Silibinin

Name	AC	CK
Liver Damage: Drug-Induced	8	32
Hepatitis C	3	30
Oxidative Stress	13	29
Lung Cancer	14	28
Liver Cancer	8	24
Breast Cancer	19	21
Cancers: Drug Resistant	9	21
Multiple Sclerosis	3	21
Inflammation	11	18
Nonalcoholic fatty liver disease (NAFLD)	9	16
Cancers: Multi-Drug Resistant	3	15
Liver Damage	4	15
Colon Cancer	8	14
Chemotherapy-Induced Toxicity: Doxorubicin	3	13
Colorectal Cancer	4	13
Alzheimer's Disease	7	12
Chemotherapy-Induced Toxicity: Paclitaxel	2	12
Coronavirus Infection	3	12
Liver Disease	2	12
Prostate Cancer	10	12
Cancers: All	9	11
Lipopolysaccharide-Induced Toxicity	7	11
Acute Respiratory Distress Syndrome	1	10
C-Reactive Protein	1	10
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	10
HIV Infections	1	10
Neurodegenerative Diseases	5	10
Pre-Eclampsia	1	10
Rheumatoid Arthritis	1	10
Vitiligo	1	10
Brain Inflammation	5	9
Carcinoma: Non-Small-Cell Lung	5	9
Breast Cancer: Triple Negative	7	7
Obesity	4	7
Parkinson's Disease	4	7
Aluminum Toxicity	3	6
Diabetes Mellitus: Type 2	4	6
Memory Disorders	3	6
Breast Cancer: estrogen receptor alpha-positive	1	5
Chemically-Induced Liver Damage	3	5
Ovarian Cancer	5	5
Acetaminophen (Tylenol) Toxicity	2	4
Anxiety	2	4
Basal Cell Carcinoma	2	4
Bladder Cancer	4	4
Colitis	2	4
Depression	2	4
Diabetic Nephropathy	2	4
Drug Toxicity: Methotrexate	2	4
Hepatic Steatosis	3	4
Osteoporosis	2	4
Periodontitis	3	4
Polycystic Ovary Syndrome	2	4
Ultraviolet Radiation Induced Damage	3	4
Bisphenol Toxicity	2	3
Chemotherapy-Induced Toxicity: Cisplatin	2	3
Cognitive Decline/Dysfunction	2	3
DNA damage	2	3
Glioblastoma	3	3
Glioma	3	3
Liver Fibrosis	2	3
Pancreatic Cancer	2	3
Radiotherapy	2	3
Skin Cancer: Prevention	2	3
Thalassemia	1	3
Anxiety Disorders	1	2
Atherosclerosis	1	2
Benzo[a]pyrene-induced Toxicity	1	2
Cachexia: Cancer	1	2
Cancer Metastasis	2	2
Candida Albicans	2	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Cholestasis	1	2
Chronic Obstructive Pulmonary Disease	1	2
Diabetes Mellitus: Type 1	1	2
Diabetic Neuropathy	1	2
Diabetic Retinopathy	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Dyslipidemias	1	2
Ehrlich carcinoma	1	2
Endometriosis	1	2
Endotoxemia	1	2
Formaldehyde Toxicity	1	2
Head and Neck Cancer	1	2
Hypertension	1	2
Inflammation: Neutrophil-Mediated	1	2
Iron Overload	1	2
Ischemia	1	2
Kidney Cancer	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Fibrosis	1	2
Learning disorders	1	2
Liver Cirrhosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Lung Cancer: Prevention	1	2
Lung Injury: Smoke-Induced	1	2
Metabolic Syndrome X	1	2
Multiple Myeloma	2	2
Muscle Atrophy	1	2
Paraquat Toxicity	1	2
Pesticide Toxicity	1	2
Radiation	1	2
Radiation Induced Illness	1	2
Schizophrenia	1	2
Sepsis	1	2
Stress	1	2
Acute Myeloid Leukemia	1	1
Advanced Glycation End products (AGE)	1	1
Aging	1	1
Alcoholic Liver Disease	1	1
Blue Light Toxicity	1	1
Breast Cancer: Metastatic	1	1
Chemotherapy	1	1
Chemotherapy and Radiation Toxicity	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chikungunya Virus	1	1
Diabetes: Oxidative Stress	1	1
Diabetic Complications	1	1
Endometrial Cancer	1	1
Enterovirus	1	1
Escherichia coli Infections	1	1
Fructose-Induced Toxicity	1	1
Gastric Cancer	1	1
Gout	1	1
Hepatitis B	1	1
High Sugar Diet	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hyperuricemia	1	1
Klebsiella Infections	1	1
Leukemia: Acute myelogenous leukemia (AML)	1	1
Lipid Peroxidation	1	1
Lymphoma	1	1
Mucositis	1	1
Promyelocytic leukemia	1	1
Prostate Cancer: Prevention	1	1
Pseudomonas aeruginosa	1	1
Squamous cell carcinoma	1	1
Staphylococcus aureus infection	1	1
Streptococcus Infections	1	1

