Berberine

Name	AC	CK
Diabetes Mellitus: Type 2	52	189
Inflammation	58	167
Obesity	41	137
Hyperlipidemia	24	121
Insulin Resistance	33	119
Alzheimer's Disease	38	95
Colorectal Cancer	29	70
Cardiovascular Diseases	14	65
Polycystic Ovary Syndrome	16	63
Dyslipidemias	5	62
Nonalcoholic fatty liver disease (NAFLD)	34	60
Ulcerative Colitis	24	59
Breast Cancer	28	50
C-Reactive Protein	3	50
Cancers: All	27	49
Lipopolysaccharide-Induced Toxicity	25	48
Diabetic Nephropathy	14	46
Lung Cancer	21	45
Schizophrenia	7	45
Liver Cancer	35	44
Colitis	22	43
Atherosclerosis	17	41
Oxidative Stress	22	39
Helicobacter Pylori Infection	6	37
Myocardial Ischemia	12	34
Diabetes: Cognitive Dysfunction	7	32
Hypercholesterolemia	4	32
Metabolic Syndrome X	7	31
Colon Cancer	20	27
Diabetic Complications	10	27
Depression	13	25
Sepsis	15	24
Stroke: Ischemic	3	24
Cerebral Ischemia	12	23
High Fat Diet	12	23
High Cholesterol	2	22
Hyperglycemia	13	22
Metabolic Diseases	9	22
Rheumatoid Arthritis	12	22
Triglycerides: Elevated	2	22
Atrial Fibrillation	2	20
Gastric Cancer	16	20
Weight Gain: Drug-Induced	2	20
Chemotherapy-Induced Toxicity: Doxorubicin	9	19
Osteoporosis	6	18
Brain Inflammation	10	17
Breast Cancer: Triple Negative	15	17
Fatty Liver	5	17
Chemically-Induced Liver Damage	8	16
Parkinson's Disease	5	16
Diarrhea	4	15
Kidney Diseases	4	14
Cognitive Decline/Dysfunction	7	13
Hypertension	8	13
Carcinoma: Non-Small-Cell Lung	11	12
Endothelial Dysfunction	2	12
Epilepsy	6	12
Neurodegenerative Diseases	10	12
Prediabetes	2	12
Arthritis	6	11
Cholesterol: Oxidation	2	11
Diabetic Neuropathy	6	11
Gastrointestinal Diseases	2	11
Glioblastoma	8	11
Glioma	6	11
Osteosarcoma	6	11
Pancreatitis	7	11
Acetaminophen (Tylenol) Toxicity	5	10
Bacterial Vaginosis	1	10
Cardiac Surgery	1	10
Gout	1	10
Graves Disease	1	10
Heart Failure	6	10
Primary Sclerosing Cholangitis	1	10
Radiation Induced Illness	1	10
Wound Healing: Periodontal	1	10
Candida Albicans	9	9
Chemotherapy-Induced Toxicity: Cyclophosphamide	5	9
Diabetic Retinopathy	6	9
Melanoma	8	9
Staphylococcus aureus infection	8	9
Cancers: Drug Resistant	7	8
Cardiomyopathy	4	8
Diabetes Mellitus: Type 1	5	8
Influenza	5	8
Ischemia	5	8
Liver Damage	5	8
Myocardial Infarction	4	8
Ovarian Cancer	8	8
Prostatic Hyperplasia: Benign	4	8
Staphylococcus aureus: Methicillin-resistant (MRSA)	8	8
Cervical Cancer	7	7
Chemotherapy-Induced Kidney Damage	4	7
