Acetaminophen

Name	AC	CK
Paracetamol	280	739
Acetaminophen	268	675
Tylenol	3	40
Ibuprofen	6	35
Diclofenac	5	34
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	4	31
Analgesic: Non-opioid	2	12
Aspirin	2	11
Naproxen	2	11
Dipyrone	1	10
Endocrine Disruptors	2	7
Indomethacin	2	3
Isoniazid	1	2
Cadmium	1	1
Lead	1	1
Meloxicam	1	1

Name	AC	CK
Acetaminophen (Tylenol) Toxicity	269	670
Liver Damage: Drug-Induced	105	204
Prenatal Chemical Exposures	22	133
Oxidative Stress	51	97
Chemically-Induced Liver Damage	41	74
Attention Deficit Disorder with Hyperactivity	6	42
Fever	2	30
Kidney Damage: Drug-Induced	14	28
Inflammation	9	24
Autism Spectrum Disorders	5	23
Hypersensitivity	1	20
Neurodevelopmental Disorders	3	13
Attention Deficit Hyperactivity Disorder	1	10
Cardiac Mortality	1	10
Children: Drug-Induced Toxicity	1	10
Chronic Pain	1	10
Common Cold	1	10
Febrile Seizures	1	10
Gastrointestinal Diseases	1	10
Migraine Disorders	1	10
Rhinovirus Infection	1	10
Lipid Peroxidation	4	8
Kidney Damage: Chemically-Induced	3	6
Asthma	1	4
Infertility: Female	2	4
Liver Damage	3	4
Mitochondrial Dysfunction	2	4
Testicular Injury: Chemical/Metal Induced	2	4
Alcohol Toxicity	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
DNA damage	1	2
Fetal Origin of Adult Disease	1	2
Gastric Ulcer	1	2
Glutathione Deficiency	1	2
Ibuprofen Toxicity	1	2
Infertility: Male	1	2
Liver Disease	1	2
Lung Inflammation	1	2
Male Reproductive Development Abnormalities	1	2
Sexual Behavior	1	2
Alzheimer's Disease	1	1
Anemia	1	1
Autism	1	1
Cadmium Poisoning	1	1
Cervical Cancer	1	1
Endometrial Cancer	1	1
Endometrial Neoplasms	1	1
Liver Cancer	1	1
Neurodegenerative Diseases	1	1

Name	AC	CK
Neurotoxic	5	15
Immunosuppressive	1	10
Nephrotoxic	1	10
Cytotoxic	1	5
Immunotoxic	1	4
Genotoxic	1	1
Mutagenic	1	1
Necrotic	1	1

Name	AC	CK
Ginsenosides	12	23
Dandelion	7	13
NAC (N-acetyl-L-cysteine)	7	13
Flavonoids	6	11
B-complex	1	10
Curcumin	5	8
Fisetin	4	8
Nigella sativa (aka Black Seed)	4	8
Silymarin	4	8
Vitamin C	4	8
Apigenin	3	6
Berberine	3	6
Chrysin	3	6
Cinnamon	3	6
Burdock	3	5
Citrus naringin	3	5
Licorice	3	5
Tanshinone IIA	3	5
Artichoke	2	4
Baccharis trimera	2	4
Betanin	2	4
Echinacea	2	4
Honokiol	2	4
Lycopene	2	4
Mulberry	2	4
Panax Ginseng	2	4
Passion Flower	2	4
Poria cocos	2	4
Prickly Pear Cactus	2	4
Pterostilbene	2	4
Schisandra	2	4
Silibinin	2	4
Sinomenine	2	4
Sulforaphane	2	4
Thymoquinone	2	4
White Clover	2	4
Zataria multiflora	2	4
Carvacrol	2	3
Diallyl sulfide	2	3
Ferulic acid	1	3
Honeysuckle	2	3
Naringenin	2	3
Rose	2	3
Salvia miltiorrhiza	1	3
Shikonin	2	3
6-Shogaol	1	2
Acacia catechu	1	2
Achiote	1	2
Allicin	1	2
Alpha-Lipoic Acid	1	2
Andrographis	1	2
Andrographolide	1	2
Anthocyanins	1	2
Astaxanthin	1	2
Astragaloside	1	2
Bamboo	1	2
Basil	1	2
Bee Propolis	1	2
Bergamot	1	2
Beta-glucan	1	2
Bitter Apple	1	2
Bixin	1	2
Black Tea	1	2
Butterfly Pea	1	2
Carbon 60	1	2
Carnosic Acid	1	2
Carotenoids	1	2
Chamomile	1	2
Chives	1	2
Citrus Triterpenoids	1	2
Coconut Water	1	2
Coenzyme Q10	1	2
Corn Silk	1	2
Cumin	1	2
D-Limonene	1	2
Date Seeds	1	2
Emodin	1	2
Eriodictyol	1	2
Fig	1	2
Frankincense	1	2
Garden Cress (Lepidium sativum)	1	2
Garlic	1	2
Germanium	1	2
Ginkgo biloba	1	2
Ginseng (American)	1	2
Glycyrrhizin	1	2
Gold (nanoparticles)	1	2
Goldenseal	1	2
Gotu Kola	1	2
Grape Seed Extract	1	2
Guava	1	2
Horse Chestnut	1	2
Hydrogen Water	1	2
Isoflavones	1	2
Jujube	1	2
Juniper	1	2
Lignans	1	2
Loquat	1	2
MSM (Methylsulfonylmethane)	1	2
Mangiferin	1	2
Mango	1	2
Methionine	1	2
Milk Thistle	1	2
Moringa oleifera	1	2
Nicotinamide	1	2
Nobiletin	1	2
Nutmeg	1	2
Olive Oil	1	2
Organosulfur Compounds	1	2
P-Coumaric Acid	1	2
Paeoniflorin	1	2
Paeonol	1	2
Papaya	1	2
Parsley	1	2
Phellinus Linteus	1	2
Piperine	1	2
Plantago major	1	2
Polyphenols	1	2
Pomegranate	1	2
Pomegranate Peel	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pycnogenol (Pine Bark)	1	2
Quercetin	1	2
Resveratrol	1	2
Rosmarinic acid	1	2
Saffron	1	2
Seaweed	1	2
Selenium	1	2
Silver (nanoparticles)	1	2
St. Johns Wort	1	2
Tongkat Ali	1	2
Toona sinensis	1	2
Urolithin A	1	2
Vitamin D	1	2
Wheat Grass	1	2
Wogonin	1	2
Xanthohumol	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
Zerumbone	1	2
Cannabinoids	1	1
Citrus Peel	1	1
Curcuminoids	1	1
Ginseng (Korean)	1	1
Lactobacillus fermentum	1	1
Lotus	1	1
Reishi Mushroom	1	1
Rosemary	1	1
Tetrahydrocurcumin	1	1
Thymol	1	1
Tryptophan	1	1
Turmeric	1	1

Name	AC	CK
Electroacupuncture	1	10
Hyperbaric Treatment	1	2
Ozone Therapy	1	2

Name	AC	CK
Hepatoprotective	190	363
Antioxidants	114	218
Anti-Inflammatory Agents	68	133
Renoprotective	27	52
Nrf2 activation	27	51
Tumor Necrosis Factor (TNF) Alpha Inhibitor	23	44
Anti-Apoptotic	22	43
Interleukin-1 beta downregulation	21	40
Interleukin-6 Downregulation	13	24
Malondialdehyde Down-regulation	11	21
NF-kappaB Inhibitor	7	13
Superoxide Dismutase Up-regulation	7	13
Cyclooxygenase 2 Inhibitors	6	11
Heme oxygenase-1 up-regulation	7	11
Analgesics	1	10
Autophagy Up-regulation	3	7
MicroRNA modulator	2	5
Neuroprotective Agents	3	5
Cytoprotective	2	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	4
SIRT1 Activator	2	4
Hypolipidemic	2	3
Interleukin-4 downregulation	2	3
Antioxidant	1	2
Bcl-2 protein down-regulation	1	2
Chemoprotective Agents	1	2
Enzyme Inhibitors	1	2
Glutathione Upregulation	1	2
Interleukin-17 downregulation	1	2
NF-E2-Related Factor-2 (Nrf2) Modulator	1	2
Prophylactic Agents	1	2
Antiproliferative	1	1
Aphrodisiac	1	1
Chemopreventive	1	1
Interleukin-10 upregulation	1	1
Transient Receptor Potential Melastatin 2 Inhibition	1	1

[+]

Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

Click here to read the entire abstract

Pubmed Data : Chest. 2009 Nov ;136(5):1316-1323. Epub 2009 Aug 20. PMID: 19696122

Article Published Date : Oct 31, 2009

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Allergol Immunopathol (Madr). 2017 ;45(6):528-533. Epub 2017 Feb 22. PMID: 28237129

Article Published Date : Dec 31, 2016

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

The use of paracetamol during pregnancy is associated with an increased risk of childhood asthma.Mar 31, 2011

Click here to read the entire abstract

Pubmed Data : Clin Exp Allergy. 2011 Apr ;41(4):482-9. Epub 2011 Feb 22. PMID: 21338428

Article Published Date : Mar 31, 2011

Study Type : Meta Analysis

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Int Arch Allergy Immunol. 2018 ;176(2):106-114. Epub 2018 Apr 3. PMID: 29614487

Article Published Date : Dec 31, 2017

Study Type : Meta Analysis, Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Hypersensitivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2002(2):CD003676. PMID: 12076499

Article Published Date : Jan 01, 2002

Study Type : Meta Analysis

Additional Links

Diseases : Fever

Problem Substances : Paracetamol, Tylenol

[+]

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Click here to read the entire abstract

Pubmed Data : Pediatr Int. 2021 Sep ;63(9):1069-1074. Epub 2021 Jul 30. PMID: 33464662

Article Published Date : Aug 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Gastrointestinal Diseases

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort.Sep 25, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Environ Res Public Health. 2021 Sep 26 ;18(19). Epub 2021 Sep 26. PMID: 34639411

Article Published Date : Sep 25, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn.Mar 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Epigenet. 2019 Apr ;5(2):dvz010. Epub 2019 Aug 6. PMID: 31404209