Name	AC	CK
Antioxidants	53	109
Anti-Inflammatory Agents	47	102
Hepatoprotective	32	97
Apoptotic	51	78
Antiproliferative	45	63
Tumor Necrosis Factor (TNF) Alpha Inhibitor	15	41
Neuroprotective Agents	20	37
Antiviral Agents	7	25
Chemosensitizer	11	25
Chemoprotective Agents	10	23
NF-kappaB Inhibitor	9	23
Chemopreventive	15	22
Interleukin-1 beta downregulation	8	22
Interleukin-6 Downregulation	9	22
Anticarcinogenic Agents	7	21
Chemotherapeutic	11	21
Cell cycle arrest	7	16
Anti-metastatic	14	15
Antineoplastic Agents	6	15
Cardioprotective	4	15
Immunomodulatory	5	14
STAT3 Inhibitor	4	13
Insulin-Like Growth Factor Inhibition/Downregulation	2	12
Interleukin-10 downregulation	2	11
Renoprotective	6	11
Anti-Retroviral Agents	1	10
Antihypertensive Agents	1	10
Hypolipidemic	6	10
Immunomodulatory: Th17 downregulation	1	10
Interleukin-10 upregulation	1	10
Interleukin-8 downregulation	1	10
Radioprotective	6	10
Autophagy Up-regulation	4	8
Nrf2 activation	5	8
MicroRNA modulator	6	7
Angiogenesis Inhibitors	5	6
Anti-Fibrotic	3	6
Cyclooxygenase 2 Inhibitors	4	6
Enzyme Inhibitors	4	6
Estrogen Receptor Modulators	1	5
Glucose transporter-1 (GLUT1) expression down-regulation	1	5
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	5
Superoxide Dismutase Up-regulation	3	5
Anti-Anxiety Agents	2	4
Anti-Apoptotic	3	4
Antidepressive Agents	2	4
Hypoglycemic Agents	2	4
Malondialdehyde Down-regulation	3	4
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	4
Neurogenesis	2	4
Photoprotective	3	4
SIRT1 Activator	2	4
Vascular Endothelial Growth Factor Inhibitors	2	4
Analgesics	1	3
Anti-Angiogenic	2	3
Bax/Bcl2 ratio: Increase	1	3
Bcl-2 protein down-regulation	3	3
Insulin Sensitizers	2	3
Iron Chelating Agents	1	3
Matrix metalloproteinase-3 (MMP-3) inhibitor	2	3
Osteoprotective	2	3
Radiosensitizer	2	3
Anti-Bacterial Agents	2	2
Antioxidant	1	2
Brain-derived neurotrophic factor modulator	1	2
Catalase Up-Regulation	1	2
Cytoprotective	1	2
Gastrointestinal Agents	1	2
Genoprotective	1	2
Interleukin-1 alpha downregulation	1	2
Interleukin-4 downregulation	1	2
Neuroplasticity enhancement	1	2
Osteogenic	1	2
Tumor Suppressor Protein p53 Upregulation	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vasodilator Agents	1	2
Anti-Glycation Agents	1	1
Anticoagulants	1	1
Antimicrobial	1	1
Autophagy Inhibitors	1	1
Caspase-8 activation	1	1
DNA Repair Up-regulation	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
Glutathione Upregulation	1	1
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Nitric Oxide Inhibitor	1	1
Pancreato Protective Agents	1	1
Postaglandin PGE2 downregulation	1	1
Prophylactic Agents	1	1
Xanthine oxidase inhibitor	1	1

