Morphine

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32 Diseases Researched for Morphine
NameACCKFocus
Chronic Pain212Locked
Lung Cancer212Locked
Atrial Fibrillation110Locked
Cancer Mortality110Locked
Pruritus110Locked
Sepsis110Locked
Sleep Disorders110Locked
Breast Cancer59Locked
Cancers: All37Locked
Leukemia: Acute myelogenous leukemia (AML) 15Locked
Brain Inflammation 24Locked
Brain: Oxidative Stress24Locked
Cancer Metastasis34Locked
Chemically-Induced Liver Damage24Locked
Infertility: Male24Locked
Kidney Damage: Drug-Induced24Locked
Liver Damage: Drug-Induced24Locked
Morphine Tolerance/Dependence24Locked
Prenatal Chemical Exposures24Locked
Hearing Loss13Locked
Alcohol Toxicity 12Locked
Breast Cancer: Triple Negative 12Locked
Cognitive Decline/Dysfunction12Locked
Dysbiosis12Locked
Head and Neck Cancer12Locked
Hyperalgesia12Locked
Neuropathic Pain12Locked
Postoperative Recovery12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Acute Myeloid Leukemia11Locked
Breast Cancer Stem Cells11Locked
Breast Cancer: Drug Resistant11Locked
2 Adverse Pharmacological Actions Researched for Morphine
NameACCKFocus
Immunosuppressive12Locked
Inflammatory12Locked

View the Evidence:
40 Abstracts with Morphine Research

[+]

Association of opioid use in the week before death among patients with advanced lung cancer having sepsis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Control. 2019 Jan-Dec;26(1):1073274819871326. PMID: 31452400
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Cancer Mortality, Lung Cancer, Sepsis
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

Night-time sleep disturbance is common in individuals suffering from chronic pain and may be further exacerbated by opioid treatment.Aug 21, 2016

Pubmed Data : Anaesthesia. 2016 Aug 22. Epub 2016 Aug 22. PMID: 27545291
Article Published Date : Aug 21, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Pain, Sleep Disorders
Problem Substances : Morphine
[+]

Pruritus after intrathecal morphine for cesarean delivery: incidence, severity and its relation to serum serotonin level.Feb 15, 2018

Pubmed Data : Int J Obstet Anesth. 2018 Feb 16. Epub 2018 Feb 16. PMID: 29544720
Article Published Date : Feb 15, 2018
Study Type : Human Study
Additional Links
Diseases : Pruritus
Problem Substances : Morphine
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These results indicate that atrial fibrillation incidence is associated with morphine treatment.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2016 Mar ;95(11):e3102. PMID: 26986153
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

Exposure of NK cells to morphine decreased their ability to induce apoptosis in K562 cells.Oct 14, 2019

Pubmed Data : Brain Behav Immun. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31626971
Article Published Date : Oct 14, 2019
Study Type : Human In Vitro
Additional Links
Diseases : Cancers: All, Leukemia: Acute myelogenous leukemia (AML)
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

A 52-year-old man developed tinnitus and hearing loss after receiving high doses of oral morphine sulfate.Nov 14, 2016

Pubmed Data : Am J Health Syst Pharm. 2016 Nov 15 ;73(22):1840-1843. PMID: 27821396
Article Published Date : Nov 14, 2016
Study Type : Human: Case Report
Additional Links
Diseases : Hearing Loss
Problem Substances : Morphine
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antioxidant effect of thymoquinone could protect damage of liver parameters against morphine toxicity.Dec 31, 2017

Pubmed Data : Int J Prev Med. 2018 ;9:8. Epub 2018 Jan 29. PMID: 29441185
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Morphine
[+]

B. monnieri having strong antioxidant activity exerted a protective effect against morphine induced cerebellar toxicity.Oct 31, 2017

Pubmed Data : Pak J Pharm Sci. 2017 Nov ;30(6):2067-2074. PMID: 29175775
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Bacopa
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Morphine
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Bacopa monnieri may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2016 Feb ;2(2):e00068. Epub 2016 Feb 15. PMID: 27441247
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Morphine
[+]

Crocin administration could protect the liver damage induced by morphine.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2016 Mar-Apr;11(2):120-9. PMID: 27168751
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Morphine
[+]

Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats.Oct 31, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov ;392(11):1383-1391. Epub 2019 Jun 24. PMID: 31236657
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Problem Substances : Morphine
[+]

Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice.Jun 30, 2005

Pubmed Data : Pharmazie. 2005 Jul ;60(7):539-43. PMID: 16076083
Article Published Date : Jun 30, 2005
Study Type : Animal Study
Additional Links
Substances : Luteolin, Verbascoside
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Heroin, Morphine
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Genistein administration could increase the quality of spermatozoa and prevent morphine- induced adverse effects on sperm parameters.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Reprod Biomed (Yazd). 2016 Feb ;14(2):95-102. PMID: 27200423
Article Published Date : Jan 31, 2016
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Infertility: Male
Pharmacological Actions : Spermatogenic
Problem Substances : Morphine
[+]

Genistein administration might improve liver damages induced by morphine in mice.Jul 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med J (Engl). 2018 Jul 5 ;131(13):1598-1604. PMID: 29941714
Article Published Date : Jul 04, 2018
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Problem Substances : Morphine
[+]

Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Apr ;13(4):1584-1591. Epub 2017 Feb 2. PMID: 28413513
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Morphine Tolerance/Dependence
Problem Substances : Morphine
[+]

Improvement of Petroselinum crispum on morphine toxicity in prefrontal cortex in rats. Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Appl Basic Med Res. 2020 Apr-Jun;10(2):110-116. Epub 2020 Apr 2. PMID: 32566527
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Parsley
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Morphine
[+]

Korean traditional music suppresses morphine-seeking behaviour via GABA receptor pathway.Apr 30, 2018

Pubmed Data : Neurosci Lett. 2018 May 1 ;674:81-87. Epub 2018 Mar 17. PMID: 29559416
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Diseases : Morphine Tolerance/Dependence
Problem Substances : Morphine
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Low dose of morphine may lead to chemoresistance of cisplatin in NPC models in vitro and in vivo.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:18706. Epub 2016 Jan 5. PMID: 26729257
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Additional Keywords : Chemoresistance
Problem Substances : Morphine
[+]

Melatonin is a potential means for countering hyperalgesia induced by neonatal morphine exposure in young and adult rats.Aug 17, 2016

Pubmed Data : Neurosci Lett. 2016 Aug 18. Epub 2016 Aug 18. PMID: 27546822
Article Published Date : Aug 17, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Hyperalgesia
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Morphine
[+]

Morphine at clinical relevant doses promotes angiogenesis and increases breast cancer progression.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2015 ;2015:161508. Epub 2015 May 3. PMID: 26064880
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Additional Keywords : Risk Factors
Problem Substances : Morphine
[+]

Morphine can inhibit dendritic cell-mediated anti-tumor immunity by suppressing DC maturation and function.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2016 ;6(2):157-72. Epub 2016 Jan 15. PMID: 27186393
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Breast Cancer, Head and Neck Cancer, Lung Cancer
Problem Substances : Morphine
Adverse Pharmacological Actions : Immunosuppressive
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Morphine does not affect the onset of tumour development, but it promotes growth of existing tumours, and reduces overall survival in mice.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Anaesth. 2014 Jul ;113 Suppl 1:i4-13. Epub 2014 May 26. PMID: 24861561
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.Feb 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Feb 26 ;8(1):3596. Epub 2018 Feb 26. PMID: 29483538
Article Published Date : Feb 25, 2018
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis
Problem Substances : Morphine
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Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.May 30, 2016

Pubmed Data : Proc Natl Acad Sci U S A. 2016 May 31. Epub 2016 May 31. PMID: 27247388
Article Published Date : May 30, 2016
Study Type : Animal Study
Additional Links
Diseases : Neuropathic Pain
Problem Substances : Morphine
Adverse Pharmacological Actions : Inflammatory
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Morphine promotes the angiogenesis of postoperative recurrent tumors and metastasis of dormant breast cancer cells.Sep 05, 2019

Pubmed Data : Pharmacology. 2019 Sep 6:1-11. Epub 2019 Sep 6. PMID: 31494660
Article Published Date : Sep 05, 2019
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer, Cancer Metastasis
Additional Keywords : Increased Risk
Problem Substances : Morphine
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P. dactylifera extract has a protective effect against the adverse effects of morphine on the male rat reproductive organs.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Res Med Sci. 2020 ;25:20. Epub 2020 Feb 20. PMID: 32174992
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Dates
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Cytoprotective
Problem Substances : Morphine
[+]

The data revealed that the endogenous opioid system may be altered in the offspring of morphine-treated parent.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2019 ;18:1019-1036. Epub 2019 Nov 5. PMID: 31762726
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Transgenerational inheritance
Problem Substances : Morphine
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The effect of morphine might be transmitted to the next generation even after stop consuming morphine.Jan 16, 2020

