Acid Blockers

Name	AC	CK
Pneumonia	10	121
Clostridium Infections	9	100
Magnesium Deficiency	9	78
Diarrhea	5	60
Dysbiosis	9	56
Gastroesophageal Reflux	7	55
Osteoporosis	6	44
All-Cause Mortality	4	40
Chronic Kidney Disease (CKD)	4	40
Dementia	3	40
Myocardial Infarction	4	31
Childhood Infections	2	30
Cirrhosis	2	30
Esophageal Cancer	3	30
Gastroenteritis	2	30
Peritonitis: Bacterial	2	30
Drug-Induced Nutrient Depletion: Vitamin B-12	4	24
Gastric Cancer	7	24
Acid Reflux	3	21
Diabetes Mellitus: Type 2	2	20
Hepatic Cirrhosis	2	20
Hepatitis C	2	20
Hip Fracture	2	20
Infection: In Infants & Children	1	20
Liver Cirrhosis	2	20
Pancreatic Cancer	1	20
Rheumatoid Arthritis	2	20
Bone Fractures	3	12
Colitis	2	12
Colorectal Cancer	2	12
Enterobacteriaceae Infections	2	12
Alzheimer's Disease	2	11
Liver Disease	2	11
Vitamin B 12 Deficiency	2	11
Vitamin C Deficiency	2	11
Acid Reflux: In Infants & Children	1	10
Anxiety	1	10
Asthma	1	10
Bacterial Infections and Mycoses	1	10
Bone Diseases	1	10
Cancers: All	1	10
Carcinoma: Non-Small-Cell Lung	1	10
Cardiac Mortality	1	10
Cholangitis	1	10
Coronary Artery Disease	1	10
Coronary Stenting	1	10
Cystic Fibrosis	1	10
Cystic Fibrosis: Infections	1	10
Depression	1	10
Drug-Induced Toxicity	1	10
Elderly: Age Specific Diseases	1	10
Gastrointestinal Cancer	1	10
Hemodialysis	1	10
Hypothyroidism	1	10
Infant Infections	1	10
Inflammatory Bowel Diseases	1	10
Irritable Bowel Syndrome	1	10
Kidney Cancer	1	10
Kidney Damage: Drug-Induced	1	10
Kidney Infection	1	10
Liver Cancer	1	10
Liver Damage	1	10
Low Immune Function: Natural Killer Cells	1	10
Lung Cancer	1	10
Memory Disorders: Drug-Induced	1	10
Multiple Myeloma	1	10
Myocardial Infarction: Prevention	1	10
Nephrolithiasis	1	10
Neuroendocrine Tumors	1	10
Respiratory Infections	1	10
Rosacea	1	10
Streptococcus Infections	1	10
Stroke	1	10
Drug-Induced Nutrient Depletion: Iron	2	4
Infertility: Female	1	4
Anemia: Hemolytic	1	3
Encephalopathies	1	3
Seizures: Drug-Induced	1	3
Thrombocytopenia	1	3
Animal Diseases: Scrapie	1	2
Prion Diseases	1	2
Scrapie	1	2
Arrhythmias: Drug-Induced	1	1
Fractures: Bone	1	1
Gastrointestinal Infections	1	1
Gynecomastia	1	1
Hearing Loss	1	1
Lupus Erythematosus: Cutaneous	1	1
Mineral Deficiencies	1	1
Myopathies	1	1
Nephritis	1	1
Neutropenia: Drug-Induced	1	1
Pneumonia: Drug-Induced	1	1
Polymicrobial Small Bowel Bacterial Overgrowth	1	1
Polymyositis	1	1
Rebound Acid Hypersecretion Syndrome	1	1
Stomach Cancer	1	1
Water-Electrolyte Imbalance	1	1

Name	AC	CK
Immunosuppressive	7	100
Cardiotoxic	6	37
Circulating Gastrin and Chromogranin A: Elevated	1	10
Gastrotoxic	1	10
Neurotoxic	1	10
Tumor Marker Elevation: Chromogranin	1	10
Renotoxic	1	5
Carcinogenic	1	4
Endocrine Disruptor	1	4
Carcinogen	1	2

