Focused Research Topics Statin Drugs & Neurotoxic

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Associated Topics included in this Focused Research

Atorvastatin Cerivastatin Fluvastatin Lovastatin Pravastatin Rosuvastatin Simvastatin Statin Drugs

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54 Research Articles in Total

Atorvastatin-induced polyneuropathy has been reported.

Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471
Article Published Date : Nov 04, 2003
Authors : Chad Silverberg
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Polyneuropathies : CK(38) : AC(7), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Atorvastatin : CK(516) : AC(99)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lipid lowering drugs increase the risk of peripheral neuropathy.

Pubmed Data : J Epidemiol Community Health. 2004 Dec ;58(12):1047-51. PMID: 15547071
Article Published Date : Dec 01, 2004
Authors : Giovanni Corrao, Antonella Zambon, Lorenza Bertù, Edoardo Botteri, Olivia Leoni, Paolo Contiero
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Cholesterol Lowering Drugs : CK(2451) : AC(391), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy.

Pubmed Data : Neurology. 2002 May 14 ;58(9):1333-7. PMID: 12011277
Article Published Date : May 14, 2002
Authors : D Gaist, U Jeppesen, M Andersen, L A García Rodríguez, J Hallas, S H Sindrup
Study Type : Human Study
Additional Links
Diseases : Polyneuropathies : CK(38) : AC(7), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68), Pravastatin : CK(251) : AC(42), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Long-term statin treatment may be associated with chronic peripheral neuropathy.

Pubmed Data : Eur J Clin Pharmacol. 1999 Jan ;54(11):835-8. PMID: 10027656
Article Published Date : Jan 01, 1999
Authors : U Jeppesen, D Gaist, T Smith, S H Sindrup
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Long-term treatment with statins caused a clinically silent but still definite damage to peripheral nerves when the treatment lasts longer than 2 years.

Pubmed Data : Neuro Endocrinol Lett. 2011 Sep 3 ;32(5):688-690. Epub 2011 Sep 3. PMID: 22167150
Article Published Date : Sep 03, 2011
Authors : Pavel Otruba, Petr Kanovsky, Petr Hlustik
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves.

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec ;151(2):307-10. PMID: 18345269
Article Published Date : Dec 01, 2007
Authors : Pavel Otruba, Petr Kanovsky, Petr Hlustik
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin exhibits neurotoxic properties.

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443
Article Published Date : Oct 01, 1995
Authors : Y V Bobryshev, O V Pavlov, Y V Balabanov, K Ashwell
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251)
Problem Substances : Lovastatin : CK(267) : AC(68)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival.

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870
Article Published Date : Feb 01, 2001
Authors : N García-Román, A M Alvarez, M J Toro, A Montes, M J Lorenzo
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin induces neuronal cell death.

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836
Article Published Date : Jun 01, 1999
Authors : M Michikawa, K Yanagisawa
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage : CK(93) : AC(44), Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin may adversely affect myelin formation and the remyelination process.

Pubmed Data : J Neurochem. 1994 Apr ;62(4):1539-45. PMID: 8133281
Article Published Date : Apr 01, 1994
Authors : L Sepp-Lorenzino, P S Coleman, J N Larocca
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Statin-Induced Pathologies : CK(1638) : AC(327)
Additional Keywords : Remyelination : CK(16) : AC(11)
Problem Substances : Lovastatin : CK(267) : AC(68), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin may adversely affect neuropsychological tests of attention and psychomotor speed.

Pubmed Data : Am J Med. 2000 May ;108(7):538-46. PMID: 10806282
Article Published Date : May 01, 2000
Authors : M F Muldoon, S D Barger, C M Ryan, J D Flory, J P Lehoczky, K A Matthews, S B Manuck
Study Type : Human Study
Additional Links
Diseases : Neuropsychological Dysfunction: Psychomotor Speed : CK(10) : AC(1), Psychological Well-Being : CK(13) : AC(2), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Lovastatin : CK(267) : AC(68)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in neurons.

Pubmed Data : Neurobiol Aging. 2010 Sep ;31(9):1543-53. Epub 2008 Oct 31. PMID: 18951667
Article Published Date : Sep 01, 2010
Authors : Madhuvanthi Kannan, Joern R Steinert, Ian D Forsythe, Andrew G Smith, Tatyana Chernova
Study Type : In Vitro Study
Additional Links
Diseases : Aging : CK(1658) : AC(438), Cognitive Decline/Dysfunction : CK(1163) : AC(215), Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230), Apoptotic : CK(2958) : AC(2075)
Problem Substances : Lovastatin : CK(267) : AC(68)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Peripheral neuropathy associated with simvastatin has been reported.

