Daidzein

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64 Diseases Researched for Daidzein
NameACCKFocus
Menopausal Syndrome220Locked
Breast Cancer717Locked
Ovarian Cancer313Locked
Prostate Cancer212Locked
Cancers: Drug Resistant211Locked
Cholesterol: Oxidation110Locked
Fibroids: Uterine110Locked
Hemodialysis110Locked
Hot Flash110Locked
Prostate Cancer: Prevention110Locked
Bladder Cancer34Locked
Fatty Liver24Locked
Inflammation34Locked
Choriocarcinoma23Locked
Insulin Resistance23Locked
Metabolic Syndrome X23Locked
Oxidative Stress23Locked
Parkinson's Disease23Locked
Spinal Cord Injuries23Locked
Stroke23Locked
Aneurysm: Aortic12Locked
Atherosclerosis12Locked
Cardiovascular Diseases12Locked
Chemotherapy-Induced Kidney Damage12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Chemotherapy-Induced Toxicity: Gentamicin12Locked
Chronic Kidney Disease (CKD)12Locked
Colon Cancer22Locked
Colorectal Cancer12Locked
Diabetes Mellitus: Type 112Locked
Diabetes Mellitus: Type 222Locked
Diabetic Complications12Locked
Diabetic Cystopathy12Locked
Heart Failure12Locked
High Cholesterol12Locked
Hypothyroidism12Locked
Ischemia12Locked
Low Testosterone12Locked
Lung Cancer22Locked
Myocardial Fibrosis 12Locked
Neurodegenerative Diseases12Locked
Obesity12Locked
Prostatitis: Acute12Locked
Prostatitis: Chronic12Locked
Rheumatoid Arthritis12Locked
Alzheimer's Disease11Locked
BRCA1/BRCA2: Prevalence11Locked
Benzene Toxicity11Locked
Breast Cancer: Chemically-Induced11Locked
Cancers: All11Locked
Cancers: Multi-Drug Resistant11Locked
Chemotherapy-Induced Toxicity: Cisplatin11Locked
Coronavirus Infection11Locked
Dengue11Locked
Endometrial Cancer11Locked
Endometriosis11Locked
Estrogen Dominance11Locked
Lipopolysaccharide-Induced Toxicity11Locked
Liver Cancer11Locked
Melanoma11Locked
Neurological Conditions11Locked
Optic Nerve Diseases11Locked
Pancreatic Cancer11Locked
Urinary Tract Cancer11Locked
41 Pharmacological Actions Researched for Daidzein
NameACCKFocus
Apoptotic1124Locked
Antioxidants721Locked
Anti-Inflammatory Agents1117Locked
Antineoplastic Agents515Locked
Cell cycle arrest1115Locked
Chemopreventive414Locked
Anticarcinogenic Agents312Locked
Antiproliferative 911Locked
Neuroprotective Agents58Locked
NF-kappaB Inhibitor35Locked
Renoprotective35Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor35Locked
Cyclooxygenase 2 Inhibitors34Locked
Immunomodulatory24Locked
Interleukin-1 beta downregulation24Locked
Interleukin-6 Downregulation34Locked
Anti-Apoptotic23Locked
Chemoprotective Agents23Locked
Angiogenesis Inhibitors12Locked
Anti-Fibrotic12Locked
Anticholesteremic Agents12Locked
Antiviral Agents22Locked
Cardioprotective12Locked
Chemotherapeutic12Locked
Cyclin D1 Down-Regulation22Locked
Estradiol 3-glucuronide enhancer 22Locked
Hypoglycemic Agents22Locked
Insulin-Like Growth Factor Inhibition/Downregulation12Locked
Interleukin-8 downregulation22Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor12Locked
Secretagogue12Locked
Stearoyl coenzyme A desaturase-1 modulator12Locked
Steroidogenesis12Locked
Arginase 1 (Arg1) up-regulation11Locked
Aromatase Inhibitors11Locked
Chemosensitizer11Locked
Enzyme Inhibitors11Locked
Estrogen Receptor Agonist11Locked
Glucagon Like peptide 1 (GLP-1) Up-regulation11Locked
Insulinotrophic11Locked
Neuritogenic11Locked
Related Topics

