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60 Diseases Researched for Adlay
NameACCKFocus
Chemotherapy and Radiation Toxicity110Locked
Dermatitis110Locked
Colon Cancer68Locked
Inflammation78Locked
Lung Cancer57Locked
Nonalcoholic fatty liver disease (NAFLD)37Locked
Obesity47Locked
Diabetes Mellitus: Type 236Locked
Hyperlipidemia36Locked
Allergies35Locked
Cancers: All55Locked
Hypertension45Locked
Lipopolysaccharide-Induced Toxicity55Locked
High Fat Diet24Locked
Oxidative Stress34Locked
Hyperuricemia23Locked
Lipid Peroxidation23Locked
Aging12Locked
Breast Cancer22Locked
Breast Cancer: Triple Negative 22Locked
Cachexia: Cancer12Locked
Carcinoma: Non-Small-Cell Lung22Locked
Cervical Cancer22Locked
Chronic Disease12Locked
Colitis12Locked
Dysmenorrhea12Locked
Gastric Cancer12Locked
Gastric Ulcer12Locked
High Cholesterol12Locked
Hypercholesterolemia12Locked
Influenza B 22Locked
Insulin Resistance12Locked
Leukemia12Locked
Metabolic Diseases12Locked
Osteoporosis12Locked
Pancreatic Cancer22Locked
Rheumatoid Arthritis12Locked
Snake Bite: Venom Toxicity 12Locked
Alzheimer's Disease11Locked
Asthma11Locked
Cancer Metastasis11Locked
Cancers: Drug Resistant11Locked
Cancers: Multi-Drug Resistant11Locked
Celiac Disease11Locked
Colorectal Cancer11Locked
Endometrial Cancer11Locked
Glaucoma11Locked
Inflammatory Bowel Diseases11Locked
Influenza A11Locked
Irritable Bowel Syndrome11Locked
Leiomyoma11Locked
Liver Cancer11Locked
Lung Injury: Smoke-Induced11Locked
Melanoma11Locked
Metabolic Syndrome X11Locked
Mycotoxin Toxicity11Locked
Oral Cancer11Locked
Testosterone: Too High11Locked
Toxoplasma gondii Infection11Locked
Uterine Cancer 11Locked
47 Pharmacological Actions Researched for Adlay
NameACCKFocus
Anti-Inflammatory Agents2129Locked
Gastrointestinal Agents825Locked
Antioxidants1320Locked
Antiproliferative 1617Locked
Immunomodulatory516Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1116Locked
Hypoglycemic Agents510Locked
Radioprotective110Locked
Apoptotic99Locked
Hypolipidemic49Locked
Interleukin-6 Downregulation69Locked
Cyclooxygenase 2 Inhibitors68Locked
Anti-Allergic Agents47Locked
Hepatoprotective37Locked
Cell cycle arrest66Locked
Chemopreventive46Locked
Chemotherapeutic46Locked
Interleukin-1 beta downregulation36Locked
Superoxide Dismutase Up-regulation36Locked
Antihypertensive Agents34Locked
Antineoplastic Agents34Locked
Malondialdehyde Down-regulation24Locked
NF-kappaB Inhibitor44Locked
Enzyme Inhibitors23Locked
Gastroprotective23Locked
Interleukin-4 downregulation23Locked
Nitric Oxide Inhibitor33Locked
Protein Kinase Inhibitors23Locked
Anti-Apoptotic22Locked
Anti-Cachexic Agents12Locked
Anti-metastatic22Locked
Anticarcinogenic Agents12Locked
Anticholesteremic Agents12Locked
Antiviral Agents22Locked
Cytotoxic12Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor12Locked
Osteoprotective 12Locked
Prophylactic Agents12Locked
Uricosuric Agents12Locked
interleukin-13 down-regulation12Locked
Analgesics11Locked
Antimutagenic Agents11Locked
Autophagy Inhibitors11Locked
Chemosensitizer11Locked
Neuroprotective Agents11Locked
Nrf2 activation11Locked
Xanthine oxidase inhibitor11Locked

