Benzene

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31 Diseases Researched for Benzene
NameACCKFocus
Leukemia634Locked
Benzene Toxicity1033Locked
Leukemia: Acute myelogenous leukemia (AML) 431Locked
DNA damage625Locked
Chronic Myeloid Leukemia321Locked
Acute Myeloid Leukemia110Locked
Air Pollution Linked Toxicity110Locked
All-Cause Mortality110Locked
Atopic Disease110Locked
Breast Cancer110Locked
Cancer Mortality110Locked
Cardiac Mortality 110Locked
Endothelial Dysfunction110Locked
Hypertension110Locked
Infertility: Male110Locked
Leukemia: Monocytic110Locked
Lymphoma110Locked
Multiple Myeloma110Locked
Myelodysplastic Syndrome110Locked
Prenatal Chemical Exposures110Locked
Sick Building Syndrome110Locked
Smoking110Locked
Sperm Quality: Low110Locked
Oxidative Stress23Locked
Chemically-Induced Liver Damage12Locked
Dysbiosis12Locked
Leucopenia12Locked
Leukopenia12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Cancers: All11Locked
Hematologic Diseases11Locked
3 Adverse Pharmacological Actions Researched for Benzene
NameACCKFocus
Carcinogen110Locked
Carcinogenic110Locked
Hypertensive110Locked

View the Evidence:
37 Abstracts with Benzene Research

[+]

A broccoli seed and sprout extract significantly upregulated detoxification of the tobacco carcinogens benzene, acrolein, and crotonaldehyde.Apr 23, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2022 Apr 24 ;14(9). Epub 2022 Apr 24. PMID: 35565256
Article Published Date : Apr 23, 2022
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts
Diseases : Benzene Toxicity, Smoking
Pharmacological Actions : Detoxifier
Problem Substances : Benzene
[+]

Benzene and Aspergillus exposures are associated with sick building syndrome.Sep 15, 2009

Pubmed Data : Sci Total Environ. 2009 Sep 15;407(19):5223-8. Epub 2009 Jul 15. PMID: 19608217
Article Published Date : Sep 15, 2009
Study Type : Human Study
Additional Links
Diseases : Sick Building Syndrome
Problem Substances : Aspergillus, Benzene
[+]

Benzene exposure at below 1 part per million (1 ppm) causes hematotoxicity in exposed workers.Mar 19, 2010

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):86-93. Epub 2009 Dec 21. PMID: 20026094
Article Published Date : Mar 19, 2010
Study Type : Human Study
Additional Links
Diseases : DNA damage
Problem Substances : Benzene
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Benzene exposure in parts per billion has been shown to adversely effect DNA in a manner consisent with increased risk for lymphoma and leukemia.May 30, 2005

Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:75-83. Epub 2005 Apr 1. PMID: 15935802
Article Published Date : May 30, 2005
Study Type : Human Study
Additional Links
Diseases : DNA damage, Leukemia, Lymphoma
Problem Substances : Benzene
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Benzene exposure is associated with hypertension, possibly due to disturbance of nitric oxide process.Jul 01, 2007

Pubmed Data : Cardiovasc J Afr. 2007 Jul-Aug;18(4):264-5. PMID: 17940673
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction, Hypertension
Problem Substances : Benzene
Adverse Pharmacological Actions : Hypertensive
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Benzene exposure is associated with leukemia-associated changes in the peripheral blood lymphocytes of workers.Jan 07, 2011

Pubmed Data : Carcinogenesis. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216845
Article Published Date : Jan 07, 2011
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene
Adverse Pharmacological Actions : Carcinogen
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Benzene exposure near the US permissible limit is associated wtih sperm aneuploidy (chromosomal abnormality).Jan 06, 2010