Pubmed Data : J Neurol Neurosurg Psychiatry. 1995 May ;58(5):625-8. PMID: 7745415
Article Published Date : May 01, 1995
Authors : T Phan, J G McLeod, J D Pollard, O Peiris, A Rohan, J P Halpern
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Lovastatin : CK(267) : AC(68), Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Postmortem analysis of Alzheimer brains reveals a loss in membrane cholesterol content, indicating that statin drugs may be contribute to neurodegenerative conditions.

Pubmed Data : Neurol Sci. 2011 Apr ;32(2):195-201. Epub 2010 Oct 19. PMID: 20957505
Article Published Date : Apr 01, 2011
Authors : Elisa Biondi
Study Type : Review
Additional Links
Diseases : Neurodevelopmental Disorders : CK(179) : AC(24), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Psychiatric disorders with use of simvastatin have been reported.

Pubmed Data : Ned Tijdschr Geneeskd. 1993 Jun 26 ;137(26):1312-5. PMID: 8345888
Article Published Date : Jun 26, 1993
Authors : N Duits, F M Bos
Study Type : Human: Case Report
Additional Links
Diseases : Mood Disorders : CK(156) : AC(19), Psychiatric Disorders : CK(110) : AC(27), Psychological Well-Being : CK(13) : AC(2), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Severe statin-induced rhabdomyolysis mimicking Guillain-Barré syndrome in four patients with diabetes mellitus treated with fusidic acid has been reported.

Pubmed Data : Diabet Med. 2010 Jun ;27(6):696-700. PMID: 20546290
Article Published Date : Jun 01, 2010
Authors : T A Collidge, S Razvi, C Nolan, M Whittle, C Stirling, A J C Russell, A C Mann, C J Deighan
Study Type : Human: Case Report
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Guillain-Barre Syndrome : CK(110) : AC(18), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anti-Bacterial Agents : CK(1367) : AC(475)
Problem Substances : Antibiotics : CK(330) : AC(44), Fusidic acid : CK(6) : AC(2), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Short-term memory loss associated with rosuvastatin has been reported.

Pubmed Data : Pharmacotherapy. 2006 Aug ;26(8):1190-2. PMID: 16863497
Article Published Date : Aug 01, 2006
Authors : Laura Galatti, Giovanni Polimeni, Francesco Salvo, Marcello Romani, Aurelio Sessa, Edoardo Spina
Study Type : Human: Case Report
Additional Links
Diseases : Memory Disorders : CK(344) : AC(104), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Rosuvastatin : CK(71) : AC(17), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin exhibits neurotoxic properties.

Pubmed Data : Brain Res. 2000 Mar 17 ;859(1):169-72. PMID: 10720627
Article Published Date : Mar 17, 2000
Authors : T Kumano, T Mutoh, H Nakagawa, M Kuriyama
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage : CK(93) : AC(44), Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin exhibits neurotoxicity in a neuronal cell model.

Pubmed Data : Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139
Article Published Date : Dec 06, 1996
Authors : I Sato-Suzuki, S Murota
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage : CK(93) : AC(44), Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Enzyme Inhibitors : CK(473) : AC(251)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin exhibits neurotoxicity in the animal model.

Pubmed Data : Glia. 2007 Jan 15 ;55(2):130-43. PMID: 17078030
Article Published Date : Jan 15, 2007
Authors : Veronique E Miron, Sathyanath Rajasekharan, Andrew A Jarjour, Scott S Zamvil, Timothy E Kennedy, Jack P Antel
Study Type : Animal Study
Additional Links
Diseases : Multiple Sclerosis : CK(964) : AC(184), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin inhibits brain cholesterol biosynthesis without positively alterting molecular indices of Alzheimer disease pathology.

Pubmed Data : Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):220-6. PMID: 20473136
Article Published Date : Jul 01, 2010
Authors : Alberto Serrano-Pozo, Gloria L Vega, Dieter Lütjohann, Joseph J Locascio, Marsha K Tennis, Amy Deng, Alireza Atri, Bradley T Hyman, Michael C Irizarry, John H Growdon
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin interferes with oligodendrocyte function, particularly the prior step in remyelination, indicating it may be harmful in demyelination diseases like MS.

