Naringenin

Name	AC	CK
Inflammation	27	52
Oxidative Stress	27	45
Cancers: All	13	33
Nonalcoholic fatty liver disease (NAFLD)	9	31
Chemically-Induced Liver Damage	11	22
Parkinson's Disease	13	19
Alzheimer's Disease	14	17
Lipopolysaccharide-Induced Toxicity	10	17
Breast Cancer	13	16
Cognitive Decline/Dysfunction	4	16
Diabetes Mellitus: Type 2	8	14
Neurodegenerative Diseases	10	14
Lung Cancer	10	13
Rheumatoid Arthritis	8	13
Diabetic Complications	7	12
Myocardial Ischemia	7	12
Pneumonia	2	12
Osteosarcoma	2	11
Arthritis	5	10
Atherosclerosis	6	10
Brain Inflammation	6	10
Chemotherapy-Induced Toxicity: Doxorubicin	6	10
DNA damage	4	10
Depression	5	10
Insulin Resistance	5	10
Lipid Peroxidation	4	10
Obesity	5	10
Liver Fibrosis	4	9
Aluminum Toxicity	4	8
Autoimmune Diseases	5	8
Diabetic Neuropathy	4	8
Hyperglycemia	5	8
Hypertension	4	8
Kidney Damage: Chemically-Induced	4	8
Multiple Sclerosis	5	8
Testicular Injury: Chemical/Metal Induced	4	8
Cadmium Poisoning	5	7
Colorectal Cancer	5	7
Diabetic Nephropathy	4	7
Hyperuricemia	3	7
Pancreatic Cancer	2	7
Polycystic Ovary Syndrome	4	7
Bisphenol Toxicity	4	6
Breast Cancer: Triple Negative	5	6
Cardiac Hypertrophy	3	6
Cerebral Ischemia	3	6
Dengue	2	6
Diabetes: Oxidative Stress	3	6
Fibrosis	4	6
Gestational Diabetes	4	6
Kidney Damage	4	6
Liver Damage	4	6
Radiation	3	6
Aging	3	5
Cancers: Drug Resistant	4	5
Inflammatory Bowel Diseases	4	5
Lead Poisoning	1	5
Liver Damage: Drug-Induced	3	5
Skin Cancer	3	5
Ultraviolet Radiation Induced Damage	3	5
Alcohol Toxicity	2	4
Alcoholic Liver Disease	2	4
Anxiety	2	4
Asthma	2	4
Atopic Dermatitis	2	4
Carcinoma: Non-Small-Cell Lung	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Coronavirus Infection	4	4
Cough	2	4
HIV Drug-Induced Toxicity	2	4
Hepatitis C	3	4
Hydrogen Peroxide Induced Toxicity	3	4
Kidney Damage: Drug-Induced	2	4
Memory Disorders	2	4
Ovarian Cancer	3	4
Pancreatitis	2	4
Phthalate Toxicity	2	4
Tuberculosis Drug Induced Toxicity	2	4
Acetaminophen (Tylenol) Toxicity	2	3
Advanced Glycation End products (AGE)	3	3
Aging: Heart	2	3
Brain: Oxidative Stress	2	3
Cancer: Pain	2	3
Cardiomyopathy	2	3
Chemotherapy and Radiation Toxicity	2	3
Chronic Myeloid Leukemia	1	3
Colon Cancer	3	3
Diabetic Retinopathy	2	3
Endothelial Damage	2	3
Endothelial Dysfunction	3	3
Fatty Liver	2	3
Glioblastoma	3	3
Gram-Negative Bacterial Infections	1	3
Hepatitis B	2	3
Liver Cancer	3	3
Myocardial Infarction	1	3
Oral Cancer	3	3
Osteoporosis	2	3
Prostate Cancer	3	3
Snake Bite: Venom Toxicity	1	3
Squamous cell carcinoma	3	3
Staphylococcus aureus infection	3	3
Ulcerative Colitis	2	3
Wound Healing	2	3
Acute Myeloid Leukemia	2	2
