Chlorogenic Acid

Name	AC	CK
Inflammation	21	41
Insulin Resistance	5	34
Hypertension	3	23
Cognitive Decline/Dysfunction	3	22
Melanoma	1	20
Skin Cancer	1	20
Oxidative Stress	12	19
Nonalcoholic fatty liver disease (NAFLD)	5	17
Breast Cancer	6	16
Obesity	6	16
Cardiovascular Diseases	3	13
Diabetes Mellitus: Type 2	7	13
Chemically-Induced Liver Damage	6	12
High Fructose Diet	2	12
Arteriosclerosis	1	10
Dyslipidemias	1	10
Fatty Liver	1	10
Hyperlipidemia	1	10
Lipopolysaccharide-Induced Toxicity	7	10
Metabolic Syndrome X	1	10
Urinary Tract Infections	1	10
Depression	4	8
Alcohol Toxicity	3	6
Colitis	3	6
Diabetes Mellitus: Type 1	3	6
Neurodegenerative Diseases	4	6
Hyperglycemia	4	5
Parkinson's Disease	4	5
Pseudomonas aeruginosa	5	5
Aging	2	4
Aluminum Toxicity	3	4
Cancers: All	4	4
Cerebral Ischemia	2	4
Escherichia coli Infections	4	4
High Fat Diet	2	4
Klebsiella Infections	3	4
Liver Fibrosis	2	4
Liver Steatosis	2	4
Pulmonary Fibrosis	2	4
Acute Respiratory Distress Syndrome	1	3
Alzheimer's Disease	2	3
Cardiomyopathy	2	3
Esophageal Cancer	2	3
Hyperuricemia	2	3
Lung Cancer	3	3
Osteoporosis	2	3
Staphylococcus aureus infection	2	3
Valvular Heart Diseases	1	3
Advanced Glycation End products (AGE)	2	2
Alcoholic Liver Disease	1	2
Anxiety	1	2
Arsenic Poisoning	1	2
Atopic Dermatitis	1	2
Brain Inflammation	1	2
Brain Ischemia	1	2
Cadmium Poisoning	1	2
Carcinoma: Non-Small-Cell Lung	2	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chemotherapy-Induced Toxicity: Peripheral Neuropathy	1	2
Colon Cancer	2	2
Colorectal Cancer	2	2
Coronavirus Infection	2	2
Dermatitis	1	2
Diabetes Mellitus: Type 2: Prevention	1	2
Diabetes: Oxidative Stress	1	2
Encephalopathy	1	2
Endothelial Dysfunction	1	2
Gastric Ulcer	1	2
Glaucoma	1	2
Glioma	1	2
Heart Failure	1	2
Hypoxia	1	2
Inflammatory Bowel Diseases	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Damage	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Fibrosis	1	2
Klesiella Pneumonia Infection	1	2
Lead Poisoning	1	2
Liver Cancer	2	2
Lung Damage	1	2
Memory Loss	1	2
Myocardial Fibrosis	1	2
Nephropathy	1	2
Neurological Conditions	1	2
Osteosarcoma	2	2
Periodontitis	1	2
Polycystic Ovary Syndrome	1	2
Prediabetes	1	2
Psoriasis	1	2
Spinal Cord Injuries	1	2
Stroke	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	1	2
Adenoviridae Infections	1	1
Air Pollution Linked Toxicity	1	1
Bacterial Infections	1	1
Brain: Oxidative Stress	1	1
Cancer Metastasis	1	1
Candida Albicans	1	1
DNA damage	1	1
Dopamine Deficiency	1	1
Dysbiosis	1	1
Dysbiosis: Bifidobacteria Deficiency	1	1
Ebola Virus Infections	1	1
Fibrosis	1	1
Food Allergies	1	1
Hepatic Steatosis	1	1
Hepatitis B	1	1
Herpes Simplex Virus Type 2	1	1
Histamine: Elevated	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Infection: Antibiotic Resistant	1	1
Influenza A	1	1
Kidney Cancer	1	1
Liver Damage: Aflatoxin-Induced	1	1
Malaria	1	1
Neuropathic Pain	1	1
Ovarian Cancer	1	1
Pancreatic Cancer	1	1
Periodontal Diseases	1	1
Pesticide Toxicity	1	1
Radiation Induced Illness	1	1
Salmonella Infections	1	1
Snake Bite: Venom Toxicity	1	1