Article Published Date : Mar 31, 2019

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infants: Low Birth Weight

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.Jul 31, 2018

Click here to read the entire abstract

Pubmed Data : Am J Epidemiol. 2018 Aug 1 ;187(8):1817-1827. PMID: 29688261

Article Published Date : Jul 31, 2018

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Autism Open Access. 2016 Apr ;6(2). Epub 2016 Mar 28. PMID: 27695658

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders

Additional Keywords : Endocannabinoid System

Problem Substances : Acetaminophen, Paracetamol

[+]

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Indian J Physiol Pharmacol. 2014 Jan-Mar;58(1):69-76. PMID: 25464680

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Diseases : Migraine Disorders

Therapeutic Actions : Electroacupuncture

Additional Keywords : Therapeutic Action Superior to Drug Therapy

Problem Substances : Paracetamol

[+]

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Click here to read the entire abstract

Pubmed Data : Pediatr Nephrol. 2005 Sep;20(9):1295-8. Epub 2005 Jun 23. PMID: 15973524

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Children: Drug-Induced Toxicity

Problem Substances : Diclofenac, Dipyrone, Ibuprofen, Naproxen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

Adverse Pharmacological Actions : Nephrotoxic

[+]

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Click here to read the entire abstract

Pubmed Data : J Infect Dis. 1990 Dec ;162(6):1277-82. PMID: 2172402

Article Published Date : Nov 30, 1990

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Common Cold, Rhinovirus Infection

Additional Keywords : Increased Risk, Viral Shedding

Problem Substances : Acetaminophen, Aspirin , Ibuprofen, Paracetamol

Adverse Pharmacological Actions : Immunosuppressive

[+]

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Arch Pediatr Adolesc Med. 2009 Sep ;163(9):799-804. PMID: 19736332

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Diseases : Febrile Seizures, Fever

Problem Substances : Diclofenac, Ibuprofen, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol, Tylenol

[+]

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JAMA Pediatr. 2016 Oct 1 ;170(10):964-970. PMID: 27533796

Article Published Date : Sep 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JAMA Pediatr. 2020 Nov 1 ;174(11):1073-1081. PMID: 32986124

Article Published Date : Oct 31, 2020

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Epigenet. 2022 ;8(1):dvac002. Epub 2022 Feb 2. PMID: 35317219

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : DNA Methylation

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(9):e108210. Epub 2014 Sep 24. PMID: 25251831

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Diseases : Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Paracetamol, Tylenol

[+]

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Allergy Asthma Immunol. 2024 Jun ;132(6):705-712.e5. Epub 2024 Mar 12. PMID: 38484838

Article Published Date : May 31, 2024

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Paediatr Perinat Epidemiol. 2020 May ;34(3):267-277. Epub 2020 Jan 22. PMID: 31965601

Article Published Date : Apr 30, 2020

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Click here to read the entire abstract

Pubmed Data : Cir Cir. 2010 ;78(5):400-9. PMID: 21219810

Article Published Date : Dec 31, 2009

Study Type : Human Study

Additional Links

Substances : B-complex

Diseases : Chronic Pain

Pharmacological Actions : Analgesics

Additional Keywords : Natural Substance/Drug Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.May 31, 2000

Click here to read the entire abstract

Pubmed Data : Clin Pharmacol Ther. 2000 Jun ;67(6):591-9. PMID: 10872641

Article Published Date : May 31, 2000

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Alcohol Toxicity , Liver Damage

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):1998-2008. PMID: 27585674

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Gestational exposure to acetaminophen was associated with a small increased risk of ADHD.Sep 29, 2025

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Am Acad Child Adolesc Psychiatry. 2025 Sep 30. Epub 2025 Sep 30. PMID: 41062061

Article Published Date : Sep 29, 2025

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair.Jun 30, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Toxicol. 2024 Jul ;98(7):2261-2268. Epub 2024 Apr 14. PMID: 38615315

Article Published Date : Jun 30, 2024

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Epigenetics. 2017 ;9:77. Epub 2017 Aug 2. PMID: 28785368

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Additional Keywords : DNA Methylation, Epigenetic Modification

Problem Substances : Acetaminophen, Paracetamol

[+]

Male urinary paracetamol and semen quality.Oct 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Andrology. 2017 Nov ;5(6):1082-1088. Epub 2017 Aug 29. PMID: 28853221

Article Published Date : Oct 31, 2017

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Sperm Quality: Low

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Sci. 2018 Jul 3 ;8(7). Epub 2018 Jul 3. PMID: 29970852

Article Published Date : Jul 02, 2018

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Hyperactivity Disorder, Prenatal Chemical Exposures

Additional Keywords : Increased Risk

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen use and cognitive development at 4 years.Feb 28, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pediatr Res. 2023 Mar ;93(4):959-963. Epub 2022 Jul 7. PMID: 35794252

Article Published Date : Feb 28, 2023

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : JAMA Pediatr. 2014 Apr ;168(4):313-20. PMID: 24566677

Article Published Date : Mar 31, 2014

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Click here to read the entire abstract

Pubmed Data : Epidemiology. 2016 Nov ;27(6):912-8. PMID: 27479646

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal exposure to paracetamol is associated with disadvantages to the offspring in scholastic abilities such as mathematics and reading at secondary school ages.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2023 ;14:1116683. Epub 2023 Dec 12. PMID: 38149049

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):2009-2017. PMID: 28031314

Article Published Date : Nov 30, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal paracetamol use in pregnancy is associated with an enhanced risk of asthma and wheezing in their children.Feb 23, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Med. 2023 Feb 24 ;12(5). Epub 2023 Feb 24. PMID: 36902618

Article Published Date : Feb 23, 2023

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures, Wheezing: Infants

Additional Keywords : Increased Risk

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2022 ;17(9):e0272593. Epub 2022 Sep 28. PMID: 36170224

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sonsDec 31, 2016

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Pubmed Data : Hum Reprod. 2017 Jan ;32(1):223-231. Epub 2016 Nov 16. PMID: 27852690

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, Analgesic: Non-opioid, Risk Factors

Problem Substances : Acetaminophen, Analgesic: Non-opioid

[+]

Paracetamol use during pregnancy was associated with an increased risk of asthma and wheezing in childhood.May 31, 2008

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Pubmed Data : Int J Epidemiol. 2008 Jun ;37(3):583-90. Epub 2008 Apr 9. PMID: 18400839

Article Published Date : May 31, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures, Wheezing: Infants

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Brain Behav. 2015 Aug ;5(8):e00338. Epub 2015 May 29. PMID: 26357585

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Cardiac Mortality , Inflammation

Additional Keywords : Increased Risk, Mortality, Synergistic Toxicity

Problem Substances : Acetaminophen, Diclofenac, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Paracetamol

[+]

Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity.Apr 30, 1991

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Pubmed Data : Xenobiotica. 1991 May ;21(5):689-93. PMID: 1949902

Article Published Date : Apr 30, 1991

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Rheumatoid Arthritis

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2016 12 1 ;45(6):1987-1996. PMID: 27353198

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Autism Spectrum Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pediatr. 2022 ;10:828089. Epub 2022 Apr 5. PMID: 35450103

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal and early-life antibiotic exposure and the risk of atopic dermatitis in children.Apr 30, 2023

Click here to read the entire abstract

Pubmed Data : Pediatr Allergy Immunol. 2023 May ;34(5):e13959. PMID: 37232285

Article Published Date : Apr 30, 2023

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Antibiotic Toxicity , Atopic Dermatitis, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Antibiotics, Paracetamol

[+]

Prenatal and infant paracetamol exposure and development of asthma.Mar 31, 2016

Click here to read the entire abstract

Pubmed Data : Int J Epidemiol. 2016 Apr ;45(2):512-22. Epub 2016 Feb 9. PMID: 26861478

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal exposure to acetaminophen and children's language development at 30 months.May 31, 2018

Click here to read the entire abstract

Pubmed Data : Eur Psychiatry. 2018 Jun ;51:98-103. Epub 2018 Jan 10. PMID: 29331486

Article Published Date : May 31, 2018

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children.Jun 30, 2021

Click here to read the entire abstract

Pubmed Data : Pediatr Allergy Immunol. 2021 Jul ;32(5):1080-1088. Epub 2021 Mar 8. PMID: 33544946

Article Published Date : Jun 30, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Atopic Dermatitis, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Epidemiol. 2013 Dec ;42(6):1702-13. Epub 2013 Oct 24. PMID: 24163279

Article Published Date : Nov 30, 2013

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.Dec 31, 2004

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Pubmed Data : Clin Exp Allergy. 2005 Jan ;35(1):18-25. PMID: 15649261

Article Published Date : Dec 31, 2004

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol exposure and risk of wheeze at preschool age.Nov 30, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Paediatr. 2011 Dec ;100(12):1567-71. Epub 2011 Jul 27. PMID: 21767300

Article Published Date : Nov 30, 2011

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Wheezing: Infants

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants.Oct 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Hum Reprod. 2016 Nov ;31(11):2642-2650. Epub 2016 Sep 8. PMID: 27609981

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Male Reproductive Development Abnormalities, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.Mar 31, 2018

Click here to read the entire abstract

Pubmed Data : J Epidemiol Community Health. 2018 Apr ;72(4):349-355. Epub 2018 Jan 25. PMID: 29371328

Article Published Date : Mar 31, 2018

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Neurotoxicol Teratol. 2024 ;101:107319. Epub 2024 Jan 8. PMID: 38199313

Article Published Date : Dec 31, 2023

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life.Aug 31, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Allergy Asthma Immunol. 2008 Sep ;101(3):271-8. PMID: 18814450

Article Published Date : Aug 31, 2008

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Psychiatry. 2016 Mar ;77(3):e312-4. PMID: 27046315

Article Published Date : Feb 29, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Attention Deficit Disorder with Hyperactivity

Problem Substances : Acetaminophen, Paracetamol

[+]

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

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Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646

Article Published Date : Jun 18, 2015

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Mesenchymal Stem Cells

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Cytotoxic

[+]

This study highlights the potential for acetaminophen to interfere with hormone regulation during pregnancy.Jan 05, 2021

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Pubmed Data : Toxicol Sci. 2021 Jan 6 ;179(1):44-52. PMID: 33098425

