Bisphosphonates

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45 Diseases Researched for Bisphosphonates
NameACCKFocus
Osteonecrosis787Locked
Osteoporosis1482Locked
Gastric Ulcer866Locked
Osteopetrosis260Locked
Atrial Fibrillation340Locked
Drug-Induced Toxicity: Gastrointestinal331Locked
Kidney Damage: Drug-Induced330Locked
Drug-Induced Toxicity 223Locked
Bone Fractures422Locked
Prostate Cancer221Locked
Kidney Damage214Locked
Breast Cancer313Locked
Esophageal Cancer211Locked
Acid Reflux110Locked
Acidosis110Locked
Cystic Fibrosis110Locked
Drug-Induced Toxicity: L-Thyroxine110Locked
Duodenal Ulcer110Locked
Esophageal Diseases110Locked
Esophagitis110Locked
Kidney Diseases110Locked
Kidney Failure: Chronic110Locked
Multiple Myeloma110Locked
Subtrochanteric stress fractures110Locked
Osteopenia15Locked
Mevalonate Pathway Enzyme Disorders14Locked
Hypocalcemia13Locked
Chemically-Induced Liver Damage12Locked
Oxidative Stress12Locked
Periodontal Wound Healing12Locked
Cachexia: Cancer11Locked
Cancer Metastasis11Locked
Cancers: All11Locked
Colon Cancer11Locked
Conjunctival Diseases11Locked
Conjunctivitis11Locked
Dry Eye Syndromes11Locked
Esophageal Ulcer11Locked
Gastric Cancer11Locked
Gastrointestinal Diseases11Locked
Oral Cancer11Locked
Oral Ulceration: Drug-Induced11Locked
Prostate Cancer: Bone Metastatic11Locked
Squamous cell carcinoma11Locked
Vitamin D Deficiency11Locked
9 Adverse Pharmacological Actions Researched for Bisphosphonates
NameACCKFocus
Ulcerogenic873Locked
Gastrotoxic230Locked
Nephrotoxic226Locked
Corrosive110Locked
Cytotoxic26Locked
Mevalonate Pathway Enzyme Inhibitors14Locked
Hepatotoxic12Locked
Oxidant12Locked
Apoptotic11Locked
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View the Evidence:
64 Abstracts with Bisphosphonates Research

[+]

42.4% of those who receive intravenous zoledronic acid experience adverse events of mild to moderate severity.Sep 01, 2010

Pubmed Data : J Clin Endocrinol Metab. 2010 Sep;95(9):4380-7. Epub 2010 Jun 16. PMID: 20554708
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates, Zoledronic Acid
[+]

Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

Pubmed Data : Arch Intern Med. 2001 Jan 8;161(1):107-10. PMID: 11146706
Article Published Date : Jan 08, 2001
Study Type : Human Study
Additional Links
Diseases : Duodenal Ulcer, Gastric Ulcer
Additional Keywords : Toxic Drug Synergy
Problem Substances : Alendronate (trade name Fosamax) , Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendronate has been associated with esophageal injury in users.Dec 01, 1999

Pubmed Data : Mod Pathol. 1999 Dec;12(12):1152-7. PMID: 10619269
Article Published Date : Dec 01, 1999
Study Type : Human Study
Additional Links
Diseases : Esophageal Cancer, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Pubmed Data : Aliment Pharmacol Ther. 2000 Nov;14(11):1451-7. PMID: 11069316
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
[+]

Alendronate therapy is assoaciated with an emerging pattern of increasingly prevalent subtrochanteric stress fractures. Feb 01, 2008

Pubmed Data : Injury. 2008 Feb;39(2):224-31. Epub 2008 Jan 28. PMID: 18222447
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Problem Substances : Alendronate (trade name Fosamax)
[+]

Alendronate use is associated with an increased risk for atrial fibrillation in women. Apr 28, 2008

Pubmed Data : Arch Intern Med. 2008 Apr 28;168(8):826-31. PMID: 18443257
Article Published Date : Apr 28, 2008
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
[+]

