Bromelain

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90 Diseases Researched for Bromelain
NameACCKFocus
Inflammation1841Locked
Breast Cancer821Locked
Osteoarthritis: Knee220Locked
Sinusitis220Locked
Wound Healing516Locked
Coronavirus Infection615Locked
Osteoarthritis415Locked
Lung Cancer313Locked
Thrombosis313Locked
Periodontitis212Locked
Cancers: All611Locked
Celiac Disease110Locked
Chemotherapy-Induced Toxicity: Peripheral Neuropathy110Locked
Constipation: Post-Operative110Locked
Dental Care110Locked
Dyspepsia110Locked
Edema110Locked
Endothelial Dysfunction110Locked
Hypertension110Locked
Oral Surgical Procedures110Locked
Pain110Locked
Perineal trauma 110Locked
Postoperative Edema110Locked
Postoperative Recovery110Locked
Prostatitis: Bacterial110Locked
Tooth Extraction: Wisdom110Locked
Alzheimer's Disease39Locked
Colorectal Cancer38Locked
Inflammatory Bowel Diseases46Locked
Oxidative Stress36Locked
Rheumatoid Arthritis36Locked
Asthma35Locked
Cervical Cancer15Locked
Allergic Airway Diseases24Locked
Aluminum Toxicity 24Locked
Colitis24Locked
Colon Cancer24Locked
Diabetic Complications24Locked
Lipopolysaccharide-Induced Toxicity44Locked
Liver Damage24Locked
Neuropathic Pain24Locked
Tendon Injury24Locked
Chemotherapy-Induced Toxicity: Cisplatin23Locked
Liver Cirrhosis13Locked
Liver Fibrosis13Locked
Pancreatic Cancer23Locked
Skin Cancer33Locked
Ataxia12Locked
Atherosclerosis12Locked
Bisphenol Toxicity12Locked
Breastfeeding: Complications12Locked
Burns12Locked
Cadmium Poisoning 12Locked
Cancer Metastasis12Locked
Chemically-Induced Liver Damage12Locked
Diabetes Mellitus: Type 112Locked
Drug-Induced Toxicity: Indomethacin12Locked
Gastric Cancer22Locked
Gastrointestinal Inflammation12Locked
Kidney Damage: Chemically-Induced12Locked
Lactation Disorders12Locked
Lead Poisoning12Locked
Liver Cancer22Locked
Myocardial Infarction12Locked
Myocardial Ischemia12Locked
Non-Hodgkin Lymphoma12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Obesity12Locked
Prostate Cancer22Locked
Sciatic Nerve Crush Injury12Locked
Sperm Quality: Low12Locked
Arthritis11Locked
Benzo[a]pyrene-induced Toxicity 11Locked
Breast Cancer: Triple Negative 11Locked
Cholangiocarcinoma11Locked
Cholera11Locked
Digestive System Diseases11Locked
Escherichia coli Infections11Locked
Glioma11Locked
Gram-Positive Bacterial Infections11Locked
Immune Disorders11Locked
Influenza11Locked
Intestinal Permeability 11Locked
Leaky Gut Syndrome11Locked
Melanoma11Locked
Oral Cancer11Locked
Parkinson's Disease11Locked
Periodontal Diseases11Locked
Respiratory Diseases11Locked
Thrombophlebitis11Locked
60 Pharmacological Actions Researched for Bromelain
NameACCKFocus
Anti-Inflammatory Agents40112Locked
Analgesics543Locked
Antioxidants1130Locked
Apoptotic1625Locked
Anti-Bacterial Agents422Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor721Locked
Interleukin-6 Downregulation619Locked
Interleukin-1 beta downregulation517Locked
Malondialdehyde Down-regulation416Locked
Neuroprotective Agents716Locked
Anti-metastatic414Locked
Antiproliferative 1013Locked
Chemoprotective Agents313Locked
Immunomodulatory413Locked
NF-kappaB Inhibitor912Locked
Anti-Platelet211Locked
Chemotherapeutic211Locked
Hepatoprotective511Locked
Osteoprotective 110Locked
Prostaglandin PGE2 downregulation110Locked
Antineoplastic Agents48Locked
Antinoceceptive 36Locked
Interleukin-10 downregulation36Locked
Antiviral Agents55Locked
Chemosensitizer45Locked
Cyclooxygenase 2 Inhibitors55Locked
Radiosensitizer34Locked
Anti-Fibrotic13Locked
Anticarcinogenic Agents33Locked
Anticoagulants23Locked
Autophagy Up-regulation23Locked
Cell cycle arrest23Locked
Chemopreventive33Locked
Chondroprotective13Locked
Interleukin-4 downregulation23Locked
Interleukin-8 downregulation13Locked
Anti-Adipogenic12Locked
Anti-Allergic Agents12Locked
Anti-Anxiety Agents12Locked
Anti-Asthmatic Agents12Locked
Antimicrobial22Locked
Bcl-2 protein down-regulation22Locked
Cardioprotective12Locked
Cytoprotective12Locked
Cytotoxic22Locked
Gastroprotective12Locked
Hypoglycemic Agents12Locked
Hypolipidemic12Locked
Immunostimulatory22Locked
Interferon Gamma Reducer12Locked
Interleukin-12 downregulation12Locked
Interleukin-17 downregulation12Locked
Postaglandin PGE2 downregulation 12Locked
Radioprotective12Locked
Renoprotective12Locked
Tumor Suppressor Protein p53 Upregulation22Locked
Anti-thrombotic11Locked
Antifibrinolytic Agents11Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor11Locked
Thrombolytic11Locked
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View the Evidence:
119 Abstracts with Bromelain Research

