Bisphenol Toxicity https://greenmedinfo.com/category/keywords/Bisphenol%20Toxicity en 7 Ways Probiotics DETOXIFY Your Body https://greenmedinfo.com/blog/7-ways-probiotics-help-you-detoxify-your-health <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="7 Ways Probiotics Help You To DETOXIFY Your Health" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/detoxify_your_health.jpg" style="height: 400px; width: 600px;" title="7 Ways Probiotics DETOXIFY Your Body" /></p> <p><span style="font-size:18px;"><em><strong>Did you know that probiotic bacteria are capable of helping you detoxify the most noxious chemicals known to humankind?&nbsp;</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/7-ways-probiotics-help-you-detoxify-your-health" target="_blank">read more</a></p> https://greenmedinfo.com/blog/7-ways-probiotics-help-you-detoxify-your-health#comments Bifidobacterium Bifidum Bifidobacterium Breve Bisphenol Toxicity Fermented Foods and Beverages Kimchi Lactobacillus casei Lactobacillus casei: Shirota Lactobacillus probiotics Nitrosamnine-induced Toxicity Perchlorate Toxicity Pesticide Toxicity Pesticide-Induced Toxicity: Organophosphates Probiotics Sodium nitrate toxicity Detoxifier Health Guide: Probiotics Heavy Metals Heterocyclic Aromatic Amine N-Nitrosamines Perchlorate Bisphenol Toxicity Detoxifier Heavy metals Heterocyclic Aromatic Amine N-Nitrosamines Perchlorate Fri, 30 Mar 2018 13:09:26 +0000 Sayer Ji 113213 at https://greenmedinfo.com A high fat diet and a low-dose BPA exposure during pregnancy increases mammary tumor incidence in offspring. https://greenmedinfo.com/article/high-fat-diet-and-low-dose-bpa-exposure-during-pregnancy-increases-mammary-tum n/a PMID:  Endocr Relat Cancer. 2017 May 9. Epub 2017 May 9. PMID: 28487351 Abstract Title:  Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Abstract:  In utero exposure to bisphenol A (BPA) increases mammary cancer susceptibility in offspring. High fat diet is widely believed to be a risk factor of breast cancer. The objective of this study was to determine whether maternal exposure to BPA in addition to high-butterfat (HBF) intake during pregnancy further impacts carcinogen-induced mammary cancer risk in offspring, and its dose-response curve. In this study, we found that gestational HBF intake in addition to a low-dose BPA (25µg/kg BW/day) exposure increased mammary tumor incidence in a 50-day-of-age chemical carcinogen administration model and altered mammary gland morphology in offspring in a non-monotonic manner, while shortening tumor-free survival time compared with the HBF-alone group. In utero HBF and BPA exposure elicited differential effects at the gene level in PND21 mammary glands through DNA methylation, compared with HBF intake in the absence of BPA. Top HBF+BPA-dysregulated genes (ALDH1B1, ASTL, CA7, CPLX4, KCNV2, MAGEE2, and TUBA3E) are associated with poor overall survival in The Cancer Genomic Atlas (TCGA) human breast cancer cohort (n=1,082). Furthermore, the prognostic power of the identified genes was further enhanced in the survival analysis of Caucasian patients with estrogen receptor-positive tumors. In conclusion, concurrent HBF dietary and a low-dose BPA exposure during pregnancy increases mammary tumor incidence in offspring, accompanied by alterations in mammary gland development and gene expression, and possibly through epigenetic reprogramming. https://greenmedinfo.com/article/high-fat-diet-and-low-dose-bpa-exposure-during-pregnancy-increases-mammary-tum#comments Bisphenol Toxicity Breast Cancer High Fat Diet Bisphenol A Bisphenol A Bisphenol Toxicity Breast Cancer high fat diet Increased Risk Transgenerational Epigenetic Modification Human Study Mon, 15 May 2017 22:19:09 +0000 greenmedinfo 147800 at https://greenmedinfo.com Adolescent BPA exposure below the safe daily limit leads to alterations in some behaviours and neuronal morphology that endure into adulthood. https://greenmedinfo.com/article/adolescent-bpa-exposure-below-safe-daily-limit-leads-alterations-some-behaviou n/a PMID:  Horm Behav. 