Chemotherapy-Induced Toxicity: 5-fluorouracil	4	7
Coronavirus Infection	5	7
Escherichia coli Infections	5	7
Fibrosis	4	7
Kidney Cancer	5	7
Pesticide Toxicity	4	7
Alcohol Toxicity	3	6
Alcoholic Liver Disease	3	6
Hepatic Steatosis	4	6
Hypoxia	4	6
Irritable Bowel Syndrome	3	6
Liver Fibrosis	4	6
Liver Steatosis	3	6
Mucositis	3	6
Pseudomonas aeruginosa	5	6
Wound Healing	3	6
Autoimmune Diseases	3	5
Bladder Cancer	4	5
Bone Diseases	3	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Hyperuricemia	3	5
Peripheral Neuropathies	3	5
Psoriasis	1	5
Spinal Cord Injuries	3	5
Systemic Lupus Erythematosus	1	5
Advanced Glycation End products (AGE)	3	4
Aging	2	4
Aging: Brain	2	4
Allergic Rhinitis	2	4
Anxiety	3	4
Asthma	3	4
Brain: Oxidative Stress	3	4
Chemotherapy-Induced Toxicity: Paclitaxel	2	4
Chikungunya Virus	3	4
Endometrial Cancer	3	4
Enterocolitis: Necrotiziing	2	4
Erectile Dysfunction	2	4
Fructose-Induced Toxicity	2	4
Gastritis	2	4
Hepatitis: Lectin-Induced (concanavalin)	2	4
High Sugar Diet	2	4
Hyperalgesia	2	4
Intracerebral Hemorrhage	2	4
Iron Overload	2	4
Kidney Damage: Drug-Induced	2	4
Leishmaniasis	3	4
Morphine Tolerance/Dependence	2	4
Multiple Sclerosis	3	4
Nasopharyngeal Cancer	3	4
Neuropathic Pain	2	4
Osteoarthritis	3	4
Pancreatic Cancer	4	4
Periodontitis	2	4
Prostate Cancer	4	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Thrombosis	2	4
Traumatic Brain Injury	2	4
Acute T cell Leukemias	3	3
Brain Ischemia	2	3
Cancer Metastasis	3	3
Cancers: Multi-Drug Resistant	2	3
Chronic Kidney Disease (CKD)	2	3
Coxsackievirus Infections	2	3
Degenerative Disk Disease	3	3
Dementia	2	3
Depression	2	3
Diabetes: Cardiovascular Illness	2	3
Diabetes: Oxidative Stress	2	3
Dry Eye Syndromes	1	3
Gastrointestinal Cancer	3	3
Herpes Simplex Virus Type 1	3	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoglycemia	2	3
Kidney Damage	2	3
Leg Ulcer	1	3
Liver Disease	2	3
Liver Injury: Ischemia/reperfusion	2	3
Lung Injury: Acute	2	3
Periodontal Diseases	2	3
Radiation	2	3
Uveitis	2	3
Vascular Calcification	1	3
Acute Myeloid Leukemia	2	2
Acute Respiratory Distress Syndrome	1	2
Acute lymphoblastic leukemia (ALL)	2	2
Adenomyosis	2	2
Aluminum Toxicity	1	2
Amphetamine Addiction/Withdrawal	1	2
Aneurysm: Cerebral	1	2
Animal Diseases: Infectious	1	2
Arsenic Poisoning	1	2
Arterial Hardening: Elasticity	1	2
Atopic Dermatitis	1	2
Autism	1	2
Bacterial Infections: Resistance/Biofilm Formation	1	2