[+]

A supplement with Ribes Nigrum, Boswellia Serrata, bromelain and vitamin D to stop local inflammation in chronic sinusitis.Apr 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2023 Apr 18 ;12(8). Epub 2023 Apr 18. PMID: 37109265
Article Published Date : Apr 17, 2023
Study Type : Human Study
Additional Links
Substances : Black Currant, Bromelain, Frankincense, Vitamin D
Diseases : Inflammation, Sinusitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Benefits of a food supplement containing Boswellia serrata and bromelain for improving the quality of life in patients with osteoarthritis.Oct 31, 2019

Pubmed Data : J Altern Complement Med. 2019 Nov 1. Epub 2019 Nov 1. PMID: 31674795
Article Published Date : Oct 31, 2019
Study Type : Human Study
Additional Links
Substances : Bromelain, Frankincense
Diseases : Osteoarthritis
Pharmacological Actions : Osteoprotective
[+]

Bromelain has anti-platelet properties.Feb 01, 2006

Pubmed Data : Platelets. 2006 Feb;17(1):37-41. PMID: 16308185
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet
[+]

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. Jan 01, 1988

Pubmed Data : J Cancer Res Clin Oncol. 1988;114(5):507-8. PMID: 3182910
Article Published Date : Jan 01, 1988
Study Type : Human Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic
[+]

Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Pubmed Data : Clin Rheumatol. 2016 Oct ;35(10):2531-40. Epub 2016 Jul 28. PMID: 27470088
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation
Problem Substances : Diclofenac
[+]

Bromelain is effective in treating postoperative edema after third molar surgery.Sep 01, 2010

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):771-4. PMID: 21061836
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Edema, Oral Surgical Procedures, Postoperative Edema, Postoperative Recovery
Pharmacological Actions : Analgesics, Anti-Bacterial Agents, Anti-Inflammatory Agents
Additional Keywords : Dental
[+]

Bromelain may benefit children diagnosed with acute sinusitis. Mar 01, 2005

Pubmed Data : In Vivo. 2005 Mar-Apr;19(2):417-21. PMID: 15796206
Article Published Date : Mar 01, 2005
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Sinusitis
[+]

Bromelain may benefit patients with postoperative constipation. Sep 01, 2007

Pubmed Data : Pharmacol Res. 2007 Sep;56(3):254-60. Epub 2007 Jul 14. PMID: 16137711
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Constipation: Post-Operative
[+]

Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.Dec 01, 2002

Pubmed Data : Phytomedicine. 2002 Dec;9(8):681-6. PMID: 12587686
Article Published Date : Dec 01, 2002
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Analgesics
[+]

Bromelain-loaded nanocomposites decrease inflammatory and cytotoxicity effects of gliadin on Caco-2 cells and peripheral blood mononuclear cells of celiac patients.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2023 Dec 1 ;13(1):21180. Epub 2023 Dec 1. PMID: 38040898
Article Published Date : Nov 30, 2023
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Celiac Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status.Jan 27, 2021

Pubmed Data : Br J Nutr. 2021 Jan 28 ;125(2):161-171. Epub 2020 Jul 14. PMID: 32660675
Article Published Date : Jan 27, 2021
Study Type : Human Study
Additional Links
Substances : Anthocyanins, Bromelain
Diseases : Endothelial Dysfunction, Hypertension
Pharmacological Actions : Antioxidants
[+]

Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar.Apr 30, 2019

Pubmed Data : Clin Oral Investig. 2019 May ;23(5):2443-2453. Epub 2018 Oct 11. PMID: 30311061
Article Published Date : Apr 30, 2019
Study Type : Human Study
Additional Links
Substances : Bromelain, Flavonoids
Diseases : Dental Care
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

