Focused Research Topics Turmeric & Diabetes Mellitus: Type 2

The GMI-Pub system automates the natural medical research retrieval process by creating an individualized document that matches your search requirements in order to fit the needs of real people, in real time.

Our technology pulls from the equivalent of 20,454+ years of scientific experimental labor years of scientific experimentation, analysis, and synthesis, and pulls results based on variables the user decides are relevant.

Below you will find compelling research hard-referenced to peer-reviewed biomedical research sourced from the US National Library of Medicine. For more research on over 6000 validated topics, please visit http://GreenMedInfo.com/research-dashboard

Associated Topics included in this Focused Research

Curcumin Curcumin: Lipidated Curcuminoids Curcumol Demethoxycurcumin Tetrahydrocurcumin Turmeric Turmeric: Fermented Turmeric: Topical Turmerin Turmerones

This document was generated from a Focused Research webpage from GreenMedInfo.com

View the Evidence
36 Research Articles in Total

A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.

Pubmed Data : Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID: 20339905
Article Published Date : Aug 01, 2010
Authors : Leelavinothan Pari, Krishnamoorthy Karthikesan, Venugopal P Menon
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid : CK(13) : AC(7), Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682)

Tetrahydrocurcumin displays antihyperlipidaemic effect in addition to its antidiabetic effect in type 2 diabetic rats.

Pubmed Data : Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):122-7. PMID: 16918712
Article Published Date : Aug 01, 2006
Authors : Pidaran Murugan, Leelavinothan Pari
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Hypolipidemic : CK(1288) : AC(265)

Tetrahydrocurcumin has antioxidant and anti-diabetic activity in streptozotocin-nicotinamide induced diabetic rats.

Pubmed Data : Life Sci. 2006 Sep 27;79(18):1720-8. Epub 2006 Jun 9. PMID: 16806281
Article Published Date : Sep 27, 2006
Authors : Pidaran Murugan, Leelavinothan Pari
Study Type : Animal Study
Additional Links
Substances : Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682)

Turmeric supplementation could be an adjuvant to T2DM on metformin treatment having a beneficial effect on blood glucose, oxidative stress and inflammation.

Pubmed Data : Indian J Clin Biochem. 2015 Apr ;30(2):180-6. Epub 2014 May 8. PMID: 25883426
Article Published Date : Mar 31, 2015
Authors : N Maithili Karpaga Selvi, M G Sridhar, R P Swaminathan, R Sripradha
Study Type : Human Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Compounds within turmeric suppress an increase in blood glucose levels in type 2 diabetic mice.

Pubmed Data : J Agric Food Chem. 2005 Feb 23;53(4):959-63. PMID: 15713005
Article Published Date : Feb 23, 2005
Authors : Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Misuzu Tsukagawa, Yoshihiro Mimaki, Minpei Kuroda, Yutaka Sashida, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alcohol Toxicity : CK(337) : AC(125), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcuma longa extracts may be effective in both the prevention of diabetes mellitus and in attenuating the development of complications.

Pubmed Data : Exp Ther Med. 2015 Nov ;10(5):1681-1688. Epub 2015 Sep 2. PMID: 26640536
Article Published Date : Oct 31, 2015
Authors : Denisa Margină, Octavian Tudorel Olaru, Mihaela Ilie, Daniela Grădinaru, Claudia GuȚu, Sorina Voicu, Anca Dinischiotu, Demetrios A Spandidos, Aristidis M Tsatsakis
Study Type : In Vitro Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetes Mellitus: Type 2: Prevention : CK(651) : AC(86), Hyperglycemia : CK(539) : AC(130)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin extract for prevention of type 2 diabetes.

Pubmed Data : Diabetes Care. 2012 Nov ;35(11):2121-7. Epub 2012 Jul 6. PMID: 22773702
Article Published Date : Oct 31, 2012
Authors : Somlak Chuengsamarn, Suthee Rattanamongkolgul, Rataya Luechapudiporn, Chada Phisalaphong, Siwanon Jirawatnotai
Study Type : Human In Vitro
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346), Prediabetes : CK(150) : AC(17)
Additional Keywords : Beta Cell Protection : CK(61) : AC(25), Plant Extracts : CK(7645) : AC(2539)

This review focusses on some medicinal plants that have antidiabetic effects.