Alendronate use is associated with low-energy femoral shaft fractures. May 01, 2008

Pubmed Data : J Orthop Trauma. 2008 May-Jun;22(5):346-50. PMID: 18448990
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax)
[+]

Alendronate users have an increased rate of esophageal and gastric events.Sep 01, 2000

Pubmed Data : Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):371-6. PMID: 19025842
Article Published Date : Sep 01, 2000
Study Type : Human Study
Additional Links
Diseases : Esophageal Diseases, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Bisphophonate use is associated with gastrointestinal toxicity and osteonecrosis.Dec 01, 2008

Pubmed Data : Curr Opin Endocrinol Diabetes Obes. 2008 Dec;15(6):508-13. PMID: 18971679
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
[+]

Bisphosphonate exposure was significantly associated with risk of atrial fibrillation serious adverse events in a meta-analysis of four trial datasets. Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(3):219-28. PMID: 19338379
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use in chronic kidney disease is associated wtih adynamic bone disease.Jan 01, 2010

Pubmed Data : Blood Purif. 2010;29(3):293-9. Epub 2010 Jan 21. PMID: 20090316
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Kidney Diseases, Kidney Failure: Chronic, Osteoporosis
Additional Keywords : Diseases that are Linked
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use in early breast cancer does not appeasr to reduce the number of fractures. Jan 08, 2010

Pubmed Data : Gynecol Oncol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061004
Article Published Date : Jan 08, 2010
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Breast Cancer
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use is associated with a significant increase in the risk of serious atrial fibrillation in postmenopausal women.Jan 03, 2010

Pubmed Data : Int J Cardiol. 2010 Jan 3. Epub 2010 Jan 3. PMID: 20051297
Article Published Date : Jan 03, 2010
Study Type : Human Study
Additional Links
Diseases : Atrial Fibrillation
Problem Substances : Alendronate (trade name Fosamax)
[+]

Bisphosphonate use is associated with an increased risk of deep venous thromboembolism and pulmonary embolism.Oct 27, 2009

Pubmed Data : Osteoporos Int. 2009 Oct 27. Epub 2009 Oct 27. PMID: 19859641
Article Published Date : Oct 27, 2009
Study Type : Human Study
Additional Links
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use is associated with osteonecrosis of the jaw. Sep 01, 2009

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Sep;108(3):e1-8. Epub 2009 Jul 1. PMID: 19570696
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
[+]

Bisphosphonate use may cause osteopetrosis.Oct 01, 2008

Pubmed Data : J Bone Miner Res. 2008 Oct;23(10):1698-707. PMID: 18505375
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Osteopetrosis
Problem Substances : Bisphosphonates, Pamidronate
[+]

Bisphosphonates are less effective in women receiving TSH-suppressing doses of thyroxine.May 01, 2009

Pubmed Data : Thyroid. 2009 May;19(5):437-42. PMID: 19415993
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: L-Thyroxine
Problem Substances : Alendronate (trade name Fosamax) , Thyroxine
[+]

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Pubmed Data : Am J Gastroenterol. 1997 Aug;92(8):1322-5. PMID: 9260798
Article Published Date : Aug 01, 1997
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate
Adverse Pharmacological Actions : Gastrotoxic, Ulcerogenic
[+]

Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws. Nov 01, 2005

Pubmed Data : J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75. PMID: 16243172
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis, Osteopetrosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate, Zoledronic Acid
[+]

Bisphosphonates used for osteoporosis in patients with cystic fibrosis increases bone mineral density without increasing bone quality/strength, while causing bone pain and flu-like symptoms. Jan 01, 2009

Pubmed Data : Cochrane Database Syst Rev. 2009(4):CD002010. Epub 2009 Oct 7. PMID: 19821288
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Cystic Fibrosis, Osteoporosis
Problem Substances : Bisphosphonates
[+]

Esophagitis associated with use of alendronate has been reported in postmenopausic patients.May 01, 2001

