C-Reactive Protein (CRP) https://greenmedinfo.com/category/disease/C-Reactive%20Protein%20%28CRP%29 en These findings suggest that inflammation could be relevant to a large number of patients with depression. https://greenmedinfo.com/article/these-findings-suggest-inflammation-could-be-relevant-large-number-patients-de PMID:  Psychol Med. 2019 Jul 1:1-13. Epub 2019 Jul 1. PMID: 31258105 Abstract Title:  Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Abstract:  BACKGROUND: Peripheral low-grade inflammation in depression is increasingly seen as a therapeutic target. We aimed to establish the prevalence of low-grade inflammation in depression, using different C-reactive protein (CRP) levels, through a systematic literature review and meta-analysis.METHODS: We searched the PubMed database from its inception to July 2018, and selected studies that assessed depression using a validated tool/scale, and allowed the calculation of the proportion of patients with low-grade inflammation (CRP&gt;3 mg/L) or elevated CRP (&gt;1 mg/L).RESULTS: After quality assessment, 37 studies comprising 13 541 depressed patients and 155 728 controls were included. Based on the meta-analysis of 30 studies, the prevalence of low-grade inflammation (CRP&gt;3 mg/L) in depression was 27% (95% CI 21-34%); this prevalence was not associated with sample source (inpatient, outpatient or population-based), antidepressant treatment, participant age, BMI or ethnicity. Based on the meta-analysis of 17 studies of depression and matched healthy controls, the odds ratio for low-grade inflammation in depression was 1.46 (95% CI 1.22-1.75). The prevalence of elevated CRP (&gt;1 mg/L) in depression was 58% (95% CI 47-69%), and the meta-analytic odds ratio for elevated CRP in depression compared with controls was 1.47 (95% CI 1.18-1.82).CONCLUSIONS: About a quarter of patients with depression show evidence of low-grade inflammation, and over half of patients show mildly elevated CRP levels. There are significant differences in the prevalence of low-grade inflammation between patients and matched healthy controls. These findings suggest that inflammation could be relevant to a large number of patients with depression. <p><a href="https://greenmedinfo.com/article/these-findings-suggest-inflammation-could-be-relevant-large-number-patients-de" target="_blank">read more</a></p> https://greenmedinfo.com/article/these-findings-suggest-inflammation-could-be-relevant-large-number-patients-de#comments C-Reactive Protein (CRP) Depression Inflammation Meta Analysis Risk Factors Review Mon, 08 Jul 2019 22:19:25 +0000 greenmedinfo 190841 at https://greenmedinfo.com 3 months supplementation of ginger improved glycemic indices, TAC and PON-1 activity in patients with type 2 diabetes. https://greenmedinfo.com/article/3-months-supplementation-ginger-improved-glycemic-indices-tac-and-pon-1-activi PMID:  J Complement Integr Med. 2015 Feb 10. Epub 2015 Feb 10. PMID: 25719344 Abstract Title:  The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Abstract:  Abstract Background: Ginger (Zingiber officinale) is one of the functional foods which contains biological compounds including gingerol, shogaol, paradol and zingerone. Ginger has been proposed to have anti-cancer, anti-thrombotic, anti-inflammatory, anti-arthritic, hypolipidemic and analgesic properties. Here, we report the effect of ginger supplementation on glycemic indices in Iranian patients with type 2 diabetes. Methods: A double-blind, placebo-controlled, randomized clinical trial was conducted on 20-60 -year-old patients with type 2 diabetes who did not receive insulin. Participants in the intervention and control groups were received 3 g of powdered ginger or placebo (lactose) (in capsules) daily for 3 months. Glycemic indices, total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), serum paraoxonase, dietary intake and physical activity were measured at the beginning and end of the study, and after 12 h fasting. Results: Comparison of the indices after 3 months showed that the differences between the ginger and placebo groups were statistically