OPERA was able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapy.Feb 28, 2017

Pubmed Data : Med Oncol. 2017 Mar ;34(3):46. Epub 2017 Feb 15. PMID: 28205185
Article Published Date : Feb 28, 2017
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid, Bromelain
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Chemoprotective Agents
[+]

Sodium alginate, sodium bicarbonate, bromelain and essential oils have therapeutic value in the treatment of functional dyspepsia.Jun 01, 2009

Pubmed Data : Clin Exp Allergy. 2009 Jun;39(6):875-82. PMID: 19829282
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Substances : Bromelain, Essential Oils: Unspecified, Sodium Alginate, Sodium Bicarbonate
Diseases : Dyspepsia
[+]

The combination of serenoa repens, selenium, lycopene and bromelain are beneficial in patients with chronic bacterial prostatitis.Oct 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Ital Urol Androl. 2016 Oct 5 ;88(3):177-182. Epub 2016 Oct 5. PMID: 27711089
Article Published Date : Oct 04, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain, Lycopene, Saw Palmetto, Selenium
Diseases : Prostatitis: Bacterial
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

The effect of bromelain in periodontal surgery.May 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Oral Health. 2023 May 13 ;23(1):286. Epub 2023 May 13. PMID: 37179311
Article Published Date : May 12, 2023
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Periodontitis
[+]

These results showed the effectiveness of bromelain on episiotomy pain and wound healing.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran Red Crescent Med J. 2016 Mar ;18(3):e21019. Epub 2016 Mar 1. PMID: 27247780
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Pain, Perineal trauma , Wound Healing
Pharmacological Actions : Analgesics
[+]

This study thus clearly supports the clinical relevance of treatment of postoperative conditions with bromelain.Sep 05, 2016

Pubmed Data : Phytother Res. 2016 Sep 6. Epub 2016 Sep 6. PMID: 27601419
Article Published Date : Sep 05, 2016
Study Type : Human Study
Additional Links
Substances : Bromelain
Diseases : Tooth Extraction: Wisdom
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Treatment of COVID-19 patients with quercetin: a prospective, single center, randomized, controlled trial.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Biol. 2021 ;45(4):518-529. Epub 2021 Aug 30. PMID: 34803451
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Bromelain, Quercetin, Vitamin C
Diseases : Coronavirus Infection
[+]

Use of an alfa-lipoic, Methylsulfonylmethane, Boswellia serrata and Bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management.Jun 05, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Oncol. 2022 Jun 6 ;39(8):113. Epub 2022 Jun 6. PMID: 35666314
Article Published Date : Jun 05, 2022
Study Type : Human Study
Additional Links
Substances : Bromelain, Frankincense
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Anti-cancer activity of bromelain nanoparticles by oral administration.Nov 30, 2014

Pubmed Data : J Biomed Nanotechnol. 2014 Dec ;10(12):3558-75. PMID: 26000370
Article Published Date : Nov 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Bromelain
Diseases : Breast Cancer, Cancers: All, Cervical Cancer, Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
[+]

Bromelain degrades Aβ1-42 monomers and soluble aggregates.Jan 22, 2018

Pubmed Data : Curr Alzheimer Res. 2018 Jan 23. Epub 2018 Jan 23. PMID: 29359669
Article Published Date : Jan 22, 2018
Study Type : Human In Vitro
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2021 Oct 23 ;10(11). Epub 2021 Oct 23. PMID: 34834636
Article Published Date : Oct 22, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells.May 31, 2023

Pubmed Data : Tissue Cell. 2023 Jun ;82:102118. Epub 2023 May 27. PMID: 37269556
Article Published Date : May 31, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2021 ;11(5):2252-2263. Epub 2021 May 15. PMID: 34094682
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, Cysteine (see N-Acetylcysteine)
Diseases : Colon Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease.Jan 31, 2023

Pubmed Data : Int J Biol Macromol. 2023 Feb 1 ;227:1119-1131. Epub 2022 Dec 1. PMID: 36462588
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
[+]

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Pain. 2020 Jan 1 ;33(1):13-22. PMID: 31888313
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Neuropathic Pain
Pharmacological Actions : Antinoceceptive , Neuroprotective Agents
[+]

Bromelain Ameliorates Atherosclerosis.Dec 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Dec 29 ;12(1). Epub 2022 Dec 29. PMID: 36670934
Article Published Date : Dec 28, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypolipidemic
[+]

Bromelain ameliorates D-galactosamine-induced acute liver injury.Nov 24, 2022

Pubmed Data : J Pharm Pharmacol. 2022 Nov 25 ;74(12):1765-1775. PMID: 36227279
Article Published Date : Nov 24, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain ameliorates hepatic microcirculation after warm ischemia indicating it may have liver protective effects after injury. May 01, 2007

