Ginsenosides

Name	AC	CK
Inflammation	77	114
Depression	39	111
Oxidative Stress	62	111
Lung Cancer	53	100
Alzheimer's Disease	63	94
Liver Cancer	51	94
Lipopolysaccharide-Induced Toxicity	56	84
Carcinoma: Non-Small-Cell Lung	16	68
Obesity	39	68
Colorectal Cancer	28	67
Myocardial Ischemia	33	61
Diabetes Mellitus: Type 2	35	58
Stroke: Ischemic	15	58
Breast Cancer	46	57
Cancers: All	44	57
Cerebral Ischemia	28	48
Parkinson's Disease	21	45
Diabetic Nephropathy	14	43
Chemically-Induced Liver Damage	21	40
Gastric Cancer	16	39
Brain Inflammation	23	36
Cancers: Drug Resistant	21	36
Chemotherapy-Induced Toxicity: Cisplatin	21	36
Athletic Performance	4	35
Cognitive Decline/Dysfunction	20	35
Ulcerative Colitis	9	35
Memory Disorders	18	34
Spinal Cord Injuries	20	34
Liver Damage	8	33
High Fat Diet	16	32
Brain Ischemia	12	31
Nonalcoholic fatty liver disease (NAFLD)	19	31
Atherosclerosis	19	29
Diabetic Complications	16	29
Esophageal Cancer	9	29
Insulin Resistance	17	29
Aging	11	28
Cardiovascular Diseases	15	28
Myocardial Infarction	17	28
Pancreatic Cancer	5	26
Colitis	13	25
Sepsis	16	25
Liver Fibrosis	13	24
Acetaminophen (Tylenol) Toxicity	12	23
Colon Cancer	19	23
Heart Failure	13	23
Chemotherapy-Induced Toxicity: Cyclophosphamide	13	22
Osteoporosis	15	22
Ovarian Cancer	17	22
Stroke	9	22
Wound Healing	11	22
Neurodegenerative Diseases	17	21
Chemotherapy Induced Myelotoxicity	1	20
Melanoma	13	20
Osteoarthritis	11	20
Breast Cancer: Triple Negative	14	19
Hypoxia	13	19
Aging: Brain	5	18
Diabetes Mellitus: Type 1	9	18
Aging Skin	5	16
Chemotherapy-Induced Toxicity: Doxorubicin	10	16
Leukemia: Acute myelogenous leukemia (AML)	6	16
Cancer Metastasis	14	15
DNA damage	5	15
Cardiomyopathy	8	14
HIV Infections	4	14
Hair Loss	5	14
Cardiac Hypertrophy	6	13
Cervical Cancer	13	13
Chronic Kidney Disease (CKD)	3	13
Diabetic Retinopathy	7	13
Hydrogen Peroxide Induced Toxicity	11	13
Lung Injury: Acute	7	13
Alcoholic Liver Disease	6	12
Hypertension	7	12
Alcohol Toxicity	6	11
Arthritis	6	11
Inflammatory Bowel Diseases	7	11
Ischemia	7	11
Liver Damage: Drug-Induced	6	11
Psoriasis	6	11
Radiation Induced Illness	2	11
Ultraviolet Radiation Induced Damage	8	11
Dry Eye Syndromes	1	10
Endometriosis	6	10
Endothelial Dysfunction	6	10
Glioblastoma	7	10
Huntington Disease	7	10
Hyperglycemia	8	10
Hypertension: Pulmonary	5	10
Liver Cirrhosis	7	10
Myocardial Fibrosis	6	10
Osteopenia	1	10
Prostate Cancer	9	10
Skin Cancer	7	10
Testosterone: Too High	1	10
Atopic Dermatitis	6	9
Chemotherapy-Induced Kidney Damage	5	9
Hyperlipidemia	5	9
Leukemia	8	9
Periodontitis	4	9
Altitude Sickness	4	8
Asthma	7	8
Brain: Oxidative Stress	4	8
Dementia	5	8
Diabetes: Cardiovascular Illness	4	8
Kidney Fibrosis	4	8
Squamous cell carcinoma	7	8
Air Pollution Linked Toxicity	2	7
Chronic Obstructive Pulmonary Disease	4	7
Learning disorders	4	7
Lipid Peroxidation	4	7
Lung Injury: Smoke-Induced	4	7
Osteosarcoma	7	7
