Focused Research Topics Aspartame & Neurotoxic

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Associated Topics included in this Focused Research

Aspartame

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View the Evidence
12 Research Articles in Total

Beta-caryophyllene mitigates the cognitive impairment caused by repeated exposure to aspartame.

Pubmed Data : Behav Brain Res. 2023 Sep 13 ;453:114615. Epub 2023 Aug 7. PMID: 37558167
Article Published Date : Sep 12, 2023
Authors : Érica Vanessa Furlan Rosa, Alice Rosa Da Silveira, Marcel Henrique Marcondes Sari, Tuane Bazanella Sampaio, Jamila Trindade Dos Santos, Sabrina Grendene Müller, Michele Rechia Fighera, Luiz Fernando Freire Royes, Cristina Wayne Nogueira, Mauro Schneider Oliveira, Ana Flávia Furian
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene : CK(171) : AC(92)
Diseases : Memory Disorders : CK(2227) : AC(614)
Pharmacological Actions : Brain-derived neurotrophic factor modulator : CK(745) : AC(280), Neuroprotective Agents : CK(20061) : AC(7949)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males.

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Authors : Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Soad M Saleh, Bernard Andres, Angela Inglis, Rana Al-Rabiah, Futwan A Al-Mohanna
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(5382) : AC(1059), Insulin Resistance : CK(4864) : AC(1098)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(151) : AC(37), Neurotoxic : CK(2976) : AC(726)

In the quest for the ideal sweetener: Aspartame exacerbates selected biomarkers in the fruit fly ( Drosophila melanogaster) model of Alzheimer's disease more than sucrose.

Pubmed Data : Aging Brain. 2023 ;4:100090. Epub 2023 Jul 30. PMID: 37559954
Article Published Date : Dec 31, 2022
Authors : Bukola Christiana Adedayo, Stephanie Tolulope Akinniyi, Opeyemi Babatunde Ogunsuyi, Ganiyu Oboh
Study Type : Insect Study
Additional Links
Diseases : Alzheimer's Disease : CK(5355) : AC(2210)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Authors : Karen Lau, W Graham McLean, Dominic P Williams, C Vyvyan Howard
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity : CK(679) : AC(93), Excitotoxicity : CK(59) : AC(36), Neurodevelopmental Disorders : CK(504) : AC(88)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(965) : AC(266)
Problem Substances : Aspartame : CK(317) : AC(101), Brilliant Blue FCF : CK(4) : AC(3), L-glutamic Acid : CK(13) : AC(3), Quinoline Yellow : CK(1) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Aspartame induces brain oxidative stress and vascular congestion in the animal model.

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Authors : M Abhilash, M V Sauganth Paul, Mathews V Varghese, R Harikumaran Nair
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(644) : AC(347), Brain: Vascular Congestion : CK(2) : AC(1)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Aspartame ingestion led to alterations in behaviour, cerebral cortical morphology and cerebral oxidative stress markers.

Pubmed Data : J Chem Neuroanat. 2016 Aug 24 ;78:42-56. Epub 2016 Aug 24. PMID: 27565676
Article Published Date : Aug 23, 2016
Authors : Adejoke Y Onaolapo, Olakunle J Onaolapo, Polycarp U Nwoha
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(644) : AC(347)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Aspartame may be responsible for adverse neurobehavioral health outcomes.

Pubmed Data : Nutr Neurosci. 2017 Feb 15:1-11. Epub 2017 Feb 15. PMID: 28198207
Article Published Date : Feb 14, 2017
Authors : Arbind Kumar Choudhary, Yeong Yeh Lee
Study Type : Review
Additional Links
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium.

Pubmed Data : Metab Brain Dis. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30264280
Article Published Date : Sep 27, 2018
Authors : Anayelly Solis-Medina, José Jaime Martínez-Magaña, Valeria Quintanar-Jurado, Ileana Gallegos-Silva, Isela E Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, Juan C Díaz-Zagoya, Yazmín Hernández-Díaz, Thelma Beatriz González-Castro, María Lilia López-Narváez, Alma Delia Genis-Mendoza, Humberto Nicolini
Study Type : Animal Study
Additional Links
Problem Substances : Acesulfame potassium : CK(66) : AC(20), Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation.

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Aug 31, 2012
Authors : Ashok Iyyaswamy, Sheeladevi Rathinasamy
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation : CK(1784) : AC(928), Excitotoxicity : CK(59) : AC(36), Lipid Peroxidation : CK(2057) : AC(806)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Oral aspartame significantly altered behaviour, anti-oxidant status and morphology of the hippocampus in mice.

Pubmed Data : Neurobiol Learn Mem. 2016 Dec 31 ;139:76-88. Epub 2016 Dec 31. PMID: 28049023
Article Published Date : Dec 30, 2016
Authors : Adejoke Y Onaolapo, Olakunle J Onaolapo, Polycarp U Nwoha
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

Subchronic intake of aspartame and soft drink significantly disrupted the brain energy production.

Pubmed Data : Metab Brain Dis. 2017 Jun 28. Epub 2017 Jun 28. PMID: 28660358
Article Published Date : Jun 27, 2017
Authors : Mohamed A Lebda, Kadry M Sadek, Yasser S El-Sayed
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

These findings demonstrate that aspartame metabolites could be a contributing factor for the development of oxidative stress in the brain.

Pubmed Data : J Food Drug Anal. 2018 Apr ;26(2):903-916. Epub 2017 Dec 6. PMID: 29567262
Article Published Date : Mar 31, 2018
Authors : Ashok Iyaswamy, Ananth Kumar Kammella, Citarasu Thavasimuthu, Wankhar Wankupar, Wankhar Dapkupar, Sambantham Shanmugam, Ravindran Rajan, Sheeladevi Rathinasamy
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(644) : AC(347)
Problem Substances : Aspartame : CK(317) : AC(101)
Adverse Pharmacological Actions : Neurotoxic : CK(2976) : AC(726)

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