Name	AC	CK
Anti-Inflammatory Agents	44	91
Antioxidants	43	77
Hepatoprotective	21	54
Neuroprotective Agents	20	51
Tumor Necrosis Factor (TNF) Alpha Inhibitor	18	49
Chemopreventive	7	35
Interleukin-6 Downregulation	15	35
Antihypertensive Agents	4	24
Cardioprotective	6	20
Anti-Apoptotic	11	18
Anti-Bacterial Agents	8	18
Hypoglycemic Agents	6	18
Hypolipidemic	5	17
Interleukin-1 beta downregulation	9	16
Nrf2 activation	10	16
Antiproliferative	13	15
NF-kappaB Inhibitor	10	15
Apoptotic	13	14
Gastrointestinal Agents	7	13
Renoprotective	7	13
Anti-Fibrotic	6	11
Insulin Sensitizers	1	10
Vasoprotective	1	10
Antidepressive Agents	4	8
Antiviral Agents	6	6
Cell cycle arrest	5	6
Chemoprotective Agents	3	6
Anti-metastatic	3	4
Antimicrobial	4	4
Cyclooxygenase 2 Inhibitors	3	4
Gastroprotective	2	4
Osteoprotective	2	4
Quorum Sensing Inhibition	4	4
Interleukin-10 upregulation	2	3
MicroRNA modulator	3	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Vascular Endothelial Growth Factor Inhibitors	3	3
Anti-Anxiety Agents	1	2
Anti-Ulcer Agents	1	2
Anticarcinogenic Agents	2	2
Antineoplastic Agents	2	2
Autophagy Inhibitors	1	2
Autophagy Up-regulation	2	2
Brain-derived neurotrophic factor modulator	1	2
Chemotherapeutic	2	2
Heme oxygenase-1 up-regulation	2	2
Immunomodulatory	2	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	2
Alpha-amylase inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inhibitors	1	1
Anti-Adipogenic	1	1
Anti-Allergic Agents	1	1
Antifungal Agents	1	1
Antimalarials	1	1
Chelating Agents	1	1
Chemosensitizer	1	1
Cytoprotective	1	1
Dopaminergic	1	1
Enzyme Inhibitors	1	1
Genoprotective	1	1
Gluconeogenesis Inhibitor	1	1
Histamine down-regulation	1	1
Hypnotics and Sedatives	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Interleukin-8 downregulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
Neurominidase Inhibitor	1	1
Nitric Oxide Inhibitor	1	1
Phase II Detoxification Enzyme Inducer	1	1
Postaglandin PGE2 downregulation	1	1
Radioprotective	1	1
Uricosuric Agents	1	1

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Pubmed Data : J Agric Food Chem. 2017 Nov 22 ;65(46):10093-10100. Epub 2017 Nov 7. PMID: 29056047

Article Published Date : Nov 21, 2017

Study Type : Human Study

Additional Links

Substances : Chlorogenic Acid, Yerba Mate

Additional Keywords : Plant Extracts

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These results suggest that chlorogenic acids may improve some cognitive functions, which would help in the efficient performance of complex tasks.Sep 19, 2018

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Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Chlorogenic acid ameliorates endothelial dysfunction in diabetes.Dec 31, 2020

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Pubmed Data : Eur J Neurosci. 2019 Aug 22. Epub 2019 Aug 22. PMID: 31437868

Article Published Date : Aug 21, 2019

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Brain Ischemia, Memory Loss

Pharmacological Actions : Neuroprotective Agents

[+]

Chlorogenic acid ameliorates post-infectious irritable bowel syndrome.Aug 23, 2023

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Pubmed Data : Iran J Basic Med Sci. 2023 Apr ;26(4):478-485. PMID: 37009010

Article Published Date : Mar 31, 2023

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Chlorogenic acid attenuates the neuronal damage induced in alcohol exposed neonatal rat by decreasing the apoptosis of neuronal cells.Dec 31, 2016

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Pubmed Data : Cell Cycle. 2019 May 6. Epub 2019 May 6. PMID: 31055996

Article Published Date : May 05, 2019

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Glaucoma, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

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Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-Type Ca 2+ channel suppression.Oct 22, 2021

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Pubmed Data : J Cell Mol Med. 2019 Apr 29. Epub 2019 Apr 29. PMID: 31033175