Ovarian Diseases	1	7
Pulmonary Fibrosis	5	7
Rheumatoid Arthritis	4	7
Staphylococcus aureus infection	4	7
Brain: Microglial Activation	5	6
Burns	3	6
Cancers: Multi-Drug Resistant	3	6
Diabetes: Cognitive Dysfunction	3	6
Diabetes: Oxidative Stress	3	6
Fatigue	3	6
Gastric Ulcer	3	6
Hepatic Steatosis	3	6
Kidney Damage	3	6
Memory Disorders: Drug-Induced	3	6
Nasopharyngeal Cancer	6	6
Ovarian Failure	3	6
Sleep Disorders	3	6
Aluminum Toxicity	3	5
Chemotherapy	3	5
Degenerative Disk Disease	4	5
Dermatitis	3	5
Epilepsy	2	5
Erectile Dysfunction	3	5
Fibrosis	3	5
Glioma	5	5
Hearing Loss: Noise-Induced	3	5
Metabolic Diseases	3	5
Multiple Myeloma	5	5
Multiple Sclerosis	3	5
Muscle Atrophy	4	5
Neuropathic Pain	3	5
Sarcopenia	3	5
Scars	3	5
Stroke: Attenuation/Recovery	3	5
Acute lymphoblastic leukemia (ALL)	2	4
Allergies	4	4
Anxiety	2	4
Autoimmune Diseases	3	4
Cardiac Arrest	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
Chemotherapy-Induced Toxicity: Bleomycin	2	4
Fatigue: Excercise-Induced	2	4
Fatty Liver	3	4
Heart Disease	3	4
Hepatitis: Autoimmune	2	4
Influenza A	2	4
Intestinal Ischemia	2	4
Liver Failure: Acute	2	4
Memory Disorders: Sleep Deprivation Induced	2	4
Middle Cerebral Artery Occlusion (MCAO)	2	4
Mitochondrial Diseases	3	4
Nephropathy	2	4
Neuroblastoma	3	4
Pancreatitis	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Stress	2	4
Acute Myeloid Leukemia	3	3
Allergic Rhinitis	2	3
Antibiotic Toxicity	1	3
Benzo[a]pyrene-induced Toxicity	2	3
Cataract	2	3
Central Nervous System Diseases	3	3
Chemobrain	2	3
Chronic Pain	2	3
Coronary Artery Disease	3	3
Coronavirus Infection	2	3
Deep Vein Thrombosis	2	3
Dental Caries	2	3
Escherichia coli Infections	2	3
Gallbladder Cancer	2	3
Kidney Cancer	3	3
Lung Damage	3	3
Lupus Nephritis	1	3
Mitochondrial Dysfunction	2	3
Oral Cancer	2	3
Promyelocytic leukemia	3	3
Steptococcus Mutans Infections	2	3
Tertiary butyl hydroperoxide toxicity	2	3
Thyroid Cancer	2	3
Traumatic Brain Injury	2	3
Acute T cell Leukemias	2	2
Adiponectin: Low Levels	1	2
Anemia	1	2
Anemia: Iron Deficiency	1	2
Aneurysm: Aortic	1	2
Anti-Glomerular Basement Membrane Disease	1	2
Antibiotic-Associated Colitis	1	2
Arterial Hardening: Elasticity	1	2
Attention Deficit Disorder with Hyperactivity	1	2
Cachexia	1	2
Cancer: Pain	1	2
Cerebral Aneurysm	1	2
Cerebral Hemorrhage	1	2
Chemotherapy-Induced Neurotoxicity	1	2
Cholestasis	1	2
Choreoathetosis Self-Mutilation Hyperuricemia Syndrome	1	2
Chronic Fatigue Syndrome	1	2
Coxsackievirus Infections	2	2
Depression	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetic Ulcer	1	2
Drug Toxicity: Cephaloridine	1	2
Drug-Induced Toxicity: Epilepsy Drugs	1	2
Dysmenorrhea	1	2
Encephalomyelitis	1	2
Encephalopathy	1	2
Endometrial Cancer	2	2
Endometritis	1	2
Exercise-Induced Tissue Damage	1	2
Fatigue: Cancer-Associated	1	2
Gastrointestinal Cancer	2	2
H1N1 Infection	1	2
Hashimoto's thyroiditis	1	2
Hearing Loss	2	2
Hepatitis B	2	2
