Focused Research Topics Green Tea & Apoptotic

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EGCG (Epigallocatechin gallate) Green Tea

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58 Research Articles in Total

Combinations of EGCG and anticancer compounds induced synergistic anticancer effects in vitro and in vivo experiments, and showed an average reduction in tumor volume by 70.3 %.

Pubmed Data : J Cancer Res Clin Oncol. 2015 Sep ;141(9):1511-22. Epub 2014 Dec 28. PMID: 25544670
Article Published Date : Aug 31, 2015
Authors : Hirota Fujiki, Eisaburo Sueoka, Tatsuro Watanabe, Masami Suganuma
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Cancer Stem Cells : CK(135) : AC(88), Natural Substance/Drug Synergy : CK(352) : AC(142)

The anti-cancer effect of green tea can be explained by either its anti-oxidative or pro-oxidative property.

Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(4):1649-54. PMID: 27221834
Article Published Date : Dec 31, 2015
Authors : Sumio Hayakawa, Kieko Saito, Noriyuki Miyoshi, Tomokazu Ohishi, Yumiko Oishi, Mamoru Miyoshi, Yoriyuki Nakamura
Study Type : Review
Additional Links
Substances : Green Tea : CK(1976) : AC(562)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Fibronectin : CK(26) : AC(7)

This review highlights specific biological processes that could be exploited as targets for the prevention and therapy of cancer.

Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25865775
Article Published Date : Apr 09, 2015
Authors : Stephanie C Casey, Amedeo Amedei, Katia Aquilano, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan E Bilsland, Chandra S Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G Georgakilas, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Kanya Honoki, W Nicol Keith, Sid P Kerkar, Sulma I Mohammed, Elena Niccolai, Somaira Nowsheen, H P Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H Talib, Vasundara Venkateswaran, Richard L Whelan, Xujuan Yang, Dean W Felsher
Study Type : Review
Additional Links
Substances : Berberine : CK(325) : AC(166), Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Genistein : CK(515) : AC(228), Naringenin : CK(53) : AC(37), Piperine : CK(114) : AC(60), Resveratrol : CK(1283) : AC(746)
Diseases : Cancers: All : CK(14773) : AC(4596)
Pharmacological Actions : Angiogenesis Inhibitors : CK(114) : AC(62), Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-metastatic : CK(634) : AC(414), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Tumor Microenvironment : CK(29) : AC(21)

EGCG sensitizes human cholangiocarcinoma cells to chemotherapy-induced programmed cell death.

Pubmed Data : Liver Int. 2009 May;29(5):670-7. Epub 2009 Feb 17. PMID: 19226332
Article Published Date : May 01, 2009
Authors : Molly Lang, Roger Henson, Chiara Braconi, Tushar Patel
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Cholangiocarcinoma : CK(96) : AC(21)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286)
Additional Keywords : Drug: 5-flourouracil : CK(108) : AC(29), Drug: Mitomycin : CK(4) : AC(3), Plant Extracts : CK(7645) : AC(2539)

Phytochemicals have the potential of modulating various molecular processes, including signaling pathways involved in the development and progression of tumors.

Pubmed Data : Onco Targets Ther. 2015 ;8:2053-66. Epub 2015 Aug 6. PMID: 26273208
Article Published Date : Dec 31, 2014
Authors : Roxana Cojocneanu Petric, Cornelia Braicu, Lajos Raduly, Oana Zanoaga, Nicolae Dragos, Paloma Monroig, Dan Dumitrascu, Ioana Berindan-Neagoe
Study Type : Review
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Genistein : CK(515) : AC(228)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682), Apoptotic : CK(2958) : AC(2075), Chemotherapeutic : CK(397) : AC(152), MicroRNA modulator : CK(264) : AC(145)

This reviews the molecular mechanisms by which the bioactive compounds can inhibit carcinogenesis by regulating antioxidant enzyme activities.

Pubmed Data : Mini Rev Med Chem. 2015 Jul 9. Epub 2015 Jul 9. PMID: 26156544
Article Published Date : Jul 08, 2015
Authors : Daniela Bonofiglio, Cinzia Giordano, Francesca De Amicis, Marilena Lanzino, Sebastiano Andò
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Omega-3 Fatty Acids : CK(4090) : AC(396), Resveratrol : CK(1283) : AC(746)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antioxidants : CK(7529) : AC(2682), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

A combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis.