Aging: Brain	1	2
Allodynia	1	2
Aortic Aneurysm	1	2
Autism Spectrum Disorders	2	2
Burns	1	2
Cancers: Multi-Drug Resistant	2	2
Cardiomegaly	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Pain	1	2
Colitis	1	2
Colon Cancer: Prevention	1	2
Constipation	1	2
Coronavirus Disease (Covid-19)	2	2
Dementia	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cataract	1	2
Drug Induced Toxicity: Metformin	1	2
Drug Toxicity: Methotrexate	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Encephalitis	1	2
Endometriosis	2	2
Endotoxemia	1	2
Epilepsy	1	2
Erectile Dysfunction	1	2
Glioma	1	2
Hair Loss	1	2
Heavy Metal Toxicity	1	2
Hepatic Steatosis	1	2
High Fat Diet	1	2
Huntington Disease	1	2
Hypercholesterolemia	1	2
Hyperlipidemia	1	2
Inflammation: Neutrophil-Mediated	1	2
Iron Overload	1	2
Ischemia	1	2
Ischemia: Myocardial	1	2
Kidney Fibrosis	1	2
Liver Failure: Acute	1	2
Lung Cancer: Prevention	1	2
Lung Injury: Acute	1	2
Melanoma	2	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	2	2
Mycoplasma Infections	1	2
Neuropathic Pain	1	2
Neutrophils: Elevated	1	2
Osteoarthritis	1	2
Osteoarthritis: Knee	1	2
Pesticide Toxicity	2	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Pseudomonas aeruginosa	2	2
Pulmonary Fibrosis	1	2
Pyrethroid Insecticide Induced Toxicity	1	2
Radiation Induced Illness	1	2
Radiation Induced Illness: Bone Marrow	1	2
Sciatic Nerve Crush Injury	1	2
Sepsis	2	2
Skin Cancer: Prevention	1	2
Skin Diseases	1	2
Social Behavior	1	2
Spinal Cord Injuries	1	2
Traumatic Brain Injury	1	2
Adiponectin: Low Levels	1	1
Advanced Glycation Endproduct (AGE) Formation	1	1
Androgen-Induced Diseases	1	1
Bladder Cancer	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Burkitt Lymphoma	1	1
Cancer Metastasis	1	1
Cardiovascular Diseases	1	1
Chikungunya Virus	1	1
Cholesterol: Oxidation	1	1
Choriocarcinoma	1	1
Coronary Artery Disease	1	1
Coronaviridae Infections	1	1
Diabetes: Cardiovascular Illness	1	1
Drug-Induced Toxicity: Gastrointestinal	1	1
Drug-Induced Toxicity: Indomethacin	1	1
Dyslipidemias	1	1
Gastric Ulcers	1	1
Glioblastoma Multiforme	1	1
Hepatitis	1	1
Hepatitis A	1	1
Herpes Simplex Virus Type 1	1	1
Hyperhomocysteinemia	1	1
Hypersensitivity	1	1
Hypersensitivity: Immediate	1	1
Influenza	1	1
Leukemia	1	1
Liposarcoma	1	1
Liver Diseases	1	1
Low Back Pain	1	1
Macular Degeneration	1	1
Myocardial Fibrosis	1	1
Nephroblastoma	1	1
Periodontitis	1	1
Retinoblastoma	1	1
Rotavirus Infections	1	1
Scars	1	1
Sciatica	1	1
Skin Cancer: Squamous Cell	1	1
Smoking	1	1
Steptococcus Mutans Infections	1	1
Stroke: Ischemic	1	1
Systemic Lupus Erythematosus	1	1
Tumors	1	1