Herbicide Toxicity	1	2
Herpes Simplex Virus Type 1	2	2
High Sugar Diet	1	2
Hypercapnia	1	2
Hypoglycemia	1	2
Hypothyroidism	1	2
IgA Nephropathy	1	2
Infertility: Female	1	2
Ischemia: Myocardial	1	2
Itching	1	2
Kawasaki Disease	1	2
Keloid	1	2
Kidney Failure: Acute	1	2
Leukemia: Acute promyelocytic leukemia	2	2
Liver Steatosis	2	2
Low Libido	1	2
Low Testosterone	1	2
Lung Inflammation	1	2
Mastitis	1	2
Morphine Tolerance/Dependence	1	2
Mucositis	1	2
Nerve Injuries	1	2
Non-Small-Cell Lung Carcinoma	2	2
Obstructive Nephropathy	1	2
Osteoarthrosis	1	2
Pain	1	2
Polycystic Ovary Syndrome	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postoperative Recovery	1	2
Pre-Eclampsia	1	2
Prenatal Chemical Exposures	1	2
Proctitis	1	2
Psychiatric Disorder: Conditioned Fear	1	2
Radiation	1	2
Right Ventricular Hypertrophy	1	2
Rotavirus Infections	1	2
Sciatic Nerve Crush Injury	1	2
Sciatica	1	2
Seizures	1	2
Smoking: Pulmonary	1	2
Space Flight Associated Adverse Changes	1	2
Subarachnoid hemorrhage	1	2
Surgery: Anesthesiology	2	2
Tendon Injury	1	2
Toxoplasma gondii Infection	1	2
Tuberculosis	1	2
Aging: Heart	1	1
Alopecia	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Bladder Cancer	1	1
Bone Diseases	1	1
Bone Fractures	1	1
Brain Hypoxia	1	1
Brain Injury: Hippocampal Damage	1	1
Brain Injury: Traumatic	1	1
Cholesterol: Oxidation	1	1
Cold: Common	1	1
Demyelinating Diseases	1	1
Diarrhea	1	1
Dyslipidemias	1	1
Ehrlich carcinoma	1	1
Endothelial Damage	1	1
Enterococcus Infections	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Fibroma: Uterine	1	1
Fibrosarcoma	1	1
Gastrointestinal Inflammation	1	1
Gastrointestinal polyps	1	1
Glaucoma	1	1
Glioblastoma Multiforme	1	1
Heart Disease: Ischemic	1	1
Hepatitis A	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 2	1	1
Histamine: Elevated	1	1
Homocysteine: Elevated	1	1
Hyperhomocysteinemia	1	1
Immune Dysregulation: TH1 dominance	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Influenza	1	1
Insulin Disorders	1	1
Kidney Damage: Chemically-Induced	1	1
Kidney Damage: Drug-Induced	1	1
Kidney Failure	1	1
Lead Poisoning	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Leukemia: Multi-Drug Resistant	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Liver Disease	1	1
Liver Injury: Ischemia/reperfusion	1	1
Medulloblastoma	1	1
Metabolic Syndrome X	1	1
Monkeypox	1	1
Neurological Conditions	1	1
Neurological Disorders	1	1
Parasitic Diseases	1	1
Periodontal Diseases	1	1
Pesticide Toxicity	1	1
Prion Diseases	1	1
Prostatic Hyperplasia: Benign	1	1
Pruritus	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Rectal Cancer	1	1
Respiratory Diseases	1	1
Retinal Diseases	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Salmonella Infections	1	1
Scars: Hyperplastic	1	1
Schizophrenia	1	1
Schwannoma: Vestibular	1	1
Skin Diseases	1	1
Sperm Quality: Low	1	1
Tachycardia	1	1
Tongue Cancer	1	1
Vascular Calcification	1	1