Article Published Date : Apr 28, 2019

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Heart Failure, Inflammation

Pharmacological Actions : Cardioprotective

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Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition.Dec 31, 2021

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Pubmed Data : Pak J Pharm Sci. 2020 May ;33(3):1063-1072. PMID: 33191230

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Diabetes Mellitus: Type 2, Diabetes Mellitus: Type 2: Prevention

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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Chlorogenic acid inhibits human glioma U373 cell progression.Dec 31, 2020

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Chlorogenic acid protects against advanced alcoholic steatohepatitis.Nov 19, 2021

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Pubmed Data : Nutrients. 2021 Nov 20 ;13(11). Epub 2021 Nov 20. PMID: 34836410

Article Published Date : Nov 19, 2021

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Alcohol Toxicity , Liver Steatosis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

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Pubmed Data : Life Sci. 2021 Mar 31 ;277:119460. Epub 2021 Mar 31. PMID: 33811899

Article Published Date : Mar 30, 2021

Study Type : Animal Study

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Substances : Chlorogenic Acid, Coenzyme Q10, Quercetin

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

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Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on type 1 diabetic rats.Mar 01, 2010

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Pubmed Data : Gen Physiol Biophys. 2010 Mar;29(1):23-30. PMID: 20371877

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Pubmed Data : Molecules. 2023 Jul 24 ;28(14). Epub 2023 Jul 24. PMID: 37513484

Article Published Date : Jul 23, 2023

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid, Loquat

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

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Effects of dietary chlorogenic acid on intestinal barrier function and the inflammatory response in broilers during lipopolysaccharide-induced immune stress.Apr 30, 2023

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Pubmed Data : Poult Sci. 2023 May ;102(5):102623. Epub 2023 Mar 4. PMID: 36972676

Article Published Date : Apr 30, 2023

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Effects of exercise training and chlorogenic acid supplementation on hepatic lipid metabolism in pre-diabetes.Sep 07, 2023

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct ;392(10):1293-1309. Epub 2019 Jun 12. PMID: 31190087

Article Published Date : Sep 30, 2019

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

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Pentaherbs formula can ameliorate allergic inflammation and attenuate the activation of eosinophils.Dec 31, 2015

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Pubmed Data : Animals (Basel). 2021 May 29 ;11(6). Epub 2021 May 29. PMID: 34072384

Article Published Date : May 28, 2021

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Chlorogenic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Cadmium

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Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis.Aug 16, 2022

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Pubmed Data : Biomater Sci. 2022 Aug 17. Epub 2022 Aug 17. PMID: 35975567

Article Published Date : Aug 16, 2022

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Osteoprotective

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Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection.Jan 16, 2020

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Pubmed Data : Sci Rep. 2020 11 17 ;10(1):20013. Epub 2020 Nov 17. PMID: 33203903

Article Published Date : Jan 16, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Chlorogenic Acid

Diseases : Klebsiella Infections, Klesiella Pneumonia Infection

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

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The beneficial effects of coffee on diabetes may be due to the action of chlorogenic acid. Dec 31, 2011

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Pubmed Data : PLoS One. 2012 ;7(3):e32718. Epub 2012 Mar 7. PMID: 22412912

Article Published Date : Dec 31, 2011

Study Type : Animal Study

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Substances : Chlorogenic Acid, Coffee

Diseases : Diabetes Mellitus: Type 2

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The combination of lapatinib and chlorogenic acid can effectively inhibit macrophage M2 polarization and metastasis of breast cancer.May 24, 2015

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Pubmed Data : Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 May 25 ;44(5):493-499. PMID: 26713522

Article Published Date : May 24, 2015

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic

Additional Keywords : Gene Expression Regulation

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These data indicated that chlorogenic acid may play a potential treatment strategy for lead toxicity.Apr 30, 2019

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Pubmed Data : Biol Trace Elem Res. 2019 May ;189(1):109-117. Epub 2018 Sep 9. PMID: 30196488

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Pubmed Data : Prep Biochem Biotechnol. 2020 Jul 7:1-10. Epub 2020 Jul 7. PMID: 32633686

Article Published Date : Jul 06, 2020

Study Type : Review

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Substances : Chlorogenic Acid, Coffee: Green/Unroasted

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

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Adaptive immunoregulation of luteolin and chlorogenic acid in lipopolysaccharide-induced interleukin-10 expression.Mar 31, 2019