Daidzein is a Sub of the following Topic

View the Evidence:
62 Abstracts with Daidzein Research

[+]

Daidzein-rich isoflavone are effective in reducing hot flashes in menopausal women. Apr 24, 2007

Pubmed Data : Life Sci. 2007 Apr 24;80(20):1821-31. Epub 2007 Feb 3. PMID: 18257146
Article Published Date : Apr 24, 2007
Study Type : Human Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Hot Flash, Menopausal Syndrome
[+]

Fermented soy therapy may have therapeutic value in treating platinum-resistant ovarian cancer. Jan 01, 2006

Pubmed Data : Gynecol Oncol. 2006 Jan;100(1):205-9. Epub 2005 Sep 19. PMID: 16171852
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Additional Keywords : Drug: Doxorubicin
[+]

Genistein and daidzein consumption are associated with a lower risk of prostate cancer. Aug 01, 2009

Pubmed Data : J Altern Complement Med. 2009 Aug;15(8):905-9. PMID: 19838933
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones
Diseases : Prostate Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Risk Reduction
[+]

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.Jul 01, 2008

Pubmed Data : Int J Gynaecol Obstet. 2008 Jul;102(1):44-9. Epub 2008 Apr 8. PMID: 18395723
Article Published Date : Jul 01, 2008
Study Type : Human Study
Additional Links
Substances : Daidzein, Equol, Isoflavones
Diseases : Menopausal Syndrome
[+]

Soy isoflavones consumed at levels comparable to those in Asian populations may reduce the risk of cancer recurrence in women receiving tamoxifen therapy and moreover, appears not to interfere with tamoxifen efficacy.Nov 01, 2009

Pubmed Data : Breast Cancer Res Treat. 2009 Nov;118(2):395-405. Epub 2009 Feb 17. PMID: 19221874
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Breast Cancer
Additional Keywords : Risk Reduction
[+]

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

Pubmed Data : Nutr Cancer. 2003;47(2):111-7. PMID: 15087261
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Soy protein reduces cholesterol oxidation in patients on hemodialysis. Jan 01, 2006

Pubmed Data : J Med Food. 2006;9(3):368-72. PMID: 17004900
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy Protein
Diseases : Cholesterol: Oxidation, Hemodialysis
Pharmacological Actions : Antioxidants
[+]

There is a modest inverse association between lignan excretion and uterine fibroid risk. Jan 01, 2005

Pubmed Data : Cytotechnology. 2005 Jan;47(1-3):97-105. PMID: 16960173
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Substances : Daidzein, Enterodiol, Enterolactone, Equol, Genistein, Isoflavones, Lignans
Diseases : Fibroids: Uterine
[+]

Coffee contains the isoflavones genistein, daidzein and formononetin.Mar 10, 2010

Pubmed Data : J Agric Food Chem. 2010 Mar 10;58(5):3002-7. PMID: 20131840
Article Published Date : Mar 10, 2010
Study Type : Animal Study
Additional Links
Substances : Coffee, Daidzein, Genistein, Isoflavones
Additional Keywords : Substances that are Linked
[+]

Daidzein alleviates doxorubicin-induced heart failure.Sep 21, 2022

Pubmed Data : Food Funct. 2022 Sep 22 ;13(18):9576-9588. Epub 2022 Sep 22. PMID: 36000402
Article Published Date : Sep 21, 2022
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Heart Failure
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemopreventive
[+]

Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4878-4886. Epub 2017 Sep 21. PMID: 29201192
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Ischemia, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.Jun 30, 2016

Pubmed Data : Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID: 27222119
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Aneurysm: Aortic
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Daidzein attenuates urinary bladder dysfunction in streptozotocin-induced diabetes in rats by NOX-4 and RAC-1 inhibition.May 10, 2022