2015 Mar ;69:89-97. Epub 2014 Dec 30. PMID: 25554518 Abstract Title:  Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats. Abstract:  We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescents in both sexes. The present study examined whether the behavioral and morphological alterations following BPA exposure during adolescent development are maintained into adulthood. Male and female, adolescent rats received BPA, 40μg/kg/bodyweight, or control treatments for one week. In adulthood, subjects were tested for anxiety and locomotor activity, spatial memory, non-spatial visual memory, and sucrose preference. Additionally, stress-induced serum corticosterone levels and dendritic spine density in the mPFC and CA1 were measured. BPA-treated males, but not females, had decreased arm visits on the elevated plus maze, but there was no effect on anxiety. Non-spatial memory, object recognition, was also decreased in BPA treated males, but not in females. BPA exposure did not alter spatial memory, object placement, but decreased exploration during the tasks in both sexes. No significant group differences in sucrose preference or serum corticosterone levels in response to a stress challenge were found. However, BPA exposure, regardless of sex, significantly decreased spine density of both apical and basal dendrites on pyramidal cells in CA1 but had no effect in the mPFC. Current data are discussed in relation to BPA dependent changes, which were present during adolescence and did, or did not, endure into adulthood. Overall, adolescent BPA exposure, below the current reference safe daily limit set by the U.S.E.P.A., leads to alterations in some behaviors and neuronal morphology that endure into adulthood. https://greenmedinfo.com/article/adolescent-bpa-exposure-below-safe-daily-limit-leads-alterations-some-behaviou#comments Anxiety Disorders Bisphenol Toxicity Bisphenol A Anxiety Disorders Bisphenol A Bisphenol Toxicity Animal Study Tue, 23 May 2017 14:26:29 +0000 greenmedinfo 148127 at https://greenmedinfo.com Bile acids and tryptophan metabolism are novel pathways involved in metabolic abnormalities in BPA-exposed pregnant mice and male offspring. https://greenmedinfo.com/article/bile-acids-and-tryptophan-metabolism-are-novel-pathways-involved-metabolic-abn n/a PMID:  Endocrinology. 2017 May 25. Epub 2017 May 25. PMID: 28549143 Abstract Title:  Bile acids and tryptophan metabolism are novel pathways involved in metabolic abnormalities in BPA-exposed pregnant mice and male offspring. Abstract:  Increasing evidence has demonstrated that exposure to endocrine disrupting chemicals (EDCs) impacts maternal and fetal health, but the underlying mechanisms are still unclear. We have previously shown that dietary exposure to 10µg/kg bw/day and 10 mg/kg bw/day bisphenol A (BPA) during pregnancy induced metabolic abnormalities in F1 male offspring and gestational glucose intolerance in F0 pregnant mice. The aim of this study is to elucidate the underlying etiologies of BPA exposure-induced metabolic disease by analyzing male fetal liver metabolome. Using the Metabolon Discover HD4 Platform, our laboratory has identified metabolic pathways that are altered by BPA exposure including biochemicals in lipid and amino acid metabolism. Specifically, primary and secondary bile acids were increased in liver from BPA-exposed embryonic day (E) 18.5 male fetuses. We subsequently showed that increased bile acid was associated with defective Fxr- dependent negative feedback mechanism in BPA exposed-fetuses. Additionally, through metabolomics, we observed that BPA-exposed fetuses had elevated tryptophan levels. Independent liquid chromatography and mass spectrometry (LC-MS) measurement revealed that BPA-exposed dams also had increased tryptophan relative to controls. Because several key enzymes in tryptophan catabolism are vitamin B6-dependent and vitamin B6 deficiencies have been previously linked to gestational diabetes, we tested the impact of vitamin B6 supplementation and showed that it rescued gestational glucose intolerance in BPA-exposed pregnant mice. Our study has therefore identified two novel pathways (bile acid and tryptophan metabolism) that potentially underlie BPA-induced maternal and fetal metabolic