Name	AC	CK
Anti-Inflammatory Agents	120	213
Antioxidants	126	206
Neuroprotective Agents	55	96
Hepatoprotective	36	73
Apoptotic	38	69
Antiproliferative	43	64
Cardioprotective	25	49
Anti-Apoptotic	27	46
Tumor Necrosis Factor (TNF) Alpha Inhibitor	25	41
Renoprotective	22	40
NF-kappaB Inhibitor	20	35
Nrf2 activation	23	34
Hypolipidemic	9	33
Interleukin-6 Downregulation	18	29
Interleukin-1 beta downregulation	16	26
Chemoprotective Agents	13	24
Immunomodulatory	14	22
Anti-Fibrotic	9	16
Anti-metastatic	14	14
Cell cycle arrest	11	13
Gastrointestinal Agents	7	12
Anticarcinogenic Agents	7	11
Antidepressive Agents	6	11
Antiviral Agents	7	11
Chemosensitizer	8	11
Hypoglycemic Agents	7	11
Radioprotective	6	11
Superoxide Dismutase Up-regulation	4	11
Analgesics	5	10
Gastroprotective	6	10
Heme oxygenase-1 up-regulation	7	10
Malondialdehyde Down-regulation	6	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	8	10
MicroRNA modulator	6	10
Chemotherapeutic	8	9
Chemopreventive	6	8
Cyclooxygenase 2 Inhibitors	6	8
Cytoprotective	4	8
Insulin Sensitizers	4	8
Interferon Gamma Reducer	4	8
Anti-Bacterial Agents	5	7
Antineoplastic Agents	6	7
Matrix metalloproteinase-2 (MMP-2) inhibitor	7	7
Tumor Suppressor Protein p53 Upregulation	3	7
Antihypertensive Agents	3	6
Brain-derived neurotrophic factor modulator	3	6
Genoprotective	2	6
Pancreato Protective Agents	3	6
Transforming growth factor beta (TGF-β) inhibitor	4	5
Acetylcholinesterase Inhibitor	2	4
Anti-Anxiety Agents	2	4
Antinoceceptive	2	4
Antitussive Agents	2	4
Interleukin-10 upregulation	3	4
Interleukin-12 downregulation	2	4
Interleukin-5 downregulation	2	4
Radiosensitizer	2	4
Angiogenesis Inducing Agents	1	3
Angiogenesis Inhibitors	3	3
Anticholesteremic Agents	2	3
Autophagy Inhibitors	2	3
Chelating Agents	2	3
Cyclin D1 Down-Regulation	2	3
Interleukin-17 downregulation	2	3
Photoprotective	2	3
Uricosuric Agents	1	3
Anti-Allergic Agents	1	2
Anti-Asthmatic Agents	1	2
Anti-Glycation Agents	2	2
Anti-atherogenic	1	2
Expectorants	1	2
Heat Shock Protein Inducer	1	2
Heme oxygenase-1 inducer	1	2
Interleukin-10 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-4 upregulation	2	2
Interleukin-8 downregulation	2	2
Laxative	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	2
SIRT1 Activator	2	2
Vasoprotective	1	2
Xanthine oxidase inhibitor	1	2
interleukin-13 down-regulation	2	2
Anti-Androgen	1	1
Anti-Infective Agents	1	1
Antimicrobial	1	1
Bcl-2 protein down-regulation	1	1
Caspase-3 Activation	1	1
Catalase Up-Regulation	1	1
Cytotoxicity	1	1
Glutathione Upregulation	1	1
Immunosuppressive Agents	1	1
Nitric Oxide Enhancer	1	1
Nitric Oxide Inhibitor	1	1
Osteoprotective	1	1
Proteasome Inhibitors	1	1
Quorum Sensing Inhibition	1	1
Regenerative	1	1
STAT3 Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells.May 28, 2022