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Acid suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients.Nov 27, 2012

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Pubmed Data : J Gastroenterol Hepatol. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23190338

Article Published Date : Nov 27, 2012

Study Type : Meta Analysis

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Diseases : Cirrhosis, Peritonitis: Bacterial

Problem Substances : Acid Blockers

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Exposure to proton pump inhibitors and risk of pancreatic cancer.Jan 10, 2020

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Pubmed Data : Expert Opin Drug Saf. 2020 Jan 11. Epub 2020 Jan 11. PMID: 31928106

Article Published Date : Jan 10, 2020

Study Type : Meta Analysis

Additional Links

Diseases : Pancreatic Cancer

Additional Keywords : Increased Risk

Problem Substances : Proton-Pump Inhibitors

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Proton pump inhibitor use may increase the risk of hypomagnesemia.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(11):e112558. Epub 2014 Nov 13. PMID: 25394217

Article Published Date : Dec 31, 2013

Study Type : Meta Analysis, Review

Additional Links

Substances : Magnesium

Diseases : Magnesium Deficiency

Additional Keywords : Risk Factors

Problem Substances : Proton-Pump Inhibitors

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This meta-analysesa found a dose-response between the proton pump inhibitors use and development of hypomagnesemia.Oct 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Diseases : Hypothyroidism

Problem Substances : Antacids: Aluminium-Containing, Bile Acid Sequestrants, Calcium Carbonate, Ferrous Sulphate, Phosphate Binders, Proton-Pump Inhibitors, Raloxifene, Sucralfate

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Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

Problem Substances : Proton-Pump Inhibitors

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Lactobacillus probiotics could restore the gastric barrier effect in patients treated with proton pump inhibitors. Sep 30, 2012

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Pubmed Data : J Clin Gastroenterol. 2012 Oct ;46 Suppl:S18-26. PMID: 22955351

Article Published Date : Sep 30, 2012

Pubmed Data : JAMA. 2006 Dec 27;296(24):2947-53. PMID: 17190895

Article Published Date : Dec 27, 2006

Study Type : Human Study

Additional Links

Diseases : Bone Fractures, Hip Fracture, Osteoporosis

Problem Substances : Proton-Pump Inhibitors

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Long-term proton pump inhibitor therapy leads to small bowel bacterial overgrowth.Nov 27, 2017

Pubmed Data : CMAJ. 2004 Jul 6;171(1):33-8. PMID: 15238493

Article Published Date : Jul 06, 2004

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections, Diarrhea

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Immunosuppressive

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Pubmed Data : Sci Rep. 2019 Nov 21 ;9(1):17280. Epub 2019 Nov 21. PMID: 31754136

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Pubmed Data : BMJ. 2019 05 29 ;365:l1580. Epub 2019 May 29. PMID: 31147311

Article Published Date : Jan 28, 2019

Study Type : Human Study

Additional Links

Diseases : All-Cause Mortality, Chronic Kidney Disease (CKD), Gastrointestinal Cancer

Additional Keywords : Risk Factors

Problem Substances : Proton-Pump Inhibitors

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The association between proton pump inhibitors and myocardial infarction.Jun 30, 2019

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Treatment with proton pump inhibitors and H2 receptor antagonists was associated with increased risk for pneumonia in stroke patients.Dec 31, 2018

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Long-term exposure to rats with the proton pump inhibitor omeprazole resulted in hypergastrinaemia and gastric cancer.Jan 01, 1986

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Pubmed Data : Scand J Gastroenterol Suppl. 1986;118:31-8. PMID: 3460170

Article Published Date : Jan 01, 1986

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Additional Keywords : Drug: Omeprazole

Problem Substances : Omeprazole (trade name Prilosec), Proton-Pump Inhibitors

Adverse Pharmacological Actions : Carcinogen

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Long-term proton pump inhibitor administration caused physiological and microbiota changes in rats.Jan 20, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Presse Med. 2012 Dec 10. Epub 2012 Dec 10. PMID: 23237784

Article Published Date : Dec 09, 2012

Study Type : Review

Additional Links

Diseases : Bone Fractures, Neutropenia: Drug-Induced, Osteoporosis, Stomach Cancer

Problem Substances : Proton-Pump Inhibitors

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Pubmed Data : J Dig Dis. 2022 Mar 31. Epub 2022 Mar 31. PMID: 35357775

Article Publish Status : This is a free article. Click here to read the complete article.