Bipolar Disorder	1	2
Bladder Dysfunction	1	2
Blood-Brain-Barrier Disorders	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Chemically-Induced	1	2
Bubonic Plague	1	2
Candida Infection	2	2
Cardiac Hypertrophy	1	2
Cerebral Hemorrhage	1	2
Cerebral Hypoperfusion	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Cholangiocarcinoma	2	2
Cholangitis	1	2
Cholesterol: High	1	2
Chronic Lymphocytic Leukemia	2	2
Chronic Myeloid Leukemia	1	2
Cocaine Withdrawal	1	2
Colon Cancer: Prevention	1	2
Colorectal Cancer: Prevention	1	2
Colorectal Tumors	1	2
Congestive Heart Failure	1	2
Convulsions	1	2
Coronavirus Disease (Covid-19)	1	2
Cytomegalovirus Infections	2	2
Demyelinating Diseases	1	2
Diabesity	1	2
Diabetic Neuropathies	1	2
Diarrhea: Drug-Associated	1	2
Drug Toxicity: Methotrexate	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Drug-Induced Toxicity: L-Thyroxine	1	2
Drug-Induced Toxicity: Methotrexate	1	2
Endothelial Damage	1	2
Eye Damage	1	2
Fatigue	1	2
Fetal Origin of Adult Disease	1	2
Gastric Polyposis	1	2
Gastrointestinal Inflammation	1	2
Gestational Diabetes	1	2
Graft vs Host Disease	1	2
HIV Infections	2	2
Hearing Loss: Noise-Induced	1	2
Heavy Metal Toxicity	1	2
Hepatitis: Autoimmune	1	2
Herpes Simplex Virus Type 2	2	2
High Homocysteine	1	2
Huntington Disease	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Hypertension: Renal	1	2
Immune Dysregulation: TH1 dominance	1	2
Immune Dysregulation: TH17 over-expression	1	2
Infection: Antibiotic Resistant	2	2
Infertility: Male	1	2
Insomnia	1	2
Intestinal Permeability	1	2
Intestinal Polyps	1	2
Intima Media Thickening	1	2
Kidney Fibrosis	1	2
Laryngeal Cancer	2	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia	2	2
Leukemia: Chronic Lymphocytic Leukemia (CLL)	2	2
Lipid Peroxidation	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Damage: Drug-Induced	1	2
Liver Stress: Fructose-Induced	1	2
Lung Cancer: Prevention	1	2
Lung Inflammation	1	2
Malignant Melanoma	2	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Miscarriage	1	2
Multiple Myeloma	2	2
Muscle Damage: Exercise-Induced	1	2
Myocardial Fibrosis	1	2
Myocarditis: Viral	1	2
Nerve Injuries	1	2
Neuroblastoma	2	2
Non-Small-Cell Lung Carcinoma	2	2
Ovarian Failure	1	2
Peripheral Nerve Diseases	1	2
Pneumonia	1	2
Post-Traumatic Stress Disorders (PTSD)	1	2
Postmenopausal Disorders	1	2
Postoperative Recovery	1	2
