Choline

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26 Diseases Researched for Choline

Name	AC	CK
Diabetes Mellitus: Type 2	2	20
Breast Cancer	2	12
Cardiovascular Diseases	1	10
Cognitive Decline/Dysfunction	1	10
Colorectal Cancer	1	10
Colorectal Cancer: Prevention	1	10
Cystic Fibrosis	1	10
Depression	1	10
Obesity	1	10
Stroke: Attenuation/Recovery	1	10
Alcohol Toxicity	1	2
Brain Inflammation	1	2
Chemically-Induced Liver Damage	1	2
Down Syndrome	1	2
Endothelial Dysfunction	1	2
Fetal Alcoholism	1	2
Liver Damage	1	2
Liver Damage: Aflatoxin-Induced	1	2
Neurodegenerative Diseases	2	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Traumatic Brain Injury	1	2
Infant Nutrition	1	1
Liver Cancer	1	1
Oxidative Stress	1	1
Prenatal Nutrition	1	1
Hyperhomocysteinemia	1	0

13 Pharmacological Actions Researched for Choline

Name	AC	CK
Chemopreventive	2	20
Neuroprotective Agents	4	14
Anti-Anxiety Agents	1	10
Anticarcinogenic Agents	1	10
Antidepressive Agents	1	10
Hypolipidemic	1	10
Hepatoprotective	4	8
Antioxidants	3	5
Anti-Inflammatory Agents	2	3
Interleukin-8 downregulation	1	2
Malondialdehyde Down-regulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2
Prostaglandin PGE2 downregulation	1	1

Research Articles 21
Cumulative Knowledge Score 33
Overall Research Rating GOOD

View the Evidence:
21 Abstracts with Choline Research

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[+]

A greater intake of choline and lutein and zeaxanthin was associated with faster performance on a cognitive flexibility task in overweight people.Jan 14, 2021

Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2021 Jan 15:1-16. Epub 2021 Jan 15. PMID: 33448903

Article Published Date : Jan 14, 2021

Study Type : Human Study

Additional Links

Substances : Choline, Lutein, Zeaxanthin

Diseases : Cognitive Decline/Dysfunction, Obesity

Pharmacological Actions : Neuroprotective Agents

[+]

Choline, betaine, and choline-containing compounds was inversely associated with colorectal cancer risk.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(3):e0118661. Epub 2015 Mar 18. PMID: 25785727

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Betaine , Choline

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

Choline-related supplements may improve status of children with Cystic FibrosisMar 01, 2007

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Pubmed Data : Am J Clin Nutr. 2007 Mar;85(3):702-8. PMID: 17344490

Article Published Date : Mar 01, 2007

Study Type : Human Study

Additional Links

Substances : Choline

Diseases : Cystic Fibrosis

[+]

Dietary choline and betaine consumption could significantly reduce the risk of breast cancer. Jan 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Sci. 2013 Feb ;104(2):250-8. Epub 2012 Dec 26. PMID: 23140534

Article Published Date : Jan 31, 2013

Study Type : Human Study

Additional Links

Substances : Betaine , Choline

Diseases : Breast Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

Additional Keywords : Risk Reduction

[+]

Dietary intake of choline and phosphatidylcholine could reduce the risk of type 2 diabetes in men.Mar 19, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Nutr. 2020 Mar 20. Epub 2020 Mar 20. PMID: 32198672

Article Published Date : Mar 19, 2020

Study Type : Human Study

Additional Links

Substances : Choline, Phosphatidylcholine

Diseases : Diabetes Mellitus: Type 2

Additional Keywords : Risk Reduction

[+]

Egg consumption in U.S. children is associated with greater daily nutrient intakes.May 21, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121847

Article Published Date : May 21, 2019

Study Type : Human Study

Additional Links

Substances : Alpha Linolenic Acid, Choline, DHA (Docosahexaenoic Acid), Egg, Zeaxanthin

[+]

Role of citicoline and choline in the treatment of post-stroke depression.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Int Med Res. 2021 Nov ;49(11):3000605211055036. PMID: 34727752

Article Published Date : Oct 31, 2021

Study Type : Human Study

Additional Links

Substances : Choline, Citicoline

Diseases : Depression, Stroke: Attenuation/Recovery

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents

[+]