The Following are Sub-Topics of Acid Blockers

View the Evidence: 131 Abstracts with Acid Blockers Research

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Acid suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients.Nov 27, 2012

Exposure to proton pump inhibitors and risk of pancreatic cancer.Jan 10, 2020

Proton pump inhibitor use may increase the risk of hypomagnesemia.Dec 31, 2013

This meta-analysesa found a dose-response between the proton pump inhibitors use and development of hypomagnesemia.Oct 31, 2019

This meta-analysis supports the hypothesis that proton pump inhibitors increase the risk of dementia.Nov 20, 2019

This study found possible evidence linking proton pump inhibitors use to an increased risk of community-acquired pneumonia.May 20, 2020

A number of commonly used drugs interfere with the absorption of levothyroxine. Dec 01, 2009

Acid-suppressing drug use substantially increased the likelihood of recurrent pneumonia in high-risk elderly patients. Jan 01, 2010

An increased risk of pneumonia was observed both immediately before and immediately after PPI initiation.Apr 20, 2022

Association between proton pump inhibitor use and overactive bladder risk in adults.Sep 17, 2024

Association between proton pump inhibitors and asthma: a population-based cohort study.Dec 31, 2019

Association between proton pump inhibitors and severe hematological toxicity in patients receiving pemetrexed-based anticancer treatment.Dec 31, 2021

Association of proton pump inhibitor use with survival and adverse effects outcomes in patients with multiple myeloma.Jan 04, 2024

Children exposed to proton pump inhibitor therapy are at higher risk for the development of Clostridium difficile-associated disease. Dec 29, 2009

Chronic PPI use resulted in significant increases in CGA (including the tumor marker chromogranin A) and significant increases in gastrin compared to controls. Mar 28, 2012

Community prescribed ASMs were associated with increased rates of C. difficile and Campylobacter positive gastroenteritis.Jan 04, 2017

Concomitant use of a proton pump inhibitor and clopidogrel compared with clopidogrel alone was associated with a higher rate of major adverse cardiovascular events within 1 year after coronary stent placement.Aug 01, 2010

Current use of gastric acid-suppressive therapy was associated with an increased risk of community-acquired pneumonia.Oct 27, 2004

Deleterious effect of proton pump inhibitors on the disease course of cirrhosis.Aug 26, 2019

Drug use is associated with lower plasma magnesium levels in geriatric outpatients.Dec 05, 2018

Exposure to Proton pump inhibitors is associated with higher numbers of hospitalizations for pulmonary exacerbation in cystic fibrosis patients.Sep 30, 2017

Hypomagnesemia and hypocitraturia associated with PPI exposure may contribute to kidney stone risk. May 01, 2022

In addition to ipilimumab use, chronic use of PPIs may be associated with ICI colitis in patients with mRCC.Jan 31, 2022

Increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial C difficile infection. May 10, 2010

Lactobacillus paracasei F19 supplementation prevents bowel symptom onset in patients on long-term proton pump inhibitors.Mar 31, 2015

Lactobacillus probiotics could restore the gastric barrier effect in patients treated with proton pump inhibitors. Sep 30, 2012

Long term use of proton pump inhibitors is associated with increased risk of oesophageal adenocarcinoma in the absence of other risk factors.Dec 31, 2017

Long-term PPI was significantly associated with osteoporosis.May 01, 2022

Long-term proton pump inhibitor therapy is associated with an increased risk of hip fracture.Dec 27, 2006

Long-term proton pump inhibitor therapy leads to small bowel bacterial overgrowth.Nov 27, 2017

Long-term Proton pump inhibitor use has an effect on the gut microbiome.Feb 28, 2016

Long-term proton pump inhibitors use is associated with risk of bone complications.Feb 28, 2018