View the Evidence:
79 Abstracts with Adlay Research

[+]

Coix seed consumption affects the gut microbiota and the peripheral lymphocyte subset profiles of healthy male adults.Nov 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Nov 15 ;13(11). Epub 2021 Nov 15. PMID: 34836336
Article Published Date : Nov 14, 2021
Study Type : Human Study
Additional Links
Substances : Adlay
Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory
[+]

Prophylactic treatment with adlay bran extract reduces the risk of severe acute radiation dermatitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:312072. Epub 2015 Oct 1. PMID: 26495009
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Adlay
Diseases : Chemotherapy and Radiation Toxicity, Dermatitis
Pharmacological Actions : Radioprotective
[+]

Adlay polyphenol improves hepatic glucose and lipid homeostasis.Oct 09, 2022

Pubmed Data : Mol Nutr Food Res. 2022 Oct 10:e2200447. Epub 2022 Oct 10. PMID: 36214059
Article Published Date : Oct 09, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Adlay
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic
[+]

Adlay and cisplatin led to pronounced antitumor activity in mice with Lewis lung carcinoma.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Public Health. 2018 Jun ;47(6):838-843. PMID: 30087869
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Lung Cancer
Pharmacological Actions : Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Immunomodulatory
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.Jul 13, 2010

Pubmed Data : J Agric Food Chem. 2010 Jul 14 ;58(13):7616-23. PMID: 20536243
Article Published Date : Jul 13, 2010
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Adlay, Anti-Inflammatory Agents, Chemopreventive, COLON CANCER, Cyclooxygenase 2 Inhibitors, Plant Extracts
[+]

Adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses.Sep 30, 2012

Pubmed Data : Food Chem Toxicol. 2012 Oct ;50(10):3808-13. Epub 2012 Jul 15. PMID: 22809477
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents, Immunomodulatory
Additional Keywords : Adlay, allergies, Anti-Allergic Agents, Immunomodulatory, Plant Extracts
[+]

Adlay bran extract reduced the release of histamines and cytokines and suppressed the production of Akt.May 06, 2012

Pubmed Data : J Ethnopharmacol. 2012 May 7 ;141(1):119-27. Epub 2012 Feb 14. PMID: 22353428
Article Published Date : May 06, 2012
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Leukemia
Pharmacological Actions : Anti-Allergic Agents, Interleukin-4 downregulation, Interleukin-6 Downregulation, Protein Kinase Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Adlay, Anti-Allergic Agents, Interleukin-4 downregulation, leukemia, Phytotherapy, Plant Extracts
[+]

Adlay bran oil displays a potential for improving hyperlipidemia and hyperglycemia in diabetes.Dec 31, 2018

Pubmed Data : J Med Food. 2019 Jan ;22(1):22-28. PMID: 30673500
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Diabetes Mellitus: Type 2, Hyperlipidemia, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Phytotherapy
[+]

Adlay may be a helpful healthy food for osteoporosis prevention.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2013 Apr ;3(2):134-8. PMID: 24716168
Article Published Date : Mar 31, 2013
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Adlay seed extracts exhibit a prophylactic effect on diet-induced metabolic dysfunction and nonalcoholic fatty liver disease.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:9519625. Epub 2020 May 29. PMID: 32595752
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Metabolic Diseases, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Prophylactic Agents
[+]

Changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus-fermented adlay.Aug 31, 2011

Pubmed Data : J Sci Food Agric. 2011 Sep ;91(12):2271-6. Epub 2011 May 26. PMID: 21618546
Article Published Date : Aug 31, 2011
Study Type : Animal Study
Additional Links
Substances : Adlay, Fermented Foods and Beverages
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Hypolipidemic, Superoxide Dismutase Up-regulation
[+]