Supplementation of magnesium and choline is more effective than either magnesium or choline alone to improve coagulation in subjects with T2DM.Aug 04, 2019

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Pubmed Data : Biol Trace Elem Res. 2019 Aug 5. Epub 2019 Aug 5. PMID: 31385202

Article Published Date : Aug 04, 2019

Study Type : Human Study

Additional Links

Substances : Choline, Magnesium

Diseases : Cardiovascular Diseases, Diabetes Mellitus: Type 2

Pharmacological Actions : Hypolipidemic

[+]

Adolescent choline supplementation can attenuate some of the behavioural deficits associated with early developmental alcohol exposure.Mar 31, 2016

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Pubmed Data : Alcohol Clin Exp Res. 2016 Apr ;40(4):897-905. PMID: 27038598

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Choline

Diseases : Alcohol Toxicity , Fetal Alcoholism

Additional Keywords : Supplementation

[+]

Comparative efficacy of silymarin and choline chloride (Liver Tonics) in preventing the effects of aflatoxin B1 in bovine calves.Aug 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pol J Vet Sci. 2016 Sep 1 ;19(3):545-551. PMID: 27760040

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Choline, Milk Thistle

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

[+]

Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury.Aug 01, 2008

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Pubmed Data : J Neurotrauma. 2008 Aug;25(8):975-83. PMID: 18665805

Article Published Date : Aug 01, 2008

Study Type : Animal Study

Additional Links

Substances : Choline

Diseases : Brain Inflammation , Traumatic Brain Injury

[+]

Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2016 Aug ;94:203-12. Epub 2016 Jun 15. PMID: 27316781

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Choline, Phloretin

Diseases : Endothelial Dysfunction, Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

[+]

These results support the lifelong attentional benefits of maternal choline supplementation for Ts65Dn and 2N offspring.Nov 09, 2016

Click here to read the entire abstract

Pubmed Data : Neuroscience. 2016 Nov 10. Epub 2016 Aug 10. PMID: 27840230

Article Published Date : Nov 09, 2016

Study Type : Animal Study

Additional Links

Substances : Choline

Diseases : Down Syndrome

Pharmacological Actions : Neuroprotective Agents

[+]

Treatment of non-alcoholic steatosis using a nutraceutical multitarget formulation.Jun 17, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2020 Jun 18 ;12(6). Epub 2020 Jun 18. PMID: 32570937

Article Published Date : Jun 17, 2020

Study Type : Animal Study

Additional Links

Substances : Choline, Feverfew, Green Coffee Bean, Milk Thistle, Vitamin E: alpha tocopherol

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ursolic acid could protect against liver damage from high intake of choline. Aug 23, 2016

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27567547

Article Published Date : Aug 23, 2016

Study Type : Animal Study

Additional Links

Substances : Choline, Ursolic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

[+]

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.Nov 25, 2019

Click here to read the entire abstract

Pubmed Data : Brain Res. 2019 Nov 26:146567. Epub 2019 Nov 26. PMID: 31783002

Article Published Date : Nov 25, 2019

Study Type : In Vitro Study

Additional Links

Substances : Choline

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

Deficiency of dietary sources of methyl groups (e.g. methionine, choline, b12, folate, sam-e) reduce DNA methylation in the liver which leads to liver cancer.Aug 01, 2003

Click here to read the entire abstract

Pubmed Data : Clin Chem Lab Med. 2003 Aug;41(8):1012-9. PMID: 12964806

Article Published Date : Aug 01, 2003

Study Type : In Vitro Study

Additional Links

Substances : Choline, Folic Acid , Methionine, SAMe (S-adenosylmethionine), Vitamin B-12

Diseases : Liver Cancer

[+]

Neuroprotective effects of choline and other methyl donors.Dec 05, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 6 ;11(12). Epub 2019 Dec 6. PMID: 31817768

Article Published Date : Dec 05, 2019

Study Type : Review

Additional Links

Substances : Choline

Diseases : Neurodegenerative Diseases

Pharmacological Actions : Neuroprotective Agents

[+]

Novel combination of choline with Withania somnifera and Bacopa monnieri reduced oxidative stress in microglia cells, promoting neuroprotection.Sep 12, 2023