Name	AC	CK
Anti-Inflammatory Agents	331	661
Antioxidants	215	459
Neuroprotective Agents	234	451
Antiproliferative	206	279
Anti-Apoptotic	133	244
Apoptotic	185	227
Cardioprotective	123	215
Tumor Necrosis Factor (TNF) Alpha Inhibitor	115	214
Hepatoprotective	87	175
Interleukin-6 Downregulation	78	162
Interleukin-1 beta downregulation	92	160
NF-kappaB Inhibitor	87	143
Anti-metastatic	84	128
Chemotherapeutic	50	119
Chemoprotective Agents	42	106
Immunomodulatory	51	106
Antidepressive Agents	35	104
Gastrointestinal Agents	43	97
Anti-Fibrotic	36	82
Nrf2 activation	50	80
Chemosensitizer	39	73
Angiogenesis Inhibitors	23	69
Renoprotective	33	64
Malondialdehyde Down-regulation	21	59
Superoxide Dismutase Up-regulation	22	59
MicroRNA modulator	34	50
Matrix metalloproteinase-2 (MMP-2) inhibitor	30	43
Antineoplastic Agents	33	40
Cyclooxygenase 2 Inhibitors	26	40
Cell cycle arrest	35	39
Matrix metalloproteinase-9 (MMP-9) inhibitor	24	39
Vascular Endothelial Growth Factor Inhibitors	22	39
Hypoglycemic Agents	21	38
Osteoprotective	17	35
Heme oxygenase-1 up-regulation	20	34
Chemopreventive	17	33
Autophagy Up-regulation	21	32
Hypolipidemic	17	30
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	15	26
Anti-Angiogenic	10	23
Brain-derived neurotrophic factor modulator	12	23
Neurogenesis	2	22
Pancreato Protective Agents	11	21
Autophagy Inhibitors	13	20
Transforming growth factor beta (TGF-β) inhibitor	13	20
Bcl-2 protein down-regulation	15	19
Interleukin-18 down-regulation	10	18
Antiviral Agents	13	17
SIRT1 Activator	10	17
Tumor Suppressor Protein p53 Upregulation	13	17
Angiogenesis Inducing Agents	9	16
Insulin Sensitizers	9	16
Radioprotective	5	16
Anti-Bacterial Agents	9	15
Gastroprotective	6	12
Interleukin-10 upregulation	7	12
Anti-HIV Agents	2	11
Anti-atherogenic	6	11
Anticarcinogenic Agents	6	11
Cytoprotective	6	11
Photoprotective	8	11
STAT3 Inhibitor	5	11
HIV Protease Inhibitors	1	10
Chondroprotective	3	9
Nitric Oxide Inhibitor	6	9
Wnt/β-catenin signaling pathway modulation	8	9
Analgesics	4	8
Antihypertensive Agents	5	8
Antinoceceptive	4	7
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	3	7
Histone deacetylase inhibitor	4	6
Interleukin-4 downregulation	4	6
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	6
Postaglandin PGE2 downregulation	3	6
Radiosensitizer	5	6
Immunostimulatory	5	5
Interferon Gamma Reducer	3	5
Interleukin-8 downregulation	4	5
Prophylactic Agents	3	5
Prostaglandin PGE2 downregulation	1	5
Transforming growth factor beta (TGF-β) upregulation	3	5
Anti-Asthmatic Agents	3	4
Anticonvulsants	2	4
Enzyme Inhibitors	3	4
Fertility Agents: Female	2	4
Neuritogenic	3	4
Osteogenic	2	4
Vascular Endothelial Growth Factor A Inhibitor	3	4
Vasodilator Agents	2	4
interleukin-13 down-regulation	2	4
Heat Shock Protein Down-Regulation	2	3
Immunomodulatory: Th17 downregulation	2	3
Interleukin-23 Downregulation	2	3
Adiponectin upregulation	1	2
Anti-Adipogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Cachexic Agents	1	2
Anti-Platelet	1	2
Anti-Ulcer Agents	1	2
Anticholesteremic Agents	1	2
Anticoagulants	1	2
Antimicrobial	2	2
Antioxidant Effects	1	2
Antipruritics	1	2
Aphrodisiac	1	2
DNA Repair Up-regulation	2	2
E-cadherin down-regulation	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
GABA Modulators	1	2
Genoprotective	1	2
Heme oxygenase-1 inducer	2	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-22 Downregulation	1	2
Interleukin-4 upregulation	1	2
Interleukin-5 downregulation	1	2
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	2	2
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	2
Multidrug Resistance Gene Modulators	1	2
Neuroplasticity enhancement	1	2
Nitric Oxide Enhancer	1	2
Regenerative	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Regulator	2	2
Viral Hemagglutinin Inhibitor	1	2
Acetylcholinesterase Down-Regulation	1	1
Anti-Allergic Agents	1	1
Anti-Retroviral Agents	1	1
Antiparasitic Agents	1	1
Catalase Up-Regulation	1	1
Cyclin D1 Down-Regulation	1	1
Fertility Agents: Male	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Histamine down-regulation	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Insulin-Like Growth Factor Enhancer/Upregulation	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-12 downregulation	1	1
Interleukin-2 upregulation	1	1
P21 Activation	1	1
Paraptosis	1	1
Survivin Down-Regulation	1	1
Vascular Endothelial Growth Factor A Enhancer	1	1
Vasoprotective	1	1
Wnt/β-catenin pathway down-regulation	1	1