disease. https://greenmedinfo.com/article/bile-acids-and-tryptophan-metabolism-are-novel-pathways-involved-metabolic-abn#comments Bisphenol Toxicity Fetal Origin of Adult Disease Bisphenol A Bisphenol A Bisphenol Toxicity Fetal Origin of Adult Disease Animal Study Fri, 18 Aug 2017 01:15:54 +0000 greenmedinfo 151850 at https://greenmedinfo.com Bisphenol A influences oestrogen and thyroid hormone-regulated thyroid hormone receptor expression. https://greenmedinfo.com/article/bisphenol-influences-oestrogen-and-thyroid-hormone-regulated-thyroid-hormone-r n/a PMID:  Acta Vet Hung. 2016 Dec ;64(4):497-513. PMID: 27993100 Abstract Title:  Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture. Abstract:  Thyroid hormones (THs) and oestrogens are crucial in the regulation of cerebellar development. TH receptors (TRs) mediate these hormone effects and are regulated by both hormone families. We reported earlier that THs and oestradiol (E2) determine TR levels in cerebellar cell culture. Here we demonstrate the effects of low concentrations (10(-10) M) of the endocrine disruptor (ED) bisphenol A (BPA) on the hormonal (THs, E2) regulation of TRα,β in rat cerebellar cell culture. Primary cerebellar cell cultures, glia-containing and glia-destroyed, were treated with BPA or a combination of BPA and E2 and/or THs. Oestrogen receptor and TH receptor mRNA and protein levels were determined by real-time qPCR and Western blot techniques. The results show that BPA alone decreases, while BPA in combination with THs and/or E2 increases TR mRNA expression. In contrast, BPA alone increased receptor protein expressions, but did not further increase them in combination with THs and/or E2. The modulatory effects of BPA were mediated by the glia;however, the degree of changes also depended on the specific hormone ligand used. The results signify the importance of the regulatory mechanisms interposed between transcription and translation and raise the possibility that BPA could act to influence nuclear hormone receptor levels independentlyof ligand-receptor interaction. https://greenmedinfo.com/article/bisphenol-influences-oestrogen-and-thyroid-hormone-regulated-thyroid-hormone-r#comments Bisphenol Toxicity Bisphenol A Bisphenol A Bisphenol Toxicity Risk Factors Thyroid Animal Study Thu, 22 Dec 2016 19:03:31 +0000 greenmedinfo 140853 at https://greenmedinfo.com Bisphenol A was detected above the detection limit in all samples in individuals affected by non-alcoholic fatty liver disease. https://greenmedinfo.com/article/bisphenol-was-detected-above-detection-limit-all-samples-individuals-affected- n/a PMID:  J Pharm Biomed Anal. 2017 Jun 5 ;140:105-112. Epub 2017 Mar 10. PMID: 28346880 Abstract Title:  Human exposure to Bisphenol A and liver health status: Quantification of urinary and circulating levels by LC-MS/MS. Abstract:  A selective and highly sensitive analytical methodology for determination of Bisphenol A in human plasma was developed and validated. The method was based on selective liquid/solid extraction, combined with liquid chromatography-electrospray ionization tandem mass spectrometry in the multiple reaction monitoring mode and negative ionization. The linearity of the detector response was verified in human plasma over the concentration range 0.100-200ngmL(-1). The detection limit was 0.03ngmL(-1) and the quantification limit was 0.100ngmL(-1). The analytical features of the proposed in-house validated method were satisfactory: precision was&lt;10% and recoveries were around 84-104%. The matrix effect was studied and compensated using deuterated labeled standard. The applicability of the proposed method was demonstrated analyzing human plasma samples from individuals affected by non-alcoholic fatty liver disease. Bisphenol A was detected above the detection limit in all samples. The data show a persistence of unconjugated Bisphenol A levels in plasma and indicate a chronic Bisphenol A exposure of the target organ, suggesting an association between liver health status and Bisphenol A exposure. The results from our study are valuable for further investigation with large sample size and longitudinal study designs, necessary