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Pubmed Data : Nutr Res. 2022 May 29 ;105:33-52. Epub 2022 May 29. PMID: 35797732

Article Published Date : May 28, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Naringenin

Diseases : Cancers: All

Pharmacological Actions : Apoptotic

[+]

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Altern Complement Med. 2008 May ;14(4):423-5. PMID: 18576924

Article Published Date : Apr 30, 2008

Study Type : Human Study

Additional Links

Substances : Bitter Orange, Flavonoids, Naringenin

Therapeutic Actions : Acupressure: Auricular

Additional Keywords : Absorption

[+]

Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline.Oct 16, 2022

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Pubmed Data : Nutr J. 2022 Oct 17 ;21(1):64. Epub 2022 Oct 17. PMID: 36253765

Article Published Date : Oct 16, 2022

Study Type : Human Study

Additional Links

Substances : Naringenin

Diseases : Cognitive Decline/Dysfunction, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Ameliorative role of naringenin against lead-induced genetic damage and oxidative stress in cultured human lymphocytes.May 31, 2022

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Pubmed Data : J Biochem Mol Toxicol. 2022 Jun ;36(6):e23036. Epub 2022 Mar 15. PMID: 35289026

Naringenin isolated from Citrus reticulata blanco fruit peel inhibits the toxicity of snake venom proteins.Nov 30, 2022

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Pubmed Data : Toxicon. 2022 Dec ;220:106943. Epub 2022 Oct 13. PMID: 36244432

Article Published Date : Nov 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Snake Bite: Venom Toxicity

Pharmacological Actions : Cytoprotective

[+]

Naringenin promotes angiogenesis of ischemic myocardium after myocardial infarction.Nov 30, 2022

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Pubmed Data : Regen Ther. 2022 Dec ;21:362-371. Epub 2022 Sep 9. PMID: 36161098

Article Published Date : Nov 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Myocardial Infarction

Pharmacological Actions : Angiogenesis Inducing Agents, Cardioprotective, MicroRNA modulator

[+]

Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo.Dec 31, 2021

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Pubmed Data : Drug Deliv. 2022 Dec ;29(1):3256-3269. PMID: 36321805

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Formulations containing naringenin may be a promising approach to protecting the skin from the deleterious effects of UVB irradiation.Dec 31, 2015

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Pubmed Data : Int J Endocrinol. 2022 ;2022:7275765. Epub 2022 Aug 1. PMID: 35958293

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Diabetic Complications, Endothelial Damage

Pharmacological Actions : Heat Shock Protein Inducer

[+]

Higher dose of naringenin was comparable to the standard drug sodium valproate in effectiveness.Dec 31, 2016

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Pubmed Data : Pharmacogn Mag. 2017 Jan ;13(Suppl 1):S154-S160. Epub 2017 Apr 7. PMID: 28479741

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Epilepsy

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substances Versus Drugs

[+]

Influence of quercetin, naringenin and berberine on glucose transporters and insulin signalling molecules in brain of streptozotocin-induced diabetic rats.Sep 30, 2017

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Pubmed Data : Arch Biochem Biophys. 2022 Jan 19 ;717:109121. Epub 2022 Jan 19. PMID: 35065059

Article Published Date : Jan 18, 2022

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Lipopolysaccharide-Induced Toxicity, Liver Failure: Acute

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

[+]

Naringenin alleviates bone cancer pain.Dec 31, 2023

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Pubmed Data : Toxicol Mech Methods. 2021 Aug 4:1-39. Epub 2021 Aug 4. PMID: 34348583

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Pubmed Data : Exp Ther Med. 2021 Aug ;22(2):810. Epub 2021 May 27. PMID: 34093766

Article Published Date : Jul 31, 2021

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective, MicroRNA modulator

[+]

Naringenin ameliorates Cyclophosphamide-induced nephrotoxicity in experimental model.May 31, 2023

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Pubmed Data : Atherosclerosis. 2019 May 9 ;286:60-70. Epub 2019 May 9. PMID: 31102954

Article Published Date : May 08, 2019

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Atherosclerosis

Pharmacological Actions : Anticholesteremic Agents

[+]