[+]

Efficacy of ginsenoside Rg1 on rodent models of depression.Jul 22, 2024

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Pubmed Data : Psychopharmacology (Berl). 2024 Jul 23. Epub 2024 Jul 23. PMID: 39039242

Article Published Date : Jul 22, 2024

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginsenosides

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants

[+]

Exploratory systematic review and meta-analysis of Panax genus plant ingestion evaluation in exercise endurance.Mar 10, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Mar 11 ;14(6). Epub 2022 Mar 11. PMID: 35334841

Article Published Date : Mar 10, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginseng, Ginsenosides

Diseases : Athletic Performance

Therapeutic Actions : Exercise

[+]

Ginsenoside can protect against the renal failure in diabetes.Oct 28, 2022

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Pubmed Data : J Ethnopharmacol. 2022 Oct 29 ;302(Pt A):115860. Epub 2022 Oct 29. PMID: 36341813

Article Published Date : Oct 28, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginsenosides

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 1994 Oct ;74(10):626-8, 648. PMID: 7842343

Article Published Date : Sep 30, 1994

Study Type : Human Study

Additional Links

Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharmaceuticals (Basel). 2022 Jun 17 ;15(6). Epub 2022 Jun 17. PMID: 35745677

Article Published Date : Jun 16, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic

[+]

Ginsenoside Rh4 suppresses metastasis of gastric cancer.Apr 08, 2022

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Pubmed Data : Cureus. 2024 May ;16(5):e59942. Epub 2024 May 9. PMID: 38854305

[+]

Protopanaxadiol improves lupus nephritis.May 31, 2024

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Pubmed Data : Neurosci Lett. 2010 Jul 5 ;478(2):66-71. Epub 2010 May 8. PMID: 20438804

Article Published Date : Jul 04, 2010

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Nerve Injuries

Pharmacological Actions : Neuritogenic, Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

20 (R) -ginsenoside Rg3 entrapped in chitosan microspheres may have a beneficial effect against fatigue.Jan 05, 2017

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Pubmed Data : Curr Drug Deliv. 2017 09 6 ;14(6):867-874. PMID: 27834150

Article Published Date : Jan 05, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Fatigue

[+]

20 (S)-ginsenoside Rg3 can inhibit the formation of gastric ulcer.Sep 30, 2019

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A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

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Pubmed Data : Nanomedicine (Lond). 2020 Jan ;15(1):41-54. PMID: 31868113

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Betulinic acid, Ginsenosides, Honokiol, Parthenolide

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Natural Substance Synergy

[+]

A Ginkgo biloba and ginsenoside Rg3 extract possesses significant protective activities against ADHD-like conditions.Feb 28, 2014

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Pubmed Data : Food Chem Toxicol. 2014 Mar ;65:280-92. Epub 2014 Jan 3. PMID: 24394491

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Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113500. Epub 2020 Oct 19. PMID: 33091499

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, NF-kappaB Inhibitor

[+]

Ameliorative effect of ginsenoside Rg1 on dextran sulfate sodium-induced colitis.Nov 30, 2022

