Lutein

Name	AC	CK
Cognitive Decline/Dysfunction	6	51
Macular Degeneration	13	49
Breast Cancer	7	34
Oxidative Stress	14	31
Coronary Artery Disease	2	30
Cataract	7	24
Alzheimer's Disease	3	21
Stroke	2	21
Aging: Brain	2	20
Hypertension	2	20
Metabolic Diseases	1	20
Vision Disorders	2	20
Eye Diseases	4	13
Colon Cancer	2	12
Depression	2	12
Inflammation	7	12
Memory Disorders	2	12
Obesity	2	12
DNA damage	2	11
Dementia	2	11
Nonalcoholic fatty liver disease (NAFLD)	2	11
Breast Cancer: Prevention	1	10
Clostridium Infections	1	10
Colon Cancer: Prevention	1	10
Computer display light exposure	1	10
Diabetic Retinopathy	8	10
Hypercholesterolemia	1	10
Infant Nutrition	1	10
Kidney Cancer	1	10
Learning disorders	1	10
Myopia	1	10
Pre-Eclampsia	1	10
Prostate Cancer: Prevention	1	10
Radiation Induced Illness	1	10
Retinal Diseases	1	10
Retinoblastoma	1	10
Vision Loss	1	10
Visual Display Terminal Eye Fatigue	1	10
Visual Fatigue	1	10
Alcohol Toxicity	4	8
Photooxidative Stress	4	6
Retinitis Pigmentosa	3	4
Cancers: All	3	3
Diabetes Mellitus: Type 1	2	3
Diabetic Complications	2	3
Drug Toxicity: Methotrexate	2	3
Eye Damage	2	3
Kidney Damage	1	3
Parkinson's Disease	2	3
Air Pollution Linked Toxicity	1	2
Alcoholic Liver Disease	1	2
Arsenic Poisoning	1	2
Chemically-Induced Liver Damage	1	2
Chemotherapy and Radiation Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Diabetes: Low Immune Function	1	2
Fatty Liver	1	2
Heart Failure	1	2
Hyperglycemia	1	2
Immune Disorders: Low Immune Function	1	2
Ischemia	1	2
Lung Damage	1	2
Maculopathy: Age-Related	1	2
Neurodegenerative Diseases	2	2
Polycystic Ovary Syndrome	1	2
Retinal Degeneration: Light-Induced	2	2
Spinal Cord Injuries	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Atherosclerosis	1	1
Blindness	1	1
Blue Light Toxicity	1	1
Cancers: Multi-Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cardiovascular Diseases	1	1
Cholesterol: Oxidation	1	1
Deoxynivalenol Induced Toxicity	1	1
Diabetes Mellitus: Type 2	1	1
Diabetes: Cognitive Dysfunction	1	1
Encephalopathy	1	1
Gastric Cancer	1	1
Glaucoma	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Hypoxia	1	1
Liver Cancer: Prevention	1	1
Liver Diseases	1	1
Melanoma	1	1
Pancreatitis	1	1
Prostate Cancer	1	1
Retinal Detachment	1	1
Streptococcus pyogenes	1	1
Ultraviolet Radiation Induced Damage	1	1
Uveitis	1	1