Prehypertension	1	2
Promyelocytic leukemia	2	2
Psychiatric Disorders	1	2
Retinal Diseases	1	2
Sarcopenia	1	2
Seizures	1	2
Seizures: Drug-Induced	1	2
Smoking Cessation: Nicotine Addiction	1	2
Squamous cell carcinoma	2	2
Staphylococcal Infections	1	2
Statin-Induced Pathologies	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Thyroid Cancer	2	2
Tongue Cancer	1	2
Toxoplasma gondii Infection	1	2
Tuberculosis	2	2
Ultraviolet Radiation Induced Damage	1	2
Uremia	1	2
Uveoretinitis	1	2
Varicocele	1	2
Vitiligo	1	2
Allergic Airway Diseases	1	1
Allergies	1	1
Alphavirus Infections	1	1
Arthritis: Rheumatoid	1	1
Autoimmune Disease	1	1
Bacillus Cereus infection	1	1
Bacillus subtilis infections	1	1
Bacterial Infections and Mycoses	1	1
Breast Cancer Stem Cells	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cachexia: Cancer	1	1
Calcium Homeostasis: Impairment	1	1
Cancer: Virus-Induced	1	1
Cancers	1	1
Cardiac Arrhythmias	1	1
Chemobrain	1	1
Chemotherapy	1	1
Chondrosarcoma	1	1
Chronic Disease	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Corticosteroid-Induced Toxicity	1	1
Cystitis: Interstitial	1	1
Dementia: Senile	1	1
Dental Caries	1	1
Diabetes Mellitus: Type 2: Prevention	1	1
Diabetes: Glycation/A1C	1	1
Diabetes: Kidney Function	1	1
Diarrhea: in Children	1	1
Dysbiosis	1	1
Echinococcosis	1	1
Encephalopathy	1	1
Enterococcus Infections	1	1
Enteropathy	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Esophageal Cancer	1	1
Eye Diseases	1	1
Friend Virus	1	1
Fungal Infection	1	1
Fungus Diseases	1	1
HIV Drug-Induced Toxicity	1	1
Head and Neck Cancer	1	1
Heart Disease	1	1
Human Papillomavirus (HPV)	1	1
Hydatid Cyst	1	1
Inflammatory Bowel Diseases	1	1
Kawasaki Disease	1	1
Klebsiella Infections	1	1
Leaky Gut Syndrome	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Virus-Induced	1	1
Liver Cirrhosis	1	1
Lower Respiratory Infections	1	1
Lung Damage	1	1
Lymphangioendothelioma	1	1
Lymphoma: B-Cell	1	1
Macular Degeneration	1	1
Memory Disorders	1	1
Mesothelioma	1	1
Microcystis aeruginosa	1	1
Myasthenia Gravis	1	1
Mycobacterium Infections	1	1
Myocarditis: Autoimmune	1	1
Oral Cancer	1	1
Overweight	1	1
Pulmonary Fibrosis	1	1
Respiratory Syncytial Virus Infections	1	1
Retinoblastoma	1	1
Rhabdomyosarcoma	1	1
Salmonella Infections	1	1
Skin Cancer: Squamous Cell	1	1
Streptococcus pyogenes	1	1
Subarachnoid hemorrhage	1	1
Thrombocytopenia	1	1

