Venous Insufficiency https://greenmedinfo.com/category/disease/venous-insufficiency en Buckwheat herb tea protects against leg edemia in patients with chronic venous insufficiency. https://greenmedinfo.com/article/buckwheat-herb-tea-protects-against-leg-edemia-patients-chronic-venous-insuffi PMID:  Eur J Clin Pharmacol. 1996;50(6):443-7. PMID: 8858269 Abstract Title:  Leg oedema protection from a buckwheat herb tea in patients with chronic venous insufficiency: a single-centre, randomised, double-blind, placebo-controlled clinical trial. Abstract:  OBJECTIVES: The efficacy of a buckwheat herb tea was determined in patients with chronic venous insufficiency (CVI) in a single-centre, randomised, double-blind, placebo-controlled clinical trial. METHODS: Sixty-seven male and female patients (22-74 years) with CVI were randomly divided into two groups after a 2-week run-in period. They received either buckwheat herb tea (Fagopyrum esculentum) or a placebo tea for a period of 3 months. The main outcome measure was the lower leg volume determined by ultrasound. Subjective symptoms were assessed by a clinical symptom score system. The femoral vein diameters were measured by B-scan sonography. In a subgroup of patients capillary permeability was determined by cutaneous fluorescence angiography. RESULTS: Although the mean partial leg volume did not change in the treatment group (from 2041 to 2073 ml), it increased in the placebo group by 110 ml (from 1972 to 2082 ml) according to intent to treat. The difference between the groups was significant. The subjective clinical symptoms were significantly reduced in both groups. The mean diameters of the femoral veins were reduced and capillary permeability was improved, but neither change was statistically significant. No drug-related adverse effects were observed. CONCLUSION: CVI is a very placebo-sensitive condition. The treatment with buckwheat herb tea is safe and could have a favourable influence on patients with CVI such that further oedema development is prevented. https://greenmedinfo.com/article/buckwheat-herb-tea-protects-against-leg-edemia-patients-chronic-venous-insuffi#comments Buckwheat Chronic Venous Insufficency Edema Leg Edema Rutin Venous Insufficiency Plant Extracts Human Study Tue, 23 Nov 2010 17:40:56 +0000 greenmedinfo 58952 at https://greenmedinfo.com Butcher's broom is a safe and effective treatment for chronic venous insufficiency. https://greenmedinfo.com/article/butchers-broom-safe-and-effective-treatment-chronic-venous-insufficiency PMID:  Arzneimittelforschung. 2002;52(4):243-50. PMID: 12040966 Abstract Title:  Efficacy and safety of a Butcher&#039;s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency. Abstract:  Extracts from Butcher&#039;s broom rhizome (Ruscus aculeatus) have been widely used in the oral treatment of lower leg edema in patients with chronic venous insufficiency. The aim of the present multi-center, double-blind, randomized, placebo-controlled trial was to confirm the efficacy and safety of a ruscus extract (Fagorutin Ruscus Kapseln) according to the latest scientific standards. 166 women suffering from chronic venous insufficiency (Widmer grade I and II, CEAP (Clinical signs, Etiological classification, Anatomic distribution, Pathophysiology) 3-4) were included. The data of 148 patients (30-89 years, 150-182 cm height, 49-97 kg body weight) with a mean disease duration of 14.6 years in the ruscus extract group and 15.1 years in the placebo group were eligible for the intent-to-treat-analysis. The primary parameter was the area under baseline of the leg volume changes over 12 weeks (AUB0-12). Secondary parameters were the changes in circumference of the lower leg and the ankle, changes in subjective symptoms and quality of life, the overall efficacy and tolerability and safety parameters. The study was carried out according to the guidelines for testing drugs for chronic venous insufficiency. There were significant differences between the treatment groups ruscus and placebo for the AUB0-12 (-827 ml x day), for the change of leg volume after 8 and 12 weeks of treatment (-16.5 ml and -20.5 ml), for changes in ankle and leg circumferences after 8 and 12 weeks of treatment, and for the changes in subjective symptoms, heavy tired legs and sensation of tension (week 12). For the changes in the symptoms heavy lower legs, sensation of tension, and tingling sensation a significant positive correlation with the changes in leg volume was shown. Overall assessment of efficacy was significantly better for ruscus extract compared to placebo. Overall tolerability for both treatments was assessed as good and very good. Of all 48 adverse events