Pubmed Data : Acta Gastroenterol Latinoam. 2001 May;31(2):59-63. PMID: 11471319
Article Published Date : May 01, 2001
Study Type : Human Study
Additional Links
Diseases : Esophagitis
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Corrosive, Ulcerogenic
[+]

Long-term oral bisphosphonate therapy may result in excessive suppression of bone turnover in postmenopausal osteoporotic patients. Aug 01, 2008

Pubmed Data : Climacteric. 2008 Aug;11(4):287-95. PMID: 18645694
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Additional Keywords : Turned to Stone
Problem Substances : Bisphosphonates
[+]

Long-term use of bisphosphonates is assocated with low-energy femoral fractures. Jan 01, 2009

Pubmed Data : Drug Saf. 2009;32(9):775-85. PMID: 19670917
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Bisphosphonates
[+]

Patients on long-term alendronate therapy have been reported to experience bilateral low-energy simultaneous or sequential femoral fractures. Nov 01, 2009

Pubmed Data : J Bone Joint Surg Am. 2009 Nov;91(11):2556-61. PMID: 19884427
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Problem Substances : Alendronate (trade name Fosamax)
[+]

Pill-induced esophageal injury is a common occurence.Aug 01, 2005

Pubmed Data : Endoscopy. 2005 Aug;37(8):740-4. PMID: 16032493
Article Published Date : Aug 01, 2005
Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity
Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Bisphosphonates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Potassium Chloride
[+]

Subtrochanteric stress fractures in patients on oral bisphosphonate therapy is an emerging problem. Oct 01, 2011

Pubmed Data : Acta Orthop Belg. 2011 Oct ;77(5):632-7. PMID: 22187839
Article Published Date : Oct 01, 2011
Study Type : Human Study
Additional Links
Diseases : Bone Fractures, Subtrochanteric stress fractures
Problem Substances : Bisphosphonates
[+]

The pathogenesis of bisphosphonate-related osteonecrosis of the jaw may be due to local tissue acidosis in the jaw.May 01, 2010

Pubmed Data : J Oral Maxillofac Surg. 2010 May;68(5):1158-61. PMID: 20138420
Article Published Date : May 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acidosis, Osteonecrosis
Additional Keywords : Diseases that are Linked
Problem Substances : Bisphosphonates
[+]

The prolonged use of alendronate has been reported to be the cause of non-traumatic femoral shaft fracture. Dec 01, 2007

Pubmed Data : Hong Kong Med J. 2007 Dec;13(6):485-9. PMID: 18057440
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
[+]

Treatment with proton pump inhibitors increases the rate of subsequent treatment with anti-osteoporotic drugs.Jul 01, 2010

Pubmed Data : Pharmacoepidemiol Drug Saf. 2010 Jul;19(7):763-9. PMID: 20582909
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Diseases : Acid Reflux, Osteoporosis
Additional Keywords : Downward Spiral of Drug Treatment
Problem Substances : Bisphosphonates
[+]

Use of intravenous bisphosphanates can lead to bisphosphonate-induced necrosis of Jaw (BINJ) which may mimic malignancy or metastasis. Jan 11, 2010

Pubmed Data : Eur J Surg Oncol. 2010 Jan 11. Epub 2010 Jan 11. PMID: 20071132
Article Published Date : Jan 11, 2010
Study Type : Human Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates
[+]

Zoledronic acid may cause renal toxicity in 37.7% of patients with multiple myeloma. Jan 01, 2010

Pubmed Data : J Cancer Res Ther. 2010 Jan-Mar;6(1):31-5. PMID: 20479544
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Kidney Damage, Multiple Myeloma
Problem Substances : Zoledronic Acid
[+]

Zolendronic acid has been associated with hand ostearthritis and arthralgia. Nov 21, 2009

Pubmed Data : Osteoporos Int. 2009 Nov 21. Epub 2009 Nov 21. PMID: 19936866
Article Published Date : Nov 21, 2009
Study Type : Human Study
Additional Links
Problem Substances : Zoledronic Acid
[+]

Zolendronic acid results in renal impairment in 23,8% of the prostate cancer patients it is administered to.Mar 15, 2007