Name	AC	CK
Anti-Inflammatory Agents	284	723
Hypolipidemic	61	311
Tumor Necrosis Factor (TNF) Alpha Inhibitor	81	267
Antioxidants	123	250
Neuroprotective Agents	100	247
Interleukin-6 Downregulation	69	236
Gastrointestinal Agents	83	208
Antiproliferative	131	182
Cardioprotective	53	158
Hypoglycemic Agents	39	151
Interleukin-1 beta downregulation	55	133
Hepatoprotective	65	118
Apoptotic	94	113
Anticholesteremic Agents	13	102
Chemopreventive	34	95
NF-kappaB Inhibitor	46	88
Anti-Apoptotic	49	87
Anti-Bacterial Agents	31	63
MicroRNA modulator	36	52
Anti-metastatic	45	49
Renoprotective	27	47
Chemoprotective Agents	23	43
Insulin Sensitizers	14	42
Cell cycle arrest	34	41
Immunomodulatory	26	39
Nrf2 activation	25	38
Chemotherapeutic	33	36
Anti-Fibrotic	20	35
Interleukin-10 upregulation	8	34
Cyclooxygenase 2 Inhibitors	17	33
Gastroprotective	17	33
Antihypertensive Agents	7	31
Malondialdehyde Down-regulation	5	29
Chemosensitizer	24	26
Antidepressive Agents	13	24
Interleukin-8 downregulation	9	23
Acetylcholinesterase Inhibitor	2	22
Anticarcinogenic Agents	12	20
Autophagy Up-regulation	14	20
Matrix metalloproteinase-9 (MMP-9) inhibitor	12	18
Antiviral Agents	15	17
Matrix metalloproteinase-2 (MMP-2) inhibitor	13	17
Analgesics	4	16
Antidiarrheals	5	16
Antineoplastic Agents	7	15
Pancreato Protective Agents	10	15
SIRT1 Activator	8	15
Interleukin-18 down-regulation	4	14
Osteoprotective	8	14
Transforming growth factor beta (TGF-β) inhibitor	6	14
Radioprotective	3	13
Anticonvulsants	5	10
Antimicrobial	9	10
Bcl-2 protein down-regulation	6	10
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	7	10
Interleukin-17 downregulation	5	10
Angiogenesis Inhibitors	7	9
Vasoprotective	4	9
Wnt/β-catenin signaling pathway modulation	8	9
Anti-Anxiety Agents	5	8
Antifungal Agents	8	8
Enzyme Inhibitors	3	8
Tumor Suppressor Protein p53 Upregulation	7	8
Anti-Adipogenic	6	7
Interleukin-4 downregulation	4	7
Angiogenesis Inducing Agents	3	6
Cytoprotective	4	6
Heme oxygenase-1 up-regulation	5	6
Immunomodulatory: Th17 downregulation	3	6
Radiosensitizer	5	6
Regenerative	4	5
STAT3 Inhibitor	4	5
Uricosuric Agents	3	5
Vascular Endothelial Growth Factor Inhibitors	4	5
Autophagy Inhibitors	4	4
Brain-derived neurotrophic factor modulator	2	4
Glucagon Like peptide 1 (GLP-1) Up-regulation	2	4
Interferon Gamma Reducer	2	4
Interleukin-10 downregulation	2	4
Matrix metalloproteinase-3 (MMP-3) inhibitor	3	4
Prophylactic Agents	2	4
Prostaglandin PGE2 downregulation	2	4
Anti-Glycation Agents	2	3
Anti-Ulcer Agents	1	3
Anti-atherogenic	2	3
Caspase-3 Activation	2	3
Cytotoxic	3	3
Leishmanicidal	2	3
Photosensitizing Agents	3	3
Vascular Endothelial Growth Factor A Inhibitor	2	3
Alpha-glucosidase inhibitor	2	2
Anti-Androgen	2	2
Anti-Tumor	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Caspase-9 Activation	1	2
Cholinesterase Inhibitors	1	2
Cyclin D1 Down-Regulation	2	2
Enzyme Inhibitors: Pancreatic Amylase	1	2
Enzyme Inhibitors: Pancreatic Lipase	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Fibroblast growth factor 21 upregulation	1	2
Immunosuppressive Agents	1	2
Interleukin-1 alpha downregulation	2	2
Interleukin-2 Downregulation	1	2
Interleukin-22 Downregulation	1	2
Interleukin-4 upregulation	1	2
Iron Chelating Agents	1	2
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	2	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	2
Neuritogenic	1	2
Nitric Oxide Inhibitor	1	2
P21 Activation	2	2
Photoprotective	1	2
Postaglandin PGE2 downregulation	1	2
Wnt/β-catenin pathway down-regulation	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Alpha-amylase inhibitor	1	1
Anti-Allergic Agents	1	1
Anti-Proliferative	1	1
Antioxidant Effects	1	1
Cyclin-dependent kinase inhibitor: P16INK4	1	1
Expectorants	1	1
Fertility Agents: Female	1	1
Gluconeogenesis Inhibitor	1	1
HIV Protease Inhibitors	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Insulin-releasing	1	1
Multidrug Resistance Gene Modulators	1	1
Osteogenic	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Quorum Sensing Inhibition	1	1
RANK Downregulation	1	1
Scolicidal	1	1
Survivin Down-Regulation	1	1
Telomerase Inhibitor	1	1
Tumor Necrosis Factor (TNF) Alpha Enhancer	1	1