Article Published Date : Jan 05, 2021

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Endocrine Disruptors, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Int J Biol Sci. 2019 ;15(4):788-799. Epub 2019 Jan 29. PMID: 30906210

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

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Pubmed Data : IUBMB Life. 2022 May 5. Epub 2022 May 5. PMID: 35514074

Article Published Date : May 04, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ferulic acid

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244

Article Published Date : Apr 02, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, MicroRNA modulator

Additional Keywords : MicroRNA-485

Problem Substances : Acetaminophen, Paracetamol

[+]

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

[+]

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Prev Med. 2017 Jun 12 ;22(1):54. Epub 2017 Jun 12. PMID: 29165178

Article Published Date : Jun 11, 2017

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

Article Published Date : Feb 29, 2020

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

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Pubmed Data : Drug Chem Toxicol. 2020 Feb 3:1-7. Epub 2020 Feb 3. PMID: 32013615

Article Published Date : Feb 02, 2020

Study Type : Animal Study

Additional Links

Substances : Quercetin, Resveratrol

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Folia Morphol (Warsz). 2019 Mar 5. Epub 2019 Mar 5. PMID: 30835338

Article Published Date : Mar 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Thymoquinone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.Jun 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Future Sci OA. 2022 Jul ;8(6):FSO801. Epub 2022 Jun 17. PMID: 35909999

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Mango

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A single early-life acetaminophen exposure causes persistent abnormalities in the murine lung.Jul 31, 2025

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Pubmed Data : Am J Respir Cell Mol Biol. 2025 Aug ;73(2):232-250. PMID: 39836061

Article Published Date : Jul 31, 2025

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Dec ;108:838-844. Epub 2018 Sep 24. PMID: 30372895

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Acacia catechu

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

Click here to read the entire abstract

Pubmed Data : Pharmacol Biochem Behav. 2018 Dec ;175:146-151. Epub 2018 Oct 22. PMID: 30359628

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Conventional Medicine Erodes Empathy

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

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Pubmed Data : Toxicol Sci. 2015 Dec 31. Epub 2015 Dec 31. PMID: 26721299

Article Published Date : Dec 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Mitochondrial Dysfunction

Problem Substances : Acetaminophen, Paracetamol

[+]

acetaminophen in a subtoxic dose for a long period could result in mild toxic effects on the liver but more serious lesions in the kidney and brain.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Vet J. 2024 Jan ;14(1):316-323. Epub 2024 Jan 31. PMID: 38633179

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen interferes with the first trimester human fetal ovary development.May 16, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Endocrinol Metab. 2022 May 17 ;107(6):1647-1661. PMID: 35147701

Article Published Date : May 16, 2022

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen toxicity to cultured rat embryos.Dec 31, 1989

Click here to read the entire abstract

Pubmed Data : Teratog Carcinog Mutagen. 1990 ;10(5):361-71. PMID: 1981948

Article Published Date : Dec 31, 1989

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Teratogenic

[+]

Acetaminophen-induced alterations in blood glucose and blood insulin levels in mice.Feb 29, 1984

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Pubmed Data : Res Commun Chem Pathol Pharmacol. 1984 Mar ;43(3):381-91. PMID: 6371954

Article Published Date : Feb 29, 1984

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Acetaminophen-induced hepatotoxicity predominantly via inhibiting Nrf2 antioxidative pathway.Feb 28, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ecotoxicol Environ Saf. 2023 Mar 1 ;252:114590. Epub 2023 Feb 2. PMID: 36738614

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Alleviative effects from boswellic acid on acetaminophen-induced hepatic injury.May 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomedicine (Taipei). 2016 Jun ;6(2):9. Epub 2016 May 9. PMID: 27161000

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Boswellic Acid

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.Dec 31, 2020

Click here to read the entire abstract

Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan ;28(2):1762-1774. Epub 2020 Aug 27. PMID: 32856245

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Corn Silk

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.Aug 31, 2019

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Sep ;43(9):e12963. Epub 2019 Jul 2. PMID: 31489655

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : White Clover

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.Sep 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Food Drug Anal. 2017 Oct ;25(4):862-871. Epub 2016 Nov 5. PMID: 28987363

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.Apr 02, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2019 Apr 3. Epub 2019 Apr 3. PMID: 30944208

Article Published Date : Apr 02, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injuryApr 30, 2018

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2018 May ;111:1133-1139. Epub 2018 Feb 19. PMID: 29415408

Article Published Date : Apr 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.Apr 30, 2019

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160

Article Published Date : Apr 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Antioxidative and anti-Inflammatory protective effects of fucoxanthin against paracetamol-induced hepatotoxicity.Nov 13, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2023 Nov 14 ;21(11). Epub 2023 Nov 14. PMID: 37999416

Article Published Date : Nov 13, 2023

Study Type : Animal Study

Additional Links

Substances : Fucoxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.Feb 10, 2020

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 11:e22472. Epub 2020 Feb 11. PMID: 32048452

Article Published Date : Feb 10, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin attenuates acetaminophen-induced hepatotoxicity. Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:549057. Epub 2020 Nov 20. PMID: 33658919

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:514. Epub 2020 Apr 24. PMID: 32425778

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Hepatoprotective, SIRT1 Activator

Problem Substances : Acetaminophen, Paracetamol

[+]

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.Mar 01, 2017

Click here to read the entire abstract

Pubmed Data : Eur J Drug Metab Pharmacokinet. 2017 Mar 2. Epub 2017 Mar 2. PMID: 28255865

Article Published Date : Mar 01, 2017

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.Jul 31, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Sci. 2011 Aug ;122(2):598-605. Epub 2011 May 13. PMID: 21572097

Article Published Date : Jul 31, 2011

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):27-35. Epub 2016 Jan 27. PMID: 27069723

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Papaya

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.Dec 31, 2011

Click here to read the entire abstract

Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.Nov 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice.Jun 06, 2016

Click here to read the entire abstract

Pubmed Data : Arch Biochem Biophys. 2016 Jun 7. Epub 2016 Jun 7. PMID: 27288086

Article Published Date : Jun 06, 2016

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour.Apr 30, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Paediatr Perinat Epidemiol. 2020 May ;34(3):287-298. Epub 2019 Oct 21. PMID: 31637744

Article Published Date : Apr 30, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.Jan 29, 2017

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Astragaloside IV attenuates acetaminophen-induced liver injuries in mice.Aug 13, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942

Article Published Date : Aug 13, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

B. trimera a potential candidate drug capable of protecting the liver against damage caused by Acetaminophen overdose.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Baccharis trimera improves the antioxidant defense system and inhibits iNOS and NADPH oxidase expression in a rat model of inflammation.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Curr Pharm Biotechnol. 2013 ;14(11):975-84. PMID: 24372242

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Baccharis trimera

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation

Pharmacological Actions : Antioxidants

Additional Keywords : Gene Expression Regulation, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Basil extract may act as a natural antioxidant to treat acetaminophen -induced acute hepato-renal toxicity when used as a post-treatment.Oct 11, 2018

Click here to read the entire abstract

Pubmed Data : J Complement Integr Med. 2018 Oct 12. Epub 2018 Oct 12. PMID: 30312166

Article Published Date : Oct 11, 2018

Study Type : Animal Study

Additional Links

Substances : Basil

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine exhibits notable preventive effects on acetaminophen induced hepatotoxicity.Jun 30, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Berberine protects against the hepatic damage induced by ParacetamolFeb 01, 2000

Click here to read the entire abstract

Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466

Article Published Date : Feb 01, 2000

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Paracetamol

[+]

Beta-glucan and vitamin C co-treatment may be a promising therapeutic option for the treatment of acute acetaminophen hematotoxicity.Mar 17, 2019

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2019 Mar 18:1-8. Epub 2019 Mar 18. PMID: 30880499

Article Published Date : Mar 17, 2019

Study Type : Animal Study

Additional Links

Substances : Beta-glucan, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Betacyanins, major components in Opuntia red-purple fruits, protect against acetaminophen-induced acute liver failure.Jan 10, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Res Int. 2020 11 ;137:109461. Epub 2020 Jun 18. PMID: 33233135

Article Published Date : Jan 10, 2020

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Betanin exerted a potential anti-inflammatory and antioxidant effect against hepato-renal damage induced by paracetamol and diclofenac over consumption.Nov 25, 2019

Click here to read the entire abstract

Pubmed Data : Biomarkers. 2019 Nov 26:1-24. Epub 2019 Nov 26. PMID: 31766895

Article Published Date : Nov 25, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Betulinic acid can be used as an effective agent in the prevention and treatment of acute liver diseases.Mar 27, 2021

Click here to read the entire abstract

Pubmed Data : Turk J Med Sci. 2021 Mar 28. Epub 2021 Mar 28. PMID: 33773522

Article Published Date : Mar 27, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Liver Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Bitter apple fruit possess significant hepatoprotective and antioxidant activity.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Bitter Apple

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Paracetamol

[+]

Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Int J Pharm. 2014 Oct 1 ;473(1-2):485-92. Epub 2014 Jul 24. PMID: 25066077

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Article Published Date : Apr 20, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides, Panax Ginseng

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy

Problem Substances : Acetaminophen, Paracetamol

[+]

Both the lower and higher dose exposures resulted in measurable changes in lung morphometrics, with the lower dose exposure causing alveolar wall thinning.Oct 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1 ;321(5):L941-L953. Epub 2021 Sep 29. PMID: 34585971

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Lung Damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis.Sep 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Toxicol Pathol. 2018 Oct ;31(4):275-282. Epub 2018 Jul 1. PMID: 30393431

Article Published Date : Sep 30, 2018

Study Type : Animal Study

Additional Links

Substances : Propolis: Brazillian

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Carnosic acid protected against acetaminophen induced liver injury and enhanced antioxidant defence system.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Carnosic Acid

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Chlorogenic acid promotes liver regeneration and repair after acetaminophen-induced liver injury.Sep 28, 2025

Click here to read the entire abstract

Pubmed Data : Food Funct. 2025 Sep 29 ;16(19):7590-7606. Epub 2025 Sep 29. PMID: 40969002

Article Published Date : Sep 28, 2025

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Liver Regeneration

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin mitigated side effects of acute Paracetamol toxicity in male reproductive system proportionally in a dose-dependent manner.Feb 23, 2016