Pubmed Data : Cancer. 2007 Mar 15;109(6):1090-6. PMID: 17311345
Article Published Date : Mar 15, 2007
Study Type : Human Study
Additional Links
Diseases : Kidney Damage: Drug-Induced, Prostate Cancer
Problem Substances : Bisphosphonates, Zoledronic Acid
Adverse Pharmacological Actions : Nephrotoxic
[+]

A case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma has been reported.Jan 01, 2009

Pubmed Data : Nippon Jinzo Gakkai Shi. 2009;51(5):557-62. PMID: 19715164
Article Published Date : Jan 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Kidney Damage: Drug-Induced
Additional Keywords : Drug: Doxorubicin
Problem Substances : Bisphosphonates, Dexamethasone, Zoledronic Acid
Adverse Pharmacological Actions : Nephrotoxic
[+]

Jaw avascular osteonecrosis after treatment of multiple myeloma with zoledronate has been reported.Jan 01, 2008

Pubmed Data : J Plast Reconstr Aesthet Surg. 2008;61(1):99-106. Epub 2006 Sep 12. PMID: 18068658
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Osteonecrosis
Problem Substances : Bisphosphonates, Zoledronic Acid
[+]

Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid has been reported.Oct 01, 2010

Pubmed Data : Hormones (Athens). 2010 Oct;9(4):338-42. PMID: 21112866
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Toxicity , Hypocalcemia
Problem Substances : Zoledronic Acid
[+]

Alendronate impairs the healing of gastric ulcers in rats.Aug 01, 2007

Pubmed Data : Dig Dis Sci. 2007 Aug;52(8):1879-89. Epub 2007 Apr 5. PMID: 17410434
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Gastric Ulcer
Additional Keywords : Drug: Indomethacin
Problem Substances : Alendronate (trade name Fosamax)
[+]

Alendronate induces antral ulcers in rat stomachs, resulting in severe edema and neutrophil infiltration in the submucosa.Sep 01, 2009

Pubmed Data : J Physiol Pharmacol. 2009 Sep;60(3):85-93. PMID: 19826186
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Diseases : Gastric Ulcer, Oxidative Stress
Problem Substances : Alendronate (trade name Fosamax)
[+]

Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs. Oct 01, 2007

Pubmed Data : Inflammopharmacology. 2007 Oct;15(5):196-202. PMID: 17943251
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Gastric Ulcer
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Bisphosphonates do not improve bone material characteristics such as tissue strength, elastic modulus, and cortical toughness in an animal model of osteoporosis. Nov 26, 2009

Pubmed Data : Bone. 2009 Nov 26. PMID: 19931661
Article Published Date : Nov 26, 2009
Study Type : Animal Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Bisphosphonates
[+]

Prolonged use of bisphophonates may lead to excess mineralization, resulting in microcracks that interfere with bone quality/strength. Jan 01, 2007

Pubmed Data : Joint Bone Spine. 2007 Jan;74(1):39-47. Epub 2006 Nov 28. PMID: 17196423
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Risedronate
[+]

The combination of CS plus metronomic ZOL demonstrated significant antitumor, anti-metastatic and anti-osteolytic effects against breast cancerMay 19, 2015

Pubmed Data : Oncol Rep. 2015 May 20. Epub 2015 May 20. PMID: 25998578
Article Published Date : May 19, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Natural Substance/Drug Synergy
Problem Substances : Zoledronic Acid
[+]

Zolendronic acid causes oxidative stress in the rabbit liver.Nov 01, 2010

Pubmed Data : Transplant Proc. 2010 Nov;42(9):3820-2. PMID: 21094863
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Chemically-Induced Liver Damage
Problem Substances : Zoledronic Acid
Adverse Pharmacological Actions : Hepatotoxic, Oxidant
[+]

"Bisphosphonate stimulation of osteoblasts and osteoblastic metastasis as a mechanism of hypocalcaemia."Dec 27, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Hypotheses. 2011 Dec 27. Epub 2011 Dec 27. PMID: 22206806
Article Published Date : Dec 27, 2011
Study Type : Commentary
Additional Links
Diseases : Cancer Metastasis, Prostate Cancer, Prostate Cancer: Bone Metastatic
Problem Substances : Bisphosphonates
[+]