Pubmed Data : J Neurosci Res. 2010 Nov 15 ;88(15):3361-75. PMID: 20857509
Article Published Date : Nov 15, 2010
Authors : Inge Smolders, Ilse Smets, Olaf Maier, Martin vandeVen, Paul Steels, Marcel Ameloot
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Multiple Sclerosis : CK(964) : AC(184), Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin treatment induces morphology alterations and cell death in mouse cochlear neuronal cells.

Pubmed Data : Acta Otolaryngol. 2009 Feb ;129(2):166-74. PMID: 18607908
Article Published Date : Feb 01, 2009
Authors : Do-Sim Park, Hong-Seob So, Jeong-Han Lee, Hyun-Young Park, Young-Jin Lee, Ji-Hyun Cho, Kui-Hyun Yoon, Channy Park, Kijung Yun, Raekil Park
Study Type : In Vitro Study
Additional Links
Diseases : Cochlear Neuronal Damage : CK(3) : AC(2), DNA damage : CK(1017) : AC(387), Hearing Disorders : CK(1) : AC(1), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin-induced decline in cognition has been reported.

Pubmed Data : Ann Pharmacother. 2006 Oct ;40(10):1880-3. Epub 2006 Aug 29. PMID: 16940411
Article Published Date : Oct 01, 2006
Authors : Kalpana P Padala, Prasad R Padala, Jane F Potter
Study Type : Human: Case Report
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Memory Disorders : CK(344) : AC(104), Memory Loss : CK(153) : AC(40), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin-induced mononeuropathy has been reported.

Pubmed Data : Arq Neuropsiquiatr. 2004 Jun ;62(2B):540-2. Epub 2004 Jul 20. PMID: 15273860
Article Published Date : Jun 01, 2004
Authors : Rosana H Scola, Ana P Trentin, Francisco M B Germiniani, Elcio J Piovesan, Lineu C Werneck
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Some statin drugs are may cause neurological problems due to their ability to cross the blood-brain barrier.

Pubmed Data : Pharm Res. 1994 Feb ;11(2):305-11. PMID: 8165193
Article Published Date : Feb 01, 1994
Authors : A Saheki, T Terasaki, I Tamai, A Tsuji
Study Type : Animal Study
Additional Links
Diseases : Blood-Brain-Barrier Disorders : CK(27) : AC(16), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drug use results in decrements in cognitive functioning.

Pubmed Data : Am J Med. 2004 Dec 1 ;117(11):823-9. PMID: 15589485
Article Published Date : Dec 01, 2004
Authors : Matthew F Muldoon, Christopher M Ryan, Susan M Sereika, Janine D Flory, Stephen B Manuck
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs are associated with adverse mental effects.

Pubmed Data : Tidsskr Nor Laegeforen. 1997 Sep 20 ;117(22):3210-3. PMID: 9411859
Article Published Date : Sep 20, 1997
Authors : I Buajordet, S Madsen, H Olsen
Study Type : Human Study
Additional Links
Diseases : Aggression : CK(163) : AC(17), Anxiety Disorders : CK(1225) : AC(180), Depression : CK(2043) : AC(290), Impotence : CK(13) : AC(2), Sleep Disorders : CK(282) : AC(32), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs exhibit neurotoxicity in an animal neuronal cell line.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2011 Sep ;15(9):985-91. PMID: 22013720
Article Published Date : Sep 01, 2011
Authors : K Vural, M I Tuğlu
Study Type : Animal Study
Additional Links
Diseases : Brain Damage : CK(93) : AC(44), Neurodegenerative Diseases : CK(3376) : AC(850), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685)
Problem Substances : Atorvastatin : CK(516) : AC(99), Lovastatin : CK(267) : AC(68), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs have been linked to neurotoxicity.

Pubmed Data : Neth J Med. 2006 Oct ;64(9):334-8. PMID: 17057271
Article Published Date : Oct 01, 2006
Authors : J J de Langen, E P van Puijenbroek
Study Type : Human Study
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Neurotoxicity : CK(46) : AC(25), Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs inhibit central nervous system remyelination.