[+]

A lead in course with intravenous silibinin prior to the initiation of triple therapy resulted in a 63% sustained virologic response rate in 10/16 HIV/HCV coinfected patients.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015;10(7):e0133028. Epub 2015 Jul 15. PMID: 26176696

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

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Pubmed Data : Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010153

Article Published Date : Apr 18, 2019

Study Type : Human Study

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Substances : Silibinin

Diseases : Pre-Eclampsia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

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Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silybin might strengthen the effect of antihypertensive drugs giving further cardiovascular protection.Sep 18, 2018

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Pubmed Data : Intern Emerg Med. 2018 Sep 19. Epub 2018 Sep 19. PMID: 30232738

Article Published Date : Sep 18, 2018

Study Type : Human Study

Additional Links

Substances : Silibinin

Pharmacological Actions : Antihypertensive Agents, Cardioprotective

[+]

This demonstrates a possibly unique role of silymarin in mitigating hepatitis C.Dec 31, 2021

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:9199190. Epub 2022 Feb 2. PMID: 35154575

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : Hepatitis C, Oxidative Stress

Pharmacological Actions : Antioxidants, Antiviral Agents

Additional Keywords : Phytotherapy

[+]

This study showed that probably Silybum marianum is a good choice for patients with vitiligo.Apr 01, 2019

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Pubmed Data : J Dermatolog Treat. 2019 Apr 2:1-5. Epub 2019 Apr 2. PMID: 30935260

Article Published Date : Apr 01, 2019

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : Vitiligo

[+]

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

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Pubmed Data : Fitoterapia. 2018 Jan ;124:42-48. Epub 2017 Oct 12. PMID: 29031537

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Pubmed Data : Carcinogenesis. 2022 Feb 20. Epub 2022 Feb 20. PMID: 35184170

Article Published Date : Feb 19, 2022

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Basal Cell Carcinoma

Pharmacological Actions : Antiproliferative , Chemopreventive

[+]

Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency.Dec 31, 2018

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Pubmed Data : Acta Cir Bras. 2021 ;36(9):e360904. Epub 2021 Nov 8. PMID: 34755764

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

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Pubmed Data : Acta Histochem Cytochem. 2023 Feb 28 ;56(1):9-19. Epub 2023 Feb 25. PMID: 36890848

Article Published Date : Feb 27, 2023

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Liver Damage, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity.Dec 12, 2022

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:5981353. Epub 2022 Jun 16. PMID: 35757504

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Cognitive Decline/Dysfunction, Formaldehyde Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Formaldehyde

[+]

Silibinin can modulate TI-induced FAT10 expression and also restores normal chromosome numbers to cells treated with TI.Jul 02, 2015

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Pubmed Data : Biol Open. 2015 Jul 3. Epub 2015 Jul 3. PMID: 26142316

Article Published Date : Jul 02, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Genoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Chromosome, Cytokines, Gene Expression Regulation

[+]

Silibinin can promote bone regeneration of selenium hydrogel.Jan 19, 2022

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Pubmed Data : Calcif Tissue Int. 2022 Jan 20. Epub 2022 Jan 20. PMID: 35048133

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Pubmed Data : Behav Brain Res. 2018 Apr 19. Epub 2018 Apr 19. PMID: 29680784

Article Published Date : Apr 18, 2018

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator, Neurogenesis

[+]

Silibinin flavonolignan ameliorated some metabolic and reproductive alterations associated with PCOS.Dec 31, 2021

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[+]