Naringenin exerts a pharmacological effect against the progression of cardiac hypertrophy induced by pressure overload. Nov 30, 2015

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Pubmed Data : Food Funct. 2019 May 1. Epub 2019 May 1. PMID: 31041965

Article Published Date : Apr 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Myocardial Ischemia, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective

[+]

Naringenin improves ovalbumin-induced allergic asthma.Dec 31, 2021

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:9110798. Epub 2022 Apr 4. PMID: 35419072

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome.May 09, 2023

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Pubmed Data : Phytother Res. 2023 May 10. Epub 2023 May 10. PMID: 37165686

Naringenin may act as a potential target in the management of Parkinson's disease.Nov 14, 2018

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Pubmed Data : Int J Neurosci. 2018 Nov 15:1-7. Epub 2018 Nov 15. PMID: 30433834

Article Published Date : Nov 14, 2018

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Brain: Oxidative Stress, Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Click here to read the entire abstract

Pubmed Data : Neurochem Int. 2024 Jun 29 ;178:105799. Epub 2024 Jun 29. PMID: 38950625

Article Published Date : Jun 28, 2024

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Aluminum Toxicity , Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Problem Substances : Aluminum

[+]

Naringenin mitigates reserpine-induced anxiety-like behavior, neurodegeneration, and oxidative stress.May 17, 2023

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Pubmed Data : Avicenna J Phytomed. 2024 ;14(3):402-414. PMID: 39086864

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Naringenin

Pharmacological Actions : Immunomodulatory

[+]

Naringenin nanocrystals for improving anti-rheumatoid arthritis activity.Oct 31, 2021

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Pubmed Data : Inflammopharmacology. 2019 Jan 5. Epub 2019 Jan 5. PMID: 30612217

Article Published Date : Jan 04, 2019

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Arthritis

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Naringenin prevents carbon tetrachloride induced liver inflammation, necrosis and fibrosis.Jun 27, 2017

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Pubmed Data : Endocrinology. 2015 Jun ;156(6):2087-102. Epub 2015 Mar 16. PMID: 25774553

Article Published Date : May 31, 2015

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Fatty Liver, Obesity

Pharmacological Actions : Hypolipidemic, Insulin Sensitizers

[+]

Naringenin prevents oxidative stress and inflammation in LPS-induced liver injury.Dec 25, 2022

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Pubmed Data : J Nat Med. 2019 Jun 19. Epub 2019 Jun 19. PMID: 31218550

Article Published Date : Jun 18, 2019

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Inflammation, Inflammation: Neutrophil-Mediated, Obesity

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Naringenin suppresses the development of precancerous lesions via controlling hyperproliferation and inflammation in the colon.Jan 17, 2018

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Pubmed Data : Environ Toxicol. 2018 Jan 18. Epub 2018 Jan 18. PMID: 29345053

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Pubmed Data : Gene. 2016 Jul 15. Epub 2016 Jul 15. PMID: 27432064

Article Published Date : Jul 14, 2016

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Neutrophils: Elevated, Spinal Cord Injuries

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

[+]

Silibinin and naringenin against bisphenol A-induced neurotoxicity.Apr 14, 2022

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Pubmed Data : Molecules. 2022 Apr 15 ;27(8). Epub 2022 Apr 15. PMID: 35458770

Article Published Date : Apr 14, 2022

Study Type : Animal Study

Additional Links

Substances : Naringenin , Silibinin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Bisphenol A

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[+]

The potential protective role of naringenin against dasatinib-induced hepatotoxicity.Jun 22, 2023

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Pubmed Data : Rejuvenation Res. 2017 Dec ;20(6):462-472. Epub 2017 Jul 24. PMID: 28622086

Article Published Date : Nov 30, 2017

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

These findings indicate that flavonoids confer protection against hyperglycemia-mediated oxidative stress and enhance intestinal barrier functions.Mar 04, 2020

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Pubmed Data : Nutrition. 2020 Mar 5 ;78:110792. Epub 2020 Mar 5. PMID: 32473529

