Trigonelline

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18 Diseases Researched for Trigonelline

Name	AC	CK
Oxidative Stress	2	3
Auditory neuropathy	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Neuropathies	1	2
Heart Failure	1	2
Hyperglycemia	1	2
Insulin Resistance	1	2
Insulin: Low	1	2
Traumatic Brain Injury	1	2
Aging	1	1
Cancers: All	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Diabetes Mellitus: Type 2	1	1
Dopamine Deficiency	1	1
Lung Cancer	1	1
Neurodegenerative Diseases	1	1
Osteoarthritis	1	1
Staphylococcus aureus infection	1	1

18 Pharmacological Actions Researched for Trigonelline

Name	AC	CK
Hypoglycemic Agents	2	3
Anti-Apoptotic	1	2
Antiproliferative	2	2
Apoptotic	2	2
Cardioprotective	1	2
Insulin Sensitizers	1	2
Neuroprotective Agents	1	2
Anti-Bacterial Agents	1	1
Anti-Inflammatory Agents	1	1
Antioxidants	1	1
Bcl-2 protein down-regulation	1	1
Cell cycle arrest	1	1
Chondroprotective	1	1
Dopaminergic	1	1
Interleukin-1 beta downregulation	1	1
Neuritogenic	1	1
Nrf2 activation	1	1
Tumor Suppressor Protein p53 Upregulation	1	1

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

View the Evidence:
11 Abstracts with Trigonelline Research

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Coffee

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Coffee consumption may have a protective/restorative function on diabetic auditory neuropathy. Aug 29, 2008

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Pubmed Data : Neurosci Lett. 2008 Aug 29;441(3):302-6. Epub 2008 Jun 22. PMID: 18586072

Article Published Date : Aug 29, 2008

Study Type : Animal Study

Additional Links

Substances : Coffee, Trigonelline

Diseases : Auditory neuropathy , Diabetic Neuropathies

[+]

Elucidating trigonelline's therapeutic mechanisms for traumatic brain injury.Feb 28, 2026

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : CNS Neurosci Ther. 2026 Mar ;32(3):e70803. PMID: 41801080

Article Published Date : Feb 28, 2026

Study Type : Animal Study

Additional Links

Substances : Trigonelline

Diseases : Oxidative Stress, Traumatic Brain Injury

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

These findings suggest that trigonelline has therapeutic potential for heart failure with preserved ejection fraction. Dec 31, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Adv Sci (Weinh). 2026 Jan ;13(5):e13956. Epub 2025 Nov 5. PMID: 41194405

Article Published Date : Dec 31, 2025

Study Type : Animal Study

Additional Links

Substances : Trigonelline

Diseases : Heart Failure

Pharmacological Actions : Cardioprotective

[+]

Trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up-regulating antioxidant enzyme activity and decreasing lipid peroxidation.Dec 16, 2011

Click here to read the entire abstract

Pubmed Data : Fundam Clin Pharmacol. 2011 Dec 16. Epub 2011 Dec 16. PMID: 22172053

Article Published Date : Dec 16, 2011

Study Type : Animal Study

Additional Links

Substances : Trigonelline

Diseases : Diabetes Mellitus: Type 1, Hyperglycemia, Insulin: Low , Insulin Resistance

Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers

[+]

Coffee contains a compound called trigonelline which promotes neurite outgrowth.Jul 01, 1999

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Pubmed Data : Biol Pharm Bull. 1999 Jul;22(7):679-82. PMID: 10443461

Article Published Date : Jul 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Coffee, Trigonelline

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuritogenic

Additional Keywords : Trigonelline

[+]

Coffee contains compounds which stimulate dopamine release.Oct 13, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Oct 13. Epub 2011 Oct 13. PMID: 22019894

Article Published Date : Oct 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : 5-hydroxytryptamides, Caffeine, Catechols, Chlorogenic Acid, Coffee, N-methylpyridinium, Pyrogallol, Trigonelline

