Grape

Name	AC	CK
Hypertension	23	212
Oxidative Stress	56	210
Obesity	33	133
Inflammation	27	114
Cardiovascular Diseases	15	98
Cognitive Decline/Dysfunction	13	57
Diabetes Mellitus: Type 2	12	54
Insulin Resistance	7	54
Endothelial Dysfunction	7	52
Atherosclerosis	7	49
Hyperlipidemia	7	40
Metabolic Syndrome X	5	34
C-Reactive Protein	3	32
Lung Cancer	11	32
Athletic Performance	3	30
DNA damage	13	27
Periodontitis	6	27
Breast Cancer	13	24
High Fat Diet	11	24
Aging Skin	4	22
Chemically-Induced Liver Damage	11	21
Blood Diseases	1	20
Metabolic Diseases	2	20
Nonalcoholic fatty liver disease (NAFLD)	2	20
Overweight	2	20
Prehypertension	2	20
Wound Healing	6	20
Lipid Peroxidation	6	17
Advanced Glycation End products (AGE)	4	15
Chemotherapy-Induced Toxicity: Doxorubicin	8	15
Dyslipidemias	4	15
Arteriosclerosis	3	14
Iron Overload	3	14
Liver Cancer	12	14
Parkinson's Disease	3	14
Radiation	4	14
Chemotherapy-Induced Toxicity: Cisplatin	7	13
Colon Cancer	10	13
Colitis	6	12
Colorectal Cancer	8	12
Diabetic Retinopathy	2	12
Hypercholesterolemia	2	12
Stroke	2	12
Triglycerides: Elevated	2	12
Asthma	2	11
Coronary Artery Disease	2	11
Osteoarthritis	2	11
Chloasma	1	10
Chronic Kidney Disease (CKD)	1	10
Coronary Bypass Surgery	1	10
Dermatitis: Contact	1	10
Diabetes Mellitus: Type 1	4	10
Diabetic Nephropathy	5	10
Dry Eye Syndromes	1	10
Gastrointestinal Cancer	1	10
Hyperglycemia	5	10
Kidney Damage: Chemically-Induced	5	10
Leg Edema	1	10
Menopausal Syndrome	1	10
Muscle Damage: Exercise-Induced	1	10
Muscle Fatigue	1	10
Neurodegenerative Diseases	6	10
Postmenopausal Disorders	1	10
Prostate Cancer	8	10
Sclerosis: Systemic	1	10
Sitting Sickness	1	10
Streptococcus Infections	1	10
Thalassemia	1	10
Aging: Brain	6	9
Alzheimer's Disease	4	8
Kidney Damage	4	8
Liver Damage: Drug-Induced	4	8
Squamous cell carcinoma	4	8
Aging	4	7
Bisphenol Toxicity	4	7
Osteoarthritis: Knee	2	7
Brain Inflammation	3	6
Cadmium Poisoning	3	6
Cancers: All	6	6
Endothelial Damage	2	6
Fatty Liver	3	6
Kidney Damage: Drug-Induced	3	6
Lead Poisoning	3	6
Multiple Sclerosis	3	6
Pesticide Toxicity	3	6
Testicular Injury: Chemical/Metal Induced	3	6
Ulcerative Colitis	3	6
Ultraviolet Radiation Induced Damage	4	6
Arthritis	1	5
Depression	3	5
Fluoride Toxicity	3	5
Lipopolysaccharide-Induced Toxicity	3	5
Liver Damage	3	5
Acetaminophen (Tylenol) Toxicity	2	4
Aluminum Toxicity	2	4
Arsenic Poisoning	2	4
Brain Ischemia	2	4
Brain: Oxidative Stress	2	4
Cataract	2	4
Cervical Cancer	3	4
Circadian Dysregulation	2	4
Diabetes: Cardiovascular Illness	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetes: Oxidative Stress	2	4
Diabetic Complications	2	4
Ehrlich carcinoma	2	4
Gastrointestinal Inflammation	2	4
Gout	2	4
High Fructose Diet	2	4
Hyperalgesia	2	4
Hyperinsulinism	2	4
Hypertension: Pulmonary	2	4
Inflammatory Bowel Diseases	2	4
Kidney Diseases	2	4
Memory Disorders: Sleep Deprivation Induced	1	4
Neuropathic Pain	2	4
Spinal Cord Injuries	2	4
Antibiotic Toxicity	1	3
Breast Cancer: Triple Negative	3	3
Candida Albicans	2	3
Chronic Obstructive Pulmonary Disease	2	3
Helicobacter Pylori Infection	3	3
Irritable Bowel Syndrome	2	3
Melanoma	2	3
Pancreatic Cancer	2	3
Periodontal Diseases	2	3
Pre-Eclampsia	2	3
Rheumatoid Arthritis	2	3
Tongue Cancer	2	3
Acute Myeloid Leukemia	2	2