Pubmed Data : Food Chem Toxicol. 2010 Jan;48(1):390-5. Epub 2009 Oct 25. PMID: 19861145
Article Published Date : Jan 01, 2010
Authors : Gang Xu, Guijie Ren, Xia Xu, Huiqing Yuan, Zhenzheng Wang, Ludong Kang, Wenguang Yu, Keli Tian
Study Type : Animal Study
Additional Links
Substances : Catechin : CK(512) : AC(169), Curcumin : CK(4803) : AC(2175), Green Tea : CK(1976) : AC(562)
Diseases : Colon Cancer : CK(749) : AC(430), Colorectal Cancer : CK(1646) : AC(619)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787)
Additional Keywords : Drug Synergy : CK(351) : AC(156)

Curcumin and epigallocatechin-3-gallate in combination could enhance the toxicity of DOX and increase the intracellular level of DOX in resistant MCF-7 cells.

Pubmed Data : Am J Chin Med. 2014 ;42(5):1279-300. PMID: 25242081
Article Published Date : Dec 31, 2013
Authors : Shengpeng Wang, Ruie Chen, Zhangfeng Zhong, Zhi Shi, Meiwan Chen, Yitao Wang
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Breast Cancer : CK(3592) : AC(1064), Cancers: Drug Resistant : CK(352) : AC(223)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin : CK(44) : AC(32)

EGCG significantly lowered the concentration of curcumin required to inhibit the AKT-mTOR pathway, reduce cell proliferation and induce apoptosis.

Pubmed Data : Int J Clin Oncol. 2013 Jun ;18(3):380-8. Epub 2012 Feb 15. PMID: 22350026
Article Published Date : May 31, 2013
Authors : Akiko Kondo, Takashi Takeda, Bin Li, Kenji Tsuiji, Mari Kitamura, Tze Fang Wong, Nobuo Yaegashi
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Leiomyosarcoma : CK(1) : AC(1)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Intra-tumoral injection of TriCurin significantly inhibited tumor growth by 85.5%.

Pubmed Data : Oncotarget. 2016 Jul 16. Epub 2016 Jul 16. PMID: 27437871
Article Published Date : Jul 15, 2016
Authors : Longzhu Piao, Sumit Mukherjee, Qing Chang, Xiujie Xie, Hong Li, Mario R Castellanos, Probal Banerjee, Hassan Iqbal, Ryan Ivancic, Xueqian Wang, Theodoros N Teknos, Quintin Pan
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin : CK(4803) : AC(2175), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Resveratrol : CK(1283) : AC(746)
Diseases : Head and Neck Cancer : CK(165) : AC(44), Human Papillomavirus (HPV) : CK(212) : AC(35)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787), Tumor Suppressor Protein p53 Upregulation : CK(293) : AC(202)

EGCG exhibits anti-cancer activity in a in vitro model of breast cancer.

Pubmed Data : J Cell Physiol. 2010 Dec 30. Epub 2010 Dec 30. PMID: 21194113
Article Published Date : Dec 30, 2010
Authors : Yuan-Chang Hsu, Ying-Ming Liou
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Anti-Proliferative : CK(59) : AC(52), Apoptotic : CK(2958) : AC(2075)

Green tea catechins and black tea theaflavins inhibit SV40-associated mammary cancer in a rodent experimental model.

Pubmed Data : J Agric Food Chem. 2007 May 2;55(9):3378-85. Epub 2007 Apr 4. PMID: 17407311
Article Published Date : May 02, 2007
Authors : Siminder Kaur, Peter Greaves, Darren N Cooke, Richard Edwards, William P Steward, Andreas J Gescher, Timothy H Marczylo
Study Type : Animal Study
Additional Links
Substances : Black Tea : CK(360) : AC(80), Catechin : CK(512) : AC(169), Green Tea : CK(1976) : AC(562)
Diseases : Breast Cancer : CK(3592) : AC(1064), Simian virus 40 (SV40) : CK(102) : AC(20)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787)

Green tea polyphenols and its constituent EGCG inhibits proliferation of human breast cancer cells in vitro and in vivo.