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund's adjuvant-induced rheumatoid arthritis model.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):792-798. PMID: 31747811
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Coix lacryma-jobi seed oil reduces fat accumulation in nonalcoholic fatty liver disease.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oleo Sci. 2021 May 1 ;70(5):685-696. Epub 2021 Apr 12. PMID: 33840662
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Coix seed diet ameliorates immune function disorders in experimental colitis mice.Dec 27, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Dec 28 ;14(1). Epub 2021 Dec 28. PMID: 35010997
Article Published Date : Dec 27, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Coix seed extract may act directly on body tissues to exert anti-inflammatory effects.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:939423. Epub 2022 Jul 18. PMID: 35923203
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay, Bifidobacterium, Probiotics
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
Additional Keywords : Natural Substance Synergy
[+]

Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis.Oct 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2019 Oct 15 ;19(1):267. Epub 2019 Oct 15. PMID: 31615487
Article Published Date : Oct 14, 2019
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Cachexia: Cancer
Pharmacological Actions : Anti-Cachexic Agents, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Coix seed oil prolongs lifespan and enhances stress resistance in Caenorhabditis elegans.Dec 31, 2019

Pubmed Data : Biogerontology. 2020 04 ;21(2):245-256. Epub 2020 Jan 20. PMID: 31960183
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Aging
[+]

Coix seed polysaccharides alleviate type 2 diabetes mellitus via gut microbiota.Jan 11, 2021

Pubmed Data : Food Res Int. 2021 12 ;150(Pt A):110717. Epub 2021 Oct 4. PMID: 34865748
Article Published Date : Jan 11, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Polysaccharides
[+]

Coix seed-based milk fermented with Limosilactobacillus reuteri improves lipid metabolism and gut microbiota.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:921255. Epub 2022 Jul 12. PMID: 35903451
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay, Milk: Fermented
Diseases : High Fat Diet
Pharmacological Actions : Gastrointestinal Agents, Hypolipidemic
[+]

Consuming of dehulled adlay could be a beneficial dietary approach for people at risk of hypertension.Jul 03, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Jul 4 ;13(7). Epub 2021 Jul 4. PMID: 34371815
Article Published Date : Jul 03, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Hypertension, Obesity
Pharmacological Actions : Antihypertensive Agents
[+]

Effect of polysaccharides from adlay seed on anti-diabetic and gut microbiota.Jul 16, 2019

Pubmed Data : Food Funct. 2019 Jul 17 ;10(7):4372-4380. PMID: 31276140
Article Published Date : Jul 16, 2019
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Gastrointestinal Agents, Hypoglycemic Agents
Additional Keywords : Polysaccharides
[+]

Effects of Coix seed extract, Lactobacillus paracasei K56, and their combination on the glycolipid metabolism in obesity.Feb 28, 2023

Pubmed Data : J Food Sci. 2023 Mar ;88(3):1197-1213. Epub 2023 Jan 30. PMID: 36717373
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Adlay, Lactobacillus paracasei
Diseases : Chronic Disease, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ethanolic extracts of adlay testa and hull and their active biomolecules exert relaxing effect on uterine muscle contraction.Jun 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 Jun 15 ;11(6). Epub 2021 Jun 15. PMID: 34203783
Article Published Date : Jun 14, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Adlay
Diseases : Dysmenorrhea
[+]

Gastroprotective activities of adlay on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.Jun 07, 2011

Pubmed Data : J Agric Food Chem. 2011 Jun 8 ;59(11):6025-33. Epub 2011 May 5. PMID: 21517098
Article Published Date : Jun 07, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Adlay
Diseases : Gastric Cancer, Gastric Ulcer
Pharmacological Actions : Antioxidants, Antiproliferative , Gastroprotective
Additional Keywords : Adlay, Antioxidants, Antiproliferative, gastric cancer, Gastric Ulcer, Gastroprotective, Plant Extracts
[+]

In vitro and in vivo studies on adlay-derived seed extracts.Aug 05, 2014

Pubmed Data : J Agric Food Chem. 2014 Aug 6 ;62(31):7771-8. Epub 2014 Jul 24. PMID: 25029106
Article Published Date : Aug 05, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Adlay
Diseases : Hyperuricemia
Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Uricosuric Agents
Additional Keywords : Plant Extracts
[+]