Air Pollution Linked Toxicity	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Allodynia	1	2
Androgenic Alopecia	2	2
Appetite Disorders	1	2
Bacterial Vaginosis	1	2
Bladder Cancer	2	2
Bladder Dysfunction	1	2
Bleeding: Excessive	1	2
Blood Sugar Problems	1	2
Bone Diseases	1	2
Cancer Metastasis	2	2
Cancers: Canine	1	2
Cancers: Drug Resistant	2	2
Candida Infection	2	2
Candidiasis: Vulvovaginal	1	2
Carcinoma: Non-Small-Cell Lung	2	2
Cardiomyopathy	1	2
Cardiotoxicity: Chemotherapy-Induced	1	2
Cerebral Hypoperfusion	1	2
Cerebral Ischemia	1	2
Chemical Exposure: Nitrobenzene	1	2
Chemotherapy Induced Myelotoxicity	1	2
Chemotherapy-Induced Toxicity: Arsenic Trioxide	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Tamoxifen	1	2
Cholesterol: Oxidation	1	2
Coronavirus Infection	2	2
Deep Vein Thrombosis	1	2
Dementia	1	2
Dengue	1	2
Diabetic Neuropathy	1	2
Diarrhea	1	2
Drug-Induced Toxicity	1	2
Dysbiosis	1	2
Emphysema: Pulmonary	1	2
Endotoxemia	1	2
Enterococcus Infections	2	2
Escherichia coli Infections	2	2
Excitotoxicity	1	2
Fatigue: Excercise-Induced	1	2
Fructose-Induced Toxicity	1	2
Gastric Cancer	2	2
Gastrointestinal Complaints	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hyperthyroidism	1	2
Hyperuricemia	1	2
Insulin Disorders	1	2
Intestinal Cancer	1	2
Intestinal Polyps	1	2
Ischemia	1	2
Kidney Failure	1	2
Kidney Fibrosis	1	2
Liver Disease	1	2
Liver Fibrosis	1	2
Liver Steatosis	1	2
Lung Injury: Acute	1	2
MRSA	1	2
Memory Disorders	1	2
Memory Disorders: Drug-Induced	1	2
Memory Loss	1	2
Migraines	1	2
Morphine Tolerance/Dependence	1	2
Muscle Atrophy	1	2
Muscle Damage	1	2
Myocardial Infarction	1	2
Norovirus	2	2
Obstructive uropathy	1	2
Osteoporosis	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Polycystic Ovary Syndrome	1	2
Prostatic Hyperplasia: Benign	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Respiratory Syncytial Virus Infections	2	2
Retinal Degeneration: Light-Induced	1	2
Retinal Diseases	1	2
Seizures: Drug-Induced	1	2
Sperm Count: Low	1	2
Staphylococcus aureus infection	2	2
Steptococcus Mutans Infections	2	2
Steroid-Induced Toxicity	1	2
Stroke: Attenuation/Recovery	1	2
Stroke: Ischemic	1	2
Surgery: Oral	1	2
Temporomandibular Joint Disorders	1	2
Testicular Injury: Cadmium-Induced	1	2
Thrombosis	1	2
Tumors	1	2
Varicocele	1	2
Aging: Immunosenecence	1	1
Alopecia: Androgenic	1	1
Aspergillosis	1	1
Cardiovascular Disease: Prevention	1	1
Chronic Disease	1	1
Coronavirus Disease (Covid-19)	1	1
Dental Caries	1	1
Diabetes: Eye Disease	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Glioma	1	1
HIV Infections	1	1
Hair Loss	1	1
Head and Neck Cancer	1	1
Heavy Metal Toxicity	1	1
Hepatitis A	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Hypoglycemia	1	1
Hypoxia	1	1
Kidney Cancer	1	1
Klebsiella Infections	1	1
Leukemia	1	1
Listeria Infections	1	1
Male Pattern Baldness	1	1
Melanoma: Metastatic	1	1
Melasma	1	1
Mitochondrial Dysfunction	1	1
Mucositis	1	1
Myocardial Ischemia	1	1
Nicotine/Tobacco Toxicity	1	1
Oral Cancer	1	1
Ovarian Cancer	1	1
Peptic Ulcer	1	1
Photooxidative Stress	1	1
Pseudomonas aeruginosa	1	1
Pulmonary Cancer	1	1
Salmonella Infections	1	1
Sepsis	1	1
Skin Cancer: Squamous Cell	1	1
Staphylococcus aureus: Methicillin-resistant (MRSA)	1	1
Thyroid Cancer	1	1
Water Contamination	1	1