Pubmed Data : Environ Health Perspect. 2010 Jan 6. Epub 2010 Jan 6. PMID: 20418200
Article Published Date : Jan 06, 2010
Study Type : Human Study
Additional Links
Diseases : Infertility: Male, Sperm Quality: Low
Problem Substances : Benzene
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Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.Feb 01, 2008

Pubmed Data : Cancer Causes Control. 2008 Feb;19(1):13-23. Epub 2007 Sep 29. PMID: 17906934
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML) , Multiple Myeloma
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

Electromagnetic fields have a greater influence on women with a predisposition to allergic responses who are exposed to toxic traffic emissions than women without predispostions to allergic responses.Jul 01, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ind Health. 2000 Jul ;38(3):294-300. PMID: 10943077
Article Published Date : Jul 01, 2000
Study Type : Human Study
Additional Links
Diseases : Atopic Disease
Additional Keywords : EMF
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation
Problem Substances : Benzene, Lead
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Exposure to toxic compounds from an oil spill is correlated with an increased risk of health effects among pregnant women. Mar 01, 2009

Pubmed Data : J Prev Med Public Health. 2009 Mar;42(2):96-103. PMID: 19349738
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Diseases : Prenatal Chemical Exposures
Problem Substances : Benzene, Crude Oil/Petroleum, Ethylbenzene, Toluene, Xylene
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Exposure to various chemicals is associated with increased risk for myelodysplastic syndrome according to the WHO.Feb 01, 2011

Pubmed Data : Am J Hematol. 2011 Feb;86(2):163-169. PMID: 21264898
Article Published Date : Feb 01, 2011
Study Type : Human Study
Additional Links
Diseases : Myelodysplastic Syndrome
Problem Substances : Benzene, Crude Oil/Petroleum, Herbicide, Pesticides, Tobacco: Smoking
[+]

Hazardous air pollutants and breast cancer risk in California teachers: a cohort study.Jan 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health. 2015 Jan 30 ;14(1):14. Epub 2015 Jan 30. PMID: 25636809
Article Published Date : Jan 29, 2015
Study Type : Human Study
Additional Links
Diseases : Breast Cancer
Problem Substances : Acrylamide , Benzene, Vinyl chloride
Adverse Pharmacological Actions : Carcinogenic
[+]

Long-term exposure to low-level ambient benzene significantly increases mortality risk in the general population.Dec 20, 2023

Pubmed Data : Am J Respir Crit Care Med. 2023 Dec 21. Epub 2023 Dec 21. PMID: 38128545
Article Published Date : Dec 20, 2023
Study Type : Human Study
Additional Links
Diseases : All-Cause Mortality, Cancer Mortality, Cardiac Mortality
Problem Substances : Benzene
[+]

Myeloid leukemia was associated with benzene, a nonspecific group of solvents, occupational pesticides, and working with or near powerlines.Nov 01, 2009

Pubmed Data : Ann Hematol. 2009 Nov ;88(11):1079-88. Epub 2009 Mar 18. PMID: 19294385
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Leukemia
Additional Keywords : EMF, RF-EMF and Cancers
Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation, Microwave Radiation
Problem Substances : Benzene, Pesticides
[+]

Offshore workers have a higher risk of acute myelogenous leukemia, probably due to benzene exposure.Oct 21, 2004

Pubmed Data : Tidsskr Nor Laegeforen. 2004 Oct 21;124(20):2627-9. PMID: 15534638
Article Published Date : Oct 21, 2004
Study Type : Human Study
Additional Links
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

Pathological protein adducts are associated with benzene and benzene metabolite exposures. May 30, 2005

Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:103-9. Epub 2005 Apr 9. PMID: 15935805
Article Published Date : May 30, 2005
Study Type : Human Study
Additional Links
Problem Substances : Benzene, Benzene Metabolites
[+]

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126
Article Published Date : Jul 03, 2019
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, Benzene Toxicity
Pharmacological Actions : Antioxidant Effects, Detoxifier
Additional Keywords : Airborne Pollution, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Dose Response, Environmental Pollutant, Environmental Pollution
Problem Substances : Airborne Pollution, Benzene
[+]