Article Published Date : Mar 04, 2020

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Naringenin , Quercetin

Diseases : Diabetes: Oxidative Stress, Hyperglycemia

Pharmacological Actions : Antioxidants, Gastroprotective

[+]

Treatment with naringenin prevents cisplatin induced hepatotoxicity, nephrotoxicity, and genotoxicity.Dec 31, 2016

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Pubmed Data : Biochem Res Int. 2017 ;2017:9478958. Epub 2017 Aug 28. PMID: 28932603

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

A review of the therapeutic potential of naringenin.Jan 09, 2019

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Pubmed Data : Pharmaceuticals (Basel). 2019 Jan 10 ;12(1). Epub 2019 Jan 10. PMID: 30634637

Article Published Date : Jan 09, 2019

Study Type : Review

Additional Links

Substances : Naringenin

Diseases : Diabetic Complications, Endothelial Dysfunction

Pharmacological Actions : Antioxidants

[+]

Anti-cancer effect of nano-encapsulated boswellic acids, curcumin and naringenin against HepG-2 cell line.Jul 28, 2023

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Pubmed Data : Toxicology. 2018 Aug 25. Epub 2018 Aug 25. PMID: 30153467

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Pubmed Data : Medicine (Baltimore). 2022 Nov 18 ;101(46):e31787. PMID: 36401485

Article Published Date : Nov 17, 2022

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Autism Spectrum Disorders

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants

[+]

Fermentation extract of naringenin increases the expression of estrogenic receptor β in human colon cancer cells exposed to BPA.Oct 04, 2022

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Pubmed Data : Molecules. 2022 Oct 5 ;27(19). Epub 2022 Oct 5. PMID: 36235125

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Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876

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Pubmed Data : Life Sci. 2016 Jul 20. Epub 2016 Jul 20. PMID: 27449398

Article Published Date : Jul 19, 2016

Study Type : In Vitro Study

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Substances : Bioflavonoids, Naringenin

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Apoptotic, Chemosensitizer

[+]

Hesperidin shows good potential as a DENV-3-RdRp inhibitor.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Trop Med. 2022 ;2022:7254990. Epub 2022 Mar 20. PMID: 35356488

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Fisetin, Hesperidin, Myricetin, Naringenin

Diseases : Dengue

Pharmacological Actions : Antiviral Agents

[+]

Inhibition of biofilm formation of foodborne Staphylococcus aureus by the citrus favonoid naringenin.Oct 27, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Foods. 2021 Oct 28 ;10(11). Epub 2021 Oct 28. PMID: 34828898

Article Published Date : Oct 27, 2021

Study Type : In Vitro Study

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Substances : Naringenin

Diseases : Staphylococcus aureus infection

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation

[+]

Inhibition of tumor invasion and metastasis by targeting TGF-β-Smad-MMP2 pathway with Asiatic acid and Naringenin.Mar 25, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Neuropharmacology. 2021 Oct 13:108831. Epub 2021 Oct 13. PMID: 34655599

Article Published Date : Oct 12, 2021

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Parkinson's Disease, Pesticide Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Paraquat

[+]

Naringenin ameliorates cytotoxic effects of bisphenol A on mouse Sertoli cells.Feb 28, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Reprod Biomed. 2023 Mar ;22(3):219-228. Epub 2024 May 15. PMID: 38868445

Article Published Date : Feb 28, 2023

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Bisphenol A

[+]

Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway.Nov 30, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : BMC Complement Med Ther. 2022 May 23 ;22(1):145. Epub 2022 May 23. PMID: 35606804

Article Published Date : May 22, 2022

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Breast Cancer

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substance/Drug Synergy

[+]

Naringenin and hesperidin as promising alternatives for prevention and co-adjuvant therapy for breast cancer.Feb 26, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Pharmacol. 2024 ;15:1406619. Epub 2024 Jun 18. PMID: 38957397

