D-Limonene

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36 Diseases Researched for D-Limonene
NameACCKFocus
Breast Cancer517Locked
Cancers: All110Locked
Colitis110Locked
Oxidative Stress610Locked
Gastric Cancer34Locked
Leukemia: Chronic myelogenous leukemia (CML) 34Locked
Lipid Peroxidation24Locked
Chemically-Induced Liver Damage23Locked
Lymphoma23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Cerebral Ischemia12Locked
Chemotherapy-Induced Toxicity: Doxorubicin12Locked
Colon Cancer22Locked
Depression12Locked
Diabetes Mellitus: Type 212Locked
Diabetes: Oxidative Stress12Locked
Diabetic Complications12Locked
Dyslipidemias12Locked
Glutathione Deficiency 12Locked
High Fat Diet12Locked
Hyperglycemia12Locked
Hypertension12Locked
Inflammation12Locked
Insulin Resistance12Locked
Liver Cancer12Locked
Lung Cancer12Locked
Malignant Melanoma12Locked
Melanoma: Metastatic12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Obesity12Locked
Skin Cancer12Locked
Ulcerative Colitis12Locked
Cataract11Locked
Gastric Ulcer11Locked
Liver Cirrhosis11Locked
Promyelocytic leukemia 11Locked
34 Pharmacological Actions Researched for D-Limonene
NameACCKFocus
Anti-Inflammatory Agents517Locked
Chemopreventive517Locked
Anticarcinogenic Agents416Locked
Antioxidants712Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor211Locked
Apoptotic78Locked
Antiproliferative 55Locked
Antineoplastic Agents34Locked
Cyclooxygenase 2 Inhibitors24Locked
Hepatoprotective24Locked
Hypolipidemic24Locked
Angiogenesis Inhibitors23Locked
Bcl-2 protein down-regulation33Locked
NF-kappaB Inhibitor23Locked
Antidepressive Agents12Locked
Autophagy Up-regulation12Locked
Chemoprotective Agents12Locked
Chemotherapeutic12Locked
Hypoglycemic Agents12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor12Locked
Neuroprotective Agents12Locked
Pancreato Protective Agents12Locked
Postaglandin PGE2 downregulation 12Locked
Renoprotective12Locked
Superoxide Dismutase Up-regulation12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Anti-Fibrotic11Locked
Anti-metastatic11Locked
Caspase-3 Activation11Locked
Cell cycle arrest11Locked
Gastroprotective11Locked
Vascular Endothelial Growth Factor Inhibitors11Locked

View the Evidence:
34 Abstracts with D-Limonene Research

[+]

D-Limonene consumption as measured by citrus peel ingestion lowers the risk of human cancers. Jan 01, 2000

Pubmed Data : Nutr Cancer. 2000;37(2):161-8. PMID: 11142088
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Citrus Peel , D-Limonene
Diseases : Cancers: All
[+]

Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer.May 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2013 Jun ;6(6):577-84. Epub 2013 Apr 3. PMID: 23554130
Article Published Date : May 31, 2013
Study Type : Human Study
Additional Links
Substances : D-Limonene
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Oral administration of d-limonene controls inflammation in colitis.Jul 09, 2013

Pubmed Data : Life Sci. 2013 Jul 10 ;92(24-26):1151-6. Epub 2013 May 7. PMID: 23665426
Article Published Date : Jul 09, 2013
Study Type : Animal Study, Human Study
Additional Links
Substances : D-Limonene
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antidepressant-like effect of Citrus sinensis essential oil and its main component limoneneApr 01, 2019

Pubmed Data : J Agric Food Chem. 2019 Apr 2. Epub 2019 Apr 2. PMID: 30905156
Article Published Date : Apr 01, 2019
Study Type : Animal Study
Additional Links
Substances : D-Limonene, Orange
Diseases : Depression
Pharmacological Actions : Antidepressive Agents
[+]

D-limonene chemoprevention of hepatocarcinogenesis.Aug 31, 1999

Pubmed Data : Oncol Rep. 1999 Sep-Oct;6(5):1123-7. PMID: 10425313
Article Published Date : Aug 31, 1999
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents
[+]