Name	AC	CK
Neuroprotective Agents	18	110
Antioxidants	36	90
Chemopreventive	10	73
Anti-Inflammatory Agents	21	40
Cardioprotective	3	23
Hepatoprotective	7	20
Interleukin-1 beta downregulation	6	19
Interleukin-6 Downregulation	5	14
Anticarcinogenic Agents	3	13
Antidepressive Agents	2	12
Malondialdehyde Down-regulation	2	12
Tumor Necrosis Factor (TNF) Alpha Inhibitor	6	11
Antihypertensive Agents	1	10
Enzyme Inhibitors	1	10
Nrf2 activation	5	9
NF-kappaB Inhibitor	5	8
Heme oxygenase-1 up-regulation	3	6
Apoptotic	5	5
Antiproliferative	3	4
Interleukin-18 down-regulation	2	4
Anti-Apoptotic	2	3
Photoprotective	3	3
Renoprotective	1	3
Anticholesteremic Agents	1	2
Brain-derived neurotrophic factor modulator	1	2
Chemoprotective Agents	1	2
Chemosensitizer	2	2
Cytoprotective	2	2
Gastrointestinal Agents	1	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Anti-Bacterial Agents	1	1
Anti-metastatic	1	1
Antineoplastic Agents	1	1
Autophagy Up-regulation	1	1
Bcl-2 protein down-regulation	1	1
Cell cycle arrest	1	1
Chemotherapeutic	1	1
Cyclooxygenase 2 Inhibitors	1	1
Hypoglycemic Agents	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-8 downregulation	1	1
P-glycoprotein Inhibitors	1	1

[+]

Higher blood concentrations of lutein are generally associated with better cardiometabolic health.Jan 12, 2016

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Pubmed Data : Am J Clin Nutr. 2016 Jan 13. Epub 2016 Jan 13. PMID: 26762372

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Pubmed Data : Nutr Neurosci. 2021 Jan 15:1-16. Epub 2021 Jan 15. PMID: 33448903

Article Published Date : Jan 14, 2021

Study Type : Human Study

Additional Links

Substances : Choline, Lutein, Zeaxanthin

Diseases : Cognitive Decline/Dysfunction, Obesity

Pharmacological Actions : Neuroprotective Agents

[+]

Additional consumption of one egg per day increases serum lutein plus zeaxanthin concentration and lowers oxidized low-density lipoprotein.Aug 31, 2017

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Pubmed Data : Food Res Int. 2017 Sep ;99(Pt 2):944-949. Epub 2017 Mar 4. PMID: 28847431

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Pubmed Data : Public Health Nutr. 2020 Dec 1:1-18. Epub 2020 Dec 1. PMID: 33256873

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : B-Carotene, Fiber, Lutein, Vitamin C

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Dietary carotenoid intake and risk of developing preeclampsia.May 20, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Pregnancy Childbirth. 2022 May 21 ;22(1):427. Epub 2022 May 21. PMID: 35597902

Article Published Date : May 20, 2022

Study Type : Human Study

Additional Links

Substances : beta-Carotene, Carotenoids, Cryptoxanthin, Lutein, Lycopene

Diseases : Pre-Eclampsia

Additional Keywords : Risk Reduction

[+]

Dietary carotenoids lutein and zeaxanthin change brain activation in older adult participants.Apr 04, 2019

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Pubmed Data : Mol Nutr Food Res. 2019 Apr 5:e1801051. Epub 2019 Apr 5. PMID: 30950580

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Pubmed Data : Ophthalmologe. 2012 Feb ;109(2):112-20. PMID: 22350547

Article Published Date : Jan 31, 2012

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), Lutein, Vitamin A

Additional Keywords : Genotype, Ophthalmology, Retina Degeneration, Vitamin A Side Effects

[+]

High combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in ionizing radiation persons.Nov 01, 2009

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Pubmed Data : : Paediatr Perinat Epidemiol. 1998 Apr;12(2):176-81. PMID: 19586568

Article Published Date : Apr 01, 1998

Study Type : Human Study

Additional Links

Substances : Lutein

Diseases : Computer display light exposure

[+]

Lutein supplementation improves visual function in those with age-related macular degeneration.Apr 01, 2004

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Pubmed Data : Optometry. 2004 Apr;75(4):216-30. PMID: 15117055

Article Published Date : Apr 01, 2004

Study Type : Human Study

Additional Links

Substances : Lutein

Diseases : Macular Degeneration

Pharmacological Actions : Antioxidants

[+]

Maintaining higher concentrations of lutein in respect to plasma lipids may moderately decrease the risk of dementia and Alzheimer's disease.Aug 17, 2015

