Focused Research Topics Wheat & Immunotoxic

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Associated Topics included in this Focused Research

Gliadin Gluten Gluten exorphins Wheat Wheat Germ Agglutinin (WGA)

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View the Evidence
12 Research Articles in Total

Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage associated with infertility.

Pubmed Data : Am J Gastroenterol. 2010 Oct ;105(10):2254-61. Epub 2010 Jun 22. PMID: 20571491
Article Published Date : Oct 01, 2010
Authors : Nicoletta Di Simone, Marco Silano, Roberta Castellani, Fiorella Di Nicuolo, Maria C D'Alessio, Francesco Franceschi, Alessandra Tritarelli, Antonio M Leone, Chiara Tersigni, Giovanni Gasbarrini, Nicolò G Silveri, Alessandro Caruso, Antonio Gasbarrini
Study Type : Human In Vitro
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Anti-tissue Transglutaminase Antibodies : CK(15) : AC(2)
Problem Substances : Gliadin : CK(819) : AC(116)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

Celiac disease is a common condition in Down syndrome.

Pubmed Data : J Pediatr Gastroenterol Nutr. 1995 Nov;21(4):443-5. PMID: 8583297
Article Published Date : Nov 01, 1995
Authors : U Jansson, C Johansson
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Down Syndrome : CK(84) : AC(13)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Gliadin : CK(819) : AC(116), Gluten : CK(1088) : AC(167), Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

Intolerance to wheat (CD autoantibodies) is higher than background rates in those with Turner syndrome.

Pubmed Data : Clin Exp Immunol. 2009 May;156(2):205-10. Epub 2009 Feb 26. PMID: 19298606
Article Published Date : May 01, 2009
Authors : K H Mortensen, L Cleemann, B E Hjerrild, E Nexo, H Locht, E M Jeppesen, C H Gravholt
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Celiac Disease : CK(1612) : AC(232), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Hypothyroidism : CK(582) : AC(89), Turner Syndrome : CK(10) : AC(1)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

There is a high frequency of autoimmune thyroid disease among celiac disease patients.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2003 Jul;37(1):63-6. PMID: 12827007
Article Published Date : Jul 01, 2003
Authors : Nicoletta Ansaldi, Tiziana Palmas, Andrea Corrias, Maria Barbato, Mario Rocco D'Altiglia, Angelo Campanozzi, Mariella Baldassarre, Francesco Rea, Rosanna Pluvio, Margherita Bonamico, Rosanna Lazzari, Giovanni Corrao
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Autoimmune Thyroiditis : CK(149) : AC(19), Celiac Disease : CK(1612) : AC(232), Hypothyroidism : CK(582) : AC(89)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

There is evidence that intolerance to wheat (measured by CD associated anti-endomysial antibodies) may play a role in Graves' disease.

Pubmed Data : Digestion. 1999 Jan-Feb;60(1):86-8. PMID: 9892805
Article Published Date : Jan 01, 1999
Authors : A Carroccio, N Custro, G Montalto, L Giannitrapani, M Soresi, A Notarbartolo
Study Type : Human Study
Additional Links
Diseases : Celiac Disease : CK(1612) : AC(232), Graves Disease : CK(106) : AC(12)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Gliadin : CK(819) : AC(116)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

Thyroid autoimmunity is associated with celiac disease in children.

Pubmed Data : J Pediatr. 2010 Feb;156(2):292-5. Epub 2009 Oct 20. PMID: 19846116
Article Published Date : Feb 01, 2010
Authors : Alessandra Cassio, Giampaolo Ricci, Federico Baronio, Angela Miniaci, Milva Bal, Barbara Bigucci, Veronica Conti, Alessandro Cicognani
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Celiac Disease : CK(1612) : AC(232), Hypothyroidism : CK(582) : AC(89)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Problem Substances : Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

Children with autism show elevations against gliadin (wheat protein) and cerebellar proteins simultaneously. These proteins simulate antibodies that may cross-react, resulting in neurological damage.

Pubmed Data : Nutr Neurosci. 2004 Jun;7(3):151-61. PMID: 15526989
Article Published Date : Jun 01, 2004
Authors : A Vojdani, T O'Bryan, J A Green, J Mccandless, K N Woeller, E Vojdani, A A Nourian, E L Cooper
Study Type : Human Study
Additional Links
Diseases : Autism : CK(617) : AC(73), Autism Spectrum Disorders : CK(1493) : AC(159), Autoimmune Diseases : CK(6629) : AC(1128), Gluten Sensitivity : CK(778) : AC(105)
Additional Keywords : Molecular Mimicry : CK(67) : AC(15)
Problem Substances : Gliadin : CK(819) : AC(116), Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52)

Dietary gluten influences the development of type 1 diabetes (T1D).

Pubmed Data : PLoS One. 2012 ;7(3):e33315. Epub 2012 Mar 13. PMID: 22428018
Article Published Date : Jan 01, 2012
Authors : Julie Christine Antvorskov, Petra Fundova, Karsten Buschard, David P Funda
Study Type : Animal Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Celiac disease is associated with elevated transaminase levels in about one-third of newly diagnosed children with liver disease.

Pubmed Data : J Pediatr Gastroenterol Nutr. 2013 Feb 22. Epub 2013 Feb 22. PMID: 23434875
Article Published Date : Feb 21, 2013
Authors : Pietro Vajro, Giulia Paolella, Giuseppe Maggiore, Giuseppe Giordano
Study Type : Human Study
Additional Links
Diseases : Cryptogenic Hypertransaminasemia : CK(10) : AC(1), Hepatitis: Autoimmune : CK(43) : AC(9)
Problem Substances : Gluten : CK(1088) : AC(167), Wheat : CK(2775) : AC(335)
Adverse Pharmacological Actions : Hepatotoxic : CK(320) : AC(92), Immunotoxic : CK(294) : AC(52)

Dietary gluten reduces the number of intestinal regulatory T cells in mice which may result in loss of self-tolerance and therefore increased risk of type 1 diabetes.

Pubmed Data : Scand J Immunol. 2008 Jun ;67(6):553-9. PMID: 18476878
Article Published Date : Jun 01, 2008
Authors : M Ejsing-Duun, J Josephsen, B Aasted, K Buschard, A K Hansen
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Pharmacological Actions : Interleukin-10 downregulation : CK(128) : AC(45)
Problem Substances : Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes.

Pubmed Data : Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):59-63. PMID: 17607660
Article Published Date : Dec 31, 2007
Authors : David P Funda, Anne Kaas, Helena Tlaskalová-Hogenová, Karsten Buschard
Study Type : Animal Study
Additional Links
Diseases : Breastfeeding: Complications : CK(189) : AC(21), Breastfeeding Concerns: Chemical Exposure : CK(123) : AC(19), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50), Pregnancy Complications : CK(192) : AC(23)
Problem Substances : Gliadin : CK(819) : AC(116), Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

Gluten-free diet prevents diabetes in NOD mice.

Pubmed Data : Diabetes Metab Res Rev. 1999 Sep-Oct;15(5):323-7. PMID: 10585617
Article Published Date : Aug 31, 1999
Authors : D P Funda, A Kaas, T Bock, H Tlaskalová-Hogenová, K Buschard
Study Type : Animal Study
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 1: Prevention : CK(255) : AC(50), Hyperinsulinism : CK(251) : AC(56)
Problem Substances : Gliadin : CK(819) : AC(116), Gluten : CK(1088) : AC(167)
Adverse Pharmacological Actions : Diabetogenic : CK(269) : AC(46), Immunotoxic : CK(294) : AC(52)

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