Silibinin was demonstrated to protect the lung tissue against methotrexate induced pulmonary toxicity.Jul 31, 2015

Silibinin-loaded nanostructured lipid carriers (NLCs) ameliorated cognitive deficits and oxidative damages.Dec 31, 2021

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Pubmed Data : Toxicology. 2022 07 ;477:153260. Epub 2022 Jul 16. PMID: 35850386

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Silibinin

Diseases : Aluminum Toxicity , Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Aluminum Chloride

[+]

Silybin alleviated hepatic injury by paraquat.Mar 05, 2024

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Pubmed Data : Molecules. 2022 Dec 13 ;27(24). Epub 2022 Dec 13. PMID: 36557984

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Silibinin induces cell differentiation of human promyelocytic leukemia cells into monocytes. Jun 15, 2001

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Pubmed Data : Biochem Pharmacol. 2001 Jun 15;61(12):1487-95. PMID: 11377378

Article Published Date : Jun 15, 2001

Study Type : In Vitro Study

Additional Links

Substances : Milk Thistle, Silibinin

Diseases : Promyelocytic leukemia

Pharmacological Actions : Antioxidants, Enzyme Inhibitors

[+]

Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapy.Dec 31, 2022

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Pubmed Data : Mol Cell Biochem. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31612353

Article Published Date : Oct 13, 2019

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Silibinin inhibits the migration, invasion and epithelial-mesenchymal transition of prostate cancer.Dec 31, 2021

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Pubmed Data : Phytomedicine. 2024 Jun ;128:155493. Epub 2024 Mar 6. PMID: 38484626

Article Published Date : May 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Anti-metastatic

[+]

Silibinin might be useful in treating ALK-positive anaplastic large cell lymphoma.Jun 30, 2015

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Pubmed Data : Leuk Lymphoma. 2015 Jul 1:1-27. Epub 2015 Jul 1. PMID: 26133723

Silibinin protects cardiomyocytes from doxorubicin-induced injury. Aug 14, 2022

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Pubmed Data : Eur J Pharmacol. 2022 Aug 15 ;929:175153. Epub 2022 Jul 14. PMID: 35839932

Article Published Date : Aug 14, 2022

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

Silibinin radiosensitizes EGF receptor-knockdown prostate cancer cells.Sep 29, 2022

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Pubmed Data : J Cancer Prev. 2022 Sep 30 ;27(3):170-181. PMID: 36258717

Article Published Date : Sep 29, 2022

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Prostate Cancer

Pharmacological Actions : Radiosensitizer

[+]

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Pubmed Data : Tumour Biol. 2016 Mar 16. Epub 2016 Mar 16. PMID: 26984157

Article Published Date : Mar 15, 2016

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Silibinin suppresses tumor cell-Intrinsic resistance to nintedanib and enhances its clinical activity in lung cancer. Aug 18, 2021

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Pubmed Data : Cancers (Basel). 2021 Aug 19 ;13(16). Epub 2021 Aug 19. PMID: 34439322

[+]

Pubmed Data : Biomolecules. 2022 Nov 7 ;12(11). Epub 2022 Nov 7. PMID: 36358997

Article Published Date : Nov 06, 2022

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Curcumin, Polyphenols, Resveratrol, Silibinin

Diseases : Cancers: Drug Resistant, Multiple Myeloma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

The anticancer properties of silibinin: its molecular mechanism and therapeutic effect in breast cancer.Dec 19, 2019

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Pubmed Data : Anticancer Agents Med Chem. 2019 Dec 20. Epub 2019 Dec 20. PMID: 31858905

Article Published Date : Dec 19, 2019

Study Type : Review

Additional Links

Substances : Silibinin

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Autophagy Up-regulation, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Carboplatin, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin

[+]

The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19.Aug 21, 2022

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Pubmed Data : Biomed Pharmacother. 2022 Aug 22 ;154:113593. Epub 2022 Aug 22. PMID: 36027611

Article Published Date : Aug 21, 2022

Study Type : Review

Additional Links

Substances : Silibinin

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiviral Agents

Additional Keywords : SARS-CoV-2 Spike Protein

[+]