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2015 Aug 18. Epub 2015 Aug 18. PMID: 26286605

Article Published Date : Aug 17, 2015

Study Type : Human Study

Additional Links

Substances : Carotenoids, Lutein

Diseases : Alzheimer's Disease, Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Renal cell carcinoma risk associated with lower intake of micronutrients.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Med. 2018 08 ;7(8):4087-4097. Epub 2018 Jul 2. PMID: 29968964

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Alpha-Carotene, beta-Carotene, Cryptoxanthin, Folate, Lutein, Lycopene, Selenium, Thiamine (B-1) , Vitamin A, Vitamin C, Vitamin E, Zeaxanthin

Diseases : Kidney Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

Results of this study suggest that the carotenoids beta-cryptoxanthin, lycopene, and lutein/zeaxanthin may protect against breast cancer. Dec 31, 1997

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Pubmed Data : Cancer Causes Control. 1998 Jan ;9(1):89-97. PMID: 9486468

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Pubmed Data : Br J Nutr. 2015 Oct 20:1-9. Epub 2015 Oct 20. PMID: 26482064

Administration of lutein in combination with vitamin C improved the status of the total antioxidant defense system in SD rats.Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lab Anim Res. 2015 Sep ;31(3):117-24. Epub 2015 Sep 30. PMID: 26472964

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Substances : Lutein, Vitamin C

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Astaxanthin and lutein have neuroprotective effects and reduce ocular oxidative stress, and inflammation in the STZ diabetic rat model.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytother Res. 2022 Sep 9. Epub 2022 Sep 9. PMID: 36086831

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Pubmed Data : Photochem Photobiol Sci. 2020 Jun 26. Epub 2020 Jun 26. PMID: 32589182

Article Published Date : Jun 25, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lutein, Zeaxanthin

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats.Oct 31, 2010

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Pubmed Data : Wei Sheng Yan Jiu. 2010 Nov ;39(6):689-92. PMID: 21351632

Article Published Date : Oct 31, 2010

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Pubmed Data : Iran J Basic Med Sci. 2019 Apr ;22(4):412-417. PMID: 31168346

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Lutein

Diseases : Ischemia, Spinal Cord Injuries

Pharmacological Actions : Antioxidants

[+]

Regular exercise training with lutein/zeaxanthin isomers regulates brain transcription factors and neurotrophic and synaptic proteins.May 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31223768

Article Published Date : May 31, 2019

Study Type : Animal Study

Additional Links

Substances : Lutein, Zeaxanthin

Diseases : Inflammation, Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Brain-derived neurotrophic factor modulator, Nrf2 activation

[+]

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015;2015:759459. Epub 2015 Oct 21. PMID: 26576195

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Lutein, Quercetin

Diseases : Streptococcus pyogenes

Pharmacological Actions : Anti-Bacterial Agents

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Antibiotics

[+]

Marigold cultivars had reasonable correlations between lutein content and the capacity to inhibit α-amylase and α-glucosidase activities.Apr 07, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Feb 27 ;12(3). Epub 2020 Feb 27. PMID: 32120794

Article Published Date : Feb 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Aug 8 ;25(16). Epub 2020 Aug 8. PMID: 32784397

Article Published Date : Aug 07, 2020

Study Type : Review

Additional Links

Substances : Lutein, Zeaxanthin

Diseases : Macular Degeneration

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Photoprotective

[+]

Lutein prevents cataract development and progression in diabetic rats.Sep 03, 2008

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Pubmed Data : Graefes Arch Clin Exp Ophthalmol. 2008 Sep 3. PMID: 18766362

Article Published Date : Sep 03, 2008

Additional Links

Substances : Lutein

Diseases : Cataract

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View the Evidence: 116 Abstracts with Lutein Research

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Higher blood concentrations of lutein are generally associated with better cardiometabolic health.Jan 12, 2016