Pubmed Data : West Indian Med J. 2016 Apr 18. Epub 2016 Apr 18. PMID: 27399905
Article Published Date : Apr 17, 2016
Authors : T Khaliq, M Sarfraz, M A Ashraf
Study Type : Review
Additional Links
Substances : Black Pepper : CK(229) : AC(96), Dates : CK(116) : AC(52), Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342), Hypolipidemic : CK(1288) : AC(265)
Additional Keywords : Plant Extracts : CK(7645) : AC(2539), Risk Reduction : CK(6417) : AC(686)

"Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects."

Pubmed Data : Nat Prod Res. 2011 Oct 6. Epub 2011 Oct 6. PMID: 21972920
Article Published Date : Oct 06, 2011
Authors : P C Lekshmi, Ranjith Arimboor, K G Raghu, A Nirmala Menon
Study Type : In Vitro Study
Additional Links
Substances : Turmerin : CK(2) : AC(2)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Hyperglycemia : CK(539) : AC(130)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)

Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.

Pubmed Data : Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869
Article Published Date : Feb 01, 2008
Authors : Kwon-Il Seo, Myung-Sook Choi, Un Ju Jung, Hye-Jin Kim, Jiyoung Yeo, Seon-Min Jeon, Mi-Kyung Lee
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)

Curcumin possesses anti-diabetic effects and mitigates diabetes complications

Pubmed Data : Curr Top Med Chem. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26088351
Article Published Date : Jun 18, 2015
Authors : Seyed Fazel Nabavi, Raman Thiagarajan, Luca Rastrelli, Maria Daglia, Eduardo Sobarzo-Sanchez, Heshmatollah Alinezhad, Seyed Mohammad Nabavi
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Complications : CK(1563) : AC(333)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(7529) : AC(2682)
Additional Keywords : Advanced Glycation End Products : CK(10) : AC(1)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997
Article Published Date : Jan 04, 2016
Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Oxidative Stress : CK(79) : AC(46), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin works synergistically with insulin on muscle cell glucose metabolism.

Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944
Article Published Date : Aug 01, 2010
Authors : Changkeun Kang, Euikyung Kim
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Antioxidants : CK(7529) : AC(2682), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Drug Synergy : CK(351) : AC(156)

Abnormal electrophysiological characteristics of VGSCs can be ameliorated efficaciously by a period of treatment with curcumin.

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Nov ;31(6):541-8. PMID: 27215022
Article Published Date : Oct 31, 2015
Authors : Bo Meng, Lu-lu Shen, Xiao-ting Shi, Yong-sheng Gong, Xiao-fang Fan, Jun Li, Hong Cao
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Neuropathic Pain : CK(271) : AC(62)

Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.

Pubmed Data : JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Article Published Date : Sep 01, 1986
Authors : Leelavinothan Pari, Pidaran Murugan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes: Cardiovascular Illness : CK(700) : AC(107), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypolipidemic : CK(1288) : AC(265)

Curcumin has been demonstrated to effectively prevent or ameliorate diabetic mellitus and its complications including diabetic neuropathic pain.

Pubmed Data : Neurosci Lett. 2015 Aug 14. Epub 2015 Aug 14. PMID: 26282904
Article Published Date : Aug 13, 2015
Authors : Bo Meng, Lu-Lu Shen, Xiao-Ting Shi, Yong-Sheng Gong, Xiao-Fang Fan, Jun Li, Hong Cao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Diabetic Neuropathy : CK(59) : AC(19), Neuropathic Pain : CK(271) : AC(62)
Pharmacological Actions : Analgesics : CK(1327) : AC(217)

Curcumin may prove useful for patients with diabetes by improving both β-cell function and relieving insulin resistance.

Pubmed Data : Nutr Diabetes. 2016 ;6:e205. Epub 2016 Apr 25. PMID: 27110686
Article Published Date : Dec 31, 2015
Authors : S Weisberg, R Leibel, D V Tortoriello
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)
Pharmacological Actions : Insulin Sensitizers : CK(350) : AC(70), Proteasome Inhibitors : CK(51) : AC(33)

Curcumin significantly downregulated the plasma membrane redox system activity in a dose-dependent manner.