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Pubmed Data : Ci Ji Yi Xue Za Zhi. 2019 Apr-Jun;32(2):186-192. Epub 2019 Jun 24. PMID: 32269953

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

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Substances : Chlorogenic Acid, Luteolin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation

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An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide.Feb 06, 2015

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Pubmed Data : Int J Obes (Lond). 2023 Aug 18. Epub 2023 Aug 18. PMID: 37596386

Article Published Date : Aug 17, 2023

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Chlorogenic Acid

Diseases : Obesity

Additional Keywords : Anti-Obesity Agents

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Antimicrobial activity of Tunisian quince pulp and peel polyphenolic extracts.Feb 06, 2007

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Pubmed Data : J Agric Food Chem. 2007 Feb 7 ;55(3):963-9. PMID: 17263500

Article Published Date : Feb 06, 2007

Study Type : In Vitro Study

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Substances : Chlorogenic Acid, Quince

Diseases : Bacterial Infections

Pharmacological Actions : Antimicrobial, Antioxidants

Additional Keywords : Plant Extracts

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Additional Keywords : Biofilm, Plant Extracts

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Cancer differentiation inducer chlorogenic acid suppresses PD-L1 expression and boosts antitumor immunity of PD-1 antibody.Dec 31, 2023

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Pubmed Data : Antioxidants (Basel). 2023 Nov 22 ;12(12). Epub 2023 Nov 22. PMID: 38136147

Article Published Date : Nov 21, 2023

Study Type : In Vitro Study

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Substances : Chlorogenic Acid

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Aflatoxin

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Chlorogenic acid alleviates LPS-induced inflammation and oxidative stress.Aug 30, 2023

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Pubmed Data : Nutrients. 2018 Sep 23 ;10(10). Epub 2018 Sep 23. PMID: 30249058

Article Published Date : Sep 22, 2018

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Hyperglycemia

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

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Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma.Nov 29, 2020

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Pubmed Data : Phytother Res. 2020 Nov 30. Epub 2020 Nov 30. PMID: 33258205

Article Published Date : Nov 29, 2020

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative

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Chlorogenic acid exerts anti-proliferative effects and apoptosis in human colon cancer caco-2 cells.Mar 02, 2018

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Pubmed Data : Mol Cell Biochem. 2017 Sep 5. Epub 2017 Sep 5. PMID: 28875417

Article Published Date : Sep 04, 2017

Study Type : In Vitro Study

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Substances : Chlorogenic Acid

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Cancer Stem Cells

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Chlorogenic acid may provide effective defenses against oxidative stress.Nov 30, 2017

Pubmed Data : Free Radic Biol Med. 2019 Apr 17 ;137:1-12. Epub 2019 Apr 17. PMID: 31004750

Article Published Date : Apr 16, 2019

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Osteoporosis

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Problem Substances : Dexamethasone

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Chlorogenic acid promotes autophagy and alleviates Salmonella typhimurium infection.Dec 31, 2019

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Pubmed Data : Acta Biochim Pol. 2022 Dec 12 ;69(4):855-864. PMID: 36508480

Article Published Date : Dec 11, 2022

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator

Additional Keywords : miRNA-199

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Chlorogenic acid rich in coffee pulp extract suppresses inflammatory status.Feb 28, 2023

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Pubmed Data : Heliyon. 2023 Mar ;9(3):e13917. Epub 2023 Feb 18. PMID: 36873494

Article Published Date : Feb 28, 2023

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

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Chlorogenic acid, curcumin and beta-carotene protect against gamma-radiation-induced in vivo chromosomal damage.Jan 01, 2009

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Pubmed Data : Lipids Health Dis. 2009;8:39. Epub 2009 Oct 5. PMID: 7694126

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : beta-Carotene, Carotenoids, Chlorogenic Acid, Curcumin

Diseases : DNA damage, Radiation Induced Illness

Pharmacological Actions : Genoprotective, Radioprotective

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Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems.Dec 31, 2022

Pubmed Data : Food Chem Toxicol. 2011 Oct 13. Epub 2011 Oct 13. PMID: 22019894

Article Published Date : Oct 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : 5-hydroxytryptamides, Caffeine, Catechols, Chlorogenic Acid, Coffee, N-methylpyridinium, Pyrogallol, Trigonelline