Article Published Date : Dec 31, 2023

Study Type : Review

Additional Links

Substances : Naringenin

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic

[+]

Naringenin attenuated airway cilia structural and functional injury induced by cigarette smoke extract.Mar 31, 2024

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Pubmed Data : Phytomedicine. 2024 Apr ;126:155053. Epub 2023 Sep 2. PMID: 38359483

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Heliyon. 2024 Jun 15 ;10(11):e32288. Epub 2024 May 31. PMID: 38912485

Article Published Date : Jun 14, 2024

Study Type : In Vitro Study

Additional Links

Substances : Naringenin

Diseases : Liver Cancer

Pharmacological Actions : Chemotherapeutic

[+]

Naringenin could effectively reduce mortality and morbidity from coronary heart diseases and as cardio-protective effects in humans.Dec 31, 2016

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Pubmed Data : Afr J Tradit Complement Altern Med. 2017 ;14(1):278-287. Epub 2016 Nov 23. PMID: 28480406

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View the Evidence: 394 Abstracts with Naringenin Research

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Naringenin induces intrinsic and extrinsic apoptotic signaling pathways in cancer cells.May 28, 2022

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline.Oct 16, 2022

Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease.Dec 02, 2021

Ingestion of 150 to 900mg doses of naringenin is safe in healthy adults, and serum concentrations are proportional to the dose administered.Aug 28, 2019

Naringenin from Citrus aurantium inhibits osteosarcoma progression.Dec 31, 2017

Naringenin supplementation improves lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD.Sep 12, 2021

Naringenin was safe and beneficial to children with bronchial pneumonia.Jul 31, 2021

Ameliorative role of naringenin against lead-induced genetic damage and oxidative stress in cultured human lymphocytes.May 31, 2022

Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells.Nov 08, 2016

The citrus flavanone naringenin impairs dengue virus replication in human cells.Feb 02, 2017

Naringenin ameliorates hyperuricemia in this study.Jan 24, 2023

Naringenin increases insulin sensitivity and metabolic rate.Oct 30, 2019

Naringenin is a potential immunomodulator for inhibiting liver fibrosis.Feb 27, 2023

Naringenin isolated from Citrus reticulata blanco fruit peel inhibits the toxicity of snake venom proteins.Nov 30, 2022

Naringenin promotes angiogenesis of ischemic myocardium after myocardial infarction.Nov 30, 2022

Naringenin restores colistin activation against colistin-resistant gram-negative bacteria in vitro and in vivo.Dec 31, 2021

Oxidative lipid damage by naringenin selectively sensitizes chronic myeloid leukemia cell lines.Sep 02, 2024

Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer.Dec 31, 2023

The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition.Jul 31, 2024

Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model.Feb 20, 2020

Administration of naringenin to propofol-exposed mice resulted in significant neuroprotective effects.Dec 31, 2019

Analysis showed that naringenin corrected the altered sciatic changes in diabetic animals.Sep 30, 2015

Anti-depressant effect of naringenin-loaded hybridized nanoparticles in diabetic rats.Jun 11, 2024

Antioxidative and anti-inflammatory activities of chrysin and naringenin.Mar 05, 2022

Antioxidative effect of flavonoid naringenin in the lenses of type 1 diabetic rats.Nov 30, 2018

Anxiolytic effects of silibinin and naringenin.Oct 31, 2021

Apigenin and naringenin can ameliorate glucose and lipid metabolism, as well as endothelial dysfunction in T2D ratsJan 19, 2016

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Breast cancer suppression by curcumin-naringenin-magnetic-nano-particles: In vitro and in vivo studies.Dec 31, 2020

Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.Mar 15, 2020

Citrus naringenin increases neuron survival in optic nerve crush injury model. Dec 28, 2021

Combination antiretroviral therapy (cART)-induced hippocampal disorders: Highlights on therapeutic potential of naringenin and quercetin.May 31, 2019