Name	AC	CK
Antioxidants	163	508
Anti-Inflammatory Agents	70	246
Antihypertensive Agents	21	190
Neuroprotective Agents	46	135
Cardioprotective	23	104
Hepatoprotective	28	70
Antiproliferative	45	65
Gastrointestinal Agents	22	61
Chemopreventive	19	55
Apoptotic	35	54
Hypolipidemic	13	50
Renoprotective	21	44
Tumor Necrosis Factor (TNF) Alpha Inhibitor	19	44
Malondialdehyde Down-regulation	9	41
Anti-atherogenic	4	40
Nrf2 activation	17	39
Anti-Apoptotic	23	38
NF-kappaB Inhibitor	17	36
Interleukin-6 Downregulation	14	35
Hypotensive	2	30
Interleukin-1 beta downregulation	12	30
Chemoprotective Agents	12	24
Anti-Bacterial Agents	11	22
Cytoprotective	7	22
Insulin Sensitizers	3	22
Cyclooxygenase 2 Inhibitors	12	21
Hypoglycemic Agents	7	21
MicroRNA modulator	7	20
Superoxide Dismutase Up-regulation	9	17
Immunomodulatory	6	16
Radioprotective	6	16
Anticarcinogenic Agents	8	14
Cell cycle arrest	9	13
Antineoplastic Agents	7	12
Brain-derived neurotrophic factor modulator	2	12
Anti-Glycation Agents	2	11
Antimicrobial	2	11
Genoprotective	7	11
Matrix metalloproteinase-9 (MMP-9) inhibitor	7	11
Anti-metastatic	10	10
Appetite Depressants	1	10
Chondroprotective	1	10
Glutathione Upregulation	1	10
Nitric Oxide Enhancer	1	10
Vasoprotective	1	10
Heme oxygenase-1 up-regulation	4	8
Matrix metalloproteinase-2 (MMP-2) inhibitor	6	8
Antiviral Agents	7	7
Alpha-glucosidase inhibitor	3	6
Heme oxygenase-1 inducer	3	6
Osteoprotective	3	6
Antidepressive Agents	3	5
Antifungal Agents	4	5
Bcl-2 protein down-regulation	3	5
Gastroprotective	3	5
Adiponectin upregulation	2	4
Anti-Fibrotic	2	4
Anticholesteremic Agents	3	4
Antinoceceptive	2	4
Catalase Up-Regulation	2	4
Interleukin-10 downregulation	2	4
Interleukin-8 downregulation	3	4
Nitric Oxide Inhibitor	2	4
Aromatase Inhibitors	2	3
Chemosensitizer	3	3
Chemotherapeutic	3	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Neuroplasticity enhancement	2	3
Photoprotective	2	3
Survivin Down-Regulation	2	3
Vasodilator Agents	2	3
Adiponectin Down-Regulation	1	2
Alpha-amylase inhibitor	2	2
Analgesics	1	2
Anti-Angiogenic	1	2
Anti-Tumor	1	2
Anti-thrombotic	1	2
Antidiarrheals	1	2
Antimutagenic Agents	2	2
Appetite Stimulants	1	2
Bax/Bcl2 ratio: Increase	1	2
Cyclin D1 Down-Regulation	2	2
DNA Repair Up-regulation	1	2
Heat Shock Protein Down-Regulation	1	2
Insulin-Like Growth Factor Inhibition/Downregulation	1	2
Interleukin-10 upregulation	1	2
Interleukin-17 downregulation	1	2
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	2
Multidrug Resistance Gene Modulators	2	2
Neurogenesis	1	2
Neurorestorative	1	2
Pancreato Protective Agents	1	2
Phase I Detoxification Enzyme Inducer	1	2
Regenerative	1	2
Thermogenic	1	2
Tumor Suppressor Protein p53 Upregulation	2	2
Wnt/β-catenin signaling pathway modulation	1	2
Angiogenesis Inhibitors	1	1
Anti-Adipogenic	1	1
Anti-HIV Agents	1	1
Anti-Ulcer Agents	1	1
Autophagy Up-regulation	1	1
Caspase-3 Inhibition	1	1
Cytotoxic	1	1
E-cadherin down-regulation	1	1
Epidermal growth factor receptor (EGFR) inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
P21 Activation	1	1
Phase II Detoxification Enzyme Inducer	1	1
Radiosensitizer	1	1
SIRT1 Activator	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1