Click here to read the entire abstract

Pubmed Data : Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26914515

Article Published Date : Feb 23, 2016

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Cytoprotective

Additional Keywords : Dose Response

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.Oct 31, 2017

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID: 28682524

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Apoptotic, Antioxidants, Chrysin, Hepatoprotective, Lipid Peroxidation

Problem Substances : Acetaminophen, Paracetamol

[+]

Chrysin prevents the necrosis and injury of acute acetaminophen-induced hepatotoxicity.Nov 17, 2019

Click here to read the entire abstract

Pubmed Data : Chem Res Toxicol. 2019 Nov 18 ;32(11):2329-2337. Epub 2019 Nov 1. PMID: 31625388

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Rep. 2020 ;7:1296-1304. Epub 2020 Sep 17. PMID: 33024703

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Cinnamon oil could be an alternative nutraceutical substitute in APAP overdose poisoning.Feb 28, 2022

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2022 Mar ;45(2):633-640. Epub 2020 Apr 5. PMID: 32249599

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

Co-administration of fresh grape fruit juice and bergamottin prevented paracetamol induced hepatotoxicity.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Rep. 2015 ;2:677-684. Epub 2015 May 8. PMID: 28962403

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Bergamot

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Coconut water vinegar ameliorates recovery of acetaminophen induced liver damage in mice.Jun 24, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):195. Epub 2018 Jun 25. PMID: 29940935

Article Published Date : Jun 24, 2018

Study Type : Animal Study

Additional Links

Substances : Coconut Water

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Inflammation

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Commonly taken analgesics could decrease germ cell number and ovarian size in F1 offspring in rats.Jan 26, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Jan 27 ;6:19789. Epub 2016 Jan 27. PMID: 26813099

Article Published Date : Jan 26, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Infertility: Female, Prenatal Chemical Exposures, Transgenerational Epigenetic Modification

Problem Substances : Acetaminophen, Analgesic: Non-opioid, Indomethacin, Paracetamol

[+]

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID: 30772810

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Prophylactic Agents

Problem Substances : Acetaminophen, Paracetamol

[+]

Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in the liver and kidney.Sep 23, 2020

Click here to read the entire abstract

Pubmed Data : J Biochem. 2020 Sep 24. Epub 2020 Sep 24. PMID: 32970799

Article Published Date : Sep 23, 2020

Study Type : Animal Study

Additional Links

Substances : Dandelion , NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

CoQ10 promotes resolution of necrosis and liver regeneration after acetaminophen-induced liver injury.Dec 27, 2021

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2021 Dec 28 ;185(1):19-27. PMID: 34668565

Article Published Date : Dec 27, 2021

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Liver Regeneration

Problem Substances : Acetaminophen, Paracetamol

[+]

Curcumin prevents paracetamol-induced liver mitochondrial alterations.Jan 14, 2016

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315

Article Published Date : Jan 14, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Dandelion extracts pretreatment protects against acetaminophen-induced hepatic injury.Nov 23, 2021

Click here to read the entire abstract

Pubmed Data : Chin J Integr Med. 2021 Nov 24. Epub 2021 Nov 24. PMID: 34816363

Article Published Date : Nov 23, 2021

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Click here to read the entire abstract

Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Dandelion , Polyphenols

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Developmental exposure to paracetamol causes biochemical alterations in medulla oblongata.Aug 31, 2015

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2015 Sep ;40(2):369-74. Epub 2015 Jul 4. PMID: 26233562

Article Published Date : Aug 31, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Toxicol Res (Camb). 2019 Jan 1 ;8(1):67-76. Epub 2018 Oct 25. PMID: 30713662

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Diallyl sulfide

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury.Nov 18, 2024

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2024 Nov 19 ;734:150772. Epub 2024 Sep 30. PMID: 39362031

Article Published Date : Nov 18, 2024

Study Type : Animal Study

Additional Links

Substances : Berberine, Curcumin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Early exposure to paracetamol reduces level of testicular testosterone and changes gonadal expression of genes relevant for steroidogenesis in rats offspring.Jun 30, 2022

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2022 Jul ;45(4):1862-1869. Epub 2021 Mar 3. PMID: 33657953

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Testosterone

Diseases : Acetaminophen (Tylenol) Toxicity , Low Testosterone, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Early paracetamol exposure decreases brain-derived neurotrophic factor (BDNF) in striatum and affects social behaviour and exploration in rats.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : Pharmacol Biochem Behav. 2018 May ;168:25-32. Epub 2018 Mar 13. PMID: 29545027

Article Published Date : Apr 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Early paracetamol exposure produces major changes in serotonergic and dopaminergic neurotransmission in the prefrontal cortex and striatum.Apr 13, 2017

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096

Article Published Date : Apr 13, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Echinacoside alleviates acetaminophen-induced liver injury.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Appl Biomed. 2021 05 ;19(2):105-112. Epub 2021 Apr 26. PMID: 34907710

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol.Mar 31, 2019

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2019 Apr 1 ;302:123-134. Epub 2019 Feb 19. PMID: 30794797

Article Published Date : Mar 31, 2019

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Milk Thistle

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Effect of polysaccharide peptide (PSP) on glutathione and protection against paracetamol-induced hepatotoxicity.Nov 30, 1994

Click here to read the entire abstract

Pubmed Data : Methods Find Exp Clin Pharmacol. 1994 Dec ;16(10):723-9. PMID: 7723471

Article Published Date : Nov 30, 1994

Study Type : Animal Study

Additional Links

Substances : Turkey Tail Mushroom

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Effect of prenatal and early life paracetamol exposure on the level of neurotransmitters in rats--Focus on the spinal cord.Nov 30, 2015

Click here to read the entire abstract

Pubmed Data : Int J Dev Neurosci. 2015 Dec ;47(Pt B):133-9. Epub 2015 Sep 25. PMID: 26390956

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion.Jun 30, 1993

Click here to read the entire abstract

Pubmed Data : Xenobiotica. 1993 Jul ;23(7):809-19. PMID: 8237062

Article Published Date : Jun 30, 1993

Study Type : Animal Study

Additional Links

Substances : D-Limonene

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Glutathione Deficiency

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Effects of exposure to acetaminophen and ibuprofen on fetal germ cell development.Apr 15, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2018 Apr 16 ;126(4):047006. Epub 2018 Apr 16. PMID: 29665328

Article Published Date : Apr 15, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Ibuprofen Toxicity

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats.Apr 30, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ren Fail. 2010 May ;32(4):493-7. PMID: 20446790

Article Published Date : Apr 30, 2010

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress

Therapeutic Actions : Ozone Therapy

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden.Jun 19, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2024 Jun 20 ;14(1):14205. Epub 2024 Jun 20. PMID: 38902507

Article Published Date : Jun 19, 2024

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Aging, Cognitive Decline/Dysfunction

Problem Substances : Acetaminophen, Paracetamol

[+]

Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway.Aug 17, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Inflammation. 2021 Aug 18. Epub 2021 Aug 18. PMID: 34409550

Article Published Date : Aug 17, 2021

Study Type : Animal Study

Additional Links

Substances : Emodin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury.Oct 10, 2021

Click here to read the entire abstract

Pubmed Data : Nanomedicine (Lond). 2021 Oct 11. Epub 2021 Oct 11. PMID: 34632809

Article Published Date : Oct 10, 2021

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Eriodictyol may be used to treat acetaminophen-induced hepatotoxicity.Jan 04, 2017

Click here to read the entire abstract

Pubmed Data : Mol Pharm. 2017 09 5 ;14(9):2937-2951. Epub 2017 Jul 17. PMID: 28654297

Article Published Date : Jan 04, 2017

Study Type : Animal Study

Additional Links

Substances : Eriodictyol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Escin protects against acetaminophen-induced liver injury.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : Am J Transl Res. 2019 ;11(8):5170-5182. Epub 2019 Aug 15. PMID: 31497232

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Horse Chestnut

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats.Jul 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : An Acad Bras Cienc. 2018 Aug ;90(2 suppl 1):2347-2358. Epub 2018 Jun 25. PMID: 29947676

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Chamomile, Cumin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of Annona muricata for hepatoprotection, hematological assessment and inhibitor of TGFβR1 in liver diseases.Sep 30, 2025

Click here to read the entire abstract

Pubmed Data : Arch Physiol Biochem. 2025 Oct ;131(5):763-780. Epub 2025 May 13. PMID: 40364510

Article Published Date : Sep 30, 2025

Study Type : Animal Study

Additional Links

Substances : Soursop

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.Nov 30, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Deliv. 2022 Dec ;29(1):3256-3269. PMID: 36321805

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Naringenin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Evaluation of the reparative effect of sinomenine in an acetaminophen-induced liver injury model.Jan 20, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Curr Issues Mol Biol. 2024 Jan 21 ;46(1):923-933. Epub 2024 Jan 21. PMID: 38275673

Article Published Date : Jan 20, 2024

Study Type : Animal Study

Additional Links

Substances : Sinomenine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time.Sep 30, 2007

Click here to read the entire abstract

Pubmed Data : Exp Toxicol Pathol. 2007 Oct ;59(2):139-41. Epub 2007 Jun 29. PMID: 17601712

Article Published Date : Sep 30, 2007

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Exploration of the protective mechanism of naringin in the acetaminophen-induced hepatic injury by metabolomics.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7138194. Epub 2022 Sep 16. PMID: 36160708

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish.Dec 31, 2022

Click here to read the entire abstract

Pubmed Data : Arch Toxicol. 2023 Jan ;97(1):263-278. Epub 2022 Sep 27. PMID: 36167911

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility

Problem Substances : Acetaminophen, Paracetamol

[+]

Exposure to acetaminophen impairs vasodilation, increases oxidative stress and changes arterial morphology of rats.Apr 23, 2019

Click here to read the entire abstract

Pubmed Data : Arch Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31020376

Article Published Date : Apr 23, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol.Oct 13, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biology (Basel). 2021 Oct 14 ;10(10). Epub 2021 Oct 14. PMID: 34681141

Article Published Date : Oct 13, 2021

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Acetaminophen (Tylenol) Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Extract of Triticum aestivum sprouts suppresses acetaminophen-induced hepatotoxicity in mice.Oct 19, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Oct 20 ;26(21). Epub 2021 Oct 20. PMID: 34770745