Decreased intake of vegetables and fruits during pregnancy and the consequent decreased intake of nutrients such as folate and lutein/zeaxanthin, necessary for DNA methylation, synthesis, and retinal function, may increase risk for having a child with spJun 01, 2005

A blackcurrant product regulated the microbiota of volunteers and decreased the activity of βeta glucuronidase.Feb 28, 2014

A greater intake of choline and lutein and zeaxanthin was associated with faster performance on a cognitive flexibility task in overweight people.Jan 14, 2021

Additional consumption of one egg per day increases serum lutein plus zeaxanthin concentration and lowers oxidized low-density lipoprotein.Aug 31, 2017

Co-consuming cooked whole eggs is an effective way to enhance carotenoid absorption from other carotenoid-rich foods.May 26, 2015

Daily consumption of a lutein-enriched egg drink for one year leads to a significant increase in visual acuity.Dec 31, 2015

Dietary antioxidants and fiber intake and depressive symptoms in Iranian adolescent girls.Nov 30, 2020

Dietary carotenoid intake and risk of developing preeclampsia.May 20, 2022

Dietary carotenoids lutein and zeaxanthin change brain activation in older adult participants.Apr 04, 2019

Dietary intake of B vitamins may affect the occurrence of age-related lens opacities. Jun 30, 2015

Efficacy of lutein supplements on macular pigment optical density in highly myopic individuals.Mar 23, 2023

Genotype may codetermine potential vitamin A side effects on retinal integrity.Jan 31, 2012

High combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in ionizing radiation persons.Nov 01, 2009

Higher intake and serum levels of most carotenoids were associated with lower odds of having NAFLD.May 16, 2019

Higher intake of bioavailable lutein and zeaxanthin is associated with a long-term reduced risk of advanced age-related macular degeneration.Oct 07, 2015

Higher intake of certain nutrients among older adults is associated with better cognitive function.Dec 04, 2023

Higher lutein and zeaxanthin intake during pregnancy was associated with better offspring verbal intelligence and behaviour regulation in mid-childhood.Jan 19, 2021

Higher plasma lutein and zeaxanthin are associated with better cognitive function.Jan 19, 2017

Intake of vegetables appears to decrease premenopausal breast cancer risk. Mar 20, 1996

Lutein exerts anti-inflammatory effects in patients with coronary artery disease.May 05, 2017

Lutein produced increased ocular blood flow biomarkers within retinal vascular beds and reduced diastolic blood pressure.Mar 31, 2019

Lutein reduces oxidative stress in the term newborn.Jan 01, 2010

Lutein supplementation improves visual fatigue. Nov 01, 2009

Lutein supplementation improves visual function in patients with age-related cataracts.Jan 01, 2003

Lutein supplementation improves visual function in people exposed to long-term computer display light exposure. Apr 01, 1998

Lutein supplementation improves visual function in those with age-related macular degeneration.Apr 01, 2004

Maintaining higher concentrations of lutein in respect to plasma lipids may moderately decrease the risk of dementia and Alzheimer's disease.Aug 17, 2015

Renal cell carcinoma risk associated with lower intake of micronutrients.Dec 31, 2017

Results of this study suggest that the carotenoids beta-cryptoxanthin, lycopene, and lutein/zeaxanthin may protect against breast cancer. Dec 31, 1997

Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults.Dec 31, 2013

Supplementation with lutein and zeaxanthin improves CNS xanthophyll levels and cognitive function in healthy adults.Nov 13, 2017

Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance.Jul 01, 2006

The carotenoids meso-zeaxanthin, lutein and zeaxanthin augment macular pigmentation. Apr 01, 2010

The effects of lutein and zeaxanthin on resting state functional connectivity in older Caucasian adults.Jan 23, 2019

The results suggest a protective role of α-carotene, β-carotene, lycopene , lutein and zeaxanthin in breast cancer risk.Oct 19, 2015

