pubmed Data : Biomedicine (Taipei). 2016 Jun ;6(2):9. Epub 2016 May 9. PMID: 27161000

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Pubmed Data : Neurotox Res. 2020 Feb ;37(2):455-468. Epub 2019 Jul 30. PMID: 31364032

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

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Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan ;28(2):1762-1774. Epub 2020 Aug 27. PMID: 32856245

An extract of turmeric and white mulberry could potentially be considered as a dietary supplement product for the management of arthritis.Mar 31, 2016

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Pubmed Data : Pharmacognosy Res. 2016 Apr-Jun;8(2):112-7. PMID: 27034601

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Turmeric, White Mulberry

Diseases : Arthritis

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

Problem Substances : Ibuprofen

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An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

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Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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View the Evidence: 801 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Research

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Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

The use of paracetamol during pregnancy is associated with an increased risk of childhood asthma.Mar 31, 2011

A statistically significant elevated AKI risk among traditional NSAID users has been demonstrated in this meta-analysis. Apr 06, 2015

Aspirin did not prevent CV events, with a significantly increased risk of minor bleeding and renal events.May 29, 2023

Aspirin does not prevent cardiovascular events in diabetes mellitus.Jun 01, 2010

In this meta-analysis a positive relation between all-NSAID intake and prostate cancer was observed.Dec 31, 2013

long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women. Oct 16, 2007

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.May 01, 2009

NSAIDs may contribute to necrotising fascilitis and dermal linfections. Feb 01, 2007

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.Oct 19, 2010

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men, and the impact is larger on younger individuals.Mar 01, 2010

Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. Oct 31, 2012

This analysis suggests Helicobacter pylori increases the risk of low-dose aspirin ulcers.Nov 07, 2018

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

Zingiberaceae extracts are clinically effective hypoalgesic agents and the available data show a better safety profile than non steroidal anti inflammatory drugs.Dec 31, 2014

Paracetamol metabolism by endothelial cells - Potential mechanism underlying intravenous paracetamol-induced hypotension.Dec 31, 2024

A case of pulmonary hypertension following L-lysine ibuprofen therapy has been reported in a preterm infant with patent ductus arteriosus.Jun 20, 2006

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe. Jan 01, 2007

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort.Sep 25, 2021

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.May 01, 2008

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn.Mar 31, 2019

Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.Jul 31, 2018

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Ameliorating role of hydrogen-rich water against NSAID-induced enteropathy.Apr 30, 2023

Antiplatelet therapy does not appear to improve outcome in patients with cerebral aneurysm (subarachnoid hemorrhage).Jun 01, 2009

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Aspirin (Acetylsalicylic acid) may cause severe hemolytic anemia in some glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient) individuals. Jul 01, 1970

Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke. Jul 01, 1999

Aspirin causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. Nov 01, 2009

Aspirin given after aneurysm treatment does not appreciably reduce the occurrence of delayed ischemic neurological deficit.Sep 01, 2006

Aspirin increases mortality in diabetic patients without cardiovascular disease. Dec 01, 2009

Aspirin is a risk factor for colonic diverticular bleedingDec 24, 2012

Aspirin may contribute to the development of CD in a middle-aged to elderly populationSep 01, 2011

Aspirin treatment reduces ischemic strokes while increasing hemorrhagic stroke. Jan 01, 2009

Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in the elderly.May 01, 1998

Aspirin use was not found to lower the risk of heart attack or death from cardiovascular causes. Mar 31, 2005

Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding. Mar 01, 2010

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Boswellia serrata Extract could be recommended in patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.Dec 31, 2002

Boswellia serrata significantly reduced cerebral edema measured by MRI in the study population.Aug 14, 2011

Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs has been observed and labeled as Aspirin-exacerbated respiratory disease (AERD. Jan 01, 2012

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.May 09, 2011

Clinical use of cyclooxygenase inhibitors impair vitamin B-6 metabolism.Oct 22, 2013

Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.Apr 01, 2006

Comparative study of combination therapy with non-steroidal anti inflammatory drugs and different doses of low level laser therapy in acute low back pain.Jun 30, 2021

Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea.Apr 30, 2006

Comparison of the efficacy of diclofenac, acupuncture, and acetaminophen in the treatment of renal colic.May 31, 2015

Curcumin may be a safe and effective therapy for maintenance of remission in quiescent UC when given as adjunctive therapy along with mesalamine or sulfasalazine. Dec 31, 2011

Curcumin treatment is safe and superior to drug therapy in patients with active RA.Oct 31, 2012

Decline of aspirin use is associated with a decreased incidence of Reye's syndrome.Jun 01, 1987

Dill was as effective as mefenamic acid in reducing the pain severity in primary dysmenorrhea.Mar 31, 2014

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran Sep 01, 2009

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.Dec 31, 2013

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

View the Evidence:
801 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Research