Histamine Receptor Antagonists

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16 Diseases Researched for Histamine Receptor Antagonists

Name	AC	CK
Clostridium Infections	3	30
Pneumonia	3	30
Acid Reflux	2	20
Diarrhea	2	20
Gastroesophageal Reflux	2	12
Bacterial Infections and Mycoses	1	10
Childhood Infections	1	10
Drug-Induced Nutrient Depletion: Vitamin B-12	1	10
Elderly: Age Specific Diseases	1	10
Gastroenteritis	1	10
Infection: In Infants & Children	1	10
Low Immune Function: Natural Killer Cells	1	10
Osteoporosis	1	10
Vitamin B 12 Deficiency	1	10
Gastric Cancer	2	4
Infertility: Female	1	2

3 Adverse Pharmacological Actions Researched for Histamine Receptor Antagonists

Name	AC	CK
Immunosuppressive	6	60
Carcinogenic	1	2
Endocrine Disruptor	1	2

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

View the Evidence:
12 Abstracts with Histamine Receptor Antagonists Research

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[+]

Acid-suppressing drug use substantially increased the likelihood of recurrent pneumonia in high-risk elderly patients. Jan 01, 2010

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Pubmed Data : Am J Med. 2010 Jan;123(1):47-53. PMID: 20102991

Article Published Date : Jan 01, 2010

Study Type : Human Study

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Diseases : Elderly: Age Specific Diseases, Pneumonia

Problem Substances : Histamine Receptor Antagonists

Adverse Pharmacological Actions : Immunosuppressive

[+]

Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia.Oct 27, 2004

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Pubmed Data : JAMA. 2004 Oct 27;292(16):1955-60. PMID: 15507580

Article Published Date : Oct 27, 2004

Study Type : Human Study

Additional Links

Diseases : Pneumonia

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Immunosuppressive

[+]

Increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial C difficile infection. May 10, 2010

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Pubmed Data : Arch Intern Med. 2010 May 10;170(9):784-90. PMID: 20458086

Article Published Date : May 10, 2010

Study Type : Human Study

Additional Links

Diseases : Bacterial Infections and Mycoses, Clostridium Infections

Problem Substances : Histamine Receptor Antagonists

Adverse Pharmacological Actions : Immunosuppressive

[+]

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.Jul 06, 2004

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Pubmed Data : CMAJ. 2004 Jul 6;171(1):33-8. PMID: 15238493

Article Published Date : Jul 06, 2004

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections, Diarrhea

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Immunosuppressive

[+]

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.Jul 01, 2010

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Pubmed Data : Gastroenterology. 2010 Jul;139(1):93-101. Epub 2010 Mar 27. PMID: 20353792

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Diseases : Acid Reflux, Gastroesophageal Reflux, Osteoporosis

Problem Substances : Histamine Receptor Antagonists

[+]

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

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Pubmed Data : Gastroenterol Clin Biol. 1983 Apr ;7(4):381-4. PMID: 6135642

Article Published Date : Apr 01, 1983

Study Type : Human Study

Additional Links

Substances : Vitamin B-12

Diseases : Acid Reflux, Drug-Induced Nutrient Depletion: Vitamin B-12, Vitamin B 12 Deficiency

Pharmacological Actions : Anti-Ulcer Agents

Problem Substances : Histamine Receptor Antagonists, Ranitidine

[+]

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.Dec 21, 2005

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Pubmed Data : JAMA. 2005 Dec 21;294(23):2989-95. PMID: 16414946

Article Published Date : Dec 21, 2005

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections, Diarrhea, Low Immune Function: Natural Killer Cells

Problem Substances : Antacids: Aluminium-Containing, Histamine Receptor Antagonists, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Adverse Pharmacological Actions : Immunosuppressive

[+]

Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.May 01, 2006

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Pubmed Data : Pediatrics. 2006 May;117(5):e817-20. PMID: 16651285

Article Published Date : May 01, 2006

Study Type : Human Study

Additional Links

Diseases : Childhood Infections, Gastroenteritis, Infection: In Infants & Children , Pneumonia

Additional Keywords : Drug: Omeprazole

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Immunosuppressive

[+]

Acid blockers (H2 receptor blockers) have anti-ovulatory activity in rabbits. Apr 01, 2011

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Pubmed Data : Eur J Contracept Reprod Health Care. 2011 Apr;16(2):142-6. Epub 2011 Jan 31. PMID: 21281096

Article Published Date : Apr 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Gastroesophageal Reflux, Infertility: Female

Problem Substances : Acid Blockers, Histamine Receptor Antagonists

Adverse Pharmacological Actions : Endocrine Disruptor

[+]

Histamine receptor antagonists and proton pump inhibitors cause gastric hyperplasia and cancer in rats.Jan 01, 1988

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Pubmed Data : Toxicol Pathol. 1988;16(2):288-98. PMID: 2903544

Article Published Date : Jan 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Additional Keywords : Drug: Omeprazole

Problem Substances : Histamine Receptor Antagonists, Omeprazole (trade name Prilosec), Proton-Pump Inhibitors

[+]

Long-acting inhibitors of gastric acid secretion may result in endocrine cell hyperplasia and cancer in the gastric mucosa.Oct 01, 1990

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Pubmed Data : Eur J Clin Invest. 1990 Oct;20 Suppl 1:S65-71. PMID: 2125000

Article Published Date : Oct 01, 1990

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Carcinogenic

[+]

There are a number of risks associated with long-term acid blocking treatment.Feb 01, 2010

Click here to read the entire abstract

Pubmed Data : Vnitr Lek. 2010 Feb;56(2):115-9. PMID: 20329581

Article Published Date : Feb 01, 2010

Study Type : Commentary

Additional Links

Problem Substances : Histamine Receptor Antagonists

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

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Histamine Receptor Antagonists is a Sub of the following Topic

View the Evidence: 12 Abstracts with Histamine Receptor Antagonists Research

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Currently Available Sorting Options

Acid-suppressing drug use substantially increased the likelihood of recurrent pneumonia in high-risk elderly patients. Jan 01, 2010

Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia.Oct 27, 2004

Increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial C difficile infection. May 10, 2010

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.Jul 06, 2004

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.Jul 01, 2010

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.Dec 21, 2005

Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.May 01, 2006

Acid blockers (H2 receptor blockers) have anti-ovulatory activity in rabbits. Apr 01, 2011

Histamine receptor antagonists and proton pump inhibitors cause gastric hyperplasia and cancer in rats.Jan 01, 1988

Long-acting inhibitors of gastric acid secretion may result in endocrine cell hyperplasia and cancer in the gastric mucosa.Oct 01, 1990

There are a number of risks associated with long-term acid blocking treatment.Feb 01, 2010

Histamine Receptor Antagonists Related Articles

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Histamine Receptor Antagonists

View the Evidence:
12 Abstracts with Histamine Receptor Antagonists Research