significant as follows: serum glucose (-19.41± 18.83 vs 1.63 ± 4.28 mg/dL, p https://greenmedinfo.com/article/3-months-supplementation-ginger-improved-glycemic-indices-tac-and-pon-1-activi#comments C-Reactive Protein (CRP) Diabetes Mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Diabetes: Glycation/A1C Ginger Hyperglycemia Insulin Resistance Hypoglycemic Agents Insulin Sensitizers Human Study Sun, 22 Mar 2015 21:46:17 +0000 greenmedinfo 116482 at https://greenmedinfo.com 8 Healing Properties of Strawberries https://greenmedinfo.com/blog/8-healing-properties-strawberries <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="8 Juicy Reasons to Eat More Strawberries" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Strawberries1.jpg" style="width: 500px; height: 333px;" /></p> <p><strong><span style="font-size:18px;"><em>Who doesn't love <a href="/substance/strawberry" rel="dofollow" target="_blank">strawberries</a>? And you don't need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there's lots more to strawberries than the flavor.</em></span><a href="#_edn1" name="_ednref1" title="">[i]</a></strong></p> <p>Their study was <strong><a href="https://www.ncbi.nlm.nih.gov/pubmed/24345049" rel="nofollow" target="_blank">published in the journal <em>Critical Reviews in Food Science and Nutrition</em></a></strong> with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry's status as a "functional food."</p><p><a href="https://greenmedinfo.com/blog/8-healing-properties-strawberries" target="_blank">read more</a></p> https://greenmedinfo.com/blog/8-healing-properties-strawberries#comments Alzheimer's Disease Anthocyanins Blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases Carotenoids Catechin Ellagic Acid Flavonoids Hyperglycemia Hyperlipidemia Hypertension Kaempferol Naringenin Parkinson's Disease Phytosterols Polyphenols Potassium Quercetin Strawberry Vitamin C Vitamin E Antioxidants Health Guide: Farm/Pharma Face Off Health Guides: Healing Foods Alzheimer's disease Anthocyanins Antioxidants blackberry C-Reactive Protein (CRP) Cancer Cardiovascular Diseases CAROTENOIDS Catechin Ellagic Acid Flavonoids hyperglycemia hyperlipidemia hypertension Kaempferol Naringenin Parkinson's disease phytosterols POLYPHENOLS potassium QUERCETIN Strawberry Vitamin C VITAMIN E Sat, 18 Feb 2023 17:30:10 +0000 GMI Research Group 114933 at https://greenmedinfo.com Long- and short-term association of low-grade systemic inflammation with cardiovascular mortality. https://greenmedinfo.com/article/long-and-short-term-association-low-grade-systemic-inflammation-cardiovascular PMID:  Clin Res Cardiol. 2019 Jul 1. Epub 2019 Jul 1. PMID: 31263995 Abstract Title:  Long- and short-term association of low-grade systemic inflammation with cardiovascular mortality in the LURIC study. Abstract:  BACKGROUND: The present study aimed to evaluate biomarkers representing low-grade systemic inflammation and their association with cardiovascular mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.METHODS: The included 3134 consecutive patients underwent coronary angiography between June 1997 and May 2001 with a median follow-up of 9.9 years. Plasma levels of IL-6, and acute-phase reactants serum amyloid A (SAA) and C-reactive protein (CRP) were measured. SAA and IL-6 polymorphisms were genotyped.RESULTS: During a median observation time of 9.9 years, 949 deaths (30.3%) occurred, of these 597 (19.2%) died from cardiovascular causes. High plasma levels of IL-6, CRP and SAA were associated with unstable CAD, as well as established risk factors including type 2 diabetes mellitus, smoking, low glomerular filtration rate, low TGs and low HDL-C. After adjusting for established cardiovascular risk markers and the other two inflammatory markers, SAA was found to be an independent risk factor for cardiovascular mortality after a short-term follow-up (6 months-1 year) with a HR per SD of 1.41. IL-6 was identified as an independent risk factor for long-term follow-up (3, 5, and 9.9 years) with HRs per SD of 1.21, 1.22 and 1.18. CRP lost significance after adjustment. Although 