Alendronate (trade name Fosamax)

Focus Your Research

Click any topic below to filter + focus research

19 Diseases Researched for Alendronate (trade name Fosamax)

Name	AC	CK
Gastric Ulcer	8	56
Osteoporosis	8	27
Atrial Fibrillation	2	20
Drug-Induced Toxicity: Gastrointestinal	2	20
Drug-Induced Toxicity	1	10
Drug-Induced Toxicity: L-Thyroxine	1	10
Duodenal Ulcer	1	10
Esophageal Cancer	1	10
Esophageal Diseases	1	10
Esophagitis	1	10
Osteonecrosis	1	10
Osteopetrosis	1	10
Oxidative Stress	1	2
Bone Fractures	1	1
Esophageal Ulcer	1	1
Gastric Cancer	1	1
Mevalonate Pathway Enzyme Disorders	1	1
Oral Ulceration: Drug-Induced	1	1
Osteopenia	1	1

5 Adverse Pharmacological Actions Researched for Alendronate (trade name Fosamax)

Name	AC	CK
Ulcerogenic	8	63
Gastrotoxic	2	20
Corrosive	1	10
Cytotoxic	2	2
Mevalonate Pathway Enzyme Inhibitors	1	1

Research Articles 27
Cumulative Knowledge Score 43
Overall Research Rating GOOD

View the Evidence:
27 Abstracts with Alendronate (trade name Fosamax) Research

Filter by Study Type

Sort Abstracts

Limited to Members Only

By default, all articles on GreenMedInfo.com are sorted based on the content type which best reflects the data which most users are searching for. For instance, people viewing substances are generally most interested in viewing diseases that these substances have shown to have positive influences. This section is for allowing more advanced sorting methods. Currently, these advanced sorting methods are available for members only. If you are already a member, you can sign in by clicking here. If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process.

Currently Available Sorting Options

Article Published Date - Sort all displayed articles by their published date
Quick Summary Fieldsets - Sort alphabetically, rather than by Cumulative Knowledge
Cumulative Knowledge - Default sorting method. Allows you to sort descendingly

Free Sample of Member-Only Features

Although all 30,000+ articles on GreenMedInfo.com are made entirely free to view as an educational service to the public, we provide a powerful set of enhanced data comprehension and retrieval tools for subscribing members. Above you are viewing a free preview, limited to 10000 rows, of the membership feature called "Cumulative Knowledge" (learn more).

The Focus Article Feature is not enabled.

Upgrading to the Friend membership gives you access to unlimited rows of Cumulative Knowledge data.

To Participate

Click here to login
Click here to order a membership

[+]

Alendronate (trade name Fosamax) jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

Alendronate (trade name Fosamax) is a Sub of the following Topic

View the Evidence: 27 Abstracts with Alendronate (trade name Fosamax) Research

Limited to Members Only

Currently Available Sorting Options

Alendronate and naproxen are synergistic for development of gastric ulcers.Jan 08, 2001

Alendronate has been associated with esophageal injury in users.Dec 01, 1999

Alendronate is associated with injury and ulceration of the gastric mucosa. Nov 01, 2000

Alendronate therapy is assoaciated with an emerging pattern of increasingly prevalent subtrochanteric stress fractures. Feb 01, 2008

Alendronate use is associated with an increased risk for atrial fibrillation in women. Apr 28, 2008

Alendronate use is associated with low-energy femoral shaft fractures. May 01, 2008

Alendronate users have an increased rate of esophageal and gastric events.Sep 01, 2000

Bisphosphonate use is associated with a significant increase in the risk of serious atrial fibrillation in postmenopausal women.Jan 03, 2010

Bisphosphonates are less effective in women receiving TSH-suppressing doses of thyroxine.May 01, 2009

Bisphosphonates cause mucosal injury to the upper gastrointestinal tract similar to aspirin.Aug 01, 1997

Bisphosphonates have been linked to osteonecrosis and osteopetrosis of the jaws. Nov 01, 2005

Esophagitis associated with use of alendronate has been reported in postmenopausic patients.May 01, 2001

Patients on long-term alendronate therapy have been reported to experience bilateral low-energy simultaneous or sequential femoral fractures. Nov 01, 2009

Pill-induced esophageal injury is a common occurence.Aug 01, 2005

The prolonged use of alendronate has been reported to be the cause of non-traumatic femoral shaft fracture. Dec 01, 2007

Alendronate impairs the healing of gastric ulcers in rats.Aug 01, 2007

Alendronate induces antral ulcers in rat stomachs, resulting in severe edema and neutrophil infiltration in the submucosa.Sep 01, 2009

Alendronate is used experimentally to induce gastric damage and lesion in rat stomachs. Oct 01, 2007

Prolonged use of bisphophonates may lead to excess mineralization, resulting in microcracks that interfere with bone quality/strength. Jan 01, 2007

A placebo-controlled trial of primary prevention involving more than 4,000 patients showed no reduction in the risk of fracture after 4 years of treatment with alendronic acid.Jun 01, 2000

Alendoronate has been reported to cause esophageal ulceration.Apr 01, 2001

Bisphosphonates are associated with a wide range of adverse health effects.Apr 01, 2009

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts - Article 2.Mar 01, 2008

Bisphosphonates exhibit cytotoxicity to the bone-building cells known as osteoblasts.Jul 01, 2008

Bisphosphonates may interfere with mevalonate pathway enzymes. Jan 01, 2000

Long-term alendronate is associated with spontaneous femoral shaft fracture. Sep 01, 2009

Severe oral ulceration has occurred with the use of alendronate without inappropriate therapeutic administration of the medication.Jul 29, 2010

Alendronate (trade name Fosamax) Related Articles

Print Options

Alendronate (trade name Fosamax)

View the Evidence:
27 Abstracts with Alendronate (trade name Fosamax) Research