[+]

Grape products intake may help to decrease body weight in obese participants.Dec 20, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Periodontitis

[+]

Concord grape juice reduces blood pressure in hypertensive men. Apr 01, 1984

Pubmed Data : Nutrients. 2021 Nov 6 ;13(11). Epub 2021 Nov 6. PMID: 34836220

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Pubmed Data : Phytother Res. 2019 Nov 11. Epub 2019 Nov 11. PMID: 31713941

Article Published Date : Nov 10, 2019

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Inflammation, Obesity, Overweight

Therapeutic Actions : Dietary Modification: Low Calorie Diet

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Anti-Obesity Agents

[+]

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Pubmed Data : J Med Food. 2018 May ;21(5):445-453. Epub 2018 Apr 23. PMID: 29683391

Article Published Date : Apr 30, 2018

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Prehypertension

Therapeutic Actions : Exercise

Pharmacological Actions : Antihypertensive Agents

[+]

Grape seed extract showed complete repair of wounds averagely on day 8 for the treatment group and on day 14 for the placebo group.Apr 30, 2015

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[+]

Grape seed proanthocyanidin extract had beneficial effects on the progression of carotid atherosclerotic plaques.Jun 30, 2015

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Pubmed Data : Mol Nutr Food Res. 2008 Aug 20; PMID: 18720348

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Triglycerides: Elevated

[+]

GSE and Vitamin C had antioxidative effects and reduced deleterious effects of coronary artery bypass grafting surgery.Dec 31, 2016

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Pubmed Data : Nutr J. 2015 ;14(1):94. Epub 2015 Sep 9. PMID: 26353756

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

[+]

Nutritional doses of grape polyphenols protects against fructose induced oxidative stress and insulin resistance.May 31, 2013

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Pubmed Data : Diabetes Care. 2013 Jun ;36(6):1454-61. Epub 2012 Dec 28. PMID: 23275372

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Pubmed Data : Appl Physiol Nutr Metab. 2015 Sep ;40(9):899-906. Epub 2015 May 4. PMID: 26288392

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Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2020 03 13. Epub 2020 Mar 13. PMID: 32167433

Article Published Date : Jan 12, 2020

Study Type : Human Study

Additional Links

Substances : Grape, Polyphenols

Diseases : Dermatitis: Contact

Pharmacological Actions : Immunomodulatory

[+]

Red grape seed extract may have potential beneficial effects in preventing oxidative stress and atherosclerosis in patients with mild hyperlipidemia.May 12, 2016

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Pubmed Data : Sao Paulo Med J. 2016 May 13 ;134(3):234-9. PMID: 27191247

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Pubmed Data : Eur J Nutr. 2020 Dec ;59(8):3723-3734. Epub 2020 Feb 17. PMID: 32067098

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract, Polyphenols

Diseases : Atherosclerosis, Endothelial Dysfunction

Pharmacological Actions : Anti-atherogenic

[+]

The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease.May 15, 2024

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Pubmed Data : BMC Complement Med Ther. 2024 May 16 ;24(1):192. Epub 2024 May 16. PMID: 38755622

Article Published Date : May 15, 2024

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

The single-dose intake of purple grape juice demonstrated an ergogenic effect in recreational runners.Sep 30, 2020

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Pubmed Data : Nutr Res. 2013 Feb ;33(2):120-5. Epub 2013 Jan 17. PMID: 23399662

Pubmed Data : Environ Pollut. 2018 Jun ;237:377-387. Epub 2018 Mar 15. PMID: 29502000

Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration.Sep 30, 2023

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Pubmed Data : Toxicol Res. 2023 Oct ;39(4):749-759. Epub 2023 Jul 7. PMID: 37779581

Article Published Date : Sep 30, 2023

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Methylprednisolone

[+]