Diseases : Dopamine Deficiency

Pharmacological Actions : Dopaminergic

[+]

Preliminary investigation showed that pumpkin seeds possess hypoglycemic properties and could assist in maintaining glycemic control.Dec 31, 2013

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Pubmed Data : Crit Rev Food Sci Nutr. 2014 ;54(10):1322-9. PMID: 24564589

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Pumpkin Seeds, Trigonelline

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Hypoglycemic Agents

[+]

Quorum sensing mediated attenuation of biofilm formation and virulence traits in Staphylococcus aureus by trigonelline.Jul 31, 2025

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Pubmed Data : Microb Pathog. 2025 Aug ;205:107731. Epub 2025 May 21. PMID: 40409430

Article Published Date : Jul 31, 2025

Study Type : In Vitro Study

Additional Links

Substances : Trigonelline

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

This study offers insights into the potential application of fenugreek, diosgenin, and trigonelline as complementary therapies for managing cancer and aging.Mar 30, 2026

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Pubmed Data : Curr Drug Res Rev. 2026 Mar 31. Epub 2026 Mar 31. PMID: 41941318

Article Published Date : Mar 30, 2026

Study Type : Review

Additional Links

Substances : Diosgenin, Fenugreek, Trigonelline

Diseases : Aging, Cancers: All

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

[+]

Trigonelline shields chondrocytes from oxidative damage in osteoarthritis.Jun 30, 2025

Click here to read the entire abstract

Pubmed Data : Appl Biochem Biotechnol. 2025 Jul ;197(7):4586-4601. Epub 2025 May 5. PMID: 40323359

Article Published Date : Jun 30, 2025

Study Type : In Vitro Study

Additional Links

Substances : Trigonelline

Diseases : Osteoarthritis, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, Nrf2 activation

[+]

Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma.Mar 19, 2026

Click here to read the entire abstract

Pubmed Data : Med Oncol. 2026 Mar 20 ;43(4). Epub 2026 Mar 20. PMID: 41860653

Article Published Date : Mar 19, 2026

Study Type : In Vitro Study

Additional Links

Substances : Trigonelline

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

Research Articles 11
Cumulative Knowledge Score 17
Overall Research Rating GOOD

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Is Coffee a Medicine for the Body and Soul?

Written by Sayer Ji, Founder

Could coffee do more than just stimulate alertness and stress out the adrenals? What if there was more going on to this ritualistic beverage consumed by billions around the world than just caffeine addiction? What if it was medicine for both the body and soul?

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 11 Abstracts with Trigonelline Research

Limited to Members Only

Currently Available Sorting Options

Coffee consumption may have a protective/restorative function on diabetic auditory neuropathy. Aug 29, 2008

Elucidating trigonelline's therapeutic mechanisms for traumatic brain injury.Feb 28, 2026

These findings suggest that trigonelline has therapeutic potential for heart failure with preserved ejection fraction. Dec 31, 2025

Trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up-regulating antioxidant enzyme activity and decreasing lipid peroxidation.Dec 16, 2011

Coffee contains a compound called trigonelline which promotes neurite outgrowth.Jul 01, 1999

Coffee contains compounds which stimulate dopamine release.Oct 13, 2011

Preliminary investigation showed that pumpkin seeds possess hypoglycemic properties and could assist in maintaining glycemic control.Dec 31, 2013

Quorum sensing mediated attenuation of biofilm formation and virulence traits in Staphylococcus aureus by trigonelline.Jul 31, 2025

This study offers insights into the potential application of fenugreek, diosgenin, and trigonelline as complementary therapies for managing cancer and aging.Mar 30, 2026

Trigonelline shields chondrocytes from oxidative damage in osteoarthritis.Jun 30, 2025

Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma.Mar 19, 2026

Trigonelline Related Articles

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Trigonelline

View the Evidence:
11 Abstracts with Trigonelline Research