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Apr ;15(4):2339-2346. Epub 2017 Feb 22. PMID: 28260017
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Postaglandin PGE2 downregulation
[+]

D-limonene ihibits the metastatic progression of melanoma cells in mice. Sep 01, 2003

Pubmed Data : J Exp Clin Cancer Res. 2003 Sep;22(3):419-24. PMID: 14582701
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Malignant Melanoma, Melanoma: Metastatic
[+]

D-Limonene inhibits the growth and metastasis of human gastric cancer implanted into mice. Jul 15, 2004

Pubmed Data : World J Gastroenterol. 2004 Jul 15;10(14):2140-4. PMID: 15237454
Article Published Date : Jul 15, 2004
Study Type : Transgenic Animal Study
Additional Links
Substances : D-Limonene
Diseases : Gastric Cancer
[+]

D-Limonene is a potential therapeutic candidate for treatment of stroke-associated cerebral and vascular damage under conditions of hypertension.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Jan ;15(1):699-706. Epub 2017 Nov 14. PMID: 29399074
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Cerebral Ischemia, Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

D-limonene may have a therapeutic effect on lung cancer as it can induce apoptosis of lung cancer cells by promoting autophagy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2018 ;11:1833-1847. Epub 2018 Apr 4. PMID: 29670359
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
[+]

D-limonene might have a role in the prevention of the complication of diabetes in rats.Nov 30, 2017

Pubmed Data : Food Chem Toxicol. 2017 Dec ;110:434-442. Epub 2017 Sep 18. PMID: 28923438
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Diabetes: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Antioxidants, Hypolipidemic, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.Jul 31, 2012

Pubmed Data : Hum Exp Toxicol. 2012 Aug ;31(8):798-811. Epub 2012 Feb 8. PMID: 22318307
Article Published Date : Jul 31, 2012
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Inflammation, Oxidative Stress, Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive
[+]

D-limonene suppresses doxorubicin-induced oxidative stress and inflammation.Mar 31, 2014

Pubmed Data : Exp Biol Med (Maywood). 2014 Apr ;239(4):465-76. Epub 2014 Feb 28. PMID: 24586096
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Renoprotective
[+]

Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet.Jan 31, 2012

Pubmed Data : Eur J Nutr. 2012 Feb ;51(1):57-68. Epub 2011 Mar 29. PMID: 21445622
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : High Fat Diet, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Pancreato Protective Agents
[+]

Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion.Jun 30, 1993

Pubmed Data : Xenobiotica. 1993 Jul ;23(7):809-19. PMID: 8237062
Article Published Date : Jun 30, 1993
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Glutathione Deficiency
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene.Apr 30, 1984

Pubmed Data : Carcinogenesis. 1984 May ;5(5):661-4. PMID: 6426810
Article Published Date : Apr 30, 1984
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Intake of d-limonene may benefit patients with dyslipidemia and hyperglycemia.Sep 04, 2013

Pubmed Data : Eur J Pharmacol. 2013 Sep 5 ;715(1-3):46-55. Epub 2013 Jul 6. PMID: 23838456
Article Published Date : Sep 04, 2013
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Dyslipidemias, Hyperglycemia, Obesity
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Mammary cancers in human transgenic rats are estrogen-independenet, but responsive to d-limonene treatment. Jan 01, 2002

Pubmed Data : Jpn J Cancer Res. 2002 Jan;93(1):32-5. PMID: 11802805
Article Published Date : Jan 01, 2002
Study Type : Transgenic Animal Study
Additional Links
Substances : D-Limonene
Diseases : Breast Cancer
[+]

Regression of rat primary mammary tumors following dietary d-limonene.Jan 31, 1986

Pubmed Data : J Natl Cancer Inst. 1986 Feb ;76(2):323-5. PMID: 3080636
Article Published Date : Jan 31, 1986
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive
[+]