A placebo-controlled trial of primary prevention involving more than 4,000 patients showed no reduction in the risk of fracture after 4 years of treatment with alendronic acid.Jun 01, 2000

Pubmed Data : Prescrire Int. 2000 Jun;9(47):70-2. PMID: 11010741
Article Published Date : Jun 01, 2000
Study Type : Review
Additional Links
Diseases : Bone Fractures, Osteoporosis
Additional Keywords : Drugs that Don't Work
Problem Substances : Alendronate (trade name Fosamax)
[+]

Alendoronate has been reported to cause esophageal ulceration.Apr 01, 2001

Pubmed Data : Arq Gastroenterol. 2001 Apr-Jun;38(2):129-31. PMID: 11793943
Article Published Date : Apr 01, 2001
Study Type : Commentary
Additional Links
Diseases : Esophageal Ulcer, Gastric Cancer, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax)
Adverse Pharmacological Actions : Ulcerogenic
[+]

Bisphosphonates are associated with a wide range of adverse health effects.Apr 01, 2009

Pubmed Data : Hormones (Athens). 2009 Apr-Jun;8(2):96-110. PMID: 19570737
Article Published Date : Apr 01, 2009
Study Type : Review
Additional Links
Diseases : Osteopenia, Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Ibandronate, Risedronate, Zoledronic Acid
[+]

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts - Article 2.Mar 01, 2008

Pubmed Data : Calcif Tissue Int. 2008 Mar;82(3):191-201. Epub 2008 Feb 8. PMID: 18259679
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate (trade name Aredia)
Adverse Pharmacological Actions : Cytotoxic
[+]

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts.Jul 01, 2008

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jul;106(1):5-13. Epub 2008 May 27. PMID: 18504149
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Osteoporosis
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Zoledronic Acid
Adverse Pharmacological Actions : Cytotoxic
[+]

Bisphosphonates inhibit oral mucosal cell wound healing.May 01, 2008

Pubmed Data : J Oral Maxillofac Surg. 2008 May;66(5):839-47. PMID: 18423269
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Periodontal Wound Healing
Problem Substances : Bisphosphonates, Pamidronate
[+]

Bisphosphonates may induce conjunctival irritation.Jan 01, 2007

Pubmed Data : Bull Soc Belge Ophtalmol. 2007(304):155-78. PMID: 17718241
Article Published Date : Jan 01, 2007
Study Type : Commentary
Additional Links
Diseases : Conjunctival Diseases, Conjunctivitis, Dry Eye Syndromes
Problem Substances : Bisphosphonates
[+]

Bisphosphonates may induce gastrointestinal damage through the inhibition of the mevalonate pathway.Oct 01, 2001

Pubmed Data : Bone. 2001 Oct;29(4):336-43. PMID: 11595616
Article Published Date : Oct 01, 2001
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Toxicity: Gastrointestinal, Gastrointestinal Diseases
Additional Keywords : Mevalonate Pathway Inhibition
Problem Substances : Bisphosphonates
Adverse Pharmacological Actions : Apoptotic
[+]

Bisphosphonates may interfere with mevalonate pathway enzymes. Jan 01, 2000

Pubmed Data : Arch Biochem Biophys. 2000 Jan 1;373(1):231-41. PMID: 10620343
Article Published Date : Jan 01, 2000
Study Type : In Vitro Study
Additional Links
Diseases : Mevalonate Pathway Enzyme Disorders
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Pamidronate, Risedronate
Adverse Pharmacological Actions : Mevalonate Pathway Enzyme Inhibitors
[+]

Bisphosphonates may result in skeletal harm when combined with anti-remodeling therapy. Aug 01, 2008

Pubmed Data : J Clin Endocrinol Metab. 2008 Aug;93(8):2948-52. Epub 2008 Jun 3. PMID: 18522980
Article Published Date : Aug 01, 2008
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates
[+]