6 out of 27 SAA SNPs were significantly associated with SAA plasma concentrations, the genetic risk score was not associated with cardiovascular mortality.CONCLUSIONS: The present findings from the large, prospective LURIC cohort underline the importance of inflammation in CAD and the prognostic relevance of inflammatory biomarkers that independently predict cardiovascular mortality. <p><a href="https://greenmedinfo.com/article/long-and-short-term-association-low-grade-systemic-inflammation-cardiovascular" target="_blank">read more</a></p> https://greenmedinfo.com/article/long-and-short-term-association-low-grade-systemic-inflammation-cardiovascular#comments C-Reactive Protein (CRP) Cardiac Mortality Inflammation Risk Factors Human Study Mon, 08 Jul 2019 23:24:44 +0000 greenmedinfo 190848 at https://greenmedinfo.com Overweight and obese women who walked an average of 12,323 steps per day improved body weight, BMI, and lowered high-sensitivity C-reactive protein. https://greenmedinfo.com/article/overweight-and-obese-women-who-walked-average-12323-steps-day-improved-body-we PMID:  Clin Med Insights Womens Health. 2016 ;9(Suppl 1):75-84. Epub 2016 Oct 6. PMID: 27746679 Abstract Title:  Effects of a 12-Month Pedometer-Based Walking Intervention in Women of Low Socioeconomic Status. Abstract:  This study examined the effects of a 12-month walking intervention in overweight/obese, low socioeconomic women. Forty-six women (48.2± 8.0 years) entered the study. Outcomes included weight, waist and hip circumferences, body mass index (BMI), blood pressure, glycosylated hemoglobin, blood lipids, fibrinogen, and high-sensitivity C-reactive protein (hsCRP). Both intention-to-treat analyses in all participants and group analysesin study completers only (3K group = increased steps/day by ≥3,000; No Δ group = did not increase steps/day by ≥3,000) were conducted. Group × time ANOVA was used. In study completers, 3K significantly increased steps/day (6,903 ± 3,328 to 12,323 ± 5,736) compared to No Δ (4,926 ± 3,374 to5,174 ± 3,095) from baseline to 12 months. There was a significant time effect for weight (= 0.030), BMI (= 0.029), and hsCRP (= 0.044). Low socioeconomic women who adhere to a long-term, pedometer-based walking intervention significantly increased steps/day and may improve body weight, BMI, and hsCRP. This could help reduce health disparities in this population over time. <p><a href="https://greenmedinfo.com/article/overweight-and-obese-women-who-walked-average-12323-steps-day-improved-body-we" target="_blank">read more</a></p> https://greenmedinfo.com/article/overweight-and-obese-women-who-walked-average-12323-steps-day-improved-body-we#comments C-Reactive Protein (CRP) Obesity Exercise Human Study Mon, 13 Apr 2020 23:14:38 +0000 greenmedinfo 218506 at https://greenmedinfo.com Pre-operative C-reactive protein levels were independently associated with post-operative delirium. https://greenmedinfo.com/article/pre-operative-c-reactive-protein-levels-were-independently-associated-post-ope PMID:  Acta Anaesthesiol Scand. 2019 Jul 8. Epub 2019 Jul 8. PMID: 31283835 Abstract Title:  C-Reactive Protein for Risk Prediction of Postoperative Delirium and Postoperative Neurocognitive Disorder. Abstract:  BACKGROUND: Postoperative delirium (POD) and postoperative neurocognitive disorder (NCD) are frequently seen in the elderly. Development of biomarkers for preoperative risk prediction is of major relevance. As inflammation present before surgery might predispose to POD and postoperative NCD development, we aim to determine associations between preoperative C-reactive protein (CRP) and the incidence of POD and postoperative NCD.METHODS: In this observational study, we analyzed 314 patients enrolled in the SuDoCo trial, who had a preoperative CRP measurement the day before surgery. Primary outcomes were POD assessed according DSM-4 from day 1 until day 7 after surgery and postoperative NCD assessed 3 months after surgery. We conducted multivariable logistic regression analysis adjusted for age, sex, randomization, body mass index, MMSE, ASA status, infection/autoimmune