Pubmed Data : Brain Res Bull. 2020 Jan 17 ;156:141-149. Epub 2020 Jan 17. PMID: 31958477
Article Published Date : Jan 16, 2020
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures
Additional Keywords : Transgenerational inheritance
Problem Substances : Morphine
[+]

The results suggest that the ginger extract can reduce morphine-induced neuroinflammation.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Addict Health. 2019 Apr ;11(2):66-72. PMID: 31321003
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Morphine
[+]

These results suggest that alcohol, morphine, and morphine+alcohol co-treatment may trigger cognitive deficits and inflammatory responses in the brain.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Cell Biol. 2018 Mar ;51(1):41-51. Epub 2018 Mar 28. PMID: 29644109
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity , Brain Inflammation
Problem Substances : Morphine
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These studies indicate the morphine can have a deleterious effect on postoperative pain.Mar 26, 2018

Pubmed Data : Anesth Analg. 2018 Mar 27. Epub 2018 Mar 27. PMID: 29596097
Article Published Date : Mar 26, 2018
Study Type : Animal Study
Additional Links
Diseases : Chronic Pain, Postoperative Recovery
Problem Substances : Morphine
[+]

Thymoquinone can improve the apoptotic effects induced by morphine in the heart tissue of mice.Jun 29, 2018

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2018 Jun 30 ;64(9):33-38. Epub 2018 Jun 30. PMID: 30030951
Article Published Date : Jun 29, 2018
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
Problem Substances : Morphine
[+]

Thymoquinone could increase the quality some of spermatozoa and improves morphine-induced adverse effects on reproductive parameters in male mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Biomed Res. 2018 ;7:18. Epub 2018 Jan 30. PMID: 29456989
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Infertility: Male
Problem Substances : Morphine
[+]

Thymoquinone could protect of the kidneys against damage due to morphine toxicity.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Kidney Dis. 2017 Mar ;11(2):142-150. PMID: 28270647
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Nitric Oxide Inhibitor, Renoprotective
Problem Substances : Morphine
[+]

Accumulating evidence suggests that morphine can affect proliferation and migration of tumor cells as well as angiogenesis.Aug 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2011 Sep ;384(3):221-30. Epub 2011 Jul 29. PMID: 21800094
Article Published Date : Aug 31, 2011
Study Type : Review
Additional Links
Diseases : Cancer Metastasis, Cancers: All
Problem Substances : Morphine
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Morphine activates blast-phase chronic myeloid leukemia cells and alleviates the effects of tyrosine kinase inhibitors.Dec 09, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Dec 10 ;520(3):560-565. Epub 2019 Oct 12. PMID: 31615652
Article Published Date : Dec 09, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Acute Myeloid Leukemia
Additional Keywords : Increased Risk
Problem Substances : Morphine
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Morphine has a potential causal relationship with angiogenesis and metastasis.Jun 25, 2016

Pubmed Data : Pain Med. 2016 Jun 26. Epub 2016 Jun 26. PMID: 27346886
Article Published Date : Jun 25, 2016
Study Type : Review
Additional Links
Diseases : Cancer Metastasis
Additional Keywords : Risk Factors
Problem Substances : Morphine
[+]

Morphine may be harmful in patients with angiogenesis-dependent cancers.Oct 14, 2019

Pubmed Data : Clin Exp Pharmacol Physiol. 2019 Oct 15. Epub 2019 Oct 15. PMID: 31612523
Article Published Date : Oct 14, 2019
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All
Additional Keywords : Increased Risk
Problem Substances : Morphine
[+]

Prolonged morphine exposure may result in increased cell migration into the central nervous system.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(6). Epub 2016 Jun 9. PMID: 27294916
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Additional Keywords : Blood Brain Barrier, Risk Factors
Problem Substances : Morphine
[+]

This study found that morphine contributes to chemoresistance via expanding the population of cancer stem cells and promotes tumor growth.Feb 27, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Feb 28 ;6(6):3963-76. PMID: 25686831
Article Published Date : Feb 27, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Drug Resistant, Breast Cancer Stem Cells
Additional Keywords : Cancer Stem Cells
Problem Substances : Morphine

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A new study has found that acupuncture, the ancient practice of using needles to stimulate bodily self healing, is more effective than intravenous morphine for pain.
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Prescription drugs kill nearly fifteen times as many Americans per year than the casualty toll of domestic terrorist attacks from over thirteen years combined, but still natural alternatives are suppressed and maligned despite a growing body of evidence supporting their far greater safety and efficacy

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