Pubmed Data : Cancer Lett. 2007 Jan 8;245(1-2):232-41. Epub 2006 Mar 6. PMID: 16519995
Article Published Date : Jan 08, 2007
Authors : Rajesh L Thangapazham, Anoop K Singh, Anuj Sharma, James Warren, Jaya P Gaddipati, Radha K Maheshwari
Study Type : Animal Study
Additional Links
Substances : Catechin : CK(512) : AC(169), Flavonoids : CK(1215) : AC(379), Green Tea : CK(1976) : AC(562), Polyphenols : CK(931) : AC(335)
Diseases : Breast Cancer : CK(3592) : AC(1064)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

(-)-Epigallocatechin-3-gallate (EGCG) can inhibit the proliferation and invasiveness and induce apoptosis in nasopharyngeal carcinoma cells.

Pubmed Data : Int J Mol Sci. 2015 ;16(2):2530-58. Epub 2015 Jan 23. PMID: 25625511
Article Published Date : Dec 31, 2014
Authors : Chih-Yeu Fang, Chung-Chun Wu, Hui-Yu Hsu, Hsin-Ying Chuang, Sheng-Yen Huang, Ching-Hwa Tsai, Yao Chang, George Sai-Wah Tsao, Chi-Long Chen, Jen-Yang Chen
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Nasopharyngeal Cancer : CK(73) : AC(31)
Pharmacological Actions : Anti-metastatic : CK(634) : AC(414), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis.

Pubmed Data : Oncotarget. 2016 Aug 25. Epub 2016 Aug 25. PMID: 27582540
Article Published Date : Aug 24, 2016
Authors : Sung-Wook Kim, Ji-Hong Moon, Sang-Youel Park
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Colorectal Cancer : CK(1646) : AC(619)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Autophagy Up-regulation : CK(108) : AC(65)

Combining green tea polyphenols and quercetin significantly enhanced the antiproliferative and proapoptotic effect in vivo.

Pubmed Data : J Nutr Biochem. 2014 Jan ;25(1):73-80. Epub 2013 Oct 10. PMID: 24314868
Article Published Date : Dec 31, 2013
Authors : Piwen Wang, Jaydutt V Vadgama, Jonathan W Said, Clara E Magyar, Ngan Doan, David Heber, Susanne M Henning
Study Type : Animal Study
Additional Links
Substances : Green Tea : CK(1976) : AC(562), Quercetin : CK(568) : AC(250)
Diseases : Prostate Cancer : CK(1499) : AC(438), Prostate Cancer: Prevention : CK(243) : AC(33)
Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemopreventive : CK(2835) : AC(787)
Additional Keywords : Bioavailability : CK(182) : AC(34), Multidrug Resistance : CK(6) : AC(4), Natural Substance Synergy : CK(540) : AC(249)

Combining lower concentrations of EGCG and theaflavin results in greater cell death compared to either extract alone at the same concentration.

Pubmed Data : Cent Eur J Immunol. 2015 ;40(1):1-4. Epub 2015 Apr 22. PMID: 26155176
Article Published Date : Dec 31, 2014
Authors : Andrew J Kobalka, Rick W Keck, Jerzy Jankun
Study Type : In Vitro Study
Additional Links
Substances : Black Tea Theaflavins : CK(1) : AC(1), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562)
Diseases : Prostate Cancer : CK(1499) : AC(438)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

EGCG and theaflavins chemosensitize the cervical cancer cells to cisplatin induced growth inhibition and apoptosis.

Pubmed Data : Life Sci. 2013 Jul 19 ;93(1):7-16. Epub 2013 Feb 9. PMID: 23399702
Article Published Date : Jul 18, 2013
Authors : Madhulika Singh, Kulpreet Bhui, Richa Singh, Yogeshwer Shukla
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Theaflavins : CK(1) : AC(1)
Diseases : Cervical Cancer : CK(345) : AC(144)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286), NF-kappaB Inhibitor : CK(1114) : AC(694)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(80) : AC(57)

EGCG could be a useful chemopreventive agent for targeting HCC and colon CSCs, in combination with standard chemotherapies.