Pubmed Data : J Surg Res. 2007 May 1;139(1):88-96. Epub 2007 Feb 8. PMID: 17292418
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Bromelain and acetylcysteine alone and in combination with gemcitabine inhibit subcutaneous deposits of pancreatic cancer after intraperitoneal injection.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2021 ;13(12):13524-13539. Epub 2021 Dec 15. PMID: 35035694
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Bromelain and fresh pineapple juice have a therapeutic effect in acute crush archilles tendon injury.Apr 01, 2011

Pubmed Data : J Med Food. 2011 Apr;14(4):348-52. Epub 2011 Jan 23. PMID: 21254908
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Tendon Injury
[+]

Bromelain attenuates inflammation in an experimental mouse model of asthma. Mar 01, 2008

Pubmed Data : Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9. PMID: 18317550
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

Bromelain decreases oxidative stress and Neuroinflammation and improves motor function in adult male rats with cerebellar Ataxia induced by 3-acetylpyridine.Jul 22, 2024

Pubmed Data : Neuropeptides. 2024 Jul 23 ;107:102455. Epub 2024 Jul 23. PMID: 39094391
Article Published Date : Jul 22, 2024
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Ataxia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.Sep 01, 2005

Pubmed Data : Cell Immunol. 2005 Sep;237(1):68-75. Epub 2005 Dec 6. PMID: 16337164
Article Published Date : Sep 01, 2005
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Allergic Airway Diseases
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents
[+]

Bromelain has a healing effect in acute crush Archilles tendon injury. Jan 01, 2009

Pubmed Data : Ann Nutr Metab. 2009;54(4):283-90. Epub 2009 Jul 27. PMID: 20623610
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Tendon Injury
[+]

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Pubmed Data : Altern Ther Health Med. 2012 Sep-Oct;18(5):9-17. PMID: 22894886
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Allergic Airway Diseases, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-4 downregulation
[+]

Bromelain has cardioprotective properties against an experimental model of heart injury. Mar 01, 2008

Pubmed Data : Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70. Epub 2008 Jan 11. PMID: 18192224
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Myocardial Infarction, Myocardial Ischemia
Pharmacological Actions : Apoptotic, Cardioprotective
[+]

Bromelain has immunomodulatory properties. Dec 20, 2006

Pubmed Data : Int Immunopharmacol. 2006 Dec 20;6(13-14):2038-46. Epub 2006 Sep 5. PMID: 17161360
Article Published Date : Dec 20, 2006
Study Type : Animal Study
Additional Links
Substances : Bromelain
Pharmacological Actions : Interleukin-10 downregulation
[+]

Bromelain has the potential to reduce the side effects of BPA on the male reproductive system.Nov 30, 2022

Pubmed Data : Andrologia. 2022 Dec ;54(11):e14584. Epub 2022 Sep 6. PMID: 36068179
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Bisphenol Toxicity, Oxidative Stress, Sperm Quality: Low
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Estrogen Receptor Beta
Problem Substances : Bisphenol A
[+]

Bromelain increases milk yield, milk composition and has no adverse effects on mammary health in dairy goats.Apr 01, 2009

Pubmed Data : Trop Anim Health Prod. 2009 Apr;41(4):493-8. Epub 2008 Jul 27. PMID: 18661260
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Breastfeeding: Complications, Lactation Disorders
[+]

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2019 ;14(1):e0210274. Epub 2019 Jan 18. PMID: 30657763
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation
[+]

Bromelain loaded nano lipid carriers opens new avenue for development of novel effective therapeutic modality for rheumatoid arthritis management.Jan 31, 2021

Pubmed Data : Int J Pharm. 2021 Feb 1 ;594:120176. Epub 2020 Dec 14. PMID: 33326825
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain may be an option in periodontal therapy by regulating cytokine levels, improving the healing process, and reducing bone resorption.Jul 31, 2023

Pubmed Data : Int Immunopharmacol. 2023 Aug ;121:110446. Epub 2023 Jun 7. PMID: 37290321
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain mitigated electrolyte imbalance in chronic constricted injury of the sciatic nerve.Oct 25, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 26. Epub 2019 Oct 26. PMID: 31655851
Article Published Date : Oct 25, 2019
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : Antinoceceptive
[+]

Bromelain modulates liver injury, hematological, molecular, and biochemical perturbations induced by aluminum.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:5342559. Epub 2022 Nov 21. PMID: 36452063
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Aluminum Toxicity , Chemically-Induced Liver Damage, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Aluminum
[+]