Pubmed Data : Am J Pathol. 2009 Apr 6. PMID: 19349355
Article Published Date : Apr 06, 2009
Authors : Veronique E Miron, Simone P Zehntner, Tanja Kuhlmann, Samuel K Ludwin, Trevor Owens, Timothy E Kennedy, Barry J Bedell, Jack P Antel
Study Type : Animal Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Statin-Induced Pathologies : CK(1638) : AC(327)
Additional Keywords : Multiple Sclerosis Contraindications : CK(2) : AC(1)
Problem Substances : Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs may intefere with neurological function in the brain by inhibiting cholesterol biosynthesis and synaptic transmission.

Pubmed Data : J Neurochem. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899539
Article Published Date : Sep 07, 2011
Authors : Tiffany Mailman, Manoj Hariharan, Barbara Karten
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Neurologic Disorders : CK(65) : AC(29), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported.

Pubmed Data : Diabetes Care. 2005 Aug ;28(8):2082. PMID: 16043768
Article Published Date : Aug 01, 2005
Authors : Tom Brooks Vaughan, David S H Bell
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Atorvastatin : CK(516) : AC(99), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin therapy has been associated with small fibre neuropathy.

Pubmed Data : J Neurol Sci. 2003 Apr 15 ;208(1-2):105-8. PMID: 12639733
Article Published Date : Apr 15, 2003
Authors : Y L Lo, T H Leoh, L M Loh, C E Tan
Study Type : Human: Case Report
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin use is associated with with neuropathy.

Pubmed Data : Ann Pharmacother. 2003 Feb ;37(2):274-8. PMID: 12549960
Article Published Date : Feb 01, 2003
Authors : James M Backes, Patricia A Howard
Study Type : Human Study
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin-associated peripheral neuropathy has been recorded in the biomedical literature.

Pubmed Data : Pharmacotherapy. 2004 Sep ;24(9):1194-203. PMID: 15460180
Article Published Date : Sep 01, 2004
Authors : Pang H Chong, Alexandra Boskovich, Natasa Stevkovic, Russell E Bartt
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells.

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306
Article Published Date : Apr 01, 1986
Authors : T J Langan, J J Volpe
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Lovastatin : CK(267) : AC(68), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statins have been associated with cell death in primary neuronal culture.

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865
Article Published Date : Jan 01, 2007
Authors : Pia März, Uwe Otten, André R Miserez
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity : CK(46) : AC(25), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Atorvastatin : CK(516) : AC(99), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Article Published Date : Jan 01, 2004
Authors : Miroslaw Lańcut, Barbara Jedrych, Marta Lis-Sochocka, Krystyna Czerny
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle Changes: Ultrastructural Changes : CK(1) : AC(1), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Atorvastatin : CK(516) : AC(99), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Myotoxicity : CK(327) : AC(80), Neurotoxic : CK(1251) : AC(224)

Users of lipid-lowering drugs are at increased risk of peripheral neuropathy.

Pubmed Data : Eur J Clin Pharmacol. 2001 Mar ;56(12):931-3. PMID: 11317483
Article Published Date : Mar 01, 2001
Authors : D Gaist, L A García Rodríguez, C Huerta, J Hallas, S H Sindrup
Study Type : Human Study
Additional Links
Diseases : Neuropathies : CK(576) : AC(106), Statin-Induced Pathologies : CK(1638) : AC(327)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs have been identified to cause neuromyotoxicity.

Pubmed Data : Drugs Today (Barc). 2005 Apr ;41(4):267-93. PMID: 16034491
Article Published Date : Apr 01, 2005
Authors : Steven K Baker, Mark A Tarnopolsky
Study Type : Review
Additional Links
Diseases : Neuromyotoxicity : CK(1) : AC(1)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Myotoxicity : CK(327) : AC(80), Neurotoxic : CK(1251) : AC(224)

Cognitive impairment associated with statin drug use has been reported.

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047
Article Published Date : Dec 01, 2003
Authors : Deborah S King, Amanda J Wilburn, Marion R Wofford, T Kristopher Harrell, Brent J Lindley, Daniel W Jones
Study Type : Review
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Dementia : CK(571) : AC(79), Memory Disorders : CK(344) : AC(104)
Problem Substances : Atorvastatin : CK(516) : AC(99), Cholesterol Lowering Drugs : CK(2451) : AC(391), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Peripheral neuropathy induced by lipid-lowering therapy has been reported.