Workers exposed to petroleum products may have increased risk for certain leukemias, in part due to benzene exposure.Mar 01, 1997

Pubmed Data : Occup Environ Med. 1997 Mar;54(3):152-66. PMID: 9155776
Article Published Date : Mar 01, 1997
Study Type : Human Study
Additional Links
Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Monocytic
Problem Substances : Benzene, Crude Oil/Petroleum
[+]

An extract of moringa oleifera demonstrated chemopreventive and anti-leukemic activities as much as the standard anti-leukemic drug cyclophosphamide.Dec 31, 2013

Pubmed Data : Curr Pharm Biotechnol. 2014 ;15(6):563-8. PMID: 25051949
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Leukemia
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Benzene
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Antioxidant mechanism of diallyl sulfide in inhibiting leucopenia in peripheral blood induced by benzene.Oct 19, 2019

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2019 Oct 20 ;37(10):737-745. PMID: 31726503
Article Published Date : Oct 19, 2019
Study Type : Animal Study
Additional Links
Substances : Diallyl sulfide
Diseases : Benzene Toxicity, Leucopenia, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Problem Substances : Benzene
[+]

Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice.Feb 24, 2020

Pubmed Data : Sci Total Environ. 2020 Feb 25 ;705:135879. Epub 2019 Dec 2. PMID: 31972927
Article Published Date : Feb 24, 2020
Study Type : Animal Study
Additional Links
Diseases : Benzene Toxicity, Dysbiosis
Additional Keywords : Risk Factors
Problem Substances : Benzene
[+]

Pre-treatment with beta carotene gives protection against nephrotoxicity induced by bromobenzene.Aug 12, 2019

Pubmed Data : Appl Biochem Biotechnol. 2019 Aug 13. Epub 2019 Aug 13. PMID: 31407161
Article Published Date : Aug 12, 2019
Study Type : Animal Study
Additional Links
Substances : beta-Carotene
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Benzene
[+]

Shikonin targets to m6A-modified oxidative damage pathway to alleviate benzene-induced testicular injury.Nov 30, 2022

Pubmed Data : Food Chem Toxicol. 2022 Dec ;170:113496. Epub 2022 Oct 25. PMID: 36306860
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : Benzene Toxicity, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
Problem Substances : Benzene
[+]

The protective effects of diallyl sulfide (DAS) on benzene-induced leukopenia.Apr 19, 2019

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2019 Apr 20 ;37(4):247-254. PMID: 31177688
Article Published Date : Apr 19, 2019
Study Type : Animal Study
Additional Links
Substances : Diallyl sulfide
Diseases : Benzene Toxicity, Leukopenia
Problem Substances : Benzene
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The protective effects of diallyl sulfide (DAS) on genotoxicity induced by benzene.Aug 19, 2022

Pubmed Data : Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Aug 20 ;40(8):568-572. PMID: 36052584
Article Published Date : Aug 19, 2022
Study Type : Animal Study
Additional Links
Substances : Diallyl sulfide
Diseases : Benzene Toxicity, DNA damage
Pharmacological Actions : Genoprotective
Problem Substances : Benzene
[+]

Benzene and its metabolites are leukemogenic.May 01, 2010

Pubmed Data : Leukemia. 2010 May;24(5):986-91. Epub 2010 Mar 25. PMID: 20339439
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Chronic Myeloid Leukemia, Leukemia, Leukemia: Acute myelogenous leukemia (AML)
Problem Substances : Benzene, Benzene Metabolites, Hydroquinone
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Benzene exposure may occur through inhalation, ingestion and topical exposures.Mar 19, 2010

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):58-66. Epub 2010 Jan 6. PMID: 20056112
Article Published Date : Mar 19, 2010
Study Type : Review
Additional Links
Problem Substances : Benzene
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Benzene is a well-known carcinogen which appears to exert its deleterious effects through DNA damage.Mar 19, 2010

Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):269-72. Epub 2010 Jan 6. PMID: 20056111
Article Published Date : Mar 19, 2010
Study Type : Commentary
Additional Links
Diseases : Cancers: All, DNA damage
Problem Substances : Benzene, Benzene Metabolites
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Benzene metabolites may contribute to mutagenesis by overriding apoptosis and attenuating DNA repair capacity. May 01, 1999

Pubmed Data : Mol Pharmacol. 1999 May;55(5):894-901. PMID: 10220568
Article Published Date : May 01, 1999
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage, Oxidative Stress
Problem Substances : Benzene, Benzene Metabolites
[+]

Benzene metabolites oxidize DNA and induced programmed cell death. Nov 15, 1996

Pubmed Data : Cancer Res. 1996 Nov 15;56(22):5172-8. PMID: 8912853
Article Published Date : Nov 15, 1996
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
Problem Substances : Benzene, Benzene Metabolites
[+]

Crude mineral oil contains benzene as a natural constituent of approximately 0.1%.Jan 01, 1985

Pubmed Data : Am J Ind Med. 1985;7(5-6):375-83. PMID: 4003400
Article Published Date : Jan 01, 1985
Study Type : Commentary
Additional Links
Problem Substances : Benzene, Crude Oil/Petroleum
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European and North American countries limit indoor occupational exposures to benzene between 1.63-3.25mg/m3 (0.5-1 ppm). May 30, 2005

Pubmed Data : Chem Biol Interact. 2005 May 30;153-154:43-53. Epub 2005 Apr 18. PMID: 15935799
Article Published Date : May 30, 2005
Study Type : Review
Additional Links
Problem Substances : Benzene
[+]

Low-level laser therapy in low concentrations of benzene decreases the cytotoxicity caused by benzene.Nov 30, 2021

Pubmed Data : Lasers Med Sci. 2021 Dec ;36(9):1831-1836. Epub 2021 Jan 7. PMID: 33415460
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Diseases : Benzene Toxicity
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Cytoprotective
Problem Substances : Benzene
[+]

Plant isoflavones can prevent adverse effects of benzene on porcine ovarian activity.May 21, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 May 22. Epub 2020 May 22. PMID: 32445151
Article Published Date : May 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Daidzein, Isoflavones, Rutin
Diseases : Benzene Toxicity
Pharmacological Actions : Anti-Apoptotic
Problem Substances : Benzene
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Sodium or potassium benzoate with ascorbic acid has been shown to produce low levels of benzene in fruit-flavored soft drinks.Nov 01, 1993

Pubmed Data : J AOAC Int. 1993 Nov-Dec;76(6):1213-9. PMID: 8286958
Article Published Date : Nov 01, 1993
Study Type : Commentary
Additional Links
Problem Substances : Benzene, Benzene Metabolites, Potassium benzoate, Sodium Benzoate
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Sunscreen significantly enhances the absorption of benzene through the skin. Aug 08, 1997

Pubmed Data : J Toxicol Environ Health. 1997 Aug 8;51(5):447-62. PMID: 9233379
Article Published Date : Aug 08, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Benzene Toxicity
Additional Keywords : Toxic Substance Synergy
Problem Substances : Benzene, Sunscreen
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The consumption of aspartame is associated with higher serum levels of a benzene metabolite associated with blood disorders and leukemia. Jan 01, 2006

Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134
Article Published Date : Jan 01, 2006
Study Type : Commentary
Additional Links
Diseases : Hematologic Diseases, Leukemia
Problem Substances : Aspartame, Benzene

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Consumer Alert: Air Fresheners
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An astounding 19 pages of chemicals go into making one commonly used brand of air freshener, representing just how poorly regulated and toxic this increasingly popular class of consumer products is.

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