occurring in both treatment groups, 22 were reported in the ruscus group, one of them was considered to be related to the study medication (unlikely). Considering the study duration of three months it is concluded, that ruscus extract, in the recommended daily dosage according to the German monograph, is a safe and effective treatment for patients suffering from chronic venous insufficiency. https://greenmedinfo.com/article/butchers-broom-safe-and-effective-treatment-chronic-venous-insufficiency#comments Butchers Broom Chronic Venous Insufficency Venous Insufficiency Human Study Mon, 20 Apr 2009 06:16:04 +0000 greenmedinfo 43070 at https://greenmedinfo.com Circulation Problems https://greenmedinfo.com/disease/circulation-problems <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="450" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/VascularSystem_15.jpg" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_Eraxion&#039;&gt;Eraxion / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> https://greenmedinfo.com/disease/circulation-problems#comments Venous Insufficiency Sat, 26 Dec 2009 14:08:58 +0000 greenmedinfo 48355 at https://greenmedinfo.com Gotu kola is therapeutic in venus insufficiency, venous hypertension and edema. https://greenmedinfo.com/article/gotu-kola-therapeutic-venus-insufficiency-venous-hypertension-and-edema PMID:  Angiology. 2001 Oct;52 Suppl 2:S9-13. PMID: 11666128 Abstract Title:  Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Abstract:  Total triterpenic fraction of Centella asiatica (TTFCA) is effective in improving venous wall alterations in chronic venous hypertension and in protecting the venous endothelium. TTFCA is active on connective tissue modulation, improves the synthesis of collagen and other tissue proteins by modulating the action of fibroblasts in the vein wall, and stimulates collagen remodeling in and around the venous wall. This is due to the modulating action of TTFCA on fibroblasts as shown by experiments on the growth of human embryonal fibroblasts. TTFCA has a moderate in-vitro and in-vivo stimulating effect on collagen synthesis and, at higher dosages, an inhibition on the synthesis of collagen and acid mucopolysaccharides. Studies have indicated the role of TTFCA on the synthesis of specific venous wall elements by cell cultures of human embryonal fibroblasts. The tissue-stimulating action is shown by the increased collagen production independent from the stimulation of cell proliferation (this differentiates the action of TTFCA from cell growth factors). TTFCA is active on the microcirculation in venous and diabetic microangiopathy. Signs and symptoms of venous hypertension and edema are improved by treatment. The remodeling on collagen synthesis could be one of the possible mechanisms of actions of TTFCA in the remodeling of echolucent (soft; therefore, with risk of thrombosis and embolization) plaques at the carotid and femoral bifurcation. This compound is safe and well tolerated. In conclusion, several actions of TTFCA in vascular diseases makes the use of this compound very interesting in venous and arterial problems. https://greenmedinfo.com/article/gotu-kola-therapeutic-venus-insufficiency-venous-hypertension-and-edema#comments Chronic Venous Insufficency Edema Gotu Kola Venous Insufficiency Review Mon, 20 Apr 2009 06:09:39 +0000 greenmedinfo 41626 at https://greenmedinfo.com Horse chesnut is an effective and safe treatment for Chronic Venous Insufficiency https://greenmedinfo.com/article/horse-chesnut-effective-and-safe-treatment-chronic-venous-insufficiency PMID:  Cochrane Database Syst Rev. 2004;(2):CD003230. PMID: 15106197 Abstract Title:  Horse chestnut seed extract for chronic venous insufficiency. Abstract:  BACKGROUND: Conservative therapy of chronic venous insufficiency (CVI) consists largely of compression treatment. However, this often causes discomfort and has been associated with poor compliance. Therefore, oral drug treatment is an attractive alternative. OBJECTIVES: To review the evidence from rigorous clinical trials assessing the efficacy and safety of oral horse chestnut seed extract (HCSE) versus placebo, or other treatments for CVI. SEARCH STRATEGY: Randomised controlled trials (RCTs) of HCSE for chronic venous insufficiency were sought through EMBASE (inception to December 2001), MEDLINE and AMED (from inception to February 2004), The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2004), the Specialised Trials Register of the Cochrane Peripheral Vascular Diseases Group (last searched February 2004), and Phytobase (from inception to January 2001, no longer operational). Manufacturers of HCSE preparations and experts on the