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Authors : P E Ziajka, T Wehmeier
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Atorvastatin : CK(516) : AC(99), Cholesterol Lowering Drugs : CK(2451) : AC(391), Lovastatin : CK(267) : AC(68), Pravastatin : CK(251) : AC(42), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs interfere with neurological healing by inhibiting myelin formation.

Pubmed Data : J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034
Article Published Date : Dec 10, 2008
Authors : Steve Klopfleisch, Doron Merkler, Matthias Schmitz, Sabine Klöppner, Mariann Schedensack, Gunnar Jeserich, Hans H Althaus, Wolfgang Brück
Study Type : Animal Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Drug-Induced Nutrient Depletion: Statin Drugs : CK(147) : AC(34), Multiple Sclerosis : CK(964) : AC(184)
Additional Keywords : Remyelination : CK(16) : AC(11)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin drugs show no cognitive or anti-amyloid benefits and may be associated with cognitive impairment.

Pubmed Data : Pharmacotherapy. 2003 Jul ;23(7):871-80. PMID: 12885101
Article Published Date : Jul 01, 2003
Authors : Leslie R Wagstaff, Melinda W Mitton, Beth McLendon Arvik, P Murali Doraiswamy
Study Type : Human Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Memory Disorders : CK(344) : AC(104)
Problem Substances : Lovastatin : CK(267) : AC(68), Pravastatin : CK(251) : AC(42), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin-associated adverse cognitive effects have been reported with 90% resolving after drug discontinuation.

Pubmed Data : Pharmacotherapy. 2009 Jul ;29(7):800-11. PMID: 19558254
Article Published Date : Jul 01, 2009
Authors : Marcella A Evans, Beatrice A Golomb
Study Type : Human Study
Additional Links
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Cognitive Decline/Dysfunction : CK(1163) : AC(215), Dementia : CK(571) : AC(79), Memory Disorders : CK(344) : AC(104), Memory Loss : CK(153) : AC(40)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statin-induced memory loss has been reported.

Pubmed Data : Pharmacotherapy. 2001 Jun ;21(6):767-9. PMID: 11401190
Article Published Date : Jun 01, 2001
Authors : A Orsi, O Sherman, Z Woldeselassie
Study Type : Human: Case Report
Additional Links
Diseases : Memory Disorders : CK(344) : AC(104)
Pharmacological Actions : Anticholesteremic Agents : CK(1244) : AC(230)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Statins-induced MELAS syndrome has been reported.

Pubmed Data : Eur Neurol. 2007 ;57(4):232-5. Epub 2007 Mar 26. PMID: 17389800
Article Published Date : Jan 01, 2007
Authors : Joseph E Thomas, Nora Lee, Paul D Thompson
Study Type : Human: Case Report
Additional Links
Diseases : Melas Syndrome : CK(23) : AC(3), Mitochondrial Diseases : CK(224) : AC(90)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

The prevalence of peripheral neuropathy is significantly higher among those who used statins.

Pubmed Data : J Diabetes. 2012 Nov 1. Epub 2012 Nov 1. PMID: 23121724
Article Published Date : Oct 31, 2012
Authors : Edward F Tierney, David J Thurman, Gloria L Beckles, Betsy L Cadwell
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(214) : AC(35)
Problem Substances : Statin Drugs : CK(4171) : AC(500)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Simvastatin delays nerve regeneration.

Pubmed Data : Folia Neuropathol. 2010;48(1):49-56. PMID: 20383811
Article Published Date : Jan 01, 2010
Authors : Ergun Daglioglu, Mustafa Berker, Mehmet Demirci, Mürvet Tuncel, Erdem Karabulut, Aykut Tuncel
Study Type : Animal Study
Additional Links
Diseases : Neuropathies : CK(576) : AC(106)
Problem Substances : Simvastatin : CK(754) : AC(153)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224)

Lovastatin exhibits toxicity in human fetal brain cells.

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017
Article Published Date : Jan 01, 1995
Authors : O V Pavlov, Bobryshev YuV, Balabanov YuV, K Ashwell
Study Type : Human In Vitro
Additional Links
Diseases : Abortion: Spontaneous : CK(214) : AC(30), Birth Defects : CK(204) : AC(39), Neurotoxicity : CK(46) : AC(25), Prenatal Chemical Exposures : CK(457) : AC(112)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685)
Problem Substances : Lovastatin : CK(267) : AC(68)
Adverse Pharmacological Actions : Neurotoxic : CK(1251) : AC(224), Teratogenic : CK(320) : AC(63)

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