Krill https://greenmedinfo.com/category/keywords/Krill en Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. https://greenmedinfo.com/article/krill-oil-containing-diets-were-able-reduce-cholesterol-levels-inhibit-plaque- n/a PMID:  Mol Nutr Food Res. 2017 Aug 15. Epub 2017 Aug 15. PMID: 28812326 Abstract Title:  Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice. Abstract:  SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO). In KRILL OIL+PRO and KRILL OIL, cholesterol levels were significantly lower than in CONTROL group. Atherosclerosis in aorta of PRO, KRILL OIL and KRILL OIL+PRO was lower than in CONTROL, whereas, at the aortic sinus, atherosclerosis reduction was only observed in KRILL OIL. Liver steatosis, commonly present in CONTROL and PRO animals, was sporadic in KRILL OIL+PRO and KRILL OIL mice. Krill oil containing diets affected the expression of genes involved in cholesterol metabolism, mainly HMG-CoA reductase. No reduced systemic inflammation was found in all groups. CONCLUSION: Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. Krill proteins also reduced atherosclerosis development through mechanisms not involving lipid metabolism. This article is protected by copyright. All rights reserved. https://greenmedinfo.com/article/krill-oil-containing-diets-were-able-reduce-cholesterol-levels-inhibit-plaque-#comments Atherosclerosis Krill Anti-atherogenic Anti-atherogenic Atherosclerosis Krill Animal Study Fri, 01 Sep 2017 20:08:48 +0000 greenmedinfo 152585 at https://greenmedinfo.com Krill oil supplementation can reduce low-density lipoprotein cholesterol and triglycerides https://greenmedinfo.com/article/krill-oil-supplementation-can-reduce-low-density-lipoprotein-cholesterol-and-t n/a PMID:  Nutr Rev. 2017 May 1 ;75(5):361-373. PMID: 28371906 Abstract Title:  Lipid-modifying effects of krill oil in humans: systematic review and meta-analysis of randomized controlled trials. Abstract:  Context: Some experimental and clinical trials have shown that krill oil, extracted from small red crustaceans, might be an effective lipid-modifying agent, but the evidence is not conclusive. Objective: The effect of krill oil supplements on plasma lipid concentrations was assessed through a systematic review of the literature and a meta-analysis of available randomized controlled trials. Data sources: PubMed and Scopus were searched up to March 25, 2016, to identify RCTs investigating the effect of krill oil supplements on plasma lipids. Study selection: Randomized controlled trials that investigated the impact of at least 2 weeks of supplementation with krill oil on plasma/serum concentrations of at least one of the main lipid parameters (ie, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, or triglycerides) and that reported sufficient information on plasma/serum lipid levels at baseline and at the end of study in both krill oil and control groups were eligible for inclusion. Data extraction: Two reviewers independently extracted the following data: first author's name, year of publication, study location, study design, number of participants in the krill oil and control groups, dosage of krill oil, type of control allocation, treatment duration, demographic characteristics of study participants, and baseline and follow-up plasma concentrations of lipids. Effect size was expressed as the weighted mean difference (WMD) and 95% confidence interval (95%CI). Results: Meta-analysis of data from 7 eligible trials (14 treatment arms) with 662 participants showed a significant reduction in plasma concentrations of low-density lipoprotein cholesterol (WMD, -15.52 mg/dL; 95%CI, -28.43 to -2.61; P = 0.018) and triglycerides (WMD, -14.03 mg/dL; 95%CI, -21.38 to -6.67; P < 0.001) following supplementation with krill oil. A significant elevation in plasma concentrations of high-density lipoprotein cholesterol was also observed (WMD, 6.65 mg/dL; 95%CI, 2.30 to 10.99; P = 0.003), while a reduction in plasma concentrations of total cholesterol did not reach statistical significance (WMD, -7.50 mg/dL; 95%CI, -17.94 to 2.93; P = 0.159). Conclusion: Krill oil supplementation can reduce low-density lipoprotein cholesterol and triglycerides. Additional clinical studies with more participants are needed to assess the impact of krill oil supplementation on other indices of cardiometabolic risk and on the risk of cardiovascular outcomes. https://greenmedinfo.com/article/krill-oil-supplementation-can-reduce-low-density-lipoprotein-cholesterol-and-t#comments Hypercholesterolemia Hyperlipidemia Krill Triglycerides: Elevated Anticholesteremic Agents Hypolipidemic Anticholesteremic Agents Hypercholesterolemia hyperlipidemia Hypolipidemic Krill Meta Analysis Triglycerides: Elevated Review Fri, 01 Sep 2017 20:48:52 +0000 greenmedinfo 152592 at https://greenmedinfo.com Krill oil treatment was associated with the alleviation of hyperlipidemia in animals. https://greenmedinfo.com/article/krill-oil-treatment-was-associated-alleviation-hyperlipidemia-animals n/a PMID:  Front Microbiol. 2017 ;8:905. Epub 2017 May 17. PMID: 28567037 Abstract Title:  Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet. Abstract:  Multiple lines of evidence suggest that the gut microbiota plays vital roles in metabolic diseases such as hyperlipidemia. Previous studies have confirmed that krill oil can alleviate hyperlipidemia, but the underlying mechanism remains unclear. To discern whether krill oil changes the structure of the gut microbiota during the hyperlipidemia treatment, 72 mice were acclimatized with a standard chow diet for 2 weeks and then randomly allocated to receive a standard chow diet (control group, n = 12) or a high-sugar-high-fat (HSHF) diet supplemented with a low (100μg/g·d, HSHF+LD group, n = 12), moderate (200 μg/g·d, HSHF+MD group, n = 12) or high dosage of krill oil (600 μg/g·d, HSHF+HD group, n = 12), simvastatin (HSHF+S group, n = 12) or saline (HSHF group, n = 12) continuously for 12 weeks. The resulting weight gains were attenuated, the liver indexand the low-density lipoprotein, total cholesterol and triglyceride concentrations showed a stepwise reduction in the treated groups compared with those of the control group. A dose-dependent modulation of the gut microbiota was observed after treatment with krill oil. Low- and moderate- doses of krill oil increased the similarity between the composition of the HSHF diet-induced gut microbiota and that of the control, whereas the mice fed the high-dose exhibited a unique gut microbiota structure that was different from that of the control and HSHF groups. Sixty-five key operational taxonomicunits (OTUs) that responded to the krill oil treatment were identified using redundancy analysis, of which 26 OTUs were increased and 39 OTUs were decreased compared with those of the HSHF group. In conclusion, the results obtained in this study suggest that the structural alterations in the gut microbiota induced by krill oil treatment were dose-dependent and associated with the alleviation of hyperlipidemia. Additionally, the high-dose krill oil treatment showed combined effects on the alleviation of hyperlipidemia and obesity. https://greenmedinfo.com/article/krill-oil-treatment-was-associated-alleviation-hyperlipidemia-animals#comments High Fat Diet High Sugar Diet Hyperlipidemia Krill Obesity Gastrointestinal Agents Hypolipidemic Anti-Obesity Agents Gastrointestinal Agents high fat diet High Sugar Diet hyperlipidemia Hypolipidemic Krill obesity Animal Study Fri, 01 Sep 2017 20:28:52 +0000 greenmedinfo 152590 at https://greenmedinfo.com