Click here to read the entire abstract

Pubmed Data : Int J Mol Sci. 2023 Sep 13 ;24(18). Epub 2023 Sep 13. PMID: 37762339

Article Published Date : Sep 12, 2023

Study Type : In Vitro Study

Additional Links

Substances : Ashwagandha, Bacopa, Choline

Diseases : Neurodegenerative Diseases, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

There is evidence of increased choline needs in pre- and postnatal health. Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : J Am Diet Assoc. 2010 Aug;110(8):1198-206. PMID: 20656095

Article Published Date : Aug 01, 2010

Study Type : Review

Additional Links

Substances : Choline

Diseases : Infant Nutrition, Prenatal Nutrition

[+]

Choline may prevent increased homocysteine concentrations which may reduce cardiovascular risk.Jul 01, 2005

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2005 Jul;82(1):111-7. PMID: 16002808

Article Published Date : Jul 01, 2005

Additional Links

Substances : Choline

Diseases : Hyperhomocysteinemia

Research Articles 21
Cumulative Knowledge Score 33
Overall Research Rating GOOD

Choline Related Articles

Choline in Eggs Reduces Inflammation

Written by Dr. Joseph Mercola

Choline is a crucial nutrient for healthy fetal development and the function of your brain, nervous system, mitochondria and cardiovascular system. It also plays a role in metabolism and DNA synthesis

This Fatty Food Promotes a Healthy Heart and Waistline‏

Written by GMI Reporter

The myth persists that high fat foods gunk up your arteries and pad your hips But it’s just not true especially when it comes to the highest fat fruit on the planet - the avocado (Persea americana)

43 Natural Alternatives for Cystic Fibrosis

Written by Pat Robinson

Many individuals with cystic fibrosis have difficulty with lung infections developing into pneumonia, especially Pseudomonas. Many plant materials are being researched for their therapeutic value for our immune and lung health. Here are 43 natural substances that have been researched to possibly improve the lung status of people with cystic fibrosis.

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 21 Abstracts with Choline Research

Limited to Members Only

Currently Available Sorting Options

A greater intake of choline and lutein and zeaxanthin was associated with faster performance on a cognitive flexibility task in overweight people.Jan 14, 2021

Choline, betaine, and choline-containing compounds was inversely associated with colorectal cancer risk.Dec 31, 2014

Choline-related supplements may improve status of children with Cystic FibrosisMar 01, 2007

Dietary choline and betaine consumption could significantly reduce the risk of breast cancer. Jan 31, 2013

Dietary intake of choline and phosphatidylcholine could reduce the risk of type 2 diabetes in men.Mar 19, 2020

Egg consumption in U.S. children is associated with greater daily nutrient intakes.May 21, 2019

Role of citicoline and choline in the treatment of post-stroke depression.Oct 31, 2021

Supplementation of magnesium and choline is more effective than either magnesium or choline alone to improve coagulation in subjects with T2DM.Aug 04, 2019

Adolescent choline supplementation can attenuate some of the behavioural deficits associated with early developmental alcohol exposure.Mar 31, 2016

Comparative efficacy of silymarin and choline chloride (Liver Tonics) in preventing the effects of aflatoxin B1 in bovine calves.Aug 31, 2016

Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury.Aug 01, 2008

Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice.Jul 31, 2016

These results support the lifelong attentional benefits of maternal choline supplementation for Ts65Dn and 2N offspring.Nov 09, 2016

Treatment of non-alcoholic steatosis using a nutraceutical multitarget formulation.Jun 17, 2020

Ursolic acid could protect against liver damage from high intake of choline. Aug 23, 2016

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.Nov 25, 2019

Deficiency of dietary sources of methyl groups (e.g. methionine, choline, b12, folate, sam-e) reduce DNA methylation in the liver which leads to liver cancer.Aug 01, 2003

Neuroprotective effects of choline and other methyl donors.Dec 05, 2019

Novel combination of choline with Withania somnifera and Bacopa monnieri reduced oxidative stress in microglia cells, promoting neuroprotection.Sep 12, 2023

There is evidence of increased choline needs in pre- and postnatal health. Aug 01, 2010

Choline may prevent increased homocysteine concentrations which may reduce cardiovascular risk.Jul 01, 2005

Choline Related Articles

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Choline

View the Evidence:
21 Abstracts with Choline Research