The result of this study indicates that D-limonene has antioxidant potential in addition to its antidiabetic effect in experimental diabetes.Feb 28, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Pharmacol Toxicol. 2013 Mar ;112(3):175-81. Epub 2012 Oct 25. PMID: 22998493
Article Published Date : Feb 28, 2013
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Diabetes Mellitus: Type 2, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The results showed that d-limonene increased the survival of lymphoma-bearing mice.Apr 30, 2005

Pubmed Data : Int Immunopharmacol. 2005 May ;5(5):829-38. Epub 2005 Jan 25. PMID: 15778119
Article Published Date : Apr 30, 2005
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Lymphoma
Pharmacological Actions : Chemotherapeutic
[+]

These studies suggest promising anti-leukemic and anti-angiogenic effects of d-Limonene in the treatment of chronic myeloid leukemia.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animal Model Exp Med. 2018 Dec ;1(4):328-333. Epub 2018 Nov 21. PMID: 30891583
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Angiogenesis Inhibitors
[+]

D-Limone: a review of its safety and clinical applications. Sep 01, 2007

Pubmed Data : Altern Med Rev. 2007 Sep;12(3):259-64. PMID: 18072821
Article Published Date : Sep 01, 2007
Study Type : Review
Additional Links
Substances : D-Limonene
[+]

D-limonene can inhibit proliferation of K562 cells in dose-dependent manner.Nov 30, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Dec ;14(6):1120-2. PMID: 17204176
Article Published Date : Nov 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.Jun 30, 2003

Pubmed Data : Zhonghua Zhong Liu Za Zhi. 2003 Jul ;25(4):325-7. PMID: 12921557
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells.Oct 04, 2012

Pubmed Data : Life Sci. 2012 Oct 5 ;91(11-12):429-439. Epub 2012 Aug 20. PMID: 22935404
Article Published Date : Oct 04, 2012
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Colon Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Effects of D-limonene on leukemia cells HL-60 and K562 in vitroJul 31, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug ;14(4):692-5. PMID: 16928301
Article Published Date : Jul 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML) , Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Induction of apoptosis by d-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2013 Jan ;29(1):349-54. Epub 2012 Oct 19. PMID: 23117412
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic
[+]

Limonene and essential oil from orange has gastroprotective actions. Aug 14, 2009

Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):499-505. Epub 2009 May 3. PMID: 19410566
Article Published Date : Aug 14, 2009
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene, Orange
Diseases : Gastric Ulcer
Pharmacological Actions : Gastroprotective
[+]

Limonene exerts antiproliferative effects on a lymphoma cell line.Dec 07, 2009

Pubmed Data : Cancer Invest. 2009 Dec 7. PMID: 19968502
Article Published Date : Dec 07, 2009
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Lymphoma
Pharmacological Actions : Antiproliferative
[+]

Protective effect of d-limonene against oxidative stress-induced cell damage in human lens epithelial cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:5962832. Epub 2015 Nov 23. PMID: 26682012
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Cataract, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction.Aug 31, 2014

Pubmed Data : J Med Food. 2014 Sep ;17(9):955-62. Epub 2014 Jul 21. PMID: 25045784
Article Published Date : Aug 31, 2014
Study Type : Plant Study
Additional Links
Substances : Berberine, D-Limonene
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation
Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts
[+]

These findings indicate that D-Limonene possesses potent antifibrotic effect which may be attributed to its antioxidant and anti-inflammatory properties.Feb 28, 2018

Pubmed Data : Environ Toxicol. 2018 Mar ;33(3):361-369. Epub 2017 Dec 18. PMID: 29251412
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Various plant substances inhibit chemically-induced mammary gland tumor promotion. Mar 01, 2008

Pubmed Data : Nutr Cancer. 2008 Mar-Apr;60(2):227-34. PMID: 1905902
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Beta Sitosterol, Curcumin, D-Limonene, DHEA (Dehydroepiandrosterone), Silymarin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Chemopreventive

Copyright: molekuul / 123RF Stock Photo

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Written by GreenMedInfo Research Group
Could the key to fighting breast cancer be hiding in your fruit bowl? A surprising new study suggests that limonene, a natural compound in the peel of citrus fruits, may pack a powerful punch against this devastating disease

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