Pubmed Data : Biochem Res Int. 2016;2016:6025245. Epub 2016 Jan 19. PMID: 26904287
Article Published Date : Dec 31, 2015
Authors : Prabhakar Singh, Rajesh Kumar Kesharwani, Krishna Misra, Syed Ibrahim Rizvi
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Redox Modulator : CK(5) : AC(3)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Curcumin's blood sugar lowering effect may be due to its inhibitory effect on hepatic gluconeogenesis.

Pubmed Data : Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. PMID: 19665995
Article Published Date : Oct 16, 2009
Authors : Teayoun Kim, Jessica Davis, Albert J Zhang, Xiaoming He, Suresh T Mathews
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : AMP-activated protein kinase modulation : CK(2) : AC(2), Gluconeogenesis Inhibitor : CK(19) : AC(14)
Additional Keywords : Metformin Alternatives : CK(19) : AC(6), Natural Substances Versus Drugs : CK(1698) : AC(302)

Curcumin, berberine, catechin, quercetin and rutin had binding ability towards alpha-amylase and alpha-glucosidase.

Pubmed Data : Biofactors. 2015 Jul 7. Epub 2015 Jul 7. PMID: 26154585
Article Published Date : Jul 06, 2015
Authors : Chien-Hung Jhong, Jirawat Riyaphan, Shih-Hung Lin, Yi-Chen Chia, Ching-Feng Weng
Study Type : In Vitro Study
Additional Links
Substances : Berberine : CK(325) : AC(166), Catechin : CK(512) : AC(169), Curcumin : CK(4803) : AC(2175), Quercetin : CK(568) : AC(250), Rutin : CK(126) : AC(48)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Hyperglycemia : CK(539) : AC(130)
Pharmacological Actions : Alpha-amylase inhibitor : CK(34) : AC(20), Alpha-glucosidase inhibitor : CK(52) : AC(37)
Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)

Tetrahydrocurcumin increases the number of total cellular insulin binding sites resulting in a significant increase in plasma insulin.

Pubmed Data : J Biosci. 2008 Mar;33(1):63-72. PMID: 18376071
Article Published Date : Mar 01, 2008
Authors : Pidaran Murugan, Leelavinothan Pari, Chippada Appa Rao
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624), Insulin Resistance : CK(1683) : AC(346)

Tetrahydrocurcumin normalizes blood glucose and causes a marked improvement of altered carbohydrate metabolic enzymes in diabetic animals.

Pubmed Data : J Basic Clin Physiol Pharmacol. 2005;16(4):257-74. PMID: 16438392
Article Published Date : Jan 01, 2005
Authors : Leelavinothan Pari, Pidaran Murugan
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Tetrahydrocurcumin : CK(66) : AC(30)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)

Treatment with combinatorial extract of curcumin presented a significantly better therapeutic potential when compared with curcumin alone.

Pubmed Data : J Complement Integr Med. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27343476
Article Published Date : Jun 24, 2016
Authors : Ginpreet Kaur, Mihir Invally, Meena Chintamaneni
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), Piperine : CK(114) : AC(60), Quercetin : CK(568) : AC(250)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249), Natural Substances Versus Drugs : CK(1698) : AC(302)

Turmeric and curcumin have anti-diabetic actions.

Pubmed Data : Plant Foods Hum Nutr. 2002;57(1):41-52. PMID: 11855620
Article Published Date : Jan 01, 2002
Authors : N Arun, N Nalini
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175)
Diseases : Diabetes: Glycation/A1C : CK(210) : AC(33), Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Turmeric has significant blood-sugar lowering activity in type 2 diabetic mice.

Pubmed Data : Biol Pharm Bull. 2005 May;28(5):937-9. PMID: 15863912
Article Published Date : May 01, 2005
Authors : Minpei Kuroda, Yoshihiro Mimaki, Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Misuzu Tsukagawa, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Turmeric powder combined with milk as therapeutic properties in an animdal model of both type 1 and type 2 diabetes.

Pubmed Data : Indian J Clin Biochem. 2010 Apr ;25(2):175-81. Epub 2010 May 27. PMID: 23105906
Article Published Date : Mar 31, 2010
Authors : P K Rai, D Jaiswal, S Mehta, D K Rai, B Sharma, Geeta Watal
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(5032) : AC(2348)
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)
Pharmacological Actions : Hepatoprotective : CK(1387) : AC(594)

This document is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2016 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.