Article Published Date : Oct 19, 2021

Study Type : Animal Study

Additional Links

Substances : Wheat Grass

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Extracts of J. communis leaves was found to be potent antioxidant and hepatoprotective without any cytotoxicity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2017 Jan-Mar;13(49):108-113. PMID: 28216892

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Juniper

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Fermented ginseng was shown to possess hepatoprotective activity against paracetamol (APAP)-induced liver injury.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2015 Apr ;67(4):565-72. Epub 2014 Dec 10. PMID: 25495794

Article Published Date : Mar 31, 2015

Study Type : Animal Study

Additional Links

Substances : Panax Ginseng

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Fisetin attenuates paracetamol-induced hepatotoxicity by regulating CYP2E1 enzyme.Dec 31, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : An Acad Bras Cienc. 2023 ;95(2):e20201408. Epub 2023 Apr 3. PMID: 37018834

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Fisetin prevents acetaminophen-induced liver injury by promoting autophagy.Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:162. Epub 2020 Feb 28. PMID: 32184730

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Fisetin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(2):e0170900. Epub 2017 Feb 24. PMID: 28234915

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Isoflavones

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Fucoxanthin offers significant hepatoprotection against paracetamol-induced liver injury.Mar 31, 2025

Click here to read the entire abstract

Pubmed Data : Drug Dev Ind Pharm. 2025 Apr ;51(4):332-343. Epub 2025 Feb 28. PMID: 39992072

Article Published Date : Mar 31, 2025

Study Type : Animal Study

Additional Links

Substances : Fucoxanthin , NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Galangin provides significant protection against acetaminophen induced liver and kidney damage.Oct 31, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Nov ;18(11):1187-97. Epub 2015 Jun 4. PMID: 26501381

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.Oct 19, 2019

Click here to read the entire abstract

Pubmed Data : Neurotoxicol Teratol. 2019 Oct 20 ;77:106838. Epub 2019 Oct 20. PMID: 31644948

Article Published Date : Oct 19, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes.Nov 30, 2006

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2006 Dec 1 ;217(2):225-33. Epub 2006 Sep 12. PMID: 17045319

Article Published Date : Nov 30, 2006

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rb1 exerts protective effects against acetaminophen-induced hepatotoxicity.Dec 01, 2019

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2019 Dec 2:1-17. Epub 2019 Dec 2. PMID: 31786947

Article Published Date : Dec 01, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:1027731. Epub 2022 Oct 7. PMID: 36278209

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 prevents acetaminophen-induced oxidative stress and apoptosis.Jan 03, 2019

Click here to read the entire abstract

Pubmed Data : J Asian Nat Prod Res. 2019 Jan 4:1-16. Epub 2019 Jan 4. PMID: 30608002

Article Published Date : Jan 03, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg1 protects against acetaminophen-induced liver injury.Jul 16, 2018

Click here to read the entire abstract

Pubmed Data : Regul Toxicol Pharmacol. 2018 Jul 17 ;98:58-68. Epub 2018 Jul 17. PMID: 30030101

Article Published Date : Jul 16, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Mar 05, 2021

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2021 Mar 6 ;73(3):322-331. PMID: 33793882

Article Published Date : Mar 05, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity.Apr 01, 2018

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2018 Apr 2 ;59:21-30. Epub 2018 Apr 2. PMID: 29621733

Article Published Date : Apr 01, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rg5 exerts a liver protection effect against acetaminophen-induced acute hepatotoxicity.Oct 24, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 Oct 25 ;65(42):9226-9236. Epub 2017 Oct 16. PMID: 28965396

Article Published Date : Oct 24, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ginseng Res. 2019 Jan ;43(1):10-19. Epub 2017 Jul 25. PMID: 30662289

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury.Aug 15, 2021

Click here to read the entire abstract

Pubmed Data : Food Funct. 2021 Aug 16. Epub 2021 Aug 16. PMID: 34397062

Article Published Date : Aug 15, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Ginsenosides from the leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice.May 09, 2017

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935

Article Published Date : May 09, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Malondialdehyde Down-regulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Glabridin attenuates paracetamol-induced liver injury.Jul 06, 2021

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2021 Jul 7:1-9. Epub 2021 Jul 7. PMID: 34233566

Article Published Date : Jul 06, 2021

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Glycyrrhizic acid promotes liver regeneration through activating β-catenin in acetaminophen-induced liver injury.Jun 11, 2025

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2025 Jun 12 ;349:119895. Epub 2025 Apr 28. PMID: 40306499

Article Published Date : Jun 11, 2025

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity.Jan 29, 2017

Click here to read the entire abstract

Pubmed Data : Exp Toxicol Pathol. 2017 Jan 30. Epub 2017 Jan 30. PMID: 28153389

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Gold (nanoparticles)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Goldenseal has hepatoprotective effects that ameliorate acetaminophen induced acute liver failure in rats.Sep 30, 2011

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2011 Oct ;3(4):250-5. PMID: 22224048

Article Published Date : Sep 30, 2011

Study Type : Animal Study

Additional Links

Substances : Goldenseal

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Grape seeds extract provided biochemical and histo-pathological improvement in paracetamol induced renal cortical toxicity. Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Bratisl Lek Listy. 2017 ;118(4):233-242. PMID: 28471235

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury.Sep 22, 2020

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Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):8297-8308. PMID: 32909594

Article Published Date : Sep 22, 2020

Study Type : Animal Study

Additional Links

Substances : Guava

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice.Jun 30, 2018

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Pubmed Data : J Hepatol. 2018 Jul ;69(1):51-59. Epub 2018 Mar 8. PMID: 29524531

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Additional Keywords : Microbiota

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepato and Nephro protective potentials of lyophilized juice of Citrus reticulata L. fruit against paracetamol induced toxicity in rats.Apr 30, 2024

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Pubmed Data : Pak J Pharm Sci. 2024 May ;37(3):553-562. PMID: 39340846

Article Published Date : Apr 30, 2024

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Orange: Mandarin, Polyphenols

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice.Sep 29, 2025

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Pathol. 2025 Sep 30. Epub 2025 Sep 30. PMID: 41038273

Article Published Date : Sep 29, 2025

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective actions of ascorbic acid, alpha lipoic acid and silymarin or their combination against acetaminophen-induced hepatotoxicity in rats.May 20, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (Kaunas). 2019 May 21 ;55(5). Epub 2019 May 21. PMID: 31117289

Article Published Date : May 20, 2019

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid, Silibinin, Vitamin C

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidant, Hepatoprotective

Additional Keywords : Natural Substance Synergy

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit.Feb 27, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Open Access Maced J Med Sci. 2019 Feb 28 ;7(4):536-542. Epub 2019 Feb 27. PMID: 30894908

Article Published Date : Feb 27, 2019

Study Type : Animal Study

Additional Links

Substances : Passion Flower

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Kidney Damage: Chemically-Induced

Pharmacological Actions : Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity of Andrographis paniculata and Swertia chirayita.Nov 30, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Dec ;49(12):3367-73. Epub 2011 Sep 29. PMID: 21983487

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Andrographis

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity of andrographolide possibly through antioxidative defense mechanism.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Rep. 2022 ;9:1013-1022. Epub 2022 Apr 22. PMID: 36518448

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Andrographolide

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective activity of yellow chinese chive against acetaminophen-induced acute liver injury.Dec 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2020 ;66(4):357-363. PMID: 32863309

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Chives

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective and antioxidant potential of Pycnogenol in acetaminophen-induced hepatotoxicity in rats.Dec 15, 2018

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Pubmed Data : Phytother Res. 2018 Dec 16. Epub 2018 Dec 16. PMID: 30556209

Article Published Date : Dec 15, 2018

Study Type : Animal Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of allicin against acetaminophen-induced liver injury.Feb 09, 2020

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Pubmed Data : J Biochem Mol Toxicol. 2020 Feb 10:e22470. Epub 2020 Feb 10. PMID: 32040233

Article Published Date : Feb 09, 2020

Study Type : Animal Study

Additional Links

Substances : Allicin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of artichoke leaf extracts in comparison with silymarin on acetaminophen-induced hepatotoxicity.Nov 17, 2019

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Pubmed Data : J Immunoassay Immunochem. 2019 Nov 18:1-13. Epub 2019 Nov 18. PMID: 31739724

Article Published Date : Nov 17, 2019

Study Type : Animal Study

Additional Links

Substances : Artichoke, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury.Mar 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Res. 2021 Apr ;37(2):261-275. Epub 2020 Sep 7. PMID: 33868982

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Gotu Kola

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of dried red jujube fruit extract against acetaminophen-induced acute hepatotoxicity.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cureus. 2023 Jan ;15(1):e33272. Epub 2023 Jan 2. PMID: 36606101

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Jujube

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effect of Phellinus linteus mycelia polysaccharide (PL-N1) against acetaminophen-induced liver injury.Nov 19, 2019

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Pubmed Data : Int J Biol Macromol. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31758991

Article Published Date : Nov 19, 2019

Study Type : Animal Study

Additional Links

Substances : Phellinus Linteus

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

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Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

Article Published Date : Jul 14, 2018

Study Type : Animal Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress.Dec 13, 2024

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Pubmed Data : J Mol Histol. 2024 Dec 14 ;56(1):42. Epub 2024 Dec 14. PMID: 39673562

Article Published Date : Dec 13, 2024

Study Type : Animal Study

Additional Links

Substances : Olive leaf extract

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice.Oct 23, 2022

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Pubmed Data : Acta Biochim Pol. 2022 Oct 24 ;69(4):871-878. PMID: 36279514

Article Published Date : Oct 23, 2022

Study Type : Animal Study

Additional Links

Substances : Walnut

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective effects of zerumbone against paracetamol-induced acute hepatotoxicity.Feb 28, 2018

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Pubmed Data : Malays J Med Sci. 2018 Mar ;25(2):64-71. Epub 2018 Apr 27. PMID: 30918456

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Zerumbone

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective potential of Clitoria ternatea leaf extract against paracetamol induced damage in mice.Dec 05, 2011

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2011 Dec 6 ;16(12):10134-45. Epub 2011 Dec 6. PMID: 22146374