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Pubmed Data : Behav Med. 2011 Apr ;37(2):42-6. PMID: 21660771

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Antidepressant-like effects of ginsenosides.Dec 31, 2015

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Pubmed Data : Pharmacol Biochem Behav. 2016 Jan ;140:17-26. Epub 2015 Oct 31. PMID: 26528894

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK.Jun 26, 2018

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Pubmed Data : Biol Pharm Bull. 1995 Sep ;18(9):1197-202. PMID: 8845804

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Pubmed Data : Genet Mol Res. 2017 Mar 30 ;16(1). Epub 2017 Mar 30. PMID: 28362999

Article Published Date : Mar 29, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic

[+]

Effects of ginsenoside Rg3 on inhibiting differentiation, adipogenesis, and ER stress-mediated cell death in brown adipocytes.Dec 31, 2020

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6668665. Epub 2021 Mar 16. PMID: 33815558

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.Dec 31, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:932165. Epub 2011 Sep 20. PMID: 21941591

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Exercise-Induced Tissue Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

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Flavored black ginseng exhibited antitumor activity via improving immune function and inducing apoptosis.May 23, 2017

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Pubmed Data : Food Funct. 2017 May 24 ;8(5):1880-1889. PMID: 28426048

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Pubmed Data : Nutrients. 2016 Dec 13 ;8(12). Epub 2016 Dec 13. PMID: 27983571

Article Published Date : Dec 12, 2016

Study Type : Animal Study

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Substances : Ginsenosides, Panax Ginseng

Diseases : Fatigue: Excercise-Induced

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Fatigue: Excercise-Induced, Ginsenosides, Panax Ginseng, Polysaccharides

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Ginseng reduces neurologic damage in subarachanoid hemorrhage. Mar 31, 2010

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Pubmed Data : Curr Neurovasc Res. 2010 Mar 31. Epub 2010 Mar 31. PMID: 20353383

Article Published Date : Mar 31, 2010

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Cerebral Aneurysm, Stroke, Subarachnoid hemorrhage

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Pubmed Data : Chem Biol Interact. 2015 Dec 5 ;242:227-34. Epub 2015 Oct 19. PMID: 26482938

Article Published Date : Dec 04, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Ginsenosides

Diseases : Leukemia

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor

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Ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo.Oct 04, 2014

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Pubmed Data : Eur J Pharmacol. 2014 Oct 5 ;740:277-84. Epub 2014 Jul 20. PMID: 25054686

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Ginsenoside extract might serve as a potential agent for the prevention of NAFLD.Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2021 ;12:753881. Epub 2021 Oct 12. PMID: 34712140

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Arterial Hardening: Elasticity, Diabetic Complications

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Ginsenoside Rb1 ameliorates glycemic disorder in mice with high fat diet-induced obesity.Dec 31, 2020

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Pubmed Data : Vascul Pharmacol. 2015 Oct ;73:86-95. Epub 2015 Apr 22. PMID: 25912763

Article Published Date : Sep 30, 2015

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Aneurysm: Aortic

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor

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Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury.Jan 27, 2020

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Pubmed Data : J Integr Neurosci. 2021 Dec 30 ;20(4):813-823. PMID: 34997706

Article Published Date : Dec 29, 2021

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents

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Ginsenoside Rb1 could inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion, thus alleviating ischemia-reperfusion injury.Dec 31, 2001

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2002 ;22(3):212-5. PMID: 12658806

Article Published Date : Dec 31, 2001

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

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Pubmed Data : Am J Chin Med. 2019 Dec 2:1-17. Epub 2019 Dec 2. PMID: 31786947

Article Published Date : Dec 01, 2019

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

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Ginsenoside Rb1 from Panax ginseng attenuates monoiodoacetate-induced osteoarthritis.Jul 21, 2022

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Pubmed Data : J Food Biochem. 2022 Jul 22:e14340. Epub 2022 Jul 22. PMID: 35866931

Article Published Date : Jul 21, 2022

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator

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Pubmed Data : Front Pharmacol. 2022 ;13:991597. Epub 2022 Sep 27. PMID: 36238549