disease/malignoma and types of surgery to determine associations between CRP with POD and postoperative NCD, respectively.RESULTS: Preoperative CRP was independently associated with POD [OR 1.158 (95%CI 1.040, 1.291); p=0.008]. Patients with CRP values≥ 5 mg/L had a 4.8-fold increased POD risk [OR 5.771 (95%CI 1.765, 12.899; p=0.002)] compared to patients with lower CRP values. However, no association was seen between preoperative CRP and postoperative NCD [OR 0.552 (95%CI 0.193, 1.581); p=0.269].CONCLUSIONS: Preoperative CRP levels were independently associated with POD but not postoperative NCD after three months. Moreover, higher preoperative CRP levels showed higher risk for POD. This strengthens the role of inflammation in the development of POD. Assessment of CRP before surgery might allow risk stratification of POD. This article is protected by copyright. All rights reserved. <p><a href="https://greenmedinfo.com/article/pre-operative-c-reactive-protein-levels-were-independently-associated-post-ope" target="_blank">read more</a></p> https://greenmedinfo.com/article/pre-operative-c-reactive-protein-levels-were-independently-associated-post-ope#comments C-Reactive Protein (CRP) Delirium Inflammation Risk Factors Human Study Fri, 12 Jul 2019 23:08:02 +0000 greenmedinfo 191131 at https://greenmedinfo.com Royal jelly supplementation demonstrated a statistically significant decrease in total cholesterol. https://greenmedinfo.com/article/royal-jelly-supplementation-demonstrated-statistically-significant-decrease-to PMID:  Evid Based Complement Alternat Med. 2019 ;2019:4969720. Epub 2019 Jun 13. PMID: 31312222 Abstract Title:  Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults. Abstract:  Objectives: Obesity and overweight are chronic disorders of multifactorial origin that are characterized by high oxidative status and by chronic activation of macrophages in peripheral tissues. Effective therapeutic approaches to lower inflammation and oxidative stress are currently of general interest. Royal jelly (RJ) is a functional food with a broad range of pharmacological activities, mainly used by healthy individuals or borderline patients to protect themselves against disease onset. The objective of this randomized, double-blind, placebo-controlled trial was to investigate the effects of RJ supplementation on metabolic profile and oxidative and inflammatory parameters in asymptomatic overweight adults, considered at an early stage of developing metabolic syndrome.Material and Methods: The experimental group (n=30) was given RJ and the control group (n=30) was provided with a placebo for eight weeks. Anthropometric, biochemical parameters, biomarkers of oxidative stress, and inflammation were assessed at baseline, after 4 and 8 weeks of the intervention, and after additional 2 weeks of follow up.Results and Conclusion: Compared with the placebo, RJ supplementation demonstrated a statistically significant decrease in total cholesterol (6.7%;=0.041) and inflammatory marker C-reactive protein (19%;=0.027), whereas significant increases were observed in anti-inflammatory marker adiponectin (34%;=0.011), endogenous antioxidants bilirubin (35%;=0.002) and uric acid (5%;=0.018), total antioxidant capacity in serum (54%;=0.005), and leptin (17%;=0.025). The present study demonstrated positive effects of RJ administration on lipid profile, satiety, inflammation, and antioxidant capacity in overweight adults. Therefore, our study supports the benefits of RJ supplementation for the improvement of human health. <p><a href="https://greenmedinfo.com/article/royal-jelly-supplementation-demonstrated-statistically-significant-decrease-to" target="_blank">read more</a></p> https://greenmedinfo.com/article/royal-jelly-supplementation-demonstrated-statistically-significant-decrease-to#comments C-Reactive Protein (CRP) Inflammation Overweight Royal Jelly Anti-Inflammatory Agents Anticholesteremic Agents Anti-Obesity Agents Human Study Tue, 23 Jul 2019 19:41:47 +0000 greenmedinfo 191746 at https://greenmedinfo.com The association between insomnia, c-reactive protein, and