Article Published Date : Dec 05, 2011

Study Type : Animal Study

Additional Links

Substances : Butterfly Pea, Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatoprotective property of oral silymarin is comparable to N-Acetyl cysteine in acetaminophen poisoning. Sep 30, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterology Res. 2012 Oct ;5(5):190-194. Epub 2012 Sep 20. PMID: 27785204

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine), Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hepatotoxicity of acetaminophen in neonatal and young rats. II. Metabolic aspects.Jun 14, 1984

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Pubmed Data : Toxicol Appl Pharmacol. 1984 Jun 15 ;74(1):125-33. PMID: 6729817

Article Published Date : Jun 14, 1984

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Higher prenatal acetaminophen use during pregnancy may be associated with poorer early language development.May 31, 2024

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pediatr Res. 2024 Jun ;95(7):1883-1896. Epub 2023 Dec 11. PMID: 38081897

Article Published Date : May 31, 2024

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Histological changes in kidney structure following a long-term administration of paracetamol (acetaminophen) in pregnant Sprague Dawley rats.Dec 31, 2005

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Pubmed Data : Niger J Physiol Sci. 2006 ;21(1-2):77-81. PMID: 17242723

Article Published Date : Dec 31, 2005

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Honokiol alleviates acetaminophen-induced hepatotoxicity.Jul 31, 2019

Click here to read the entire abstract

Pubmed Data : Life Sci. 2019 Aug 1 ;230:97-103. Epub 2019 May 24. PMID: 31129139

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Honokiol

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Honokiol attenuates acetaminophen-induced acute liver injury.Mar 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin Herb Med. 2023 Apr ;15(2):231-239. Epub 2023 Mar 29. PMID: 37265773

Article Published Date : Mar 31, 2023

Study Type : Animal Study

Additional Links

Substances : Honokiol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Mitochondrial Dysfunction

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.Apr 13, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2015 Apr 14 ;21(14):4195-209. PMID: 25892869

Article Published Date : Apr 13, 2015

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model. Sep 30, 2013

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2013 Oct ;32(10):1107-16. Epub 2013 Aug 7. PMID: 23925941

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality.Jun 30, 2015

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Pubmed Data : Phytother Res. 2015 Jul ;29(7):1097-101. Epub 2015 Apr 8. PMID: 25851311

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : St. Johns Wort

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury.Feb 15, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2017 Feb 16 ;7:42736. Epub 2017 Feb 16. PMID: 28205631

Article Published Date : Feb 15, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Impaired brainstem auditory evoked potentials after in utero exposure to high dose paracetamol exposure.Nov 30, 2024

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Pubmed Data : Hear Res. 2024 Dec ;454:109149. Epub 2024 Nov 12. PMID: 39550993

Article Published Date : Nov 30, 2024

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Commun Biol. 2019 ;2:310. Epub 2019 Aug 13. PMID: 31428698

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Aging, Ibuprofen Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

In vivo effects of acetaminophen on rat RBC and role of vitamin E.Mar 31, 1995

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Pubmed Data : Indian J Exp Biol. 1995 Apr ;33(4):269-71. PMID: 7558183

Article Published Date : Mar 31, 1995

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

In vivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris LMar 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ayurveda Integr Med. 2020 Mar 31. Epub 2020 Mar 31. PMID: 32241633

Article Published Date : Mar 30, 2020

Study Type : Animal Study

Additional Links

Substances : Prunella vulgaris

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Induction of chromosome aberrations in vivo in bone-marrow cells of mice by paracetamol.Dec 31, 1994

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Pubmed Data : Rom J Morphol Embryol. 1995 ;41(3-4):117-20. PMID: 8772366

Article Published Date : Dec 31, 1994

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage

Problem Substances : Acetaminophen, Paracetamol

[+]

Inhibitory activity of black mulberry extract against testicular, liver and kidney toxicity induced by paracetamol.Jan 24, 2020

Click here to read the entire abstract

Pubmed Data : Mol Biol Rep. 2020 Jan 25. Epub 2020 Jan 25. PMID: 31983015

Article Published Date : Jan 24, 2020

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Inhibitory effect of acetaminophen on ocular pigmentation and its relationship with thyroxine in zebrafish embryos.Feb 13, 2024

Click here to read the entire abstract

Pubmed Data : Bull Environ Contam Toxicol. 2024 Feb 14 ;112(2):39. Epub 2024 Feb 14. PMID: 38353786

Article Published Date : Feb 13, 2024

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Teratogenic

[+]

Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : FASEB J. 2019 Jan ;33(1):339-357. Epub 2018 Jul 6. PMID: 29979629

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Male Reproductive Development Abnormalities

Additional Keywords : Transgenerational Epigenetic Modification

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Intrauterine exposure to paracetamol at levels commonly observed in pregnant women may block primordial germ cell proliferation.Feb 29, 2016

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2016 Mar ;150(1):178-89. Epub 2016 Jan 5. PMID: 26732887

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Female, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

[+]

Isoorientin ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2017

Click here to read the entire abstract

Pubmed Data : Front Pharmacol. 2018 ;9:1334. Epub 2018 Nov 28. PMID: 30546306

Article Published Date : Dec 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Isoquercitrin could be a potential hepatoprotective agent.Apr 30, 2016

Click here to read the entire abstract

Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Licochalcone A upregulates Nrf2 antioxidant pathway and thereby alleviates acetaminophen-induced hepatotoxicity.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2018 ;9:147. Epub 2018 Mar 23. PMID: 29628888

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Licorice

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Limonin ameliorates acetaminophen-induced hepatotoxicity.Mar 31, 2020

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2020 Apr ;69:153211. Epub 2020 Mar 20. PMID: 32259676

Article Published Date : Mar 31, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus Triterpenoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation, SIRT1 Activator

Problem Substances : Acetaminophen, Paracetamol

[+]

Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity.May 01, 2022

Click here to read the entire abstract

Pubmed Data : Drug Chem Toxicol. 2022 May 2:1-9. Epub 2022 May 2. PMID: 35502492

Article Published Date : May 01, 2022

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Long-term acetaminophen (paracetamol) treatment causes liver and kidney ultra-structural changes during rat pregnancy.Dec 31, 2003

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Pubmed Data : Clin Exp Obstet Gynecol. 2004 ;31(3):221-4. PMID: 15491069

Article Published Date : Dec 31, 2003

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Liver Damage: Drug-Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599

Article Published Date : Jan 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carotenoids, Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Antioxidants, CAROTENOIDS, Hepatoprotective, Liver Damage: Drug-Induced, lycopene, Matrix metalloproteinase-2 (MMP-2) inhibitor, oxidative stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

Article Published Date : Jan 31, 2017

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Acetaminophen (Tylenol) Toxicity, Anti-Inflammatory Agents, Hepatoprotective, Liver Damage: Drug-Induced, lycopene

Problem Substances : Acetaminophen, Paracetamol

[+]

Magnesium hydride protects against acetaminophen-induced acute kidney injury.Nov 30, 2024

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ren Fail. 2024 Dec ;46(1):2330629. Epub 2024 Mar 17. PMID: 38494199

Article Published Date : Nov 30, 2024

Study Type : Animal Study

Additional Links

Substances : Magnesium

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Mangiferin ameliorates acetaminophen-induced hepatotoxicity.Jun 14, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jun 15 ;117:109097. Epub 2019 Jun 15. PMID: 31212128

Article Published Date : Jun 14, 2019

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Melilotus officinali has strong hepatoprotective activity against paracetamol and carbon tetrachloride induced hepatotoxicity.Apr 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Pol Pharm. 2017 May ;74(3):903-909. PMID: 29513960

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Yellow Sweet Clover (Melilotus officinalis)

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Methionine in paracetamol tablets, a tool to reduce paracetamol toxicity.Aug 31, 1985

Click here to read the entire abstract

Pubmed Data : Int J Clin Pharmacol Ther Toxicol. 1985 Sep ;23(9):497-500. PMID: 4055163

Article Published Date : Aug 31, 1985

Study Type : Animal Study

Additional Links

Substances : Methionine

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Cytoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Methylsulfonylmethane pre-treatment could alleviate hepatic injury induced by acetaminophen intoxication.Jul 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2013 Aug ;16(8):896-900. PMID: 24106592

Article Published Date : Jul 31, 2013

Study Type : Animal Study

Additional Links

Substances : MSM (Methylsulfonylmethane)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury.Dec 31, 2023

Click here to read the entire abstract

Pubmed Data : Colloids Surf B Biointerfaces. 2024 Jan ;233:113656. Epub 2023 Nov 15. PMID: 37984191

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Moringa oleifera leaf extracts shielded kidneys from acetaminophen toxicity through enhancement of the endogenous antioxidant system.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534

Article Published Date : Feb 24, 2019

Study Type : Animal Study

Additional Links

Substances : Nutmeg

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

N-acetylcysteine and glycyrrhizin combination: Benefit outcome in a murine model of acetaminophen-induced liver failure.Sep 26, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Hepatol. 2020 Sep 27 ;12(9):596-618. PMID: 33033567

Article Published Date : Sep 26, 2020

Study Type : Animal Study

Additional Links

Substances : Glycyrrhizin, NAC (N-acetyl-L-cysteine)

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Naringin treatment reduced histological alteration induced by APAP in the liver and kidney.Apr 05, 2016

Click here to read the entire abstract

Pubmed Data : Ren Fail. 2016 Apr 6:1-14. Epub 2016 Apr 6. PMID: 27050864

Article Published Date : Apr 05, 2016

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective, MicroRNA modulator, Renoprotective

Problem Substances : Paracetamol

[+]

Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity.Feb 28, 2018

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2018 Mar 1 ;162(1):99-112. PMID: 29136249

Article Published Date : Feb 28, 2018

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid, Polyphenols

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:4916519. Epub 2019 May 13. PMID: 31214269

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Tongkat Ali

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nephroprotective property of Trifolium repens leaf extract against paracetamol-induced kidney damage.Nov 30, 2020

Click here to read the entire abstract

Pubmed Data : 3 Biotech. 2020 Dec ;10(12):541. Epub 2020 Nov 19. PMID: 33240744

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Substances : White Clover

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nicotinamide improves NAD + levels to protect against acetaminophen-induced acute liver injury in mice.May 04, 2021