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2022 May 11. Epub 2022 May 11. PMID: 35538367
Article Published Date : May 10, 2022
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Diabetic Complications, Diabetic Cystopathy
Pharmacological Actions : Antioxidants
[+]

Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells.May 31, 2018

Pubmed Data : Int J Mol Med. 2018 Jun ;41(6):3485-3492. Epub 2018 Mar 5. PMID: 29512690
Article Published Date : May 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Daidzein exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells.Aug 04, 2020

Pubmed Data : Plant Foods Hum Nutr. 2020 Aug 5. Epub 2020 Aug 5. PMID: 32761299
Article Published Date : Aug 04, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Daidzein inhibits choriocarcinoma proliferation by arresting cell cycle at G1 phase.Sep 30, 2017

Pubmed Data : Oncol Rep. 2017 Oct ;38(4):2518-2524. Epub 2017 Aug 28. PMID: 28849226
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Choriocarcinoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Daidzein mitigates oxidative stress and inflammation in the injured kidney of ovariectomized rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Kidney Dis. 2022 Jan ;1(1):32-43. PMID: 35271498
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Chronic Kidney Disease (CKD), Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines.May 03, 2022

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2022 May 4 ;258:109364. Epub 2022 May 4. PMID: 35523404
Article Published Date : May 03, 2022
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Daidzein suppresses TGF-β1-induced cardiac fibroblast activation.Mar 14, 2022

Pubmed Data : Eur J Pharmacol. 2022 Mar 15 ;919:174805. Epub 2022 Feb 10. PMID: 35151651
Article Published Date : Mar 14, 2022
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Dietary soy protein isolate attenuates metabolic syndrome in rats. Aug 01, 2009

Pubmed Data : J Nutr. 2009 Aug;139(8):1431-8. Epub 2009 Jun 10. PMID: 19515742
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy Protein
Diseases : Fatty Liver, High Cholesterol, Insulin Resistance, Metabolic Syndrome X
Pharmacological Actions : Anticholesteremic Agents
[+]

Hesperidin seems to be quite effective against rheumatoid arthritis and atherosclerosis.Nov 30, 2016

Pubmed Data : Mol Cell Biochem. 2016 Dec ;423(1-2):115-127. Epub 2016 Oct 4. PMID: 27704466
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Daidzein, Hesperidin
Diseases : Atherosclerosis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Isoflavone daidzein regulates immune responses in the B6C3F1 and non-obese diabetic (NOD) mice.May 31, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun ;71:277-284. Epub 2019 Mar 28. PMID: 30927738
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Immunomodulatory
[+]

Neuroprotective effect of daidzein extracted from Pueraria lobate in a stroke model.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:772485. Epub 2022 Jan 14. PMID: 35095491
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Daidzein, Kudzu
Diseases : Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

Pubmed Data : Acta Vet Scand. 2009 Dec 10;51:51. PMID: 20003293
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, phytoestrogens
Diseases : Hypothyroidism, Low Testosterone
Pharmacological Actions : Secretagogue, Steroidogenesis
[+]

Soy has an anti-inflammatory effect on experimentally-induced prostatitis in rats. May 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 May;232(5):674-81. PMID: 17463164
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy Protein
Diseases : Prostatitis: Acute, Prostatitis: Chronic
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Soy phytochemicals prevent growth and metastasis of bladder cancer in mice. Feb 01, 2006

Pubmed Data : Cancer Res. 2006 Feb 1;66(3):1851-8. PMID: 16452247
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Insulin-Like Growth Factor Inhibition/Downregulation, NF-kappaB Inhibitor
[+]

Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.Sep 01, 1999

Pubmed Data : J Nutr. 1999 Sep;129(9):1628-35. PMID: 10460196
Article Published Date : Sep 01, 1999
Study Type : Animal Study
Additional Links
Substances : Daidzein, Genistein, Soy Protein
Diseases : Prostate Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antineoplastic Agents, Apoptotic, Cell cycle arrest
[+]

Synergetic inhibition of daidzein and regular exercise on breast cancer.Mar 14, 2020