Pubmed Data : J Gastroenterol Hepatol. 2015 Aug 4. Epub 2015 Aug 4. PMID: 26241688
Article Published Date : Aug 03, 2015
Authors : Gizachew Yismaw Wubetu, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Daichi Ishikawa, Shuichi Iwahashi, Shinichiro Yamada, Yu Saito, Yusuke Arakawa, Satoru Imura
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Colon Cancer : CK(749) : AC(430), Liver Cancer : CK(1235) : AC(462)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612), Chemopreventive : CK(2835) : AC(787)
Additional Keywords : Cancer Stem Cells : CK(135) : AC(88), Dose Response : CK(1056) : AC(408)

EGCG has the potential for therapeutic effect on oral cancer and may be useful for long-term oral cancer prevention in the future.

Pubmed Data : Environ Toxicol. 2016 May 20. Epub 2016 May 20. PMID: 27200496
Article Published Date : May 19, 2016
Authors : Chien-Han Yuan, Chi-Ting Horng, Chiu-Fang Lee, Ni-Na Chiang, Fuu-Jen Tsai, Chi-Cheng Lu, Jo-Hua Chiang, Yuan-Man Hsu, Jai-Sing Yang, Fu-An Chen
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Oral Cancer : CK(214) : AC(79)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Autophagy Up-regulation : CK(108) : AC(65), Chemopreventive : CK(2835) : AC(787), Multidrug Resistance Gene Modulators : CK(20) : AC(15)
Additional Keywords : Dose Response : CK(1056) : AC(408)

EGCG has the potential for therapeutic effect on oral cancer and may be useful for long-term oral cancer prevention in the future.

Pubmed Data : Environ Toxicol. 2016 May 20. Epub 2016 May 20. PMID: 27200496
Article Published Date : May 19, 2016
Authors : Chien-Han Yuan, Chi-Ting Horng, Chiu-Fang Lee, Ni-Na Chiang, Fuu-Jen Tsai, Chi-Cheng Lu, Jo-Hua Chiang, Yuan-Man Hsu, Jai-Sing Yang, Fu-An Chen
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Oral Cancer : CK(214) : AC(79)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Autophagy Up-regulation : CK(108) : AC(65), Chemopreventive : CK(2835) : AC(787), Multidrug Resistance Gene Modulators : CK(20) : AC(15)
Additional Keywords : Dose Response : CK(1056) : AC(408)

EGCG in combination with cisplatin can be used for the management of head and neck squamous carcinoma cancer stem cells.

Pubmed Data : Eur J Cancer. 2013 Oct ;49(15):3210-8. Epub 2013 Jul 19. PMID: 23876835
Article Published Date : Sep 30, 2013
Authors : Sang Hyuk Lee, Hyo Jung Nam, Hyun Jung Kang, Hye Won Kwon, Young Chang Lim
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Head and Neck Cancer : CK(165) : AC(44), Squamous cell carcinoma : CK(152) : AC(67)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(80) : AC(57)

EGCG induced cell death via the cGMP/ASM pathway in chronic myeloid leukemia cells.

Pubmed Data : Oncol Rep. 2015 Jun 26. Epub 2015 Jun 26. PMID: 26135316
Article Published Date : Jun 25, 2015
Authors : Yuhui Huang, Motofumi Kumazoe, Jaehoon Bae, Shuhei Yamada, Mika Takai, Shiori Hidaka, Shuya Yamashita, Yoonhee Kim, Yeongseon Won, Motoki Murata, Shuntaro Tsukamoto, Hirofumi Tachibana
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Chronic Myeloid Leukemia : CK(31) : AC(16)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation.

Pubmed Data : Oncol Rep. 2016 Jan 21. Epub 2016 Jan 21. PMID: 26794417
Article Published Date : Jan 20, 2016
Authors : Min Li, Jing-Jing Li, Qi-Hua Gu, Jian An, Li-Ming Cao, Hua-Ping Yang, Cheng-Ping Hu
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Lung Cancer : CK(1043) : AC(393)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Dose Response : CK(1056) : AC(408)

EGCG is a potent apoptosis inducer that functions exclusively through a p53-dependent pathway in A549 cells.