Endothelium-dependent vasorelaxant effects of dealcoholized wine powder of wild grape.Dec 31, 2015

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Pubmed Data : Toxicol Mech Methods. 2012 Apr ;22(3):218-24. PMID: 22320862

Article Published Date : Mar 31, 2012

Study Type : Animal Study

Additional Links

Substances : Grape

Diseases : Fatty Liver, High Fat Diet, Liver Steatosis

Pharmacological Actions : Hepatoprotective, Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Grape juice concentrate protects rat liver against cadmium intoxication.Jun 30, 2016

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Pubmed Data : Drug Res (Stuttg). 2016 Jul ;66(7):339-44. Epub 2016 Apr 7. PMID: 27056637

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Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:6135319. Epub 2016 Jul 27. PMID: 27528887

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Grape

Diseases : Aging

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

Additional Keywords : Plant Extracts

[+]

Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo.Dec 31, 2011

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Pubmed Data : PLoS One. 2012 ;7(8):e43064. Epub 2012 Aug 8. PMID: 22905202

Article Published Date : Dec 31, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Grape seed and skin extract acts at multiple levels to protect dopamine neurons from degeneration in a model of Parkinson's disease.May 24, 2019

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Pubmed Data : Nutr Neurosci. 2019 May 25:1-15. Epub 2019 May 25. PMID: 31131731

Pubmed Data : Andrologia. 2018 Jun ;50(5):e13002. Epub 2018 Mar 12. PMID: 29527700

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Dexamethasone

[+]

Grape seed extract attenuates silica-induced pulmonary fibrosis in rats. Aug 01, 2009

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Pubmed Data : Reproduction. 2009 Aug;138(2):279-87. Epub 2009 Jun 3. PMID: 18547852

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Pulmonary Fibrosis

[+]

Grape seed extract can be used as an auxiliary treatment for muscle loss associated with chronic inflammation and frailty.May 19, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Med Food. 2010 Aug;13(4):917-25. PMID: 20553142

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Cardiotoxicity: Chemotherapy-Induced, Chemotherapy-Induced Toxicity: Doxorubicin, DNA damage

Pharmacological Actions : Cardioprotective, Genoprotective

Additional Keywords : Drug: Doxorubicin

[+]

Grape seed extract has a rejuvenating effect in the central nervous system of aged rats. Aug 05, 2005

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Pubmed Data : Neurosci Lett. 2005 Aug 5;383(3):295-300. PMID: 15955424

Article Published Date : Aug 05, 2005

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Pubmed Data : Toxics. 2017 Apr 11 ;5(2). Epub 2017 Apr 11. PMID: 29051443

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Pubmed Data : Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202. PMID: 17062697

Article Published Date : Oct 15, 2006

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive

Additional Keywords : Antineoplastic Agents, Antiproliferative, Plant Extracts

[+]

Grape seed extract may be beneficial as a complementary migraine therapeutic.Dec 31, 2021

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Pubmed Data : Arch Oral Biol. 2024 May 29 ;165:106014. Epub 2024 May 29. PMID: 38833771

Article Published Date : May 28, 2024

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Temporomandibular Joint Disorders

[+]

Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury.Jul 26, 2022

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Pubmed Data : Toxicol Mech Methods. 2022 Jul 27:1-10. Epub 2022 Jul 27. PMID: 35850572

Article Published Date : Jul 26, 2022

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Grape seed extract protected against cadmium-induced testicular toxicity.Jan 12, 2020

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Pubmed Data : J Med Life. 2020 Oct-Dec;13(4):580-586. PMID: 33456610

Article Published Date : Sep 30, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Atherosclerosis, C-Reactive Protein, Periodontitis

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation

[+]

Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways.May 31, 2011

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Pubmed Data : Br J Nutr. 2011 May 31:1-9. Epub 2011 May 31. PMID: 21736810

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Pubmed Data : Front Nutr. 2021 ;8:786682. Epub 2022 Jan 28. PMID: 35155513

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Proanthocyanidins

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

[+]

Grape seed proanthocyanidin ameliorates cardiac toxicity induced by boldenone undecylenate.Dec 31, 2017

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Pubmed Data : Exp Ther Med. 2018 Jan ;15(1):1053-1061. Epub 2017 Nov 13. PMID: 29403553

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Diabetic Complications

Pharmacological Actions : Antioxidants, Nitric Oxide Inhibitor, Nrf2 activation

Additional Keywords : Proanthocyanidins

[+]