Bromelain plus peroxidase reduces non-Hodgkin lymphoma progressionOct 07, 2019

Pubmed Data : Nutr Cancer. 2019 Oct 8:1-11. Epub 2019 Oct 8. PMID: 31591915
Article Published Date : Oct 07, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Non-Hodgkin Lymphoma
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation.Dec 12, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Dec 13:1-8. Epub 2021 Dec 13. PMID: 34894956
Article Published Date : Dec 12, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Jan 11 ;11(1):289. Epub 2021 Jan 11. PMID: 33432004
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Anxiety Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain represents a novel approach to the treatment of metal toxicity.May 31, 2015

Pubmed Data : Acta Biol Hung. 2015 Jun ;66(2):149-60. PMID: 26081271
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Lead Poisoning
Pharmacological Actions : Cytoprotective, Malondialdehyde Down-regulation
Problem Substances : Lead
[+]

Bromelain treatment decreases neutrophil migration to sites of inflammation.Jul 01, 2008

Pubmed Data : Clin Immunol. 2008 Jul;128(1):66-74. Epub 2008 May 14. PMID: 18482869
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in mice with colitis.Dec 01, 2010

Pubmed Data : Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493
Article Published Date : Dec 01, 2010
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colitis, Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation
[+]

Effect of bromelain on mast cell numbers and degranulation in diabetic rat wound healing.Jul 31, 2022

Pubmed Data : J Wound Care. 2022 Aug 1 ;31(Sup8):S4-S11. PMID: 36004940
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetic Complications, Wound Healing
[+]

Enhancement of the anti-inflammatory effect of bromelain by its immobilization on probiotic spore of Bacillus cereus.Nov 05, 2020

Pubmed Data : Probiotics Antimicrob Proteins. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156496
Article Published Date : Nov 05, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain, Probiotics
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Nephroprotective role of bromelain against oxidative injury induced by aluminium.Oct 31, 2020

Pubmed Data : Environ Toxicol Pharmacol. 2020 Nov ;80:103509. Epub 2020 Oct 1. PMID: 33010469
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Aluminum Toxicity , Kidney Damage: Chemically-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Renoprotective
Problem Substances : Aluminum
[+]

Pharmacological evaluation of bromelain in mouse model of Alzheimer's disease.Dec 31, 2021

Pubmed Data : Neurotoxicology. 2022 05 ;90:19-34. Epub 2022 Feb 24. PMID: 35219781
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Pineapple bromelain has anti-tumor properties superior to the chemo-agent 5-fluorouracil.Oct 01, 2007

Pubmed Data : Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24. PMID: 17893836
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic
Additional Keywords : Drug: 5-flourouracil, Food as Medicine, Hall of Fame, Superiority of Natural Substances versus Drugs
[+]

Protective effect of bromelain on corrosive burns.Dec 09, 2020

Pubmed Data : Burns. 2020 Dec 10. Epub 2020 Dec 10. PMID: 33934907
Article Published Date : Dec 09, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Burns
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Protective effects of bromelain against cadmium-induced pulmonary intoxication.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Razi Inst. 2021 11 ;76(5):1427-1436. Epub 2021 Nov 30. PMID: 35355740
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Cadmium Poisoning
Pharmacological Actions : Anti-Inflammatory Agents
Problem Substances : Cadmium
[+]

Protein stem bromelain together with all-trans retinoic-acid (atRA), may be a potent modulator of obesity by repressing the PPARγ-regulated adipogenesis pathwayDec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(1):e30831. Epub 2012 Jan 24. PMID: 22292054
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Obesity
Pharmacological Actions : Anti-Adipogenic, Apoptotic
Additional Keywords : Anti-Obesity Agents
[+]

Study of the radiosensitizing and radioprotective efficacy of bromelain.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2020 Jan-Dec;19:1534735420950468. PMID: 32783540
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : Radioprotective, Radiosensitizer
[+]

The ameliorative effect of bromelain on STZ-induced type 1 diabetes.Nov 14, 2021

Pubmed Data : Life Sci. 2021 Nov 15 ;285:119982. Epub 2021 Sep 27. PMID: 34592232
Article Published Date : Nov 14, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation
[+]

The present study provides new insights into the potential therapeutic value of bromelain for the prevention and treatment of thrombosis-related diseases.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Jun 1 ;14(11). Epub 2022 Jun 1. PMID: 35684129
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Nonalcoholic fatty liver disease (NAFLD), Thrombosis
Pharmacological Actions : Anticoagulants, Hepatoprotective
[+]

Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin.Dec 31, 2022

Pubmed Data : Int J Health Sci (Qassim). 2023 ;17(5):23-30. PMID: 37692988
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Bromelain, Papain
Diseases : Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Gastroprotective
Problem Substances : Indomethacin
[+]