Pubmed Data : Toxicol In Vitro. 2009 Aug ;23(5):834-9. Epub 2009 May 3. PMID: 19406223
Article Published Date : Jul 31, 2009
Authors : Rieko Yamauchi, Kaori Sasaki, Kenichi Yoshida
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Epicatechin : CK(3) : AC(2)
Diseases : Lung Cancer : CK(1043) : AC(393)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Tumor Suppressor Protein p53 Upregulation : CK(293) : AC(202)

EGCG significantly reduced cell viability of all eight BTC cell lines and for most cell lines a synergistic cytotoxic effect could be shown.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:194. Epub 2015 Jun 23. PMID: 26100134
Article Published Date : Dec 31, 2014
Authors : Christian Mayr, Andrej Wagner, Daniel Neureiter, Martin Pichler, Martin Jakab, Romana Illig, Frieder Berr, Tobias Kiesslich
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Bile Duct Cancer : CK(94) : AC(20), Cholangiocarcinoma : CK(96) : AC(21)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(80) : AC(57), Gene Expression Regulation : CK(431) : AC(214)

EGCG, a green tea polyphenol, encourages programmed cell death in prostate cancer cells.

Pubmed Data : Oncogene. 2008 Mar 27;27(14):2055-63. Epub 2007 Nov 12. PMID: 17998943
Article Published Date : Mar 27, 2008
Authors : I A Siddiqui, A Malik, V M Adhami, M Asim, B B Hafeez, S Sarfaraz, H Mukhtar
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Prostate Cancer : CK(1499) : AC(438)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286)

EGCG, a green tea polyphenol, induces programmed cell death and growth arrest in pancreatic cancer cell lines.

Pubmed Data : Int J Oncol. 2009 Jan;34(1):281-6. PMID: 19082499
Article Published Date : Jan 01, 2009
Authors : Aruna Basu, Subrata Haldar
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562)
Diseases : Pancreatic Cancer : CK(890) : AC(260)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

EGCG, a green tea polyphenol, induces programmed cell death in human lymphoblastoid B cells.

Pubmed Data : Biochem Biophys Res Commun. 2007 Nov 3;362(4):951-7. Epub 2007 Aug 24. PMID: 17803956
Article Published Date : Nov 03, 2007
Authors : Chiseko Noda, Jinsong He, Tomoko Takano, Chisato Tanaka, Toshinori Kondo, Kaoru Tohyama, Hirohei Yamamura, Yumi Tohyama
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Lymphoma : CK(253) : AC(83), Non-Hodgkin's lymphoma: B Cell : CK(5) : AC(5)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

EGCG, a green tea polyphenol, significantly interferes with androgen-independent prostate cancer in vivo.

Pubmed Data : Nutr Cancer. 2008;60(4):483-91. PMID: 18584482
Article Published Date : Jan 01, 2008
Authors : Suk-Ching Lee, Wing-Ki Chan, Tak-Wing Lee, Wai-Har Lam, Xianghong Wang, Tak-Hang Chan, Yong-Chuan Wong
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Prostate Cancer : CK(1499) : AC(438)
Pharmacological Actions : Anti-Angiogenic : CK(197) : AC(137), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Androgen-Independent Prostate Cancer : CK(3) : AC(2)

Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells.

Pubmed Data : Environ Health Prev Med. 2012 May ;17(3):246-51. Epub 2011 Sep 10. PMID: 21909813
Article Published Date : Apr 30, 2012
Authors : Noriyuki Nishimura, Tri Budi Hartomo, Thi Van Huyen Pham, Myeong Jin Lee, Tomoto Yamamoto, Satoru Morikawa, Daiichiro Hasegawa, Hiroki Takeda, Keiichiro Kawasaki, Yoshiyuki Kosaka, Nobuyuki Yamamoto, Ikuko Kubokawa, Takeshi Mori, Tomoko Yanai, Akira Hayakawa, Yasuhiro Takeshima, Kazumoto Iijima, Masafumi Matsuo, Hisahide Nishio
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Neuroblastoma : CK(85) : AC(52)
Pharmacological Actions : Anticarcinogenic Agents : CK(1099) : AC(519), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Dose Response : CK(1056) : AC(408)

Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in Human T-Cell Lymphotrophic Virus type 1 -positive and negative leukemia cells.