Grape seed proanthocyanidin extract ameliorates cardiac remodelling after myocardial infarction.Dec 31, 2019

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Pubmed Data : Free Radic Biol Med. 2021 10 ;174:144-156. Epub 2021 Aug 11. PMID: 34389464

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Pubmed Data : Int J Mol Sci. 2024 Jul 14 ;25(14). Epub 2024 Jul 14. PMID: 39062955

Article Published Date : Jul 13, 2024

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Proanthocyanidins

Anti Therapeutic Actions : Western Diet

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Grape seed proanthocyanidin extract attenuates cigarette smoke extract-induced lung inflammation and emphysema.Jun 30, 2023

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Pubmed Data : Food Chem Toxicol. 2023 Jul ;177:113795. Epub 2023 Apr 26. PMID: 37116776

Article Published Date : Jun 30, 2023

Study Type : Animal Study

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Substances : Grape Seed Extract

Diseases : Chronic Obstructive Pulmonary Disease, Emphysema: Pulmonary, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

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Grape seed proanthocyanidin extract can ameliorate abnormal spermatogenesis and testicular injury in varicocele rats.Dec 31, 2017

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Pubmed Data : Mol Med Rep. 2018 Jan ;17(1):1799-1806. Epub 2017 Nov 10. PMID: 29138814

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Oxidative Stress, Sperm Count: Low, Varicocele

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 inducer, Nrf2 activation, Superoxide Dismutase Up-regulation

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Grape seed proanthocyanidin extract supplementation alleviates DSS-induced colitis.Sep 22, 2020

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Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):7817-7829. PMID: 32808642

Article Published Date : Sep 22, 2020

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Grape seed proanthocyanidin extract supplementation has anti-hypertrophic and hyperplasic activities in rats with established obesity.Apr 03, 2017

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Pubmed Data : Int J Obes (Lond). 2017 Apr 4. Epub 2017 Apr 4. PMID: 28373675

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Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):865-78. Epub 2015 Mar 23. PMID: 25677201

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Melatonin, Proanthocyanidins

Diseases : Circadian Dysregulation

Additional Keywords : Chronobiotic, Circadian Clock Proteins, Plant Extracts

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Grape seed proanthocyanidin improves intestinal inflammation.Nov 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : FASEB J. 2023 Dec ;37(12):e23285. PMID: 37933950

Article Published Date : Nov 30, 2023

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract, Polyphenols

Diseases : Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

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Grape seed proanthocyanidin inhibit advanced glycation end products in diabetic rats. Jun 01, 2009

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Pubmed Data : Biosci Biotechnol Biochem. 2009 Jun;73(6):1348-54. Epub 2009 Jun 7. PMID: 19502731

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Advanced Glycation End products (AGE), Diabetes: Cardiovascular Illness

Additional Keywords : Plant Extracts, Proanthocyanidins

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Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

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Pubmed Data : Biol Trace Elem Res. 2024 Feb 17. Epub 2024 Feb 17. PMID: 38367173

Article Published Date : Feb 16, 2024

Study Type : Animal Study

Additional Links

Substances : Grape

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Nrf2 activation

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Problem Substances : Sodium Fluoride

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Grape seed procyanidin extract can protect against the toxicity of titanium dioxide nanoparticles.Sep 24, 2017

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Pubmed Data : Chem Biol Interact. 2017 Sep 25 ;275:133-144. Epub 2017 Aug 2. PMID: 28780322

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Prev Nutr Food Sci. 2020 Mar 31 ;25(1):25-31. PMID: 32292752

Article Published Date : Mar 30, 2020

Study Type : Animal Study

Additional Links

Substances : Grape

Diseases : Hypertension, Oxidative Stress

Pharmacological Actions : Antioxidants, Hypolipidemic

Additional Keywords : Plant Extracts

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Grape skin has significant wound-healing activity. Jan 11, 2010

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Pubmed Data : Phytother Res. 2010 Jan 11. Epub 2010 Jan 11. PMID: 20066659

Article Published Date : Jan 11, 2010

Study Type : Animal Study

Additional Links

Substances : Grape

Diseases : Wound Healing

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Grape stem extract reduces UVB-induced oxidative damage and hence can play a protective role in skin photo-damage.Jul 31, 2017

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Pubmed Data : J Photochem Photobiol B. 2017 Aug ;173:551-559. Epub 2017 Jun 29. PMID: 28697472