These results supply novel insights into potential inflammatory bowel disease treatment by purified fruit bromelain.Dec 31, 2016

Pubmed Data : Front Immunol. 2017 ;8:1468. Epub 2017 Nov 10. PMID: 29176974
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Gastrointestinal Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.Aug 01, 2005

Pubmed Data : Clin Immunol. 2005 Aug;116(2):135-42. PMID: 15936249
Article Published Date : Aug 01, 2005
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation
[+]

Use of bromelain in cutaneous wound healing in streptozocin-induced diabetes.Sep 01, 2020

Pubmed Data : J Wound Care. 2020 Sep 2 ;29(9):488-495. PMID: 32924815
Article Published Date : Sep 01, 2020
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Diabetic Complications, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The Combination ofBromelain and acetylcysteine (BromAc) synergistically inactivates SARS-CoV-2.Jan 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2021 03 6 ;13(3). Epub 2021 Mar 6. PMID: 33800932
Article Published Date : Jan 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

"Bromelain: biochemistry, pharmacology and medical use."Jul 31, 2001

Pubmed Data : Cell Mol Life Sci. 2001 Aug ;58(9):1234-45. PMID: 11577981
Article Published Date : Jul 31, 2001
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Thrombophlebitis
Additional Keywords : Phytotherapy
[+]

Anti-cancer effect of bromelain and its combination with cisplatin on HN5 cell line.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dent (Shiraz). 2022 Sep ;23(3):257-265. PMID: 36506883
Article Published Date : Aug 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents
[+]

Anti-inflammatory and mineralization effects of bromelain on lipopolysaccharide-induced inflammation.Jun 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicina (Kaunas). 2021 Jun 8 ;57(6). Epub 2021 Jun 8. PMID: 34201357
Article Published Date : Jun 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Anti-inflammatory effect of pineapple rhizome bromelain.May 06, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2021 May 7 ;43(1):93-106. Epub 2021 May 7. PMID: 34067064
Article Published Date : May 06, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Anti-inflammatory properties of a proprietary bromelain extract.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211034686. PMID: 34387509
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain a potential bioactive compound: A comprehensive overview.Apr 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2021 Apr 6 ;11(4). Epub 2021 Apr 6. PMID: 33917319
Article Published Date : Apr 05, 2021
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Arthritis, Digestive System Diseases, Respiratory Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Immunomodulatory
[+]

Bromelain and NAC inhibit the growth, proliferation and survival of human gastrointestinal cancer cells.Nov 11, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2014 Nov 12 ;33:92. Epub 2014 Nov 12. PMID: 25425315
Article Published Date : Nov 11, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer.Apr 22, 2021

Pubmed Data : Environ Sci Pollut Res Int. 2021 Apr 23. Epub 2021 Apr 23. PMID: 33893581
Article Published Date : Apr 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Olive leaf extract
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Natural Substance Synergy
Problem Substances : Benzo(a)pyrene
[+]

Bromelain and papain exhibit anti-flu virion properties.May 01, 2008

Pubmed Data : Bioorg Khim. 2008 May-Jun;34(3):409-15. PMID: 18672693
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Bromelain and papain have cytotoxic effects on human cholangiocarcinoma cell lines.Apr 30, 2016

Pubmed Data : Int J Oncol. 2016 May ;48(5):2025-34. Epub 2016 Mar 1. PMID: 26935541
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Cholangiocarcinoma
Pharmacological Actions : Anti-Inflammatory Agents, Cytotoxic, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Bromelain as a natural anti-inflammatory drug: a systematic review.Apr 26, 2024

Pubmed Data : Nat Prod Res. 2024 Apr 27:1-14. Epub 2024 Apr 27. PMID: 38676413
Article Published Date : Apr 26, 2024
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anim Cells Syst (Seoul). 2018 ;22(5):334-340. Epub 2018 Aug 30. PMID: 30460115
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cytotoxic
[+]

Bromelain enhances intestinal absorption and/or permeability. Jan 24, 2005

Pubmed Data : Arch Intern Med. 2005 Jan 24;165(2):200-6. PMID: 16950580
Article Published Date : Jan 24, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Intestinal Permeability , Leaky Gut Syndrome
[+]

Bromelain exerts an antibacterial effect against potent periodontal pathogens.Aug 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Oral Health. 2014 Sep ;6(5):96-8. PMID: 25395802
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Bromelain exerts anti-inflammatory activity by modulating activated CD4(+) cells. Mar 01, 2009

Pubmed Data : Int Immunopharmacol. 2009 Mar;9(3):340-6. Epub 2009 Jan 20. PMID: 19162239
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain exhibits anti-skin cancer and anti-melanoma activity. Mar 22, 2011