Pubmed Data : Life Sci. 2020 Mar 15 ;245:117387. Epub 2020 Jan 30. PMID: 32007575
Article Published Date : Mar 14, 2020
Study Type : Animal Study
Additional Links
Substances : Daidzein
Diseases : Breast Cancer
Therapeutic Actions : Exercise
Pharmacological Actions : Apoptotic, Immunomodulatory
[+]

The isoflavone daidzein reduces food intake, weight gain and reduces fat content in the livers of animals on an obesity-generating diet. May 10, 2011

Pubmed Data : Br J Pharmacol. 2011 May 10. Epub 2011 May 10. PMID: 21557739
Article Published Date : May 10, 2011
Study Type : Animal Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Fatty Liver, Obesity
Pharmacological Actions : Stearoyl coenzyme A desaturase-1 modulator
[+]

This study highlighted the potential anticancer role of chrysin and daidzein in the treatment of colon cancer.Nov 26, 2020

Pubmed Data : Eur J Pharmacol. 2020 Nov 27 ;892:173763. Epub 2020 Nov 27. PMID: 33249075
Article Published Date : Nov 26, 2020
Study Type : Animal Study
Additional Links
Substances : Chrysin, Daidzein
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic
[+]

Antiviral activity of four types of bioflavonoid against dengue virus type-2.Dec 27, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virol J. 2011 Dec 28 ;8:560. Epub 2011 Dec 28. PMID: 22201648
Article Published Date : Dec 27, 2011
Study Type : In Vitro Study
Additional Links
Substances : Bioflavonoids, Citrus naringin, Daidzein, Fisetin, Flavonoids, Quercetin
Diseases : Dengue
Pharmacological Actions : Antiviral Agents
Additional Keywords : Phytotherapy
[+]

Baicalein and daidzein had a synergistic effect estrogenic and neuroprotective activities in alzheimer's disease and enhanced the effects of different flavonoids.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:635694. Epub 2013 Aug 24. PMID: 24058373
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Baicalein, Daidzein, Flavonoids
Diseases : Alzheimer's Disease, Neurological Conditions, Parkinson's Disease
Pharmacological Actions : Estrogen Receptor Agonist, Neuroprotective Agents
Additional Keywords : Bioenhancer, Natural Substance Synergy
[+]

Daidzein and chicory extract arrest the cell cycle via inhibition of cyclin D/CDK4 and cyclin A/CDK2 gene expression in hepatocellular carcinoma.Mar 20, 2022

Pubmed Data : Recent Pat Anticancer Drug Discov. 2022 Mar 21. Epub 2022 Mar 21. PMID: 35319392
Article Published Date : Mar 20, 2022
Study Type : In Vitro Study
Additional Links
Substances : Chicory, Daidzein
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Daidzein had an ameliorative effect of on cisplatin-induced nephrotoxicity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:3140680. Epub 2017 Aug 2. PMID: 28831294
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective
[+]

Daidzein has antiproliferative effects on human estrogren-receptor-positive and negative pancreatic cancer cells. Mar 15, 2004

Pubmed Data : World J Gastroenterol. 2004 Mar 15;10(6):860-3. PMID: 15040033
Article Published Date : Mar 15, 2004
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Pancreatic Cancer
[+]

Daidzein has neuritogenic properties. Aug 28, 2012

Pubmed Data : J Biomed Sci. 2012 Aug 29 ;19(1):80. Epub 2012 Aug 29. PMID: 22931352
Article Published Date : Aug 28, 2012
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Pharmacological Actions : Neuritogenic
[+]

Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner.Mar 31, 2018

Pubmed Data : Mol Med Rep. 2018 Apr ;17(4):6093-6099. Epub 2018 Feb 13. PMID: 29436666
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Choriocarcinoma
Pharmacological Actions : Apoptotic
Additional Keywords : Dose Response
[+]

Daidzein may have therapeutic value in the treatment of spinal cord injury, optic nerve injury and/or stroke. Jan 13, 2010

