Drug: Omeprazole

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4 Problem Substances Researched for Drug: Omeprazole

Name	AC	CK	Focus
Omeprazole (trade name Prilosec)	5	34
Proton-Pump Inhibitors	6	27
Histamine Receptor Antagonists	2	12
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	2

27 Diseases Researched for Drug: Omeprazole

Name	AC	CK	Focus
Helicobacter Pylori Infection	3	21
Dyspepsia	2	20
Gastric Ulcer	4	15
Acid Reflux	2	11
Magnesium Deficiency	2	11
Vitamin C Deficiency	2	11
Childhood Infections	1	10
Duodenal Ulcer	1	10
Gastroenteritis	1	10
Gastroesophageal Reflux	1	10
Infection: In Infants & Children	1	10
Neutropenia	1	10
Neutropenia: Drug-Induced	1	10
Pneumonia	1	10
Seizures	1	10
Gastric Cancer	3	6
Oxidative Stress	2	4
Alcohol Toxicity	1	2
Drug-Induced Toxicity: Indomethacin	1	2
NSAID-induced toxicity	1	2
Wound Healing	1	2
Anemia: Iron Deficiency	1	1
Delirium: Drug-Induced	1	1
Myopathies	1	1
Polymyositis	1	1
Rhabdomyolysis	1	1
Vitamin B 12 Deficiency	1	1

3 Adverse Pharmacological Actions Researched for Drug: Omeprazole

Name	AC	CK	Focus
Immunosuppressive	1	10
Immunotoxic	1	10
Carcinogen	1	2

8 Substances Researched for Drug: Omeprazole

Name	AC	CK	Focus
Melatonin	1	10
Nigella sativa (aka Black Seed)	1	10
Vitamin C	1	10
Citrus Peel	1	2
Hesperidin	1	2
Kombucha Tea	1	2
Orange	1	2
Tea	1	2

7 Pharmacological Actions Researched for Drug: Omeprazole

Name	AC	CK	Focus
Anti-Ulcer Agents	4	24
Anti-Bacterial Agents	2	20
Antioxidants	2	4
Cyclooxygenase 2 Inhibitors	1	2
Malondialdehyde Down-regulation	1	2
Superoxide Dismutase Up-regulation	1	2
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	2

Research Articles 17
Cumulative Knowledge Score 27
Overall Research Rating GOOD

View the Evidence:
17 Abstracts with Drug: Omeprazole Research

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[+]

Adding vitamin C to one-week triple therapy can reduce the dosage of clarithromycin, but preserve the high eradication efficacy for clarithromycin susceptible H. pylori infection.Jan 01, 2007

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Pubmed Data : Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 17419283

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Duodenal Ulcer, Gastric Ulcer, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents

Additional Keywords : Drug: Amoxicillin, Drug: Omeprazole

[+]

Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.Jul 01, 2010

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Pubmed Data : Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. PMID: 20616418

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Dyspepsia, Helicobacter Pylori Infection

Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents

Additional Keywords : Drug: Amoxicillin, Drug: Omeprazole, Drug-Plant-Vitamin Synergies, Natural Substances Versus Drugs, Plant Extracts

[+]

Melatonin has a role in the improvement of gastroesophageal reflux disease.Jan 01, 2010

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Pubmed Data : BMC Gastroenterol. 2010;10:7. Epub 2010 Jan 18. PMID: 20082715

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Gastroesophageal Reflux

Additional Keywords : Drug: Omeprazole

[+]

Proton pump inhibitor-induced neutropenia has been reported.Jan 01, 2010

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Pubmed Data : Clin Drug Investig. 2010;30(8):559-63. PMID: 20586518

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Neutropenia, Neutropenia: Drug-Induced

Additional Keywords : Drug: Omeprazole

Adverse Pharmacological Actions : Immunotoxic

[+]

Proton pump inhibitors reduce the bioavailability of dietary vitamin C.Sep 15, 2005

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Pubmed Data : Aliment Pharmacol Ther. 2005 Sep 15;22(6):539-45. PMID: 16167970

Article Published Date : Sep 15, 2005

Study Type : Human Study

Additional Links

Diseases : Vitamin C Deficiency

Additional Keywords : Drug: Omeprazole

Problem Substances : Omeprazole (trade name Prilosec), Proton-Pump Inhibitors

[+]

Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy, indicating the drug causes rebound acid hypersecretion (RAHS).Jul 01, 2009

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Pubmed Data : Gastroenterology. 2009 Jul;137(1):80-7, 87.e1. Epub 2009 Apr 10. PMID: 19362552

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Diseases : Acid Reflux, Dyspepsia

Additional Keywords : Drug: Omeprazole

Problem Substances : Omeprazole (trade name Prilosec)

[+]

Severe hypomagnesaemia and subsequent seizure has been reported in long-term users of proton-pump inhibitors.Aug 01, 2008

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Pubmed Data : Clin Endocrinol (Oxf). 2008 Aug;69(2):338-41. Epub 2008 Jan 23. PMID: 18221401