Pharmacological Actions : Neuroprotective Agents

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Pubmed Data : Pharmacol Res. 2022 Oct 3 ;185:106481. Epub 2022 Oct 3. PMID: 36195307

Article Published Date : Oct 02, 2022

Study Type : Meta Analysis, Review

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Substances : Berberine

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The effects of berberine supplementation on cardiovascular risk factors in adults.Dec 31, 2021

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Pubmed Data : Front Nutr. 2022 ;9:1013055. Epub 2022 Oct 14. PMID: 36313096

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Pubmed Data : Front Pharmacol. 2021 ;12:653887. Epub 2021 Apr 26. PMID: 33981233

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

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Substances : Berberine

Diseases : Hyperlipidemia, Obesity

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

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Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

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Pubmed Data : Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID: 31410167

Article Published Date : Aug 31, 2019

Study Type : Human Study

Additional Links

Substances : Berberine

Diseases : Bacterial Vaginosis

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Pubmed Data : Am J Cardiol. 2019 Feb 15 ;123(4):588-591. Epub 2018 Nov 23. PMID: 30528419

Article Published Date : Feb 14, 2019

Study Type : Human Study

Additional Links

Substances : Artichoke, Berberine

Diseases : Hypercholesterolemia

Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

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The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

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Pubmed Data : Curr Mol Pharmacol. 2024 Jan 26. Epub 2024 Jan 26. PMID: 38284733

Article Published Date : Jan 25, 2024

Study Type : Human In Vitro

Additional Links

Substances : Berberine, Curcumin

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

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Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts.Dec 31, 2021

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Pubmed Data : ESC Heart Fail. 2022 Dec 1. Epub 2022 Dec 1. PMID: 36453191

Article Published Date : Nov 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, MicroRNA modulator

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High fructose-induced skeletal muscle insulin resistance could be alleviated by berberine.Apr 30, 2023

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Pubmed Data : Food Chem Toxicol. 2023 May ;175:113731. Epub 2023 Mar 15. PMID: 36931587

Article Published Date : Apr 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : High Sugar Diet, Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

Problem Substances : High Fructose Corn Syrup

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Immunomodulatory and anti-inflammatory effects of berberine in lung tissue and its potential application in prophylaxis and treatment of COVID-19.May 19, 2022

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A relatively low dose berberine exhibited strong neuroprotective activity against 6-OHDA-induced neurotoxicity in PC12 cells.Nov 03, 2016

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Pubmed Data : Open Vet J. 2024 Jan ;14(1):292-303. Epub 2024 Jan 31. PMID: 38633147

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Pubmed Data : Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID: 30138605

Article Published Date : Aug 20, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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Atorvastatin-induced intracerebral hemorrhage is inhibited by berberine in zebrafish.Apr 18, 2024

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Berberine alleviates dextran sodium sulfate-induced colitis.May 31, 2017

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Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content.Sep 30, 2021

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Pubmed Data : Saudi Pharm J. 2023 Mar ;31(3):433-443. Epub 2023 Feb 2. PMID: 37026044

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Diabetic Neuropathy

Pharmacological Actions : Gastrointestinal Agents, Neuroprotective Agents

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Berberine ameliorates vascular dysfunction via gut microbiota in hypertension.Jul 19, 2024

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Pubmed Data : Inflammation. 2021 Sep 14. Epub 2021 Sep 14. PMID: 34523052

Article Published Date : Sep 13, 2021

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.Sep 30, 2018

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Pubmed Data : Eur J Pharmacol. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30796904

Article Published Date : Feb 19, 2019

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, NF-kappaB Inhibitor

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Berberine attenuates atherosclerotic lesions and hepatic steatosis.Sep 30, 2021

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Berberine attenuates ischemia-reperfusion injury.Sep 27, 2018

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Pubmed Data : Acta Pharmacol Sin. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30266998

Article Published Date : Sep 27, 2018

Study Type : Animal Study

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Substances : Berberine

Diseases : Cerebral Ischemia

Pharmacological Actions : Neuroprotective Agents

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Berberine attenuates macrophages infiltration in intracranial aneurysms. Dec 31, 2017

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Pubmed Data : J Cell Physiol. 2018 Aug 5. Epub 2018 Aug 5. PMID: 30078229

Article Published Date : Aug 04, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents

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Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.May 31, 2022

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Pubmed Data : Exp Ther Med. 2022 Jun ;23(6):371. Epub 2022 Apr 5. PMID: 35495613

Article Published Date : May 31, 2022

Study Type : Animal Study

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Substances : Berberine

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

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Berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury.Aug 31, 2018

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Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):198-204. PMID: 27222833

Article Published Date : Feb 29, 2016

Study Type : Animal Study

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Substances : Berberine

Diseases : Morphine Tolerance/Dependence

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Berberine can reverse chronic inflammatory pain induced by complete freund's adjuvant and alleviated the comorbid depression.Apr 09, 2018