Modulation of gut microbiota by polyphenols from adlay in rats fed a high-cholesterol diet.Dec 31, 2014

Pubmed Data : Int J Food Sci Nutr. 2015 ;66(7):783-9. Epub 2015 Sep 25. PMID: 26406384
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : High Cholesterol, High Fat Diet
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Neutralization of Naja naja venom induced lethality, edema and myonecrosis by ethanolic root extract of Coix lacryma-jobi.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2017 ;4:637-645. Epub 2017 Nov 24. PMID: 29234602
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Snake Bite: Venom Toxicity
[+]

Protective effect of polyphenols extract of adlay on hypercholesterolemia-induced oxidative stress.Jul 25, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2012 Jul 26 ;17(8):8886-97. Epub 2012 Jul 26. PMID: 22836208
Article Published Date : Jul 25, 2012
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Hypercholesterolemia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticholesteremic Agents, Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Adlay, Anticholesteremic Agents, Antioxidants, Hypercholesterolemia, Lipid Peroxidation, oxidative stress
[+]

Suppression on allergic airway inflammation of dehulled adlay.Dec 12, 2021

Pubmed Data : Food Funct. 2021 Dec 13 ;12(24):12788-12799. Epub 2021 Dec 13. PMID: 34854443
Article Published Date : Dec 12, 2021
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Allergies, Inflammation
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

The results showed that adlay seed oil had blood lipid-reducing and antioxidant effects.Aug 14, 2011

Pubmed Data : J Sci Food Agric. 2011 Aug 15 ;91(10):1843-8. Epub 2011 Mar 30. PMID: 21452173
Article Published Date : Aug 14, 2011
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Adlay, Antioxidants, hyperlipidemia, Phytotherapy, Plant Extracts
[+]

These findings suggest the possibility that adlay bran and its ethanolic extract and residue inhibit colonic preneoplastic lesions in an early stage.Jan 31, 2011

Pubmed Data : J Sci Food Agric. 2011 Feb ;91(3):547-52. Epub 2010 Nov 19. PMID: 21218491
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Adlay, Anticarcinogenic Agents, Chemopreventive, COLON CANCER, Plant Extracts
[+]

Triterpene-loaded microemulsion using adlay seed extract as oil phase for enhanced antitumor efficacy.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2014 ;9:109-19. Epub 2013 Dec 19. PMID: 24379669
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Adlay, Reishi Mushroom
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic, Cytotoxic
Additional Keywords : Natural Substance Synergy, Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

A comparative study on hulled adlay and unhulled adlay through evaluation of their LPS-induced anti-inflammatory effects.Feb 28, 2015

Pubmed Data : Chem Biodivers. 2015 Mar ;12(3):380-7. PMID: 25766911
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor
Additional Keywords : Plant Extracts
[+]

A novel antihypertensive derived from Adlay.Jan 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Jan 13 ;22(1). Epub 2017 Jan 13. PMID: 28098801
Article Published Date : Jan 12, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
Additional Keywords : Plant Extracts
[+]

A polysaccharide fraction of adlay seed induces apoptosis in human non-small cell lung cancer A549 cells.Jan 10, 2013

Pubmed Data : Biochem Biophys Res Commun. 2013 Jan 11 ;430(2):846-51. Epub 2012 Nov 27. PMID: 23200838
Article Published Date : Jan 10, 2013
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Adlay bran ethanolic extract has antiproliferative activities.Feb 22, 2011

Pubmed Data : J Agric Food Chem. 2011 Feb 23 ;59(4):1185-94. Epub 2011 Feb 1. PMID: 21284381
Article Published Date : Feb 22, 2011
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
Additional Keywords : Adlay, Antiproliferative, Breast Cancer, Breast Cancer: Triple Negative
[+]

Adlay bran free phenolic extract would be a promising agent for preventing and treating hyperuricemia.Jun 30, 2018

Pubmed Data : Food Chem. 2018 Jul 1 ;253:108-118. PMID: 29502809
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Hyperuricemia
Pharmacological Actions : Xanthine oxidase inhibitor
[+]