These findings show that lutein and zeaxanthin influence white matter integrity, particularly in regions vulnerable to age-related decline.Nov 16, 2017

Total carotenoids showed significant reductive risk of hypertension at 100 μg/kg per day and over.Jul 25, 2019

Vegetables and fruits rich in lycopene and other carotenoids may be protective against prostate cancer.Mar 01, 2005

β-carotene and lutein/zeaxanthin appears to be associated with a lower risk of BC among Korean women.Jun 02, 2024

Co-delivery of celastrol and lutein with pH sensitive nano micelles for treating acute kidney injury.Aug 31, 2022

Lutein attenuates Propionibacterium acnes-induced inflammation.Mar 31, 2023

Protective effect of lutein on oxidative stress damage caused by acute PM2.5 exposure.Jul 19, 2020

Administration of lutein in combination with vitamin C improved the status of the total antioxidant defense system in SD rats.Aug 31, 2015

Astaxanthin and lutein have neuroprotective effects and reduce ocular oxidative stress, and inflammation in the STZ diabetic rat model.Dec 31, 2015

Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage.Mar 10, 2021

Fucoxanthin, lutein and tetrahydrocurcumin may have chemopreventive effects against colon carcinogenesis.Jan 01, 1998

Liposomal lutein administration could prevent the detrimental effects of cisplatin on the retinaApr 30, 2019

Long-term lutein administration attenuates retinal inflammation and functional deficits in early diabetic retinopathy.Jun 30, 2020

Lutein ameliorates high-fat diet-induced obesity, fatty liver, and glucose intolerance in C57BL/6J mice.Sep 08, 2022

Lutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage.Aug 12, 2019

Lutein and zeaxanthin isomers reduce photoreceptor degeneration in a mouse model of retinitis pigmentosa.Dec 31, 2017

Lutein can alleviate oxidative stress, inflammation, and apoptosis induced by excessive alcohol to ameliorate reproductive damage.Jun 08, 2022

Lutein can improve antioxidation function and has protective effect on liver injury of mice induced by arsenic.Jun 30, 2015

Lutein can improve chronic alcoholic liver injury and intestinal barrier dysfunction.Feb 27, 2023

Lutein prevented the methotrexate-induced oxidative lung damage.Sep 09, 2019

Lutein prevents corticosterone-induced depressive-like behaviour.Mar 31, 2019

Lutein prevents the effect of high glucose levels on immune system cells in vivo and in vitro.Jun 01, 2008

Lutein treatment exerted potent antioxidant and anti-inflammatory property and offered significant cytoprotection against alcohol-induced liver injury.Dec 31, 2014

Lutein was found to be an extremely good cell protector against hydroxyl radicals at all oxygen concentrations, including under physiological conditions.Jun 25, 2020

Molecular mechanism of the protective effect of lutein against retinal damage induced by blue-light in rats.Oct 31, 2010

Oleic acid can be used as a suitable fat source to modulate the absorption of dietary lutein and zeaxanthin from green leafy vegetables to manage age-related macular degeneration.Jul 25, 2007

Oleic acid significantly enhances the bioavailability of lutein. Sep 01, 2009

Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of cholinergic function.Feb 13, 2019

Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats.Mar 31, 2019

Regular exercise training with lutein/zeaxanthin isomers regulates brain transcription factors and neurotrophic and synaptic proteins.May 31, 2019

The effect of lutein and Urtica dioica extract on in vitro production of embryo and oxidative status in polycystic ovary syndrome in a model of mice.Feb 07, 2021

The present study suggests a protective role for lutein in palliating radiation-induced oxidative changes.Dec 31, 2017

The protective role of lutein on isoproterenol-induced cardiac failure.Nov 30, 2019

The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy.Dec 31, 2022

Are anti-inflammatory foods associated with a protective effect for cutaneous melanoma? Aug 31, 2020

Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis.Jul 23, 2020

Lutein

View the Evidence:
116 Abstracts with Lutein Research