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2021 May 5:9603271211014573. Epub 2021 May 5. PMID: 33949241

Article Published Date : May 04, 2021

Study Type : Animal Study

Additional Links

Substances : Nicotinamide

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Paracetamol

[+]

Nigella sativa has a significant nephroprotective activity on paracetamol-induced nephrotoxicity.Mar 08, 2016

Click here to read the entire abstract

Pubmed Data : Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID: 26956915

Article Published Date : Mar 08, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nobiletin attenuates acetaminophen-induced hepatorenal toxicity.Nov 26, 2019

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2019 Nov 27:e22427. Epub 2019 Nov 27. PMID: 31777137

Article Published Date : Nov 26, 2019

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Non-toxic dose of acetaminophen has the potential to increase carbon tetrachloride-induced liver damage and oxidative stress.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Pharm Bull. 2017 ;40(9):1590-1594. PMID: 28867745

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Oxidative Stress

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Med (Lausanne). 2022 ;9:1055252. Epub 2023 Jan 6. PMID: 36714147

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Novel pterostilbene-loaded pro-phytomicelles: preclinical pharmacokinetics, distribution, and treatment efficacy against acetaminophen-induced liver injury.Sep 01, 2022

Click here to read the entire abstract

Pubmed Data : Food Funct. 2022 Sep 2. Epub 2022 Sep 2. PMID: 36052647

Article Published Date : Sep 01, 2022

Study Type : Animal Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent acute liver failure.Oct 03, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Oct 4 ;8(10). Epub 2016 Oct 4. PMID: 27782042

Article Published Date : Oct 03, 2016

Study Type : Animal Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Oxidative stress in paracetamol-induced pathogenesis: (I). Renal damage.Jan 31, 2005

Click here to read the entire abstract

Pubmed Data : Indian J Biochem Biophys. 2005 Feb ;42(1):59-62. PMID: 23923583

Article Published Date : Jan 31, 2005

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced, Lipid Peroxidation, Oxidative Stress

Problem Substances : Acetaminophen, Paracetamol

[+]

Ozone showed beneficial effects on acetaminophen hepatotoxicity at a statistically significant level.Nov 12, 2017

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2017 Nov 13 ;70(2):340-345. Epub 2017 Nov 13. PMID: 29477043

Article Published Date : Nov 12, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Therapeutic Actions : Ozone Therapy

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

P. leschenaultii leaves extract protects the liver from paracetamol induced hepatic damage.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:1114-1121. Epub 2017 Feb 10. PMID: 28192885

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Passion Flower

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Paracetamol

[+]

P. major extracts attenuate the inflammatory reaction following APAP-induced liver injury. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:347861. Epub 2015 Aug 2. PMID: 26300946

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Plantago major

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Paeoniflorin attenuates acetaminophen-induced liver injury.Feb 10, 2025

Click here to read the entire abstract

Pubmed Data : Int J Mol Sci. 2025 Feb 11 ;26(4). Epub 2025 Feb 11. PMID: 40003959

Article Published Date : Feb 10, 2025

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Paeoniflorin protects against acetaminophen-induced liver injury.Dec 03, 2022

Click here to read the entire abstract

Pubmed Data : Molecules. 2022 Dec 4 ;27(23). Epub 2022 Dec 4. PMID: 36500627

Article Published Date : Dec 03, 2022

Study Type : Animal Study

Additional Links

Substances : Paeoniflorin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol (acetaminophen) administration during neonatal brain development affects cognitive function and alters its analgesic and anxiolytic response.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxicol Sci. 2014 Mar ;138(1):139-47. Epub 2013 Dec 21. PMID: 24361869

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Paracetamol (Acetaminophen) and its effect on the developing mouse brain.Dec 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Toxicol. 2022 ;4:867748. Epub 2022 Mar 22. PMID: 35391823

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Brain: Oxidative Stress, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure.Jun 30, 2017

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2017 Jul ;53:111-120. Epub 2017 May 8. PMID: 28545014

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage

Problem Substances : Acetaminophen, Endocrine Disrupting Chemicals (EDCs), Paracetamol

[+]

Paracetamol impairs the profile of amino acids in the rat brain.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jan ;37(1):95-102. Epub 2013 Nov 13. PMID: 24316461

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol potentiates stress-induced gastric ulceration in rats.Jun 30, 1990

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 1990 Jul ;42(7):505-7. PMID: 1980294

Article Published Date : Jun 30, 1990

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Gastric Ulcer

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol--the outcome on neurotransmission and spatial learning in rats.Sep 14, 2013

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2013 Sep 15 ;253:157-64. Epub 2013 Jul 11. PMID: 23850354

Article Published Date : Sep 14, 2013

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Memory Disorders

Problem Substances : Acetaminophen, Paracetamol

[+]

Paracetamol-induced metabolic and cardiovascular changes are prevented by exercise training.Nov 30, 2020

Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 Dec ;127(6):516-524. Epub 2020 Jul 9. PMID: 32573044

Article Published Date : Nov 30, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Lipid Peroxidation, Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Cardioprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Perinatal exposure to paracetamol: Dose and sex-dependent effects in behaviour and brain's oxidative stress markers in progeny.Jun 24, 2021

Click here to read the entire abstract

Pubmed Data : Behav Brain Res. 2021 Jun 25 ;408:113294. Epub 2021 Apr 6. PMID: 33836167

Article Published Date : Jun 24, 2021

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Neurodevelopmental Disorders, Oxidative Stress, Prenatal Chemical Exposures

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Phoenix dactylifera protects against oxidative stress and hepatic injury induced by paracetamol intoxication.Jul 31, 2018

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:366-374. Epub 2018 May 25. PMID: 29778019

Article Published Date : Jul 31, 2018

Study Type : Animal Study

Additional Links

Substances : Dates

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Piperine as therapeutic agent in paracetamol-induced hepatotoxicity.Aug 25, 2022

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmaceutics. 2022 Aug 26 ;14(9). Epub 2022 Aug 26. PMID: 36145547

Article Published Date : Aug 25, 2022

Study Type : Animal Study

Additional Links

Substances : Piperine

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation

Problem Substances : Acetaminophen, Paracetamol

[+]

Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury.Aug 31, 2022

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2022 Sep ;104:154311. Epub 2022 Jul 6. PMID: 35843188

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Acetaminophen (Tylenol) Toxicity , Inflammation, Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Polysaccharides from dandelion root have hepatoprotective effects.Aug 24, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2017 Aug 25 ;22(9). Epub 2017 Aug 25. PMID: 28841174

Article Published Date : Aug 24, 2017

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Polysaccharides

Problem Substances : Acetaminophen, Paracetamol

[+]

Pomegranate juice might have a preventive effect in paracetamol-induced acute liver damage.May 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Turk Pediatri Ars. 2016 Jun ;51(2):72-8. Epub 2016 Jun 1. PMID: 27489463

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Potentiation of gastric toxicity of ibuprofen by paracetamol.Jun 30, 1991

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 1991 Jul ;43(7):520-1. PMID: 1682470

Article Published Date : Jun 30, 1991

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Gastric Ulcer, Ibuprofen Toxicity

Additional Keywords : Synergistic Toxicity

Problem Substances : Acetaminophen, Ibuprofen, Paracetamol

[+]

Pre-treatment with cinnamon provide potential therapeutic applications in acute liver and kidney injury induced by acetaminophen.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2285-2292. Epub 2018 Nov 28. PMID: 30551486

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen exposure induces changes of placental morphology and function and its influencing factors.Aug 31, 2025

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2025 Sep ;203:115598. Epub 2025 Jun 10. PMID: 40505803

Article Published Date : Aug 31, 2025

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : J Hepatol. 2015 May ;62(5):1085-91. Epub 2014 Dec 18. PMID: 25529619

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Asthma, Inflammation, Liver Damage: Drug-Induced, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal and postnatal paracetamol exposure results in modulation of cerebellar neurotransmission with changes concerning mainly 5-HIAA and MHPG levels.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures

Additional Keywords : Acetaminophen, Acetaminophen (Tylenol) Toxicity, paracetamol, Prenatal Chemical Exposures

Problem Substances : Acetaminophen, Paracetamol

Adverse Pharmacological Actions : Neurotoxic

[+]

Prenatal cigarette smoke exposure sensitizes acetaminophen-induced liver injury by modulating miR-34a-5p in male offspring mice.Dec 31, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Cell Dev Biol. 2024 ;12:1393618. Epub 2024 Jul 30. PMID: 39139452

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage, Prenatal Chemical Exposures, Smoking

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism.Nov 30, 2023

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Pubmed Data : Chemosphere. 2023 Dec ;345:140496. Epub 2023 Oct 19. PMID: 37865203

Article Published Date : Nov 30, 2023

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Testicular Injury: Chemical/Metal Induced

Problem Substances : Acetaminophen, Paracetamol

[+]

Prenatal exposure to acetaminophen may impair male sexual behaviour in adulthood by disrupting the sexual neurobehavioral programming.Jul 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Reproduction. 2017 Aug ;154(2):145-152. Epub 2017 May 30. PMID: 28559473

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Prenatal Chemical Exposures, Sexual Behavior

Problem Substances : Acetaminophen, Paracetamol

[+]

Preventive effect of methanolic extract of Zataria Multiflora Boiss on liver toxicity of paracetamol.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Life. 2015 ;8(Spec Iss 4):270-274. PMID: 28316743

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Zataria multiflora

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

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Propolis significantly prevented paracetamol induced renal, hepatic and hematological toxicity.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res Pract. 2018 Dec ;12(6):535-540. Epub 2018 Nov 23. PMID: 30515282

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Bee Propolis

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect and mechanism of action of diallyl disulfide against acetaminophen-induced acute hepatotoxicity.Oct 31, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Nov ;109(Pt 1):28-37. Epub 2017 Aug 25. PMID: 28847761

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Garlic, Organosulfur Compounds

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue.Dec 31, 2018

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Pubmed Data : Environ Sci Pollut Res Int. 2019 Jan ;26(1):240-249. Epub 2018 Nov 3. PMID: 30392171

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of dandelion leaf water extracts on APAP-induced liver injury in rats and its mechanism.May 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2022 May 31 ;68(5):24-33. Epub 2022 May 31. PMID: 36029509