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Aging

Pharmacological Actions : Gastrointestinal Agents

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Ginsenoside Rb1 improves learning and memory ability through its anti-inflammatory effect in Aβ1-40 induced Alzheimer's disease of rats.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(5):2955-2968. Epub 2019 May 15. PMID: 31217866

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents

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Ginsenoside Rb1 prevents osteoporosis via the AHR/PRELP/NF-κB signaling axis.May 24, 2022

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Pubmed Data : Phytomedicine. 2022 May 25 ;104:154205. Epub 2022 May 25. PMID: 35716470

Article Published Date : May 24, 2022

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective

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Ginsenoside Rb1 promotes hepatic glycogen synthesis to ameliorate T2DM.Dec 31, 2022

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Pubmed Data : Diabetes Metab Syndr Obes. 2023 ;16:3223-3234. Epub 2023 Oct 17. PMID: 37867629

Article Published Date : Dec 31, 2022

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Postaglandin PGE2 downregulation

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Ginsenoside Rb1 promotes motor functional recovery and axonal regeneration in post-stroke.Dec 31, 2019

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Pubmed Data : Brain Res Bull. 2020 Jan ;154:51-60. Epub 2019 Nov 9. PMID: 31715311

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul 25. Epub 2024 Jul 25. PMID: 39052059

Article Published Date : Jul 24, 2024

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents

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Ginsenoside Rb1 reduces D-GalN/LPS-induced acute liver injury.Jun 27, 2022

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Pubmed Data : PeerJ. 2021 ;9:e10598. Epub 2021 Feb 3. PMID: 33604164

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : High Fat Diet, Obesity

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

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Ginsenoside Rb1produces pain antihypersensitivity by spinal microglial dynorphin A expression.Nov 07, 2022

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Pubmed Data : Neurosci Res. 2022 Nov 8. Epub 2022 Nov 8. PMID: 36368461

Article Published Date : Nov 07, 2022

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Neuropathic Pain

Pharmacological Actions : Analgesics

[+]

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Pubmed Data : Front Pharmacol. 2022 ;13:1027731. Epub 2022 Oct 7. PMID: 36278209

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Pubmed Data : Curr Res Food Sci. 2023 ;6:100491. Epub 2023 Mar 21. PMID: 37033737

Article Published Date : Dec 31, 2022

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents

[+]

Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation.May 31, 2013

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Pubmed Data : Neurobiol Dis. 2013 Jun ;54:320-8. Epub 2013 Jan 13. PMID: 23321003

Article Published Date : May 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 1452 Abstracts with Ginsenosides Research

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Efficacy of ginsenoside Rg1 on rodent models of depression.Jul 22, 2024

Exploratory systematic review and meta-analysis of Panax genus plant ingestion evaluation in exercise endurance.Mar 10, 2022

Ginsenoside can protect against the renal failure in diabetes.Oct 28, 2022

Protective effects of ginsenosides on ulcerative colitis.Jul 08, 2024

The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer.Apr 06, 2023

The effect of ginsenosides on liver injury.Dec 31, 2022

A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

Effect of ginsenoside-Rg1 on experimental Parkinson's disease.May 31, 2021

Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

The effect of ginsenosides on depression in preclinical studies.Apr 30, 2021

The efficacy of ginsenoside Rg3 combined with first-line chemotherapy in the treatment of advanced non-small cell lung cancer. Dec 31, 2019

American ginseng has radioprotective effect on human lymphocytes at 90 minutes postirradiation.May 01, 2010

American ginseng reduces oxidative stress in patients taking the antiviral medication zidovudine without altering drug pharmacokinetics. May 01, 2008

Both hydroponically cultivated red and wild growing white ginseng have similar beneficial effects on the cognitive functions of elderly subjects.Feb 24, 2021

Daily supplementation of Korean Red Ginseng for 8 weeks significantly improved the TBUT score and subjective dry eye symptoms, as compared to placebo.Dec 31, 2014

Effect of ginseng extracts on the improvement of osteopathic and arthritis symptoms in women with osteopenia.Sep 23, 2021

Enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content of skin. Jun 30, 2016

Ginsenoside Rb1 prevents age-related endothelial senescence.Feb 14, 2024

Ginsenoside Rb1 treatment was effective in reducing the extent of oxidative stress and inflammation in chronic kidney disease patients.Jan 31, 2017