Diseases : Dopamine Deficiency

Pharmacological Actions : Dopaminergic

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Combinatorial effects of the natural products arctigenin, chlorogenic acid, and cinnamaldehyde commit oxidation assassination on breast cancer cells.Mar 19, 2022

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Pubmed Data : Daru. 2019 Jun ;27(1):35-42. Epub 2019 Jun 12. PMID: 31187452

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Chlorogenic Acid, Green Coffee Bean

Diseases : Infection: Antibiotic Resistant, Pseudomonas aeruginosa

Pharmacological Actions : Antimicrobial, Quorum Sensing Inhibition

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Hesperidin and chlorogenic acid synergistically inhibit the growth of breast cancer cells.Sep 09, 2021

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Pubmed Data : Life (Basel). 2021 Sep 10 ;11(9). Epub 2021 Sep 10. PMID: 34575098

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Pubmed Data : Food Chem. 2022 Mar 30 ;373(Pt B):131594. Epub 2021 Nov 14. PMID: 34838409

Article Published Date : Mar 29, 2022

Study Type : In Vitro Study

Additional Links

Substances : Caffeic Acid, Chlorogenic Acid, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Ferulic acid, Polyphenols, Resveratrol

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents

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Inhibitory activity of the flower buds of Lonicera japonica Thunb. against histamine production and L-histidine decarboxylase in human keratinocytes.Jun 16, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:1515081. Epub 2020 Jun 10. PMID: 32595723

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Astragaloside, Chlorogenic Acid

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Transforming growth factor beta (TGF-β) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Tumor Microenvironment

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Tart cherry extract inhibits the mitochondrial apoptotic cell death elicited by airborne PM 10 in human epidermal keratinocytes.Mar 12, 2021

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These results suggest that dietary phenolic compounds exert an anti-proliferative effect against human colon cancer cells.Jul 30, 2023

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View the Evidence: 182 Abstracts with Chlorogenic Acid Research

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The evidence suggests that chlorogenic acids intake causes statistically significant reductions in systolic and diastolic blood pressures.Jan 31, 2015

There is some evidence for the beneficial effects of regular coffee consumption on melanoma.Mar 31, 2016

A combined nutraceutical showed to improve lipid and glucose metabolism, adipokines pattern, and systemic inflammation in dyslipidemic overweight subjects.Jul 31, 2019

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

Altilix supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in metabolic syndrome subjects.Oct 24, 2019

Bioactive yoghurt containing curcumin and chlorogenic acid reduces inflammation in postmenopausal women.Nov 01, 2022

Black chokeberry juice lowered the incidence of Urinary tract infections by 55% and a reduction in antibiotics use in patients. May 31, 2014

Chlorogenic acid increased insulin sensitivity and improved both anthropometric evaluations and the lipid profile.Dec 19, 2017

Chlorogenic acids-present in coffee, fruits, and vegetables-was associated with a lower incidence of breast cancer among postmenopausal women.Jan 21, 2020

Coffee abundant in chlorogenic acids reduces abdominal fat in overweight adults.Jul 15, 2019

Coffee consumption attenuates hepatic insulin resistance.Jan 31, 2014

Continuous intake of chlorogenic acids appears to improve attention and executive function among cognitive functions in mild cognitive impairment.Oct 28, 2019

These findings suggest that 2-week ingestion of chlorogenic acid-enriched green coffee bean extract may improve arterial stiffness.Oct 31, 2019

These results allow us to conclude that maté traditional beverages are important dietary sources of chlorogenic acids.Nov 21, 2017

These results suggest that chlorogenic acids may improve some cognitive functions, which would help in the efficient performance of complex tasks.Sep 19, 2018

A chlorogenic acid functional strategy of anti-inflammation, anti-coagulation and promoted endothelial proliferation for bioprosthetic artificial heart valves.Mar 21, 2023

Chlorogenic acid may be a viable therapeutic option for bacterial and viral-induced acute respiratory distress syndrome-like pathology.May 30, 2023

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.Aug 01, 2010

A natural compound mixture ameliorates psoriasis-like skin lesions.Dec 31, 2019

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Administration of chlorogenic acid alleviates spinal cord injury.Dec 31, 2017

Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease.Dec 31, 2022

Analysis of anti-osteoporosis function of chlorogenic acid by gene microarray profiling in ovariectomy rat model.Jan 30, 2018

Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid.Oct 31, 2023

Caffeic acid prevented dermatitis and pigmentation after UVB irradiation in mice.Dec 31, 2016

Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid.Dec 31, 2018

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposure.Nov 22, 2020

Chlorogenic acid activates Nrf2/SKN-1 and prolongs the lifespan of Caenorhabditis elegans.Mar 11, 2022

Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis.Apr 22, 2022

Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease.May 31, 2018

Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis.Nov 16, 2020

Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice.Jan 31, 2019

Chlorogenic acid alleviates thioacetamide-induced toxicity and promotes liver development.Nov 20, 2021

Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species.Jun 30, 2018

Chlorogenic acid ameliorates colitis and alters colonic microbiota in a mouse model of dextran sulfate sodium-induced colitis.Dec 31, 2018

Chlorogenic acid ameliorates endothelial dysfunction in diabetes.Dec 31, 2020

Chlorogenic acid ameliorates experimental colitis.Oct 31, 2018

Chlorogenic acid ameliorates high-fat and high-fructose diet-induced cognitive impairment.Feb 20, 2022

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia.Aug 21, 2019

Chlorogenic acid ameliorates post-infectious irritable bowel syndrome.Aug 23, 2023

Chlorogenic acid and Crataegus pinnatifida extracts prevented depressive behaviour and thereby have potential as natural antidepressants.Jun 11, 2018

Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats.Oct 31, 2019

Chlorogenic acid attenuates dextran sodium sulfate-induced ulcerative colitis.Dec 31, 2018

Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes.Jan 31, 2019

Chlorogenic acid attenuates kidney ischemic/reperfusion injury.Dec 31, 2018

Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice.Mar 31, 2023

Chlorogenic acid attenuates the neuronal damage induced in alcohol exposed neonatal rat by decreasing the apoptosis of neuronal cells.Dec 31, 2016

Chlorogenic acid co-administration alleviates cisplatin-induced peripheral neuropathy.Nov 22, 2023

Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging.Mar 19, 2023

Chlorogenic acid could be a potential therapeutic to minimize sodium arsenite-induced hepatic injury.Jan 31, 2020

Chlorogenic acid could be of benefit in glaucoma treatment. May 05, 2019

Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-Type Ca 2+ channel suppression.Oct 22, 2021

Chlorogenic acid enriched Green Coffee Ameliorated Renal InjurySep 30, 2020

Chlorogenic acid has anxiolytic effects coupled with antioxidant activity.Nov 14, 2007

Chlorogenic acid has profound cardioprotective effects through inhibiting the activation of NF-κB and JNK pathway.Apr 28, 2019

Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition.Dec 31, 2021

Chlorogenic acid improves symptoms of inflammatory bowel disease in interleukin-10 knockout mice.Sep 30, 2020

Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo.Nov 06, 2019

Chlorogenic acid inhibits forming of diabetes mellitus in rats induced by high-fat high-sucrose and streptozotocin.Apr 30, 2020

Chlorogenic acid inhibits human glioma U373 cell progression.Dec 31, 2020

Chlorogenic acid inhibits progressive pulmonary fibrosis.Jan 31, 2024

Chlorogenic acid may have therapeutic value in type 2 diabetes. Jan 17, 1997

Chlorogenic acid may improve memory function and decrease inflamation of frontal lobe.Jun 30, 2023

Chlorogenic acid might be a new anti-fibrosis agent that improves liver fibrosis.Dec 31, 2016

Chlorogenic acid modulates autophagy by inhibiting the activity of ALKBH5 demethylase, thereby ameliorating hepatic steatosis.Oct 07, 2023

Chlorogenic acid modulates the ubiquitin-proteasome system in stroke animal model.Dec 20, 2022

Chlorogenic acid prevents hyperuricemia nephropathy.Aug 10, 2022

Chlorogenic acid prevents mice from S. aureus-induced renal abscess, resulting in a significant survival advantage.Dec 31, 2014

Chlorogenic acid protective effects on paraquat-induced pulmonary oxidative damage and fibrosis.Apr 02, 2023

Chlorogenic acid protects against advanced alcoholic steatohepatitis.Nov 19, 2021

Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A.Mar 12, 2023

Chlorogenic acid relieves lead-induced cognitive impairments and hepato-renal damage.Feb 19, 2019

Chlorogenic Acid

View the Evidence:
182 Abstracts with Chlorogenic Acid Research