Adlay ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin.Jul 31, 2018

Pubmed Data : Phytomedicine. 2018 Aug 1 ;47:69-80. Epub 2018 Mar 21. PMID: 30166110
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Uterine Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Adlay hull extract fraction could be considered as a natural plant-based medicine in the prevention or treatment of uterine leiomyoma growth.Apr 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 19 ;24(8). Epub 2019 Apr 19. PMID: 31010220
Article Published Date : Apr 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Leiomyoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Plant Extracts
[+]

Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells.Jun 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2021 Jul ;26:101020. Epub 2021 May 18. PMID: 34041372
Article Published Date : Jun 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Adlay is a potential chemopreventive TCM to block multistage carcinogenesis with anti-initiation, promotion and progression properties.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2012 Oct ;2(4):267-75. PMID: 24716141
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Adlay
Diseases : Cancers: All
Pharmacological Actions : Antioxidants, Antiproliferative , Chemopreventive, Nrf2 activation
Additional Keywords : Adlay, Antioxidants, Antiproliferative, Cancers: All, Chemopreventive, Nrf2 activation
[+]

Adlay seed ethanolic extract fractions and subfractions induce cell cycle arrest and apoptosis in human breast and cervical cancer cell lines.Jun 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 21 ;27(13). Epub 2022 Jun 21. PMID: 35807238
Article Published Date : Jun 20, 2022
Study Type : In Vitro Study
Additional Links
Substances : Adlay, Quercetin
Diseases : Breast Cancer, Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Adlay seed extract decreased adipocyte differentiation and increased glucose uptake.Nov 30, 2010

Pubmed Data : J Med Food. 2010 Dec ;13(6):1331-9. PMID: 21091246
Article Published Date : Nov 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Metabolic Syndrome X, Obesity
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Adlay sprout extract has anti-metastatic activity in colon cancer cells in vitro.Nov 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Nov 6 ;17(1):486. Epub 2017 Nov 6. PMID: 29110726
Article Published Date : Nov 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative
Additional Keywords : Plant Extracts
[+]

Adlay sprout extract induces cell cycle arrest and apoptosis in human cervical carcinoma cells.Nov 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2019 Nov 15 ;19(1):312. Epub 2019 Nov 15. PMID: 31729992
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Adlay testa has antioxidative and anti-inflammatory activities.Mar 24, 2009

Pubmed Data : J Agric Food Chem. 2009 Mar 25 ;57(6):2259-66. PMID: 19243096
Article Published Date : Mar 24, 2009
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation, Lipid Peroxidation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Adlay-based attenuation of trichothecene-induced gut distress has potential use as a new gut protector against enteropathogenic insults in diets.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:186. Epub 2018 Feb 23. PMID: 29527203
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Mycotoxin Toxicity
Pharmacological Actions : Gastroprotective
[+]

Anti-cancer properties of coix seed oil against HT-29 colon cells.Nov 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Nov 17 ;10(11). Epub 2021 Nov 17. PMID: 34829119
Article Published Date : Nov 16, 2021
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran.Jun 14, 2011

Pubmed Data : Food Chem. 2011 Jun 15 ;126(4):1741-8. Epub 2010 Dec 19. PMID: 25213953
Article Published Date : Jun 14, 2011
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Adlay, Anti-Inflammatory Agents, Inflammation
[+]

Anti-influenza virus activity of adlay tea components.Nov 14, 2019

Pubmed Data : Plant Foods Hum Nutr. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31728799
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Influenza B
Pharmacological Actions : Antiviral Agents
[+]

Antimutagenic constituents of adlay with potential cancer chemopreventive activity.Jun 21, 2011

Pubmed Data : J Agric Food Chem. 2011 Jun 22 ;59(12):6444-52. Epub 2011 May 17. PMID: 21561091
Article Published Date : Jun 21, 2011
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Cancers: All
Pharmacological Actions : Antimutagenic Agents, Chemopreventive
Additional Keywords : Adlay, Antimutagenic Agents, Cancers: All, Chemopreventive
[+]

Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran.Feb 14, 2014

Pubmed Data : Food Chem. 2014 Feb 15 ;145:445-53. Epub 2013 Aug 27. PMID: 24128500
Article Published Date : Feb 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Adlay, Anti-Inflammatory Agents, Inflammation, Lipopolysaccharide-Induced Toxicity, Plant Extracts
[+]

Coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells.Oct 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 23 ;20(21). Epub 2019 Oct 23. PMID: 31652737
Article Published Date : Oct 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Coix seed oil regulates mitochondrial functional damage to induce apoptosis of human pancreatic cancer.Jun 30, 2022

Pubmed Data : Mol Biol Rep. 2022 Jul ;49(7):5897-5909. Epub 2022 May 11. PMID: 35543827
Article Published Date : Jun 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic
[+]

Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells.Dec 31, 2014

Pubmed Data : Arch Pharm Res. 2015 ;38(5):620-7. Epub 2014 Apr 15. PMID: 24733673
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Coixol is a promising effective lead compound for the treatment of toxoplasmosis.Apr 30, 2023

Pubmed Data : Int Immunopharmacol. 2023 May ;118:110031. Epub 2023 Mar 16. PMID: 36933491
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Toxoplasma gondii Infection
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Coixol suppresses NF-κB, MAPK pathways and NLRP3 inflammasome activation in lipopolysaccharide-induced RAW 264.7 cells.Feb 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Feb 18 ;25(4). Epub 2020 Feb 18. PMID: 32085388
Article Published Date : Feb 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Compounds in adlay seed hull extracts inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages.Nov 24, 2009

Pubmed Data : J Agric Food Chem. 2009 Nov 25 ;57(22):10651-7. PMID: 19886607
Article Published Date : Nov 24, 2009
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Discovery of anti-hypertensive oligopeptides from Adlay.Dec 13, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Dec 14 ;17(12). Epub 2016 Dec 14. PMID: 27983650
Article Published Date : Dec 13, 2016
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

Effect of adlay hull extracts on testosterone release from rat Leydig cells.Apr 30, 2009

Pubmed Data : Phytother Res. 2009 May ;23(5):687-95. PMID: 19107733
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Testosterone: Too High
Pharmacological Actions : Protein Kinase Inhibitors
Additional Keywords : Plant Extracts
[+]

Enhancement of anti-proliferative activity of the extracts from dehulled adlay by fermentation with Bacillus subtilis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2021 Dec 1 ;10(12). Epub 2021 Dec 1. PMID: 34945511
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Adlay, Fermented Foods and Beverages
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Fermentation with L. plantarum NCU137 could improve the nutritional, sensory and stability properties of coix seed.May 31, 2020

Pubmed Data : Food Chem. 2020 Jun 1 ;314:126037. Epub 2019 Dec 17. PMID: 31954941
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Adlay, Fermented Foods and Beverages, Lactobacillus plantarum
[+]

Gibberella moniliformis AH13 with antitumor activity, an endophytic fungus strain producing triolein isolated from Adlay.Aug 31, 2014

Pubmed Data : Curr Microbiol. 2014 Sep ;69(3):381-7. Epub 2014 May 9. PMID: 24810291
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Breast Cancer: Triple Negative , Cancers: All, Colon Cancer, Lung Cancer
Pharmacological Actions : Antineoplastic Agents
[+]

Isolation and identification of anti-inflammatory and analgesic polysaccharides from Coix seed.Dec 29, 2022

Pubmed Data : Nat Prod Res. 2022 Dec 30:1-10. Epub 2022 Dec 30. PMID: 36584288
Article Published Date : Dec 29, 2022
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Polysaccharides
[+]

Kanglaite inhibits EMT caused by TNF-α via NF-κΒ inhibition in colorectal cancer cells.Jan 22, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Jan 23 ;9(6):6771-6779. Epub 2017 Dec 22. PMID: 29467927
Article Published Date : Jan 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