chronic low back pain. https://greenmedinfo.com/article/association-between-insomnia-c-reactive-protein-and-chronic-low-back-pain PMID:  Scand J Pain. 2019 Jul 9. Epub 2019 Jul 9. PMID: 31287802 Abstract Title:  The association between insomnia, c-reactive protein, and chronic low back pain: cross-sectional analysis of the HUNT study, Norway. Abstract:  Background and aims Chronic low back pain (chronic LBP) is the number one cause for years lived with disability among 301 diseases and injuries analyzed by The Global Burden of Disease study 2013. Insomnia is highly prevalent among people with chronic LBP. To explain the sleep-pain relationship, theoretical models propose that insomnia symptoms may be associated with increased basal inflammation, operationalized as c-reactive protein (CRP) and lead to further pain and disrupted sleep. We aimed to determine the associations between insomnia, chronic LBP, and inflammation (operationalized as CRP), whilst controlling for age, body mass index, smoking, physical activity, depression, anxiety and osteoarthritis. Methods A cross-sectional analysis of the third Nord-Trøndelag Health Study (2006-2008), a rural population survey of 50,666 participants in Norway aged 20-96 years. Insomnia (dichotomous) was defined according to the Diagnostic and Statistical Manual of Mental Disorders 5th Edition, and chronic LBP (dichotomous) as low back pain or stiffness lasting at least 3 months. Data for CRP were obtained from non-fasting serum samples and assessed via latex immunoassay methodology. We excluded participants with the following self-reported chronic somatic diseases: chronic heart failure, chronic obstructive pulmonary disease, rheumatoid arthritis, fibromyalgia or ankylosing spondylosis. Possible associations between presence of insomnia and presence of chronic LBP (dependent), and the level of CRP and presence of chronic LBP (dependent), were assessed using logistic regression models. The possible association between insomnia and CRP (dependent) wasassessed using linear regression. Multivariable analyses were conducted adjusting for confounders stated in our aim that achieved p ≤ 0.2 in univariate regressions. We performed stratified analyses for participants with&quot;Normal&quot;(10 mg/L) levels of CRP. Results In our total included sample (n = 30,669, median age 52.6, 54% female), 6.1% had insomnia (n = 1,871), 21.4% had chronic LBP (n = 6,559), and 2.4% had both (n = 719). Twenty four thousand two hundred eighty-eight (79%) participants had&quot;Normal&quot;CRP, 5,275 (17%) had&quot;Elevated&quot;CRP, and 1,136 (4%) had&quot;Very High&quot;CRP. For participants with&quot;Normal&quot;levels of CRP, insomnia was associated with higher levels of CRP (adjusted B = 0.04, 95%CI [0.00-0.08], p = 0.046), but not for people with&quot;Elevated&quot;or&quot;Very High&quot;levels of CRP. There was an association between CRP and presence of chronic LBP in the total sample (adjusted OR = 1.01, [1.00-1.01], p = 0.013) and for people with&quot;Normal&quot;CRP (1.05, [1.00-1.10, p = 0.034]. Insomnia was associated with the presence of chronic LBP in the total sample (adjusted OR = 1.99, 95%CI [1.79-2.21],<p><a href="https://greenmedinfo.com/article/association-between-insomnia-c-reactive-protein-and-chronic-low-back-pain" target="_blank">read more</a></p> https://greenmedinfo.com/article/association-between-insomnia-c-reactive-protein-and-chronic-low-back-pain#comments C-Reactive Protein (CRP) Inflammation Insomnia Low Back Pain Human Study Wed, 10 Jul 2019 18:32:20 +0000 greenmedinfo 190936 at https://greenmedinfo.com These findings suggest a significant correlation between high hs-CRP levels and depression in younger adults. https://greenmedinfo.com/article/these-findings-suggest-significant-correlation-between-high-hs-crp-levels-and- PMID:  Psychoneuroendocrinology. 