Pubmed Data : J Neurosci. 2010 Jan 13;30(2):739-48. PMID: 20071539
Article Published Date : Jan 13, 2010
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Optic Nerve Diseases, Spinal Cord Injuries, Stroke
Pharmacological Actions : Arginase 1 (Arg1) up-regulation, Enzyme Inhibitors, Neuroprotective Agents
[+]

Daidzein may prove beneficial in the development of melanoma systemic therapy. Dec 31, 2019

Pubmed Data : J BUON. 2020 Jan-Feb;25(1):485-490. PMID: 32277673
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Daidzein supplements with current chemotherapeutic agents may well be an alternative strategy to improve the treatment efficacy of lung adenocarcinoma.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2022 ;18(9):3636-3652. Epub 2022 May 16. PMID: 35813479
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis.Apr 17, 2018

Pubmed Data : J Steroid Biochem Mol Biol. 2018 Apr 18. Epub 2018 Apr 18. PMID: 29679753
Article Published Date : Apr 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Aromatase Inhibitors, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Daidzein-rich isoflavones aglycone inhibits lung cancer growth.May 31, 2020

Pubmed Data : Immunol Lett. 2020 Jun ;222:67-72. Epub 2020 Mar 18. PMID: 32197974
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Lung Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Flavonoids reduces lipopolysaccharide-induced release of inflammatory mediators in human bronchial epithelial cells.Oct 10, 2019

Pubmed Data : Eur J Pharmacol. 2019 Oct 11 ;865:172731. Epub 2019 Oct 11. PMID: 31610186
Article Published Date : Oct 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Daidzein, Flavonoids, Genistein, Luteolin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Genistein and daidzein decreased ovarian cancer cell migration, invasion, proliferation and sphere formation.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2018 ;18:65. Epub 2018 May 1. PMID: 29743815
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Genistein and daidzein induce apoptosis of colon cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2018 ;62. Epub 2018 May 11. PMID: 29849534
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic
[+]

Genistein and daidzein, in combination, protect against chemically-induced mammary carcinogenesis. Jan 01, 2011

Pubmed Data : Afr J Tradit Complement Altern Med. 2011 ;8(2):91-7. Epub 2010 Dec 30. PMID: 22238489
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Chemopreventive
[+]

Isoflavonoids and peptides from meju, long-term fermented soybeans, increase insulin sensitivity and exert insulinotropic effects in vitro.Feb 01, 2011

Pubmed Data : Nutrition. 2011 Feb;27(2):244-52. Epub 2010 Jun 11. PMID: 20541368
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy, Soy: Fermented
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Metabolic Syndrome X
Pharmacological Actions : Glucagon Like peptide 1 (GLP-1) Up-regulation, Hypoglycemic Agents, Insulinotrophic
[+]

Kudzu (P. radix) isoflavones and their metabolites inhibit growth and induces cell death in breast cancer cells. Jan 23, 2009

Pubmed Data : Biochem Biophys Res Commun. 2009 Jan 23;378(4):683-8. Epub 2008 Nov 14. PMID: 19013426
Article Published Date : Jan 23, 2009
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Kudzu
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Plant isoflavones can prevent adverse effects of benzene on porcine ovarian activity.May 21, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 May 22. Epub 2020 May 22. PMID: 32445151
Article Published Date : May 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Daidzein, Isoflavones, Rutin
Diseases : Benzene Toxicity
Pharmacological Actions : Anti-Apoptotic
Problem Substances : Benzene
[+]

Soy isoflavones can inhibit bladder tumor growth through a combination of direct effects on tumor cells and indirect effects on the tumor neovasculature.Nov 15, 1998

Pubmed Data : Cancer Res. 1998 Nov 15;58(22):5231-8. PMID: 9823337
Article Published Date : Nov 15, 1998
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Cell cycle arrest
[+]