MA would be a beneficial nutritional therapy to ameliorate cigarette smoke induced lung injuryJan 14, 2013

Pubmed Data : Food Chem. 2013 Jan 15 ;136(2):765-74. Epub 2012 Aug 16. PMID: 23122125
Article Published Date : Jan 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Lung Injury: Smoke-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Autophagy Inhibitors
Additional Keywords : Plant Extracts
[+]

Melanogenesis inhibitors from Coix lacryma-jobi seeds in B16-F10 melanoma cells.Nov 30, 2017

Pubmed Data : Nat Prod Res. 2017 Dec ;31(23):2712-2718. Epub 2017 Feb 16. PMID: 28278663
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Melanoma
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Plant Extracts
[+]

Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 NSCLC cells via targeting S100A4.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Jan ;15(1):309-316. Epub 2016 Dec 5. PMID: 27922683
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Cancer Metastasis, Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Polysaccharides
[+]

Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growthAug 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Aug 24 ;7(1):9373. Epub 2017 Aug 24. PMID: 28839202
Article Published Date : Aug 23, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Phytochemical profiles and antioxidant activity of adlay varieties.May 28, 2013

Pubmed Data : J Agric Food Chem. 2013 May 29 ;61(21):5103-13. Epub 2013 May 16. PMID: 23647066
Article Published Date : May 28, 2013
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Adlay, Antioxidants, oxidative stress, Plant Extracts
[+]

Potent in vitro anti-mouth cancer and immunostimulating activities of adlay seed.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oleo Sci. 2019 ;68(4):351-359. PMID: 30930371
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Adlay, Linoleic acid
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Immunomodulatory
[+]

Rho-kinase inhibitors from adlay seeds.Jul 18, 2017

Pubmed Data : Nat Prod Res. 2017 Jul 19:1-5. Epub 2017 Jul 19. PMID: 28722478
Article Published Date : Jul 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Cancers: All, Glaucoma, Hypertension
Pharmacological Actions : Enzyme Inhibitors
[+]

Several adlay seed fractions demonstrate an antiproliferative effect on endometrial cancer cells.Mar 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Mar 31 ;26(7). Epub 2021 Mar 31. PMID: 33807346
Article Published Date : Mar 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Endometrial Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest
[+]

Structural characterization of phenolic compounds and antioxidant activity of the phenolic-rich fraction from defatted adlay.Mar 31, 2016

Pubmed Data : Food Chem. 2016 Apr 1 ;196:509-17. Epub 2015 Sep 25. PMID: 26593521
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

The results of the present study demonstrate that adlay tea had antiviral effects against influenza viruses.Feb 28, 2018

Pubmed Data : J Sci Food Agric. 2018 Mar ;98(5):1899-1905. Epub 2017 Oct 12. PMID: 28902408
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Influenza A, Influenza B
Pharmacological Actions : Antiviral Agents
[+]

These results suggest that ethanolic extracts of adlay had an inhibitory effect on allergic response.Feb 23, 2010

Pubmed Data : J Agric Food Chem. 2010 Feb 24 ;58(4):2596-601. PMID: 20102206
Article Published Date : Feb 23, 2010
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Interleukin-4 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Adlay, allergies, Anti-Allergic Agents, Anti-Inflammatory Agents, Plant Extracts
[+]

This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the adlay liposomal formulation.Mar 31, 2019

Pubmed Data : J Nanosci Nanotechnol. 2019 Apr 1 ;19(4):1996-2007. PMID: 30486940
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Total polysaccharides of adlay bran improve TNF-α induced epithelial barrier dysfunction in Caco-2 cells.May 21, 2019

Pubmed Data : Food Funct. 2019 May 22 ;10(5):2906-2913. PMID: 31070650
Article Published Date : May 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Celiac Disease, Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ultrasonic polysaccharides isolated from adlay have immune potentiation effects on macrophages.Aug 31, 2015

Pubmed Data : Int J Biol Macromol. 2015 Sep ;80:246-52. Epub 2015 Jun 27. PMID: 26123819
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Pharmacological Actions : Immunomodulatory, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides

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