Pubmed Data : Mol Carcinog. 2011 Mar 22. Epub 2011 Mar 22. PMID: 21432909
Article Published Date : Mar 22, 2011
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Melanoma, Skin Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, NF-kappaB Inhibitor
[+]

Bromelain has anti-tumor initiating activity against skin cancer cells.Sep 18, 2009

Pubmed Data : Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID: 19339108
Article Published Date : Sep 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain has inhibitory effects on colony formation in cancer cells.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Signals Sens. 2019 Oct-Dec;9(4):267-273. Epub 2019 Oct 24. PMID: 31737556
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer, Gastric Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

Bromelain in combination with cisplatin synergistically enhanced the induction of apoptosis in MDA-MB-231 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med. 2016 ;11:46. Epub 2016 Nov 15. PMID: 27891174
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Bromelain induces apoptosis-related cell death in breast cancer cells with increasing concentrations in vitro.Apr 01, 2012

Pubmed Data : J Med Food. 2012 Apr ;15(4):344-9. Epub 2011 Dec 22. PMID: 22191568
Article Published Date : Apr 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Antitumorigenic, Apoptosis, Breast Cancer, Bromelain
Anti Therapeutic Actions : Nocebo Effect
[+]

Bromelain inhibits invasive properties of glioma cells. Nov 01, 2001

Pubmed Data : Neoplasia. 2001 Nov-Dec;3(6):469-79. PMID: 11774029
Article Published Date : Nov 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Glioma
[+]

Bromelain inhibits lipopolysaccharide-induced inflammation. Jan 01, 2003

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 18569070
Article Published Date : Jan 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain inhibits SARS-CoV-2 infection in VeroE6 cells.Sep 15, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : bioRxiv. 2020 Sep 16. Epub 2020 Sep 16. PMID: 32995771
Article Published Date : Sep 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Bromelain may have anti-skin tumor activity. Jan 01, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID: 17889918
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain may have therapeutic value in the treatment of irritable bowel syndrome. Mar 01, 2008

Pubmed Data : Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21. PMID: 18160345
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bromelain may stimulate type 1 cells up-regulating both innate as well as the adaptive immune system.Aug 17, 2005

Pubmed Data : Eur J Med Res. 2005 Aug 17;10(8):325-31. PMID: 16131473
Article Published Date : Aug 17, 2005
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Immune Disorders
Pharmacological Actions : Antiproliferative , Immunostimulatory
[+]

Bromelain reduces platelet aggregation and inhibits thrombus formation.Jan 01, 1999

Pubmed Data : In Vivo. 1999 Jan-Feb;13(1):7-12. PMID: 10218125
Article Published Date : Jan 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Thrombosis
Pharmacological Actions : Anti-Platelet, Thrombolytic
[+]

Bromelain supplementation and inflammatory markers.May 31, 2023

Pubmed Data : Clin Nutr ESPEN. 2023 Jun ;55:116-127. Epub 2023 Mar 2. PMID: 37202035
Article Published Date : May 31, 2023
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain treatment could potentiate the antitumor effect of cisplatin on triple-negative breast cancer 4T1 cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2019 Jan-Dec;18:1534735419880258. PMID: 31752555
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-4 downregulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Bromelain-cisplatin chemoherbal combination demonstrated synergistic in-vitro anticancer effect on human prostatic carcinoma cell line.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Galen Med J. 2020 ;9:e1749. Epub 2020 Aug 29. PMID: 34466585
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer
[+]

Bromelain: a review of its mechanisms, pharmacological effects and potential applications.Aug 30, 2023

Pubmed Data : Food Funct. 2023 Aug 31. Epub 2023 Aug 31. PMID: 37650738
Article Published Date : Aug 30, 2023
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Asthma, Inflammation, Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Bromelain: A review on its potential as a therapy for the management of Covid-19.Jan 29, 2020

Pubmed Data : Niger J Physiol Sci. 2020 06 30 ;35(1):10-19. Epub 2020 Jun 30. PMID: 33084621
Article Published Date : Jan 29, 2020
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Anticoagulants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Cross-linked bromelain inhibits lipopolysaccharide-induced inflammation. Mar 22, 2006

Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2193-8. PMID: 16536595
Article Published Date : Mar 22, 2006
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
[+]

Cytotoxic effect of bromelain on HepG2 hepatocellular carcinoma cell line. Mar 17, 2021

Pubmed Data : Appl Biochem Biotechnol. 2021 Mar 18. Epub 2021 Mar 18. PMID: 33735410
Article Published Date : Mar 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic
[+]