Soy isoflavones may protect against colon cancer. Jan 01, 2011

Pubmed Data : Nutr Cancer. 2011 Jan;63(1):139-50. PMID: 21161820
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Glycitein, Isoflavones, Soy
Diseases : Colon Cancer
Pharmacological Actions : Cell cycle arrest
[+]

Soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer.Apr 30, 2012

Pubmed Data : OMICS. 2012 May ;16(5):235-44. Epub 2012 Feb 17. PMID: 22339411
Article Published Date : Apr 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy
Diseases : BRCA1/BRCA2: Prevalence, Breast Cancer
Additional Keywords : BRCA MYTH, Epigenetic Modification In Cancer
[+]

Soybean foods may have chemotherapeutic value in the treatment of human urinary tract cancer.Jan 01, 2000

Pubmed Data : Clin Cancer Res. 2000 Jan;6(1):230-6. PMID: 10656454
Article Published Date : Jan 01, 2000
Study Type : Review
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Soy
Diseases : Bladder Cancer, Urinary Tract Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Cell cycle arrest
[+]

The inhibitory effects of plant derivate polyphenols on the main protease of SARS coronavirus 2.Mar 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Mar 30 ;26(7). Epub 2021 Mar 30. PMID: 33808054
Article Published Date : Mar 29, 2021
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Myricetin, Polyphenols, Puerarin, Tannic Acid
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
Additional Keywords : Drug Synergy, Plant Extracts
[+]

The isoflavone content of soybeans increases during germination. Sep 01, 2005

Pubmed Data : Plant Foods Hum Nutr. 2005 Sep;60(3):147-51. PMID: 16187018
Article Published Date : Sep 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones, Sprouts
[+]

The isoflavones biochanin A, daidzein and especially genistein inhibit the growth of breast cancer cells, including those expressing the multi-drug resistance gene.Aug 30, 1991

Pubmed Data : Biochem Biophys Res Commun. 1991 Aug 30;179(1):661-7. PMID: 1883387
Article Published Date : Aug 30, 1991
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Daidzein, Genistein, Isoflavones
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
[+]

The role of isoflavones in type 2 diabetes prevention and treatment-A narrative review.Dec 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Dec 28 ;22(1). Epub 2020 Dec 28. PMID: 33379327
Article Published Date : Dec 27, 2020
Study Type : Review
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

The soy isoflavone daidzein enhances the clearance of estradiol (E2) from the body possibly contributing to its chemopreventive effect against hormonally-sensitive cancers.Dec 01, 2005

Pubmed Data : Carcinogenesis. 2005 Dec;26(12):2172-8. Epub 2005 Jul 28. PMID: 16051636
Article Published Date : Dec 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Estradiol 3-glucuronide enhancer
[+]

The soy isoflavone daidzein enhances the clearance of estradiol (E2) from the body possibly contributing to its chemopreventive effect.Feb 01, 1999

Pubmed Data : J Gastroenterol. 1999 Feb;34(1):75-82. PMID: 16598814
Article Published Date : Feb 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Isoflavones
Diseases : Breast Cancer, Endometrial Cancer, Estrogen Dominance
Pharmacological Actions : Chemopreventive, Estradiol 3-glucuronide enhancer
[+]

The soy isoflavone Daidzein exhibits anticancer effects in human breast cancer cells.Sep 01, 2008

Pubmed Data : Phytomedicine. 2008 Sep;15(9):683-90. Epub 2008 Jun 9. PMID: 18541420
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Breast Cancer
[+]

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones, Red Clover
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

We believe that studies described in this paper will be helpful in elucidating molecular mechanisms of action of genistein as modulator of cell cycle and inhibitor of DNA replication in humans.May 23, 2015

Pubmed Data : Mol Cell Biochem. 2015 May 24. Epub 2015 May 24. PMID: 26003441
Article Published Date : May 23, 2015
Study Type : In Vitro Study
Additional Links
Substances : Daidzein, Flavonoids, Genistein, Kaempferol
Pharmacological Actions : Cell cycle arrest
Additional Keywords : Dose Response, Gene Expression Regulation, Natural Substance Synergy

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