to confirm the observed association. https://greenmedinfo.com/article/bisphenol-was-detected-above-detection-limit-all-samples-individuals-affected-#comments Bisphenol Toxicity Chemically-Induced Liver Damage Bisphenol A Bisphenol A Bisphenol Toxicity Chemically-Induced Liver Damage Human Study Human In Vitro Thu, 04 May 2017 20:35:38 +0000 greenmedinfo 147247 at https://greenmedinfo.com BPA alternatives are not necessarily less estrogenic than BPA in human breast cancer cells. https://greenmedinfo.com/article/bpa-alternatives-are-not-necessarily-less-estrogenic-bpa-human-breast-cancer-c n/a PMID:  Toxicol Sci. 2017 Jun 7. Epub 2017 Jun 7. PMID: 28591870 Abstract Title:  Transcriptome profiling reveals bisphenol A alternatives activate estrogen receptor alpha in human breast cancer cells. Abstract:  Plasticizers with estrogenic activity, such as bisphenol A (BPA), have potential adverse health effects in humans. Due to mounting evidence of these health effects, BPA is being phased out and replaced by other bisphenol variants in&quot;BPA-free&quot;products. We have compared estrogenic activity of BPA to 6 bisphenol analogues (bisphenol S, BPS; bisphenol F, BPF; bisphenol AP, BPAP; bisphenol AF, BPAF; bisphenol Z, BPZ; bisphenol B, BPB) in three human breast cancer cell lines. Estrogenicity was assessed (10-11M to 10-4M) by cell growth in an estrogen receptor (ER)-mediated cell proliferation assay, and by the induction of estrogen response element-mediated transcription in a luciferase assay. BPAF was the most potent bisphenol, followed by BPB&gt;BPZ∼ BPA&gt;BPF∼ BPAP&gt;BPS. The addition of ICI 182,780 antagonized the activation of ERs. Data mining of ToxCast high-throughput screening assays confirms our results but also shows divergence in the sensitivities of the assays. Gene expression profiles were determined in MCF-7 cells by microarray analysis. The comparison of transcriptome profile alterations resulting from BPA alternatives with an ERα gene expression biomarker further indicates that all BPA alternatives act as ERα agonists in MCF-7 cells. These results were confirmed by Illumina-based RNA sequencing. In conclusion, BPA alternatives are not necessarily less estrogenic than BPA in human breast cancer cells. BPAF, BPB, and BPZ were more estrogenic than BPA. These findings point to the importance of better understanding the risk of adverse effects from exposure to BPA alternatives, including hormone-dependent breast cancer. https://greenmedinfo.com/article/bpa-alternatives-are-not-necessarily-less-estrogenic-bpa-human-breast-cancer-c#comments Bisphenol Toxicity Breast Cancer Bisphenol A Bisphenol AP Bisphenol F Bisphenol S Bisphenol A Bisphenol AP Bisphenol F Bisphenol S Bisphenol Toxicity Breast Cancer In Vitro Study Fri, 18 Aug 2017 00:57:31 +0000 greenmedinfo 151849 at https://greenmedinfo.com BPA can promote the proliferation of thyroid carcinoma B-CPAP cells and decrease the apoptosis of cells. https://greenmedinfo.com/article/bpa-can-promote-proliferation-thyroid-carcinoma-b-cpap-cells-and-decrease-apop n/a PMID:  Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 7 ;52(6):458-462. PMID: 28635220 Abstract Title:  [The bisphenol A-enhanced activity of thyroid carcinoma cell line B-CPAP is inhibited by Icarrin]. Abstract:  Objective: To investigate the effect of icariin (ICA) on the bisphenol A (BPA)-enhanced proliferation function of thyroid carcinoma cell B-CPAP and underlying mechanism. Methods: The proliferation of Gastric B-CPAP cell line was evaluated by cell counting kit-8 (CCK-8). Apoptosis and ROS expression in B-CPAP cells were detected by flow cytometry. The expression of superoxide dismutase (SOD) and malondialdehyde (MDA) in B-CPAP cells were measured by individual assay kits. The expressions of Bcl-2 andγ-HA2X were detected by Western blot. SPSS 18.0 software was used to analyze the data. Results: B-CPAP cell activity was promoted by treatment with 3×10(-7)mol/L BPA for 48 h, with significant difference in absorbance between BPA and control groups (1.089±0.053 vs 0.935±0.010, P&lt;0.05). The cell activities of BPA+ ICA(25), BPA+ ICA(50), BPA+ ICA(100) and BPA+ ICA(200) groups was 0.780±0.036, 1.007±0.050, 0.958±0.033 and 0.625±0.064, respectively (all P&lt;0.01). The proliferation of B-CPAP cells treated with BPA for 72 hours showed a similar trend to 48 hours. There was no significant difference between all treatment groups in 24 hours. The apoptosis rate was (19.272±0.186)% in BPA-treated cells, and was (22.412±0.238)% in control cells (P&lt;0.05). The apoptosis rates of BPA+ ICA(50) and BPA+ ICA(200) groups were (23.688±0.412)% and (30.270±0.696)%, respectively (P&lt;0.01). The intracellular accumulation of ROS in BPA, BPA+ ICA(50), and BPA+ ICA(200) groups were 806±21, 1 772±37, 2 041±16, respectively (P&lt;0.01). The expressions of anti-apoptotic protein Bcl-2 in control, BPA, BPA+ ICA(50), BPA+ ICA(200) groups were 7 120±151, 9 801±286, 5 902±171 and 4 203±216, respectively (P&lt;0.01). Conclusion: BPA can promote the proliferation of thyroid carcinoma B-CPAP cells and decrease the apoptosis of cells, and this effect can be inhibited by ICA. The possible mechanism is to induce high expression of intracellular ROS and inhibit the expression of antioxidase system, leading to cell oxidative damage, thereby inducing apoptosis. https://greenmedinfo.com/article/bpa-can-promote-proliferation-thyroid-carcinoma-b-cpap-cells-and-decrease-apop#comments Bisphenol Toxicity Thyroid Cancer Bisphenol A Bisphenol A Bisphenol Toxicity Thyroid Cancer In Vitro Study Fri, 18 Aug 2017 00:27:16 +0000 greenmedinfo 151844 at https://greenmedinfo.com BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. https://greenmedinfo.com/article/bpa-exposure-during-second-trimester-may-have-adverse-effect-blood-glucose-lev n/a PMID:  J Clin Endocrinol Metab. 2017 Apr 1 ;102(4):1350-1357. PMID: 28323984 Abstract Title:  Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic. Abstract:  Context: Women with a history of infertility are at increased risk of impaired glucose tolerance during pregnancy. Studies suggest higher urinary bisphenol A (BPA) concentrations are associated with diabetes in nonpregnant populations, but the association between BPA and glucose levels among pregnant women is unclear. Objective: To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women. Design: Environment and Reproductive Health Study, an ongoing prospective cohort study. Setting: A fertility center in a teaching hospital. Patients: A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015). Main Outcome Measure: Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation. Results: The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels. Conclusions: BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed. https://greenmedinfo.com/article/bpa-exposure-during-second-trimester-may-have-adverse-effect-blood-glucose-lev#comments Bisphenol Toxicity Bisphenol A Bisphenol A Bisphenol Toxicity women's health Human Study Thu, 04 May 2017 20:41:36 +0000 greenmedinfo 147250 at https://greenmedinfo.com BPA exposure has adverse effect on cardiac insulin signal transduction which may affect its function. https://greenmedinfo.com/article/bpa-exposure-has-adverse-effect-cardiac-insulin-signal-transduction-which-may- n/a PMID:  Chem Biol Interact. 2017 Jan 30. Epub 2017 Jan 30. PMID: 28153594 Abstract Title:  Dose-dependent effect of Bisphenol-A on insulin signaling molecules in cardiac muscle of adult male rat. Abstract:  Environmental contaminant, Bisphenol-A (BPA) is a xenoestrogen, an essential component used for the production of two classes of polymers such as polycarbonate and epoxy resin which disrupts the normal endocrine function. BPA has intense effects on mice endocrine pancreas, an essential tissue involved in glucose metabolism. It disrupts pancreaticβ-cell insulin content, induces hyperinsulinemia and insulin resistance in male rats. Cardiac muscle is an insulin responsive organ and insulin has direct effects on glucose transport. The present study was designed to assess the effect of BPA on insulin signaling molecules in the cardiac muscle ofadult male Wistar rat. Adult male Wistar rats (200-250 g) were selected and divided into following groups: Group 1: Control (vehicle treated), Group 2: Rats