Article Published Date : May 30, 2022

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of Phoenix dactylifera L. seeds against paracetamol-induced hepatotoxicity.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ScientificWorldJournal. 2021 ;2021:6618273. Epub 2021 Jul 6. PMID: 34326710

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Date Seeds

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents.Nov 30, 2002

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Pubmed Data : Fitoterapia. 2002 Dec ;73(7-8):557-63. PMID: 12490212

Article Published Date : Nov 30, 2002

Study Type : Animal Study

Additional Links

Substances : Rutin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Additional Keywords : Phytotherapy

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effect of the hydroalcoholic extract of Pelargonium graveolens on acetaminophen-induced nephrotoxicity.Feb 28, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Kidney Dis. 2022 Mar ;16(2):108-114. PMID: 35489079

Article Published Date : Feb 28, 2022

Study Type : Animal Study

Additional Links

Substances : Germanium

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Renoprotective

Additional Keywords : Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption.Aug 04, 2019

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Pubmed Data : Biomarkers. 2019 Aug 5:1-7. Epub 2019 Aug 5. PMID: 31305161

Article Published Date : Aug 04, 2019

Study Type : Animal Study

Additional Links

Substances : Betanin

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Acetaminophen, Diclofenac, Paracetamol

[+]

Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity.Sep 04, 2019

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Pubmed Data : Gene. 2019 Sep 5 ;712:143966. Epub 2019 Jul 4. PMID: 31279711

Article Published Date : Sep 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin, Silymarin

Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Natural Substance Synergy, Plant Extracts

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.Apr 30, 1992

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Pubmed Data : Zhongguo Yao Li Xue Bao. 1992 May ;13(3):209-12. PMID: 1442100

Article Published Date : Apr 30, 1992

Study Type : Animal Study

Additional Links

Substances : Honeysuckle

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of p-coumaric acid against acetaminophen-induced hepatotoxicity.Oct 31, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Nov ;121:131-139. Epub 2018 Aug 24. PMID: 30149109

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : P-Coumaric Acid

Diseases : Acetaminophen (Tylenol) Toxicity , DNA damage, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Acetaminophen, Paracetamol

[+]

Protective effects of resveratrol and avocado oil against paracetamol-induced hepatotoxicity in rats.Aug 31, 2022

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Pubmed Data : Drug Chem Toxicol. 2022 Sep ;45(5):2131-2139. Epub 2021 Apr 8. PMID: 33832400

Article Published Date : Aug 31, 2022

Study Type : Animal Study

Additional Links

Substances : Avocado, Resveratrol

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Protracted use of acetaminophen (1 week) may suppress fetal testosterone production, which could have adverse consequences.May 19, 2015

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Pubmed Data : Sci Transl Med. 2015 May 20 ;7(288):288ra80. PMID: 25995226

Article Published Date : May 19, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Fetal Origin of Adult Disease

Problem Substances : Acetaminophen, Paracetamol

[+]

Pterostilbene protects against acetaminophen-induced liver injury by restoring impaired autophagic flux.Dec 31, 2018

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Pubmed Data : Food Chem Toxicol. 2019 Jan ;123:536-545. Epub 2018 Dec 10. PMID: 30543896

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Pterostilbene reduces acetaminophen-induced liver injury.Sep 19, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Physiol Biochem. 2018 Sep 20 ;49(5):1943-1958. Epub 2018 Sep 20. PMID: 30235447

Article Published Date : Sep 19, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Pterostilbene

Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Problem Substances : Acetaminophen, Paracetamol

[+]

Quercitrin attenuates acetaminophen induced liver damage by the activation of defensive genes and the inhibition of pro-inflammatory genes.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID: 27428996

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Toona sinensis

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator

Problem Substances : Acetaminophen, Paracetamol

[+]

Reduced sperm count was seen at a dose level reflecting human therapeutic exposure to paracetamol. Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Endocr Connect. 2018 Jan ;7(1):139-148. Epub 2017 Dec 4. PMID: 29203468

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Infertility: Male

Additional Keywords : Risk Factors

Problem Substances : Acetaminophen, Endocrine Disruptors, Paracetamol

[+]

Renoprotective effect of taxifolin in paracetamol-induced nephrotoxicity.Jan 21, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Med. 2023 Jan 22 ;12(3). Epub 2023 Jan 22. PMID: 36769524

Article Published Date : Jan 21, 2023

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Renoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Renoprotective effects of cinnamon oil against APAP-Induced nephrotoxicity.Jan 31, 2021

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Saudi Pharm J. 2021 Feb ;29(2):194-200. Epub 2021 Jan 23. PMID: 33679180

Article Published Date : Jan 31, 2021

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : Acetaminophen (Tylenol) Toxicity , Kidney Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective

Problem Substances : Acetaminophen, Paracetamol

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View the Evidence: 410 Abstracts with Acetaminophen Research

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Acetaminophen use and the risk of asthma in children and adults.Oct 31, 2009

Prenatal paracetamol use and asthma in childhood: A systematic review and meta-analysis.Dec 31, 2016

The use of paracetamol during pregnancy is associated with an increased risk of childhood asthma.Mar 31, 2011

Prevalence of hypersensitivity reactions in children associated with acetaminophen.Dec 31, 2017

Trial evidence that paracetamol has a superior antipyretic effect than placebo is inconclusive.Jan 01, 2002

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.Aug 31, 2021

Acetaminophen exposure during pregnancy was associated with childhood asthmatic symptoms among vulnerable subgroups in this cohort.Sep 25, 2021

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn.Mar 31, 2019

Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms.Jul 31, 2018

Acetaminophen use for fever in children associated with autism spectrum disorder.Mar 31, 2016

Acupuncture was found to be a better treatment option than the conventional drug therapy in not only relieving the pain of migraine but in also improving the psychological profile in migraneurs. Dec 31, 2013

Acute renal failure has been associated with non-steroidal anti-inflammatory drugs in healthy children.Sep 01, 2005

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.Nov 30, 1990

Antipyretic agents are ineffective for the prevention of recurrences of febrile seizures and for the lowering of body temperature in patients with a febrile episode that leads to a recurrent febrile seizure.Sep 01, 2009

Association of acetaminophen use during pregnancy with behavioural problems in childhood.Sep 30, 2016

Association of prenatal acetaminophen exposure measured in meconium with risk of attention-deficit/hyperactivity disorder.Oct 31, 2020

Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns.Dec 31, 2021

Associations between Acetaminophen Use during Pregnancy and ADHD Symptoms Measured at Ages 7 and 11 Years.Dec 31, 2013

Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.May 31, 2024

Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.Apr 30, 2020

Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.Dec 31, 2009

Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.May 31, 2000

Exposure to paracetamol in utero was associated with increased risks of motor milestone delay and impaired communication skills in children at 18 months.Nov 30, 2016

Gestational exposure to acetaminophen was associated with a small increased risk of ADHD.Sep 29, 2025

Higher paracetamol levels are associated with elevated glucocorticoid concentrations in hair.Jun 30, 2024

Long-term prenatal exposure to paracetamol is associated with DNA methylation differences in children diagnosed with ADHD.Dec 31, 2016

Male urinary paracetamol and semen quality.Oct 31, 2017

Maternal acetaminophen biomarkers were specifically associated with increased risk of ADHD diagnosis in offspring. Jul 02, 2018

Maternal acetaminophen use and cognitive development at 4 years.Feb 28, 2023

Maternal acetaminophen use during pregnancy is associated with a higher risk for hyperkinetic disorders and ADHD-like behaviors in children.Mar 31, 2014

Maternal acetaminophen use during pregnancy was associated with lower performance IQ in 5-year olds.Oct 31, 2016

Maternal exposure to paracetamol is associated with disadvantages to the offspring in scholastic abilities such as mathematics and reading at secondary school ages.Dec 31, 2022

Maternal paracetamol use during pregnancy could be associated with poorer attention and executive function in 5-year-olds.Nov 30, 2016

Maternal paracetamol use in pregnancy is associated with an enhanced risk of asthma and wheezing in their children.Feb 23, 2023

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years.Dec 31, 2021

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sonsDec 31, 2016

Paracetamol use during pregnancy was associated with an increased risk of asthma and wheezing in childhood.May 31, 2008

Paracetamol was associated with increased mortality, especially cardiovascular.Jul 31, 2015

Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity.Apr 30, 1991

Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males.Dec 31, 2015

Prenatal acetaminophen was associated with adverse birth outcomes.Dec 31, 2021

Prenatal and early-life antibiotic exposure and the risk of atopic dermatitis in children.Apr 30, 2023

Prenatal and infant paracetamol exposure and development of asthma.Mar 31, 2016

Prenatal exposure to acetaminophen and children's language development at 30 months.May 31, 2018

Prenatal exposure to acetaminophen increases the risk of atopic dermatitis in children.Jun 30, 2021

Prenatal paracetamol exposure and child neurodevelopment.Nov 30, 2013

Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood.Dec 31, 2004

Prenatal paracetamol exposure and risk of wheeze at preschool age.Nov 30, 2011

Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants.Oct 31, 2016

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study.Mar 31, 2018

The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood.Dec 31, 2023

This study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life.Aug 31, 2008

This suggests that acetaminophen may not be as safe in pregnancy as is widely believed.Feb 29, 2016

The results of this in vitro study suggested that high doses of acetaminophen may cause serious damage towards human mesenchymal stem cells.Jun 18, 2015

This study highlights the potential for acetaminophen to interfere with hormone regulation during pregnancy.Jan 05, 2021

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Ferulic acid ameliorates acetaminophen-induced acute liver injury.May 04, 2022

Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

Co-administration of N-Acetylcysteine and Acetaminophen efficiently blocks Acetaminophen toxicity.Jul 31, 2015

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice Jun 11, 2017

The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.Feb 02, 2020

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.Mar 04, 2019

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.Jun 30, 2022

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.Jun 30, 2016

A single early-life acetaminophen exposure causes persistent abnormalities in the murine lung.Jul 31, 2025

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.Nov 30, 2018

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.Dec 31, 1999

Acetaminophen affects empathy-like behavior in rats.Nov 30, 2018

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.Dec 30, 2015

Acetaminophen

View the Evidence:
410 Abstracts with Acetaminophen Research