2019 Jul 30 ;109:104397. Epub 2019 Jul 30. PMID: 31377557 Abstract Title:  Elevated hs-CRP level is associated with depression in younger adults: Results from the Korean National Health and Nutrition Examination Survey (KNHANES 2016). Abstract:  INTRODUCTION: Reports on the association between the level of circulating high-sensitivity C-reactive protein (hs-CRP) and depression have been inconsistent. The aim of this study was to examine the association between hs-CRP and depression in a large sample.METHODS: This study used data obtained from a representative Korean sample of 5447 people who participated in the first (2016) year of the seventh Korean National Health and Nutrition Examination Survey (KNHNES VII-1). Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as≥ 3.0 mg/L.FINDINGS: Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007). Serum hs-CRP was independently associated with the PHQ-9 total score after adjusting for potentially confounding factors (B = 0.014; 95% CI = 0.008-0.020). After controlling for body mass index (BMI), smoking, alcohol use problems, hypertension, diabetes, dyslipidemia, chronic illness related hs-CRP, and metabolic syndrome. Furthermore, elevated hs-CRP level was significantly associated with an increased risk ofdepression (adjusted OR = 1.44; 95% CI = 1.01-2.07) in younger adults, but no significant association was observed among older adults.CONCLUSION: These findings suggest a significant correlation between high hs-CRP levels and depression in younger adults. Further studies are necessary to investigate the age-specific association and the biological mechanism involved. <p><a href="https://greenmedinfo.com/article/these-findings-suggest-significant-correlation-between-high-hs-crp-levels-and-" target="_blank">read more</a></p> https://greenmedinfo.com/article/these-findings-suggest-significant-correlation-between-high-hs-crp-levels-and-#comments C-Reactive Protein (CRP) Depression Inflammation Risk Factors Human Study Wed, 07 Aug 2019 18:57:40 +0000 greenmedinfo 193110 at https://greenmedinfo.com This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level. https://greenmedinfo.com/article/meta-analysis-suggests-thatn-sativa-seed-and-seed-oil-supplementation-can-sign PMID:  Complement Ther Med. 2019 Aug ;45:149-155. Epub 2019 Jun 14. PMID: 31331553 Abstract Title:  The effect of Nigella sativa L. supplementation on serum C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Abstract:  OBJECTIVE: Evidence on the efficacy ofNigella sativa supplementation is equivocal, thus the aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to examine the effect of Nigella sativa (N. sativa) supplementation on plasma C-reactive protein (CRP) concentrations.METHODS: PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar databases were searched (up to April 2019) to identify RCTs investigating the effects of N. sativa seed and seed oil supplementation on CRP. Weighted mean differences (WMD) was pooled using a random-effects model. Standard methods were also used for assessment of heterogeneity, sensitivity analysis, and publication bias.RESULTS: Eventually only five articles which reported data of interest entered for data analysis. The meta-analysis showed a significant reduction in serum CRP (WMD: -0.55 mg/L, 95% CI: -1.02, -0.08, P = 0.02), with significant heterogeneity between selected studies (I = 77.3%). Between-study heterogeneity disappeared following subgroup analysis, stratified by baseline BMI (≥30 kg/m: I = 2.8%). However, the effect of N. sativa seed and seed oil supplementation on CRP was only significant in studies that were conducted on participants with BMI ≥ 30 kg/m(WMD: -0.50 mg/L, 95% CI: -0.85, -0.15).CONCLUSIONS: This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level. However, RCTs with a larger sample size and longer follow-up periods should be conducted for future investigations to confirm the veracity of these results. <p><a href="https://greenmedinfo.com/article/meta-analysis-suggests-thatn-sativa-seed-and-seed-oil-supplementation-can-sign" target="_blank">read more</a></p> https://greenmedinfo.com/article/meta-analysis-suggests-thatn-sativa-seed-and-seed-oil-supplementation-can-sign#comments C-Reactive Protein (CRP) Inflammation Nigella sativa (aka Black Seed) Anti-Inflammatory Agents Meta Analysis Review Wed, 07 Aug 2019 16:08:37 +0000 greenmedinfo 193088 at https://greenmedinfo.com This study's CRP evidence points toward possible anti-inflammatory effects of cannabis smoking. https://greenmedinfo.com/article/studys-crp-evidence-points-toward-possible-anti-inflammatory-effects-cannabis- PMID:  Drug Alcohol Depend. 