treated with 10 mg BPA/kg b.wt./day for 30 days orally, Group 3: Rats treated with 100 mg BPA/kg b.wt./day for 30 days orally, Group 4: Rats treated with 400 mg BPA/kg b.wt./day for 30 days orally. IR (insulin receptor) and pIR(Tyr1162) proteins were significantly decreased in the high dose group (400 mg). There was no change in IRS1 (insulin receptor substrate-1) and Akt proteins. Whereas, a decrease in pIRS1(Tyr632) (100 mg and 400 mg), pAkt (Ser473) (400 mg) and GLUT4 (glucose transporter 4) (cytosolic and plasma membrane) proteins was observed which may affect the cardiovascular function. It is concluded that BPA exposure has adverse effect on cardiac insulin signal transduction which may affect its function. https://greenmedinfo.com/article/bpa-exposure-has-adverse-effect-cardiac-insulin-signal-transduction-which-may-#comments Bisphenol Toxicity Bisphenol A Cardiotoxic Bisphenol A Bisphenol Toxicity Risk Factors Animal Study Thu, 09 Feb 2017 01:41:50 +0000 greenmedinfo 143249 at https://greenmedinfo.com BPA exposure was associated with alterations in the timing of pubertal development. https://greenmedinfo.com/article/bpa-exposure-was-associated-alterations-timing-pubertal-development n/a PMID:  Environ Health. 2017 Jul 27 ;16(1):80. Epub 2017 Jul 27. PMID: 28750633 Abstract Title:  Urinary bisphenol A and pubertal development in Chinese school-aged girls: a cross-sectional study. Abstract:  BACKGROUND: Animal studies suggest that bisphenol A (BPA) may perturb pubertal development in females. However, evidence from human studies is limited. METHODS: This was a cross-sectional study to investigate the association between BPA exposure and pubertal development in school-aged girls. A total of 655 girls aged 9-18 years were selected from three schools in Shanghai, from May to June 2011. We collected one single spot urine sample from each girl. Urine BPA concentrations were measured by modified high-performance liquid chromatography and categorized according to LOD and the median of those above LOD. Pubertal development status was assessed by using Tanner staging, and age at menarche was collected as a milestone for mid-puberty. Modified Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for potential confounders, girls with detected BPA were more likely to have delayed menarche, a mid-puberty event, compared with girls with undetectable BPA; the prevalence ratios (PR) were 0.73 (0.56, 0.95) for those with moderate BPA(LOD-median) and 0.72 (0.52, 0.99) for those with high BPA(&gt;median), respectively. Girls aged 9-12 years with detected BPA were more likely to have reached pubic hair stage 2, the indicator of pubarche; while among girls aged&gt;15 years, those with detected BPA were less likely to have reached pubic hair stage 5, the late stage of pubic hair development. CONCLUSIONS: BPA exposure was associated with alterations in the timing of pubertal development. Results in the present study should be interpreted with caution because of its cross-sectional nature and the limited sample size in each age group. https://greenmedinfo.com/article/bpa-exposure-was-associated-alterations-timing-pubertal-development#comments Bisphenol Toxicity Puberty: Delayed Bisphenol A Bisphenol A Bisphenol Toxicity Puberty: Delayed Human Study Thu, 17 Aug 2017 23:42:26 +0000 greenmedinfo 151835 at https://greenmedinfo.com BPA may play a major role in the pathogenesis of polycystic ovarian syndrome. https://greenmedinfo.com/article/bpa-may-play-major-role-pathogenesis-polycystic-ovarian-syndrome n/a PMID:  Acta Med Iran. 2017 Dec ;55(12):759-764. PMID: 29373882 Abstract Title:  The Association Between Bisphenol A and Polycystic Ovarian Syndrome: A Case-Control Study. Abstract:  Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder with unclear etiopathogenesis among reproductive age women. Evidences show genetic susceptibility and environmental factors were associated with PCOS. The aim of this study was to find the association between urinary concentrations of Bisphenol-A as an endocrine disrupting chemical (EDC) and PCOS. A case-control study was conducted in 51 samples in each group. All cases were selected