The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.Aug 01, 2010

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Pubmed Data : Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831

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Pubmed Data : ACS Omega. 2019 May 31 ;4(5):8421-8430. Epub 2019 May 13. PMID: 31459931

Article Published Date : May 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Silibinin

Diseases : Cancers: All, Lung Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, MicroRNA modulator

Additional Keywords : Natural Substance Synergy

[+]

These findings further support silibinin usefulness against prostate cancer through inhibiting hypoxia-induced signalling.Aug 16, 2016

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Pubmed Data : Mol Carcinog. 2016 Aug 17. Epub 2016 Aug 17. PMID: 27533043

Article Published Date : Aug 16, 2016

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Prostate Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

These mechanistic studies suggest that silibinin would be effective against PCA by targeting critical aberrant lipogenesis.Oct 29, 2014

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Pubmed Data : Oncotarget. 2014 Oct 30 ;5(20):10017-33. PMID: 25294820

Article Published Date : Oct 29, 2014

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Prostate Cancer, Prostate Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Cell cycle arrest, Chemopreventive

Additional Keywords : Gene Expression Regulation

[+]

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Pubmed Data : World J Gastroenterol. 2016 Jul 14 ;22(26):6016-26. PMID: 27468193

Article Published Date : Jul 13, 2016

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Hepatic Steatosis, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

[+]

Unravelling the role of Silibinin in targeting CD44+ cancer stem cells: Therapeutic implications, effective strategies and approaches.Mar 31, 2024

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Pubmed Data : Phytother Res. 2024 Apr ;38(4):1830-1837. Epub 2024 Feb 14. PMID: 38353369

Article Published Date : Mar 31, 2024

Study Type : Review

Additional Links

Substances : Silibinin

Diseases : Cancers: All

Pharmacological Actions : Chemosensitizer, Immunomodulatory

Additional Keywords : Cancer Stem Cells

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View the Evidence: 231 Abstracts with Silibinin Research

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A lead in course with intravenous silibinin prior to the initiation of triple therapy resulted in a 63% sustained virologic response rate in 10/16 HIV/HCV coinfected patients.Dec 31, 2014

Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis.May 01, 2021

Beneficial effects of silybin treatment after viral eradication in patients with HCV.Dec 31, 2021

Clinical management of COVID-19 in cancer patients with the STAT3 inhibitor silibinin.Dec 23, 2021

Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples. May 01, 2006

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

Significant immunomodulatory and hepatoprotective impacts of Silymarin in MS patients.Apr 28, 2021

Silibinin could be beneficial in preventing drug-induced liver injury in tuberculosis treatments. Dec 31, 2014

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Silybin might strengthen the effect of antihypertensive drugs giving further cardiovascular protection.Sep 18, 2018

This demonstrates a possibly unique role of silymarin in mitigating hepatitis C.Dec 31, 2021

This study showed that probably Silybum marianum is a good choice for patients with vitiligo.Apr 01, 2019

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

Treatment with silibinin of ERα-positive MCF-7 cells down-regulates the expression of ERα.May 11, 2015

Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer.Mar 31, 2023

Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic.Dec 31, 2022

Resveratrol enhances anticancer effects of silybin on HepG2 cells and H22 tumor-bearing mice.Jan 09, 2024

Silibinin exhibits anti-tumor effects in a breast cancer stem cell model.Dec 31, 2021

Silibinin, a potential fasting mimetic, inhibits hepatocellular carcinoma by triggering extrinsic apoptosis.Dec 31, 2023

Therapeutic potential of silymarin as a natural iron-chelating agent in β-thalassemia intermedia.Dec 31, 2021

A combination therapy using silibinin and doxorubicin may show a better therapeutic efficacy in patients with HCC.Jun 30, 2016

Anxiolytic effects of silibinin and naringenin.Oct 31, 2021

Cardioprotective effect of silymarin nanoemulsion on 5-fluorouracil-induced cardiotoxicity.Apr 10, 2022