Pubmed Data : Med Oncol. 2008;25(1):30-9. Epub 2007 Aug 14. PMID: 18188712
Article Published Date : Jan 01, 2008
Authors : S Harakeh, K Abu-El-Ardat, M Diab-Assaf, A Niedzwiecki, M El-Sabban, M Rath
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Burkitt Cell Leukemia : CK(2) : AC(3), Human T-Cell Lymphotrophic Virus type 1 associated disease : CK(18) : AC(8)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Antiviral Agents : CK(938) : AC(433), Apoptotic : CK(2958) : AC(2075)

Eriodictyol synergistically potentiates the anti-tumour effect of EGCG by amplifying 67LR-dependent signalling in MM cells

Pubmed Data : Sci Rep. 2015 ;5:9474. Epub 2015 Mar 31. PMID: 25824377
Article Published Date : Dec 31, 2014
Authors : Motofumi Kumazoe, Yoshinori Fujimura, Shiori Hidaka, Yoonhee Kim, Kanako Murayama, Mika Takai, Yuhui Huang, Shuya Yamashita, Motoki Murata, Daisuke Miura, Hiroyuki Wariishi, Mari Maeda-Yamamoto, Hirofumi Tachibana
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Eriodictyol : CK(2) : AC(1), Yerba Santa : CK(10) : AC(1)
Diseases : Multiple Myeloma : CK(213) : AC(71)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Bioenhancer : CK(8) : AC(5), EGCG Sensitizer : CK(2) : AC(1), Natural Substance Synergy : CK(540) : AC(249)

Green tea (-)-epigalocatechin-3-gallate induces cell death in gastrointestinal stromal tumor including imatinib-resistant cells.

Pubmed Data : Cancer Biol Ther. 2009 Oct;8(20):1934-9. Epub 2009 Oct 22. PMID: 19770581
Article Published Date : Oct 01, 2009
Authors : Hoang Thanh Chi, Hoang Anh Vu, Reo Iwasaki, Le Ba Thao, Yukihiko Hara, Takahiro Taguchi, Toshiki Watanabe, Yuko Sato
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Gastrointestinal Stromal Tumors : CK(2) : AC(1)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

Green tea and Quercetin provides a novel therapeutic modality to enhance the efficacy of Docetaxel in a nontoxic manner.

Pubmed Data : J Nutr Biochem. 2015 Apr ;26(4):408-15. Epub 2015 Jan 15. PMID: 25655047
Article Published Date : Mar 31, 2015
Authors : Piwen Wang, Susanne M Henning, David Heber, Jaydutt V Vadgama
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562), Quercetin : CK(568) : AC(250)
Diseases : Prostate Cancer : CK(1499) : AC(438)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612), Chemosensitizer : CK(394) : AC(286), Multidrug Resistance Gene Modulators : CK(20) : AC(15)

Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice.

Pubmed Data : Am J Obstet Gynecol. 2010 Jan 12. Epub 2010 Jan 12. PMID: 20074693
Article Published Date : Jan 12, 2010
Authors : Dong Zhang, Mohamed Al-Hendy, Gloria Richard-Davis, Valerie Montgomery-Rice, Chakradhari Sharan, Veera Rajaratnam, Anjali Khurana, Ayman Al-Hendy
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562)
Diseases : Leiomyoma : CK(48) : AC(18)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

Green tea has a growth inhibitory and antimetastatic effect on metastasis-specific mouse mammary cancer.

Pubmed Data : Clin Cancer Res. 2005 Mar 1;11(5):1918-27. PMID: 15756018
Article Published Date : Mar 01, 2005
Authors : Manjeshwar S Baliga, Sreelatha Meleth, Santosh K Katiyar
Study Type : Animal Study
Additional Links
Substances : Flavonoids : CK(1215) : AC(379), Green Tea : CK(1976) : AC(562), Polyphenols : CK(931) : AC(335)
Diseases : Breast Cancer: Lung Metastasis : CK(23) : AC(14), Breast Cancer: Metastatic : CK(123) : AC(52)
Pharmacological Actions : Anti-metastatic : CK(634) : AC(414), Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)

Green Tea induces apoptosis in drug-resistant small-cell lung carcinoma.

Pubmed Data : Biochem Biophys Res Commun. 2007 Aug 17;360(1):233-7. Epub 2007 Jun 14. PMID: 17585882
Article Published Date : Aug 17, 2007
Authors : David Sadava, Elizabeth Whitlock, Susan E Kane
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Carcinoma: Small Cell Lung : CK(17) : AC(6), Lung Cancer : CK(1043) : AC(