from women who diagnosed with PCOS at Gynecology and infertility center. The control group was selected from women who had clinical file in the center due to previous problem and came for routine check-up and pap smear. The participants were asked to collect a first-morning urine sample before any medical interventions. Total BPA in urine were measured with High Performance Liquid Chromatography (HPLC) method. Comparison of BPA level between two groups shows significantly higher level in PCOS group compared with control group (3.34± 2.63 vs 1.43 ± 1.57 ng/mL, P&lt;0.001). Using logistic regression analysis, BPA as the main dependent variable, was significantly associated with PCOS with adjusted Odds Ratio (OR) equal to 1.53 (95% CI: 1.14-2.05, P =0.004). The results of this study indicated that BPA may play a major role in the PCOS pathogenesis. Further investigations with better design are necessary to confirm this association. https://greenmedinfo.com/article/bpa-may-play-major-role-pathogenesis-polycystic-ovarian-syndrome#comments Bisphenol Toxicity Polycystic Ovary Syndrome Bisphenol A Bisphenol A Bisphenol Toxicity Increased Risk Polycystic Ovary Syndrome Human Study Wed, 31 Jan 2018 04:19:31 +0000 greenmedinfo 159034 at https://greenmedinfo.com Crocin possesses hepatoprotective effects against BPA-induced liver toxicity. https://greenmedinfo.com/article/crocin-possesses-hepatoprotective-effects-against-bpa-induced-liver-toxicity n/a PMID:  Food Chem Toxicol. 2017 Jul 5. Epub 2017 Jul 5. PMID: 28689058 Abstract Title:  Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression. Abstract:  Bisphenol A (BPA) is an artificial environmental endocrine disrupting chemical and commonly used as a monomer of polycarbonate plastics and epoxy resins. The aim of the present study is to investigate the hepatoprotective effects of crocin, a constituent of saffron, against BPA-induced liver toxicity. We showed that treatment of male Wistar rats with 0.5 mg/kg BPA for 30 days increased the level of 8-isoprostane, decreased the level of reduced glutathione, elevated serum levels of aspartate aminotransferase, lactate dehydrogenase, triglyceride, and glucose, and induced periportal inflammation. Western blot results revealed that BPA increased the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK1/2), and mitogen-activated protein kinase-activated protein kinase (MAPKAPK), but not p38. BPA also reduced the Akt signaling activation and upregulated microRNA (miR-122) expression. Moreover, we showed herethat crocin 20 mg/kg administration ameliorated liver damage and improved elevated levels of TG and liver enzymes of BPA-treated rats possibly though antioxidant activity, downregulation of miR-122 transcript level and lowering the phosphorylation of JNK, ERK1/2, and MAPKAPK and subsequently theiractivities. Overall, the findings suggest that crocin possesses hepatoprotective effects against BPA-induced liver toxicity by enhancing the antioxidative defense system and regulation of important signaling pathway activities and miR-122 expression. https://greenmedinfo.com/article/crocin-possesses-hepatoprotective-effects-against-bpa-induced-liver-toxicity#comments Bisphenol Toxicity Crocin Antioxidants Bisphenol A Hepatoprotective MicroRNA modulator Antioxidants Bisphenol Toxicity Crocin Hepatoprotective MicroRNA modulator Animal Study Fri, 14 Jul 2017 00:31:42 +0000 greenmedinfo 150413 at https://greenmedinfo.com Diet and BPA appear to modulate the activation of the AR pathway and thereby optimize tumor establishment in the gerbil prostate. https://greenmedinfo.com/article/diet-and-bpa-appear-modulate-activation-ar-pathway-and-thereby-optimize-tumor- n/a PMID:  Prostate. 