Chemopreventive effects of silibinin on colitis-associated tumorigenesis.Dec 31, 2017

Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression.Feb 19, 2022

Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency.Dec 31, 2018

Combination of exercise and silymarin with vitamin C effectively reduced oxidative stress, liver inflammation, fat accumulation, and regulated liver enzymes.Jul 19, 2023

Deguelin appears to be a promising new preventive agent for lung cancer.Nov 30, 2005

Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury.Dec 31, 2020

Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin.Mar 31, 2011

Exosome-silibinin potently ameliorated cognitive deficits in Alzheimer's disease mice.Sep 30, 2021

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

Hesperidin and silibinin exert neuroprotective effects against aluminum chloride induced cognitive impairment and neurochemical changes.May 27, 2015

Intravenous administration of silibinin leads to statistically significant nephroprotective action.Apr 17, 2017

Oral administration of silibinin and DHS strongly inhibited the ASZ tumor growth and decreased the expression of proliferation biomarkers in tumor tissues.Dec 31, 2015

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation.Dec 31, 2022

Positive effects of different drug forms of silybin in the treatment of metabolic syndrome.Dec 31, 2014

Protective effect of silibinin on lipopolysaccharide-induced endotoxemia.Mar 26, 2024

Protective effect of silymarin on liver in experimental in the sepsis model.Feb 27, 2023

Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity.Dec 12, 2022

Radioprotective role of natural polyphenols: from sources to mechanisms. Apr 17, 2021

Regulation of gut microbiota in Alzheimer's disease mice by silibinin and silymarin and their pharmacological implications.Aug 31, 2019

Rutin, puerarin and silymarin regulated aluminum-induced imbalance of neurotransmitters and metal elements in brain.Jun 07, 2023

Silibinin a commonly used therapeutic agent for non-alcohol fatty liver disease.Jun 04, 2024

Silibinin alleviates muscle atrophy caused by oxidative stress induced by cisplatin.Dec 31, 2021

Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats.Dec 31, 2015

Silibinin ameliorated the impairment of learning and memory of LPS-injection rats.Mar 08, 2016

Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease.Dec 31, 2020

Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice.Feb 14, 2019

Silibinin ameliorates formaldehyde-induced cognitive impairment.Dec 31, 2021

Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis.Jun 30, 2019

Silibinin ameliorates STZ-induced impairment of memory and learning.Dec 31, 2019

Silibinin and naringenin against bisphenol A-induced neurotoxicity.Apr 14, 2022

Silibinin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model.Jan 22, 2020

Silibinin attenuates experimental periodontitis.Dec 31, 2022

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy.Dec 31, 2018

Silibinin augments the effect of clopidogrel on atherosclerosis.Sep 30, 2021

Silibinin can modulate TI-induced FAT10 expression and also restores normal chromosome numbers to cells treated with TI.Jul 02, 2015

Silibinin can promote bone regeneration of selenium hydrogel.Jan 19, 2022

Silibinin chronic treatment in a rat model of Parkinson disease.Feb 14, 2023

Silibinin could be a potential candidate for the therapy of neurodegenerative disorders.Jun 05, 2016

Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats.Sep 18, 2018

Silibinin effect on methotrexate-induced hepatotoxicity.Aug 15, 2022

Silibinin effectively suppressed the neutrophilic airway inflammation provoked by treatment with lipopolysaccharide and cigarette smoke.Jul 28, 2016

Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.Jan 17, 2020

Silibinin exerted effects in behavioral despair paradigm in chronically stressed mice.Dec 31, 2017

Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway.Apr 18, 2018

Silibinin flavonolignan ameliorated some metabolic and reproductive alterations associated with PCOS.Dec 31, 2021

Silibinin has radioprotective properties. Jan 01, 2010

Silibinin has shown neuroprotective potential in diabetes-peripheral neuropathy.Aug 08, 2022

Silibinin inhibited tumor aggressiveness in head and neck squamous cell carcinomas.Jun 07, 2015

Silibinin

View the Evidence:
231 Abstracts with Silibinin Research