Enhancing the potency of chemotherapeutic agents by combination with bromelain and N-acetylcysteine.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(11):7404-7419. Epub 2020 Nov 15. PMID: 33312377
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, NAC (N-acetyl-L-cysteine)
Diseases : Liver Cancer, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine
[+]

Evaluation of the radiosensitizing potency of bromelain for radiation therapy of 4T1 breast cancer cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Med Signals Sens. 2019 Jan-Mar;9(1):68-74. PMID: 30967992
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Radiosensitizer
[+]

Herbal anti-inflammatory agents for skin disease.Jan 01, 2000

Pubmed Data : Skin Therapy Lett. 2000 ;5(4):3-5. PMID: 10785407
Article Published Date : Jan 01, 2000
Study Type : Review
Additional Links
Substances : Bromelain, Capsaicin, Turmeric
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Naturally occurring immunomodulators with antitumor activity.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:291-304. PMID: 28734166
Article Published Date : Aug 31, 2017
Study Type : Review
Additional Links
Substances : Betulinic acid, Bromelain, Curcumin, Genistein, Resveratrol, Zerumbone
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Immunomodulatory
[+]

Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease.Nov 30, 2021

Pubmed Data : Mol Biol Rep. 2021 Dec ;48(12):7711-7717. Epub 2021 Oct 13. PMID: 34643923
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Papain and bromelain have an antibacterial effect on A. acidoterrestris.Jan 03, 2016

Pubmed Data : Int J Food Microbiol. 2016 Jan 4 ;216:121-6. Epub 2015 Oct 8. PMID: 26476327
Article Published Date : Jan 03, 2016
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Papain
Diseases : Gram-Positive Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Natural Substance Synergy
[+]

Pineapple bromelain induces apoptosis in mammary cancer cells.Sep 16, 2010

Pubmed Data : Biofactors. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20848558
Article Published Date : Sep 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Pineapple
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Autophagy
[+]

Radiosensitizing effect of bromelain.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2021 Jan-Dec;20:15347354211060369. PMID: 34825602
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : NF-kappaB Inhibitor, Radiosensitizer
[+]

Results demonstrate that bacterial nanocellulose could improve bromelain antimicrobial activity 9 times.Dec 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Dec 21 ;7(1):18031. Epub 2017 Dec 21. PMID: 29269741
Article Published Date : Dec 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Pharmacological Actions : Antimicrobial, Antioxidants
[+]

Review: Bromelain's anti-cancer potential. Apr 28, 2010

Pubmed Data : Cancer Lett. 2010 Apr 28;290(2):148-56. Epub 2009 Aug 22. PMID: 19700238
Article Published Date : Apr 28, 2010
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents
[+]

Synergic role of dietary bioactive compounds in breast cancer chemoprevention and combination therapies.Jun 13, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Jun 14 ;16(12). Epub 2024 Jun 14. PMID: 38931238
Article Published Date : Jun 13, 2024
Study Type : Review
Additional Links
Substances : Bromelain, DHA (Docosahexaenoic Acid), Eicosapentaenoic acid (EPA) , Indole-3-Carbinol, Isothiocyanates, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells.Oct 13, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2021 Oct 14 ;21(1):261. Epub 2021 Oct 14. PMID: 34649531
Article Published Date : Oct 13, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Curcumin
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabol Open. 2020 Dec ;8:100066. Epub 2020 Nov 13. PMID: 33205039
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain, Curcumin
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunostimulatory
Additional Keywords : Natural Substance Synergy
[+]

The combination of bromelain and dexamethasone sodium phosphate induced a great activation of mesenchymal stem cells.May 31, 2019

Pubmed Data : J Craniofac Surg. 2019 Jun ;30(4):1064-1067. PMID: 30358745
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Mesenchymal Stem Cells, Natural Substance/Drug Synergy
Problem Substances : Dexamethasone
[+]

The current review describes the promising clinical applications and therapeutic properties of bromelain.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2016 Sep ;5(3):283-288. Epub 2016 Jul 18. PMID: 27602208
Article Published Date : Aug 31, 2016
Study Type : Review
Additional Links
Substances : Bromelain
Diseases : Cancers: All, Cholera, Escherichia coli Infections, Inflammation, Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Anti-thrombotic, Antifibrinolytic Agents, Chemopreventive, Immunomodulatory
[+]

The potential use of bromelain as a natural oral medicine having anticarcinogenic activities.Apr 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 May ;7(5):1656-1667. Epub 2019 Apr 1. PMID: 31139378
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
[+]

This finding indicated that bromelain could have an inhibitory effect on different SARS-CoV-2 variants.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:717757. Epub 2021 Aug 20. PMID: 34489706
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents

Copyright: alex9500 / 123RF Stock Photo

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