Etidronate increases bone density without reducing non-vertebral fractures.Jan 01, 2006

Pubmed Data : Cochrane Database Syst Rev. 2006(1):CD003376. Epub 2007 Jul 18. PMID: 17636719
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Bone Fractures, Osteoporosis
Problem Substances : Bisphosphonates, Etidronate
[+]

Intravenous bisphosphonate use may cause culmulative toxicity, including some level of renal dysfunction.Jan 01, 2006

Pubmed Data : Support Cancer Ther. 2006 Jan 1;3(2):77-83. PMID: 18632443
Article Published Date : Jan 01, 2006
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates, Reclast
[+]

Long-term alendronate is associated with spontaneous femoral shaft fracture. Sep 01, 2009

Pubmed Data : Age Ageing. 2009 Sep;38(5):625-6. Epub 2009 Jun 25. PMID: 19556326
Article Published Date : Sep 01, 2009
Study Type : Commentary
Additional Links
Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates
[+]

Long-term bisphosphonate therapy may result in atypical insufficiency facture of the tibia. Feb 02, 2010

Pubmed Data : J Clin Rheumatol. 2010 Feb 2. Epub 2010 Feb 2. PMID: 20130483
Article Published Date : Feb 02, 2010
Study Type : Commentary
Additional Links
Problem Substances : Bisphosphonates
[+]

Potential chemotherapeutic effects of diosgenin on PE/CA-PJ15 oral squamous cancer cell line.Sep 30, 2017

Pubmed Data : Arch Oral Biol. 2017 Oct ;82:141-146. Epub 2017 Jun 19. PMID: 28641180
Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Diosgenin, EGCG (Epigallocatechin gallate)
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive
Problem Substances : Zoledronic Acid
[+]

Severe oral ulceration has occurred with the use of alendronate without inappropriate therapeutic administration of the medication.Jul 29, 2010

Pubmed Data : Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul 29. Epub 2010 Jul 29. PMID: 20674418
Article Published Date : Jul 29, 2010
Study Type : Commentary
Additional Links
Diseases : Oral Ulceration: Drug-Induced
Problem Substances : Alendronate (trade name Fosamax)
[+]

The mechanism behind bisphosphonate's supposedly therapeutic activity in bone may also underlie the mechanism of nephrotoxicity.Jun 01, 2008

Pubmed Data : Toxicol In Vitro. 2008 Jun;22(4):899-909. Epub 2008 Jan 26. PMID: 18325729
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Kidney Damage, Kidney Damage: Drug-Induced
Problem Substances : Bisphosphonates, Ibandronate, Pamidronate, Zoledronic Acid
[+]

There is a signal that oral bisphosphonates may increase the risk of esophageal cancer.Feb 29, 2012

Pubmed Data : Ann Pharmacother. 2012 Mar ;46(3):419-23. Epub 2012 Feb 14. PMID: 22333262
Article Published Date : Feb 29, 2012
Study Type : Review
Additional Links
Diseases : Esophageal Cancer
Problem Substances : Bisphosphonates
[+]

Vitamin D status should be monitored in all cancer patients and treated by adequate vitamin D3 supplementation. Nov 30, 2015

Pubmed Data : Med Monatsschr Pharm. 2015 Dec ;38(12):512-6. PMID: 26837159
Article Published Date : Nov 30, 2015
Study Type : Commentary
Additional Links
Substances : Vitamin D
Diseases : Breast Cancer, Cachexia: Cancer, Cancers: All, Colon Cancer, Vitamin D Deficiency
Additional Keywords : Risk Factors
Problem Substances : Aromatase Inhibitor Drugs, Bisphosphonates
[+]

Zolendronate is cytotoxic to human periodontal fibroblasts, which confirms its link to osteonecrosis. Jan 01, 2010

Pubmed Data : J Dent Res. 2010 Jan;89(1):40-5. PMID: 19948943
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Osteonecrosis
Problem Substances : Zoledronic Acid

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