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2018 Apr 10 ;98(14):1103-1108. PMID: 29690724

Article Published Date : Apr 09, 2018

Study Type : Animal Study

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Substances : Berberine

Diseases : Depression, Hyperalgesia, Inflammation

Pharmacological Actions : Analgesics, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberine can suppress the proliferation of liver cancer cells by reducing SLC1A5 expression.Dec 31, 2018

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Pubmed Data : Cancer Chemother Pharmacol. 2020 Jul ;86(1):151-161. Epub 2020 Jun 30. PMID: 32607786

Article Published Date : Jun 30, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Berberine

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative

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Berberine clears Aβ deposit and consequently ameliorates spatial learning memory impairment.Dec 31, 2018

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Pubmed Data : J Ethnopharmacol. 2024 May 17 ;332:118354. Epub 2024 May 17. PMID: 38762210

Article Published Date : May 16, 2024

Study Type : Animal Study

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Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hypolipidemic

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Berberine hydrochloride improves cognitive deficiency through hippocampal up-regulation of neurotrophins following inhalant self-administration of methamphetamine.Dec 31, 2022

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Pubmed Data : Iran J Basic Med Sci. 2023 Jan ;26(1):23-29. PMID: 36594063

Article Published Date : Dec 31, 2022

Study Type : Animal Study

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Substances : Berberine

Diseases : Amphetamine Addiction/Withdrawal, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

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Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.Dec 17, 2020

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Pubmed Data : Metabolism. 2009 Dec;58(12):1694-702. Epub 2009 Sep 19. PMID: 19767038

Article Published Date : Dec 01, 2009

Study Type : Animal Study

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Substances : Berberine

Diseases : Insulin Resistance

Pharmacological Actions : Hypoglycemic Agents

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Berberine improves inflammatory responses of diabetes mellitus.Dec 31, 2019

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Pubmed Data : J Immunol Res. 2020 ;2020:2141508. Epub 2020 Aug 18. PMID: 32908938

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Berberine

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii.Aug 29, 2023

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Pubmed Data : BMC Complement Med Ther. 2023 Aug 30 ;23(1):303. Epub 2023 Aug 30. PMID: 37649038

Article Published Date : Aug 29, 2023

Study Type : Animal Study

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Substances : Berberine

Diseases : Toxoplasma gondii Infection

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 1079 Abstracts with Berberine Research

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This study suggests that berberine may be a promising alternative for CVDs with no serious adverse reactions.Feb 11, 2023

Berberine, alone or with other nutraceuticals, can provide a modest positive impact on lipid concentrations.May 13, 2023

Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer's disease models.Dec 31, 2022

Effects of berberine and barberry on selected inflammatory biomarkers in adults.Sep 06, 2023

Glucose-lowering effect of berberine on type 2 diabetes.Dec 31, 2021

Neuroprotective effect and possible mechanisms of berberine in diabetes-related cognitive impairment.Dec 31, 2021

Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer's disease.Dec 31, 2022

Pharmacological effects of berberine on models of ulcerative colitis.Dec 31, 2021

Protective effect of berberine in diabetic nephropathy.Oct 02, 2022

The effects of berberine supplementation on cardiovascular risk factors in adults.Dec 31, 2021

A nutraceutical combination has shown to be an effective product for the improvement of the lipid profile.Apr 26, 2016

Berberine and dyslipidemia: different applications and biopharmaceutical formulations without statin-like molecules.Aug 22, 2019

Berberine can improve obesity and hyperlipidemiaDec 31, 2020

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Berberine showed a promising prospect in treating polycystic ovary syndrome patients with insulin resistance.Dec 31, 2017

Berberine supplementation may ameliorate the state of chronic inflammation.Sep 30, 2019

Effects of adjuvant berberine therapy on acute ischemic stroke.Jul 07, 2023

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas.Sep 09, 2021

Overall and sex-specific effect of berberine for the treatment of dyslipidemia in adults.Mar 31, 2023

Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemiaJan 31, 2020

The addition of berberine in standard triple therapy could improve Helicobacter pylori eradication rate and clinical symptom remission rate.Dec 31, 2018

The effect of berberine on metabolic profiles in type 2 diabetic patients.Dec 31, 2020

The effect of berberine supplementation on glycemic control and inflammatory biomarkers in metabolic disorders.Nov 26, 2023

The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders.Mar 28, 2022

The results of the current study support the use of berberine supplementation for the improvement of obesity indices.Apr 30, 2020

These results found a significant reduction in waist-hip ratio following berberine consumption in adults.Feb 29, 2020

This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.Jul 31, 2020

Berberine treats atherosclerosis via a vitamin-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.Jan 06, 2022

A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients. Aug 19, 2009

A nutraceutical formula containing berberine, chlorogenic acid, and tocotrienols was found to improve a large number of metabolic and liver parameters in overweight subjects.Mar 28, 2015

A randomized, dose-finding, proof-of-concept study of berberine ursodeoxycholate in patients with primary sclerosing cholangitis.Oct 31, 2022

Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation.Jan 31, 2019

Berberine can represent a safe novel dietary supplement, helpful in treatment strategy for PCOS.Oct 18, 2021

Berberine Capsule was effective in improving blood lipid level in mild hyperlipidemia patients.May 31, 2016

Berberine containing quadruple therapy could be used for Helicobacter pylori eradication.Jul 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Berberine improves diabetic kidney disease by reducing UACR and serum Cys C in T2DM patients.Dec 10, 2018

Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia.Apr 16, 2023

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy.Feb 01, 2007

Berberine is a potent oral hypoglycemic agent with benefical effects on lipid metabolism, comparable in efficacy to metformin. May 01, 2008

Berberine is a promising treatment for lowering cholesterol.Jul 25, 2021

Berberine is efficacious for the treatment of atrial fibrillation.Dec 31, 2016

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.Oct 06, 2009

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.Aug 31, 2018

Berberine was safe and effective in reducing the risk of recurrence of colorectal adenoma.Jan 07, 2020

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients.Dec 31, 2021

Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.Feb 14, 2019

Effect of berberine hydrochloride on the diversity of intestinal flora in Parkinson's disease patients.Dec 31, 2021

Effect of berberine on activation of TLR4-NFκB signaling pathway and NLRP3 inflammasome in patients with gout.Sep 19, 2022

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery.Dec 31, 2022

Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes.Sep 06, 2023

Findings suggest that berberine is effective in attenuating antipsychotic-associated weight gain and MetS.Dec 20, 2021

Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine.Dec 31, 2021

Hop rho iso-alpha acids, berberine, vitamin D(3) and vitamin K (1) favorably impact biomarkers of bone turnover in postmenopausal women. Dec 19, 2009

Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia.Jan 16, 2022

Preventive effect of berberine on postoperative atrial fibrillation.Sep 30, 2022

Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.Feb 29, 2020

The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.Mar 31, 2019

The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus.Aug 22, 2022

The potential prebiotic berberine combined with methimazole improved the therapeutic effect of Graves' disease patients.Dec 31, 2020

The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome.Dec 31, 2019

This study suggests that berberine is a potential weight loss and weight maintenance drug for patients with schizophrenia.Dec 31, 2021

Berberine alleviates myocardial ischemia-reperfusion injury.Nov 30, 2022

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

Berberine protects against dihydrotestosterone-induced human ovarian granulosa cell injury and ferroptosis.Dec 27, 2023

Berberine suppressed the progression of human glioma cells.Dec 31, 2021

Curcumin and berberine arrest maturation and activation of dendritic cells derived from Lupus erythematosus patients.Jan 25, 2024

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts.Dec 31, 2021

These findings indicate that the protective effects of low-dose BBR against DOX-induced cardiotoxicity are mediated by Bcl-xL.Apr 29, 2022

Berberine

View the Evidence:
1079 Abstracts with Berberine Research