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Diseases : Magnesium Deficiency, Seizures

Additional Keywords : Drug: Omeprazole

Problem Substances : Omeprazole (trade name Prilosec)

[+]

Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.May 01, 2006

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Pubmed Data : Pediatrics. 2006 May;117(5):e817-20. PMID: 16651285

Article Published Date : May 01, 2006

Study Type : Human Study

Additional Links

Diseases : Childhood Infections, Gastroenteritis, Infection: In Infants & Children , Pneumonia

Additional Keywords : Drug: Omeprazole

Problem Substances : Histamine Receptor Antagonists, Proton-Pump Inhibitors

Adverse Pharmacological Actions : Immunosuppressive

[+]

Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.Nov 30, 2010

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Pubmed Data : Food Funct. 2010 Dec ;1(3):284-93. Epub 2010 Nov 3. PMID: 21776478

Article Published Date : Nov 30, 2010

Study Type : Animal Study

Additional Links

Substances : Kombucha Tea, Tea

Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer, NSAID-induced toxicity , Oxidative Stress, Wound Healing

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants

Additional Keywords : Drug: Indomethacin, Drug: Omeprazole, Plant Extracts

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Histamine receptor antagonists and proton pump inhibitors cause gastric hyperplasia and cancer in rats.Jan 01, 1988

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Pubmed Data : Toxicol Pathol. 1988;16(2):288-98. PMID: 2903544

Article Published Date : Jan 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Additional Keywords : Drug: Omeprazole

Problem Substances : Histamine Receptor Antagonists, Omeprazole (trade name Prilosec), Proton-Pump Inhibitors

[+]

Long-term exposure to rats with the proton pump inhibitor omeprazole resulted in hypergastrinaemia and gastric cancer.Jan 01, 1986

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Pubmed Data : Scand J Gastroenterol Suppl. 1986;118:31-8. PMID: 3460170

Article Published Date : Jan 01, 1986

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Additional Keywords : Drug: Omeprazole

Problem Substances : Omeprazole (trade name Prilosec), Proton-Pump Inhibitors

Adverse Pharmacological Actions : Carcinogen

[+]

Long-term proton pump inhibitor exposure cause gastric cancer in rats.Jan 01, 1986

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Pubmed Data : Digestion. 1986;35 Suppl 1:42-55. PMID: 3792671

Article Published Date : Jan 01, 1986

Study Type : Animal Study

Additional Links

Diseases : Gastric Cancer

Additional Keywords : Drug: Omeprazole

Problem Substances : Proton-Pump Inhibitors

[+]

Protective effects of orange peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol.Aug 13, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2017 Aug 14 ;16(1):152. Epub 2017 Aug 14. PMID: 28806973

Article Published Date : Aug 13, 2017

Study Type : Animal Study

Additional Links

Substances : Citrus Peel , Hesperidin, Orange

Diseases : Alcohol Toxicity , Gastric Ulcer, Oxidative Stress

Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Drug: Omeprazole, Plant Extracts

[+]

Magnesium deficiency is an under-reported and potentially serious side effect of proton pump inhibitors.Jan 01, 2009

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Pubmed Data : Ned Tijdschr Geneeskd. 2009;153:A711. PMID: 19930736

Article Published Date : Jan 01, 2009

Study Type : Commentary

Additional Links

Diseases : Acid Reflux, Gastric Ulcer, Magnesium Deficiency

Additional Keywords : Drug: Omeprazole

[+]

Proton pump inhibitor-induced rhabdomyolysis and hyponatremic delirium has been reported.May 01, 2008

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Pubmed Data : Am J Emerg Med. 2008 May;26(4):519.e1-2. PMID: 18410837

Article Published Date : May 01, 2008

Study Type : Commentary

Additional Links

Diseases : Delirium: Drug-Induced, Rhabdomyolysis

Additional Keywords : Drug: Omeprazole

[+]

Proton pump inhibitors low gastric vitamin C levels resulting in a rise of nitrate, reduce the absorption of vitamin B-12 and reduce the absorption of non-heme iron.Mar 01, 2009

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Pubmed Data : Am J Gastroenterol. 2009 Mar;104 Suppl 2:S5-9. PMID: 19262546

Article Published Date : Mar 01, 2009

Study Type : Commentary

Additional Links

Diseases : Anemia: Iron Deficiency, Helicobacter Pylori Infection, Vitamin B 12 Deficiency, Vitamin C Deficiency

Additional Keywords : Drug: Omeprazole

[+]

Proton pump inhibitors may cause myopathy including polymyositis.Jun 01, 2006

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Pubmed Data : Eur J Clin Pharmacol. 2006 Jun;62(6):473-9. Epub 2006 Apr 22. PMID: 16758264

Article Published Date : Jun 01, 2006

Study Type : Review

Additional Links

Diseases : Myopathies, Polymyositis

Additional Keywords : Drug: Omeprazole

Problem Substances : Proton-Pump Inhibitors

Research Articles 17
Cumulative Knowledge Score 27
Overall Research Rating GOOD

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