2015 Feb 1 ;147:203-7. Epub 2014 Nov 28. PMID: 25529540 Abstract Title:  Cannabis smoking and serum C-reactive protein: a quantile regressions approach based on NHANES 2005-2010. Abstract:  BACKGROUND: Pre-clinical studies link cannabinoid-1 receptor activation to inflammation and atherosclerotic effects; anti-inflammation and immunosuppression seem to be mediated by cannabinoid-2 receptor activation. In this epidemiological study, we aim to present estimates on suspected cannabis-attributable immunomodulation as manifest in serum C-reactive protein (CRP) levels as non-specific inflammatory markers with interpretable clinical values. With strength of data from recent large nationally representative community sample surveys, the research approach illustrates value of a quantile regressions approach in lieu of the commonly used but relatively arbitrary cutpoints for CRP values.METHODS: The study population encompasses 20-59 year old participants from the National Health and Nutrition Examination Surveys, 2005-2010 (n=1115 recently active cannabis smokers and 8041 non-smokers, identified via confidential Audio Computer Assisted Self-Interviews). Age, sex, race, education, income-poverty ratio, alcohol consumption, and tobacco smoking also were measured, together with body mass index (BMI), which actually might be on a mediational path. Quantile regressions, with bootstrapping for variance estimation, made it possible to hold these covariates constant while estimating cannabis-CRP associations.RESULTS: Evidence suggesting possible cannabis-attributable immunomodulation emerges at CRP levels below the median (p https://greenmedinfo.com/article/studys-crp-evidence-points-toward-possible-anti-inflammatory-effects-cannabis-#comments C-Reactive Protein (CRP) Cannabis Inflammation Anti-Inflammatory Agents Human Study Fri, 27 Nov 2015 22:54:59 +0000 greenmedinfo 121847 at https://greenmedinfo.com Virgin coconut oil is effective in lowering C-reactive protein levels among suspect and probable cases of COVID-19. https://greenmedinfo.com/article/virgin-coconut-oil-effective-lowering-c-reactive-protein-levels-among-suspect- PMID:  J Funct Foods. 2021 Aug ;83:104557. Epub 2021 May 24. PMID: 34055047 Abstract Title:  Virgin coconut oil is effective in lowering C-reactive protein levels among suspect and probable cases of COVID-19. Abstract:  Understanding the complex pathogenesis of COVID-19 continues to evolve. With observation and quarantine as the prevailing standard of care, this study evaluated the effects of virgin coconut oil (VCO) in the biochemical markers of suspect and probable cases of COVID-19. A 28-day randomized, double-blind, controlled intervention was conducted among 63 adults in two isolation facilities in Santa Rosa City, Laguna, Philippines. The participants were randomly assigned to receive either a standardized meal (control) or a standardized meal mixed with a predefined dosage of VCO. Changes in clinical markers were measured at three time points (day 0, 14, and 28), with daily monitoring of COVID-19 symptoms. Participants in the intervention group showed a significant decline in the C-reactive protein level, with the mean CRP level normalized to ≤ 5 mg/dL on the 14th day of the intervention. As an adjunct therapy, meals mixed with VCO is effective fostering faster recovery from COVID-19. <p><a href="https://greenmedinfo.com/article/virgin-coconut-oil-effective-lowering-c-reactive-protein-levels-among-suspect-" target="_blank">read more</a></p> https://greenmedinfo.com/article/virgin-coconut-oil-effective-lowering-c-reactive-protein-levels-among-suspect-#comments C-Reactive Protein (CRP) Coconut Oil Coronavirus Infection Inflammation Anti-Inflammatory Agents Human Study Sun, 12 Jun 2022 19:59:36 +0000 greenmedinfo 259022 at https://greenmedinfo.com