subject were contacted for published and unpublished material. There were no restrictions on language. SELECTION CRITERIA: RCTs were included if they compared oral HCSE mono-preparations with placebo, or other treatments, in patients with CVI. Trials assessing HCSE as one of several active components in a combination preparation, or as a part of a combination treatment, were excluded. DATA COLLECTION AND ANALYSIS: Two reviewers independently selected and assessed methodological quality of the studies using a standardised scoring system, and extracted data. Disagreements concerning evaluation of individual trials were resolved through discussion. MAIN RESULTS: Overall, there appeared to be an improvement in CVI related signs and symptoms with HCSE compared with placebo. Leg pain was assessed in seven placebo-controlled trials. Six reported a significant reduction of leg pain in the HCSE groups compared with the placebo groups, while another reported a statistically significant improvement compared with baseline. One trial suggested a weighted mean difference (WMD) of 42.4 mm [95% confidence interval (CI) 34.9 to 49.9] measured on a 100 mm visual analogue scale. Leg volume was assessed in six placebo-controlled trials. Meta-analysis of five trials (n = 289) suggested a significant reduction in favour of HCSE compared with placebo (WMD 56.3 ml [95% CI 24.1 to 88.5]). One trial indicated that HCSE may be as effective as compression stockings at reducing leg volume. Adverse events were usually mild and infrequent. REVIEWERS&#039; CONCLUSIONS: The evidence presented implies that HCSE is an efficacious and safe short-term treatment for CVI. However, several caveats exist and more rigorous RCTs are required to assess the efficacy of this treatment option. https://greenmedinfo.com/article/horse-chesnut-effective-and-safe-treatment-chronic-venous-insufficiency#comments Chronic Venous Insufficency Horse Chestnut Venous Insufficiency Human Study Mon, 20 Apr 2009 06:16:02 +0000 greenmedinfo 43066 at https://greenmedinfo.com Leg Edema https://greenmedinfo.com/disease/leg-edema <div class="field field-image"> <div class="field-items"> <div class="field-item odd"> <img class="imagefield imagefield-field_image" width="253" height="450" alt="" src="//cdn.greenmedinfo.com/sites/default/files/Edema_1.jpg" /> </div> </div> </div> <div class="field field-copyright"> <div class="field-items"> <div class="field-item odd"> Copyright: &lt;a href=&#039;http://www.123rf.com/profile_amawasri&#039;&gt;amawasri / 123RF Stock Photo&lt;/a&gt; </div> </div> </div> <fieldset class="fieldgroup group-facebook-like-info"><legend>Facebook Like Info</legend><div class="field field-facebook-total-count"> <div class="field-items"> <div class="field-item odd"> 0 </div> </div> </div> </fieldset> https://greenmedinfo.com/disease/leg-edema#comments Edema Venous Insufficiency Tue, 23 Nov 2010 17:40:10 +0000 greenmedinfo 58951 at https://greenmedinfo.com The Powerful Aspirin Alternative Your Doctor Never Told You About https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><img alt="The Powerful Aspirin Alternative Your Doctor Never Told You About" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/clueless_doctor_greenmedinfo.jpg" title="The Powerful Aspirin Alternative Your Doctor Never Told You About" /></span></span></p> <p><span style="font-size:18px;"><em><strong><span style="font-family:verdana,geneva,sans-serif;">Given that&nbsp;<a href="https://greenmedinfo.com/blog/aspirin-your-heart-continuing-devaluation-aspirins-resume" target="_blank">cardiovascular disease prevention guidelines</a>&nbsp;now recommend against daily low-dose aspirin use, natural, safe and effective alternatives are needed now more than ever. Thankfully, one particularly therapeutic alternative has been known about by the biomedical research community for decades...</span></strong></em></span></p><p><a href="https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2" target="_blank">read more</a></p> https://greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-2#comments Acetaminophen (Tylenol) Toxicity Aspirin-Induced Toxicity Cardiovascular Disease: Prevention Clotting Deep Vein Thrombosis Ibuprofen Toxicity NSAID-induced toxicity Post-Thrombotic Syndrome Pycnogenol (Pine Bark) Venous Insufficiency Venous Thromboembolism (VTE) Anti-Platelet Aspirin Heart Health Ibuprofen Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Tylenol Acetaminophen (Tylenol) Toxicity anti-clotting antiplatelet Aspirin Aspirin Alternatives Aspirin-Induced Toxicity bleeding Cardiovascular Disease Ibuprofen pine bark pycnogenol Fri, 12 Apr 2019 11:18:20 +0000 Sayer Ji 115570 at https://greenmedinfo.com