Combined treatment with naringenin and hesperetin might be a promising anti-cancer strategy for pancreatic cancers.Nov 19, 2018

Curcumin and naringenin exhibit neuroprotective properties in an animal model of Parkinson's disease.Oct 01, 2005

Daily consumption of flavonoids such as naringenin may have a therapeutic potential to combat Parkinson's disease.Oct 04, 2023

Dibutyl phthalate-induced oxidative stress and apoptosis in swine testis cells and therapy of naringenin.Mar 31, 2022

Effects of naringenin on experimentally induced rheumatoid arthritis. Sep 30, 2021

Erectile dysfunction attenuation by naringenin in streptozotocin-induced diabetic rats.Jun 30, 2019

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein.Sep 04, 2019

Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.Nov 30, 2022

Formulations containing naringenin may be a promising approach to protecting the skin from the deleterious effects of UVB irradiation.Dec 31, 2015

Four citrus flavanones exert atherosclerosis alleviation effects.May 04, 2021

Glioma progression is suppressed by Naringenin and APO2L combination therapy.Aug 06, 2020

Heat shock protein 70 mediates the protective effect of naringenin on high-glucose-induced alterations of endothelial function.Dec 31, 2021

Higher dose of naringenin was comparable to the standard drug sodium valproate in effectiveness.Dec 31, 2016

Influence of quercetin, naringenin and berberine on glucose transporters and insulin signalling molecules in brain of streptozotocin-induced diabetic rats.Sep 30, 2017

Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in animals.Aug 31, 2018

Investigation into the protective effects of Naringenin in phthalates-induced reproductive damage.Apr 30, 2022

Isolated mangiferin and naringenin exert antidiabetic effects.Jan 24, 2018

Liposomal-naringenin radiosensitizes triple-negative breast cancer MDA-MB-231 cells.Dec 31, 2023

Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease.Jul 17, 2017

Naringenin administration significantly reduced the DNA damage induced by oxaliplatin.Feb 19, 2019

Naringenin affords protection against lipopolysaccharide/D-galactosamine-induced acute liver failure.Jan 18, 2022

Naringenin alleviates bone cancer pain.Dec 31, 2023

Naringenin alleviates cognition deficits in high-fat diet-fed SAMP8 mice.Jul 16, 2020

Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury.Dec 21, 2023

Naringenin alleviates hepatic injury from zinc oxide nanoparticles.Aug 03, 2021

Naringenin alleviates hyperglycemia-induced renal toxicity.Oct 05, 2021

Naringenin alleviates liver ﬁbrosis by triggering autophagy-dependent ferroptosis in hepatic stellate cells.Apr 14, 2024

Naringenin alleviates myocardial ischemia reperfusion injury.Jul 31, 2021

Naringenin alleviates radiation-induced intestinal injury.Apr 05, 2024

Naringenin alleviates renal ischemia reperfusion injury.Dec 31, 2021

Naringenin alleviates the excessive lipid deposition of polycystic ovary syndrome.Nov 30, 2023

Naringenin ameliorated kidney injury in an animal model of diabetic nephropathy.Dec 31, 2015

Naringenin ameliorated toxicity of high cobalt chloride via metal-flavonoid chelates.Nov 10, 2022

Naringenin ameliorates aluminum toxicity-induced testicular dysfunctions. May 18, 2023

Naringenin ameliorates amyloid-β pathology and neuroinflammation in Alzheimer's disease.Jul 27, 2024

Naringenin ameliorates atopic dermatitis by inhibiting inflammation and enhancing immunity.Oct 13, 2023

Naringenin ameliorates carbon tetrachloride-induced hepatic damage.Mar 02, 2020

Naringenin ameliorates collagen-induced arthritis.Sep 30, 2023

Naringenin ameliorates Cyclophosphamide-induced nephrotoxicity in experimental model.May 31, 2023

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View the Evidence:
394 Abstracts with Naringenin Research