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2021 Jun 16 ;13(6). Epub 2021 Jun 16. PMID: 34208508

Article Published Date : Jun 15, 2021

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

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Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet.Apr 28, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Apr 29 ;11(5). Epub 2019 Apr 29. PMID: 31035432

Article Published Date : Apr 28, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Sci. 2022 Apr 28 ;12(5). Epub 2022 Apr 28. PMID: 35624958

Article Published Date : Apr 27, 2022

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Cognitive Decline/Dysfunction

Pharmacological Actions : Chemoprotective Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Grapeseed exhibits neuroprotective properties against excitotoxicity associated neuronal injury. Jan 01, 2011

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Pubmed Data : PLoS One. 2011;6(1):e14575. Epub 2011 Jan 24. PMID: 21283677

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Excitotoxicity

Pharmacological Actions : Neuroprotective Agents

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Grapeseed extract ameliorates glycation-induced cardiac damage. Nov 01, 2007

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Pubmed Data : J Cardiovasc Pharmacol. 2007 Nov;50(5):503-9. PMID: 18030059

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Advanced Glycation End products (AGE), Cardiomyopathy

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GSSE treatment protected efficiently against all the deleterious effects of diabetes-induced kidney dysfunction.Jul 22, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Jul 23 ;83:584-592. Epub 2016 Jul 23. PMID: 27459114

Article Published Date : Jul 22, 2016

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Diabetic Complications, Kidney Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Renoprotective

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Hepatoprotective effect of grape seed and skin extract against lithium exposure.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2017 Dec ;16(6):9393-9400. Epub 2017 Oct 19. PMID: 29152654

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2018 Apr 11 ;66(14):3700-3707. Epub 2018 Mar 28. PMID: 29569905

Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci. 2018 ;7:e19. Epub 2018 May 21. PMID: 29854398

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Blueberry, Grape, Polyphenols

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 498 Abstracts with Grape Research

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Grape products intake may help to decrease body weight in obese participants.Dec 20, 2023

Daily grape polyphenol intake can significantly reduce the systolic blood pressure in humans.Dec 31, 2014

Garlic and grape seed supplement use is inversely associated with hematological malignancies.Jul 29, 2011

Grape polyphenols exert a favorable effect on lipid profile in humans.Jan 21, 2020

Grape seed extract exerted a beneficial impact on blood pressure.Jul 31, 2016

Grape seed extract reduces blood pressure, a cardiovascular risk marker.Aug 01, 2011

The effect of grape products containing polyphenols on C-reactive protein levels.Sep 13, 2020

The effect of grape seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate.Dec 31, 2021

The effect of grape seed extract supplementation on oxidative stress and inflammation.Jun 08, 2021

6-months of supplementation with Memophenol™ may improve aspects of cognitive function in adults with mild cognitive impairment.Dec 31, 2022

A combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production.Jun 09, 2015

A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes.Dec 31, 2022

A grape seed extract reduces the inflammatory response and oxidative stress in patients with systemic sclerosis.Aug 01, 2002

A multi-nutrient mixture of soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract improves signs of skin aging in post-menopausal women. Oct 01, 2006

A pilot study of a grape seed procyanidin extract for lung cancer chemoprevention.Jul 31, 2019

A polyphenol-rich extract from grape and blueberry improves age-related episodic memory decline in individuals with the highest cognitive impairments.Jul 18, 2018

Acute grape seed extract supplement can be an effective way to decrease cellular membrane damage after eccentric exercise.Jan 19, 2019

An isoflavonoid-rich herbal preparation Karinat may play an important role in the prevention of atherosclerosis progression in postmenopausal women.Dec 31, 2015

Anthocyanin oligomer (grape skin extract) administration improves dry eye disease.Feb 28, 2023

Beneficial effects of grape seed extract on malondialdehyde-modified LDL.Mar 31, 2007

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets.Dec 31, 2020

Concord grape juice reduces blood pressure in hypertensive men. Apr 01, 1984

Consumption of grape juice can improve parameters of oxidative stress by reducing the lipid and DNA damage.Dec 31, 2019

Consumptions of citrus fruits, strawberries and grapes were found associated with a lower stroke risk in women.Jan 28, 2021

Daily supplementation, of red grape cell powder, for 12 weeks affects endothelial function, diastolic BP and oxidative stress without any adverse effects. Apr 30, 2015

Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.Nov 30, 2009

Effect of standardized grape powder consumption on the gut microbiome of healthy subjects.Nov 05, 2021

Effects of grape juice consumption on oxidative stress and inflammation in male volleyball players.Oct 31, 2020

Efficacy of grape seed extract gel in the treatment of chronic periodontitisApr 30, 2018

GO extracts could be beneficial for amelioration of obesity-related dyslipidemia, inflammation, and oxidative stress.Jan 20, 2016

Grape and blueberry with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort.Dec 16, 2019

Grape juice decreases lymphocyte DNA damage by favorably altering antioxidant defense systems in hypertensive individuals. Aug 01, 2009

Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome.Aug 31, 2012

Grape pomace polyphenols reduce postprandial insulin levels and improve insulin sensitivity.Jan 12, 2019

Grape seed extract alleviates radiation-induced damages in human blood lymphocytes.Jun 30, 2020

Grape seed extract and low calorie diet has favourable effects on anthropometric measurements and inflammatory markers in obese or overweight individuals.Nov 10, 2019

Grape seed extract appears to be an ergogenic nutraceutical that can improve exercise performance in elite athletes.Oct 30, 2022

Grape seed extract can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.May 19, 2021

Grape seed extract for eight weeks had beneficial effects on the plasma GSH, MDA levels, and markers of insulin metabolism of female volleyball players.Aug 31, 2016

Grape seed extract improves insulin concentration and insulin resistance in adolescents with metabolic syndrome.Dec 31, 2020

Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children.Oct 10, 2023

Grape seed extract may act as an ergogenic aid that can improve O2 delivery to exercising muscles.Dec 31, 2022

Grape seed extract positively modulates blood pressure and perceived stress.Feb 16, 2021

Grape seed extract represents an intervention that may minimize potential increases in the risk of cardiovascular events during exercise in prehypertensives.Apr 30, 2018

Grape seed extract showed complete repair of wounds averagely on day 8 for the treatment group and on day 14 for the placebo group.Apr 30, 2015

Grape seed extract significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic roMay 01, 2009

Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals.Oct 11, 2020

Grape seed extract supplementation in non-alcoholic fatty liver disease.Feb 27, 2024

Grape seed extract was found to be safe and to improve blood pressure in people with pre-hypertension.Nov 15, 2015

Grape seed polyphenol extract and cognitive function in healthy young adults.Jan 15, 2020

Grape seed proanthocyanidin extract consumption could help maintain vascular elasticity and normal blood pressure.Nov 19, 2019

Grape seed proanthocyanidin extract had beneficial effects on the progression of carotid atherosclerotic plaques.Jun 30, 2015

Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure.Aug 31, 2014

Grape seed procyanidin extract mediates antineoplastic effects against lung cancer.Nov 30, 2016

Grapeseed procyanidin decreases plasma levels of triglycerides.Aug 01, 2008

GSE and Vitamin C had antioxidative effects and reduced deleterious effects of coronary artery bypass grafting surgery.Dec 31, 2016

High intake of fruit during adolescence could be associated with a lower risk of breast cancer.Dec 31, 2015

Hypertension- and glycaemia-lowering effects of a grape-pomace-derived seasoning in high-cardiovascular risk and healthy subjects.Feb 20, 2022

Ingestion of biscuits rich in plant-derived phenols significantly lowered the redox potential of urine by 33%. Dec 31, 2014

Muscadine grape consumption improves several metabolic responses among type 2 diabetics. May 01, 2004

Niacin-bound chromium and grape seed extract can decrease total cholesterol and LDL levels significantly. Jan 01, 2000

Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract.Nov 30, 2022

Nutritional doses of grape polyphenols protects against fructose induced oxidative stress and insulin resistance.May 31, 2013

Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.Apr 30, 2019

Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma.Oct 31, 2004

Oral intake of proanthocyanidin-rich grape seed extract up to 2500 mg for 4 weeks was found to be generally safe and well tolerated in humans.Sep 30, 2017

Polyphenol rich berry juices reduce blood pressure in hypertensive patients more so than in normotensive subjects.Oct 13, 2015

Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease.Nov 30, 2005

Potential ergogenic activity of grape juice in runners.Aug 31, 2015

Preventive and healing effect of high dosing grape seed flour on CKD patients of various stages and aetiologies.Nov 30, 2022

Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.Jan 31, 2013

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View the Evidence:
498 Abstracts with Grape Research