2018 Feb ;78(2):152-163. Epub 2017 Nov 17. PMID: 29148069 Abstract Title:  Long-term oral exposure to safe dose of bisphenol A in association with high-fat diet stimulate the prostatic lesions in a rodent model for prostate cancer. Abstract:  BACKGROUND: Studies have shown that exposure to environmental chemicals known as endocrine disruptors can cause permanent changes in genital organs, such as the prostate. Among these environmental chemicals stands out bisphenol A (BPA). Another factor associated with prostate changes is the consumption of a high-fat diet. Although the relationship between the consumption of a high-fat diet and an increased risk of prostate cancer is well established, the mechanisms that lead to the establishment of this disease are not completely understood, nor the simultaneous action of BPA and high-fat diet. METHODS: Adult gerbils (100 days old) were divided in four groups (n = 6 per group): Control (C): animals that received a control diet and filtered water; Diet (D): animals that received a high-fat diet and filtered water; BPA: animals that received a control diet and BPA - 50 µg kg-1 day-1 in drinking water; BPA + Diet (BPA + D): animals that received a high-fat diet + BPA - 50 µg kg-1 day-1 in drinking water. After the experimental period (6 months), the dorsolateral and ventral prostate lobes were removed, and analyzed by several methods. RESULTS: Histological analysis indicated premalignant and malignant lesions in both prostatic lobes. However, animals of the D, BPA, and BPA + D groups showed a higher incidence and larger number of prostatic lesions; inflammatory foci were also common. Markers to assess prostate lesions, such as increased activation of the DNA repair system (PCNA-positive cells), androgen receptor (AR), and number of basal cells, confirmed the histology. However, serum levels of testosterone did not change under the experimental conditions. CONCLUSIONS: The results indicated that the methodology used was effective in generating metabolic changes, which directly compromised prostatic homeostasis. Diet and BPA appear to modulate the activation of the AR pathway and thereby optimize tumor establishment in the gerbil prostate. https://greenmedinfo.com/article/diet-and-bpa-appear-modulate-activation-ar-pathway-and-thereby-optimize-tumor-#comments Bisphenol Toxicity Prostate Cancer Bisphenol A Bisphenol A Bisphenol Toxicity Increased Risk prostate cancer In Vitro Study Wed, 31 Jan 2018 04:35:36 +0000 greenmedinfo 159037 at https://greenmedinfo.com Exposure to nonylphenol and BPA and possibly inflammation in increasing oxidative stress and decreasing antioxidant activity during pregnancy. https://greenmedinfo.com/article/exposure-nonylphenol-and-bpa-and-possibly-inflammation-increasing-oxidative-st n/a PMID:  Environ Sci Technol. 2017 May 11. Epub 2017 May 11. PMID: 28490175 Abstract Title:  Prenatal nonylphenol and bisphenol A exposures and inflammation are determinants of oxidative/nitrative stress: A Taiwanese cohort study. Abstract:  Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs. Third-trimester urinary biomarkers of oxidative/nitrative stress were simultaneously measured, including products of oxidatively and nitratively damaged DNA (8-hydroxy-2&#039;-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) as well as products of lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)). The antioxidant glutathione peroxidase (GPx) and inflammation biomarkers, including C-reactive protein (CRP) and a panel of cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)), were analyzed in maternal and umbilical cord plasma samples. In adjusted models, we observed significant positive associations between NP exposure and 8-OHdG and 8-NO2Gua levels, between BPA and 8-isoPF2α levels, and between maternal CRP levels and HNE-MA levels. Additionally, BPA and TNF-α levels in cord blood were inversely associated with maternal and GPx levels in cord blood as well as maternal TNF-α levels were inversely associated with maternal GPx levels. These results support a role for exposure to NP and BPA and possibly inflammation in increasing oxidative/nitrative stress and decreasing antioxidant activity duringpregnancy. https://greenmedinfo.com/article/exposure-nonylphenol-and-bpa-and-possibly-inflammation-increasing-oxidative-st#comments Bisphenol Toxicity Inflammation Prenatal Chemical Exposures Bisphenol A Nonylphenol Bisphenol A Bisphenol Toxicity Inflammation Nonylphenol Prenatal Chemical Exposures Risk Factors Animal Study Mon, 15 May 2017 21:49:43 +0000 greenmedinfo 147797 at https://greenmedinfo.com