Medically treated patients with mild or absent GERD symptoms have significantly higher odds of adenocarcinogenesis compared with medically treated patients with severe GERD symptoms.Jul 01, 2011

Omeprazole treatment have caused considerable changes in stool culture results.Feb 28, 2017

Over-use of proton pump inhibitors may be fuelling the current epidemic of Clostridium difficile-associated diarrhoea.Sep 01, 2008

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.Jul 06, 2004

Patients with rheumatoid arthritis found a significantly increased risk of acute kidney injury associated with the use of proton pump inhibitors.Dec 31, 2017

Prolonged acid suppression therapy with PPIs or H2 blockers may result in serum vitamin B12 deficiency.Oct 20, 2020

Prolonged proton pump inhibitors use was associated with an increased risk of rosacea.Jun 30, 2020

Prolonged use of a proton pump inhibitor reduces microbial diversity: implications for Clostridium difficile susceptibility.Dec 31, 2013

Prolonged use of proton pump inhibitors and risk of type 2 diabetes.Apr 15, 2022

Proton pump inhibitor alters oral microbiome in gastrointestinal tract of healthy volunteers.Nov 03, 2017

Proton pump inhibitor therapy may increased the risk of clostridium difficile-associated diarrhea.May 01, 2007

Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis.Dec 18, 2014

Proton pump inhibitor use and risk of depression and anxiety in children.Jan 10, 2022

Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis.Sep 06, 2019

Proton pump inhibitor use represents an independent risk factor for myocardial infarction.Nov 14, 2014

Proton pump inhibitor use was associated with an increased risk of cholangitis.Aug 24, 2019

Proton pump inhibitor use was associated with an increased risk of gastric and oesophageal cancer.Aug 20, 2019

Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.Jul 01, 2010

Proton pump inhibitors and risk of calcium pyrophosphate deposition in a population-based study.Mar 03, 2022

Proton pump inhibitors are associated with accelerated development of cirrhosis, and hepatocellular carcinoma in patients with hepatitis C infection.Nov 02, 2017

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.Jun 26, 2019

Proton pump inhibitors prescription was associated with greater risk of pneumonia in the second year of treatment.Apr 19, 2018

Proton pump inhibitors reduce the bioavailability of dietary vitamin C.Sep 15, 2005

Proton pump inhibitors reduce the survival of advanced lung cancer patients with therapy of gefitinib or erlotinib.Apr 28, 2022

Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients.Nov 26, 2018

Proton pump inhibitors use is associated with a higher risk of incident chronic kidney disease.Dec 31, 2017

Proton pump inhibitors use is significantly associated with an increased risk of hip fracture development.Dec 11, 2018

Proton pump inhibitors use was associated with an increased risk of developing clostridium difficile infection.Jun 10, 2019

Proton pump inhibitors use was associated with progression to major adverse renal events in patients with chronic kidney disease.Jun 27, 2019

Proton pump inhibitors were associated with a modestly increased risk of IBD-related hospitalization or surgery.Mar 13, 2017

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory.Nov 20, 2019

Proton-pump inhibitors are associated with a high false-positivity rate in faecal immunochemical testing.Nov 06, 2020

Ranitidine inhibits the secretion of gastric intrinsic factor and absorption of vitamin B 12Apr 01, 1983

Regular use of proton pump inhibitors was associated with increased risk of rheumatoid arthritis in women.Jul 31, 2020

Relationship between long-term use of proton pump inhibitor (PPI) and hypomagnesemia in patients with gastroesophageal reflux disease.Dec 31, 2021

Residents who use proton pump inhibitor may be at increased risk of infection-related hospitalizations, particularly respiratory infections.Sep 03, 2019

Spirulina might be useful to relieve dyspeptic symptoms after proton pump inhibitor discontinuation.Feb 08, 2024

Symptomatic hypomagnesemia and proton pump inhibitors.Oct 31, 2014

Taking proton pump inhibitors is associated with a small excess of cause specific mortality.Jan 28, 2019

The association between proton pump inhibitors and myocardial infarction.Jun 30, 2019

Acid Blockers

View the Evidence:
131 Abstracts with Acid Blockers Research