Ginsenoside Rd is efficacious against acute ischemic stroke.Apr 30, 2016

Ginsenoside Rg3 could be used as a new regimen to delay acquired resistance of epidermal growth factor receptor-tyrosine kinase inhibitors.Oct 24, 2016

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Ginsenoside-Rd improves outcome of acute ischaemic stroke.May 31, 2012

Ginsenoside-Rd may be of some benefit in acute ischaemic stroke.Apr 30, 2009

High-dose ginsenoside supplementation augmented the improvement of aerobic capacity by exercise training.Mar 31, 2018

Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries.Sep 30, 1994

The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

These results suggest a potential role for ginseng in modulating salivary androgen levels.May 27, 2020

This data suggested that consumers on a Western diet should obtain better cancer prevention effects with American ginseng intake.Mar 31, 2017

Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction.Oct 31, 2022

Cytoprotective effects of ginsenoside Rd on apoptosis-associated cell death in the isolated human pancreatic islets.Dec 31, 2018

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Ginsenoside Rb1 shows potential for use in skin care products to protect the skin against damage by fine particles.Sep 08, 2019

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Ginsenosides in Panax ginseng extract promote anagen transition by suppressing BMP4 expression and promote human hair growth.Dec 31, 2023

Red ginseng extract promotes the hair growth in cultured human hair follicles.Feb 28, 2015

20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo.Apr 30, 2022

Ginseng polysaccharide reduces autoimmune hepatitis inflammatory response.Jul 24, 2023

Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia.Dec 31, 2022

Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells.Apr 24, 2024

Ginsenoside compound K protects against cerebral ischemia/reperfusion injury.Apr 30, 2023

Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity.Dec 31, 2022

Ginsenoside F1 protects the brain against amyloid beta-induced toxicity by regulating IDE and NEP. Dec 31, 2021

Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis.Aug 17, 2024

Ginsenoside Rb1 for overcoming cisplatin-insensitivity of A549/DDP cells.Jun 30, 2023

Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis.Apr 30, 2024

Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.May 14, 2023

Ginsenoside Rb3 inhibits osteoclastogenesis via ERK/NF-κB signaling pathway.Aug 16, 2022

Ginsenoside Rc modulates SIRT6-NRF2 interaction to alleviate alcoholic liver disease. Nov 08, 2022

Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury.Dec 31, 2023

Ginsenoside Rd promotes cardiac repair after myocardial infarction.Dec 31, 2021

Ginsenoside Re inhibits melanogenesis and melanoma growth.Aug 31, 2023

Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy.Apr 30, 2023

Ginsenoside Rg1 induces autophagy in colorectal cancer.Apr 27, 2024

Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury.May 16, 2022

Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance.Feb 28, 2022

Ginsenoside Rg3 overcomes tamoxifen resistance through inhibiting glycolysis in breast cancer cells.Jan 14, 2024

Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury.Nov 14, 2022

Ginsenoside Rh2 inhibits CBP/p300-mediated FOXO3a acetylation and epilepsy-induced oxidative damage.Nov 14, 2022

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.Apr 18, 2023

Ginsenoside Rh3 inhibits lung cancer metastasis.Jun 16, 2022

Ginsenoside Rh4 suppresses metastasis of gastric cancer.Apr 08, 2022

Ginsenoside Rk1 could be applied for the development of effective natural antiphotoaging agents for skin health.Dec 05, 2022

Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.Apr 03, 2022

Ginsenosides CK as a potential therapeutic approach for treating muscle-wasting conditions associated with obesity.Apr 30, 2022

Inhibition of cholesteryl ester transfer protein contributes to the protection of ginsenoside Re against isoproterenol-induced cardiac hypertrophy.Apr 30, 2024

Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy.Apr 28, 2024

Neuroprotective effects and metabolomics study of protopanaxatriol (PPT) on cerebral ischemia/reperfusion injury.Jan 15, 2023

Notoginsenoside R1 facilitates cell angiogenesis by inactivating the Notch signaling during wound healing.Mar 10, 2023

Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury.Jan 30, 2023

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy.Sep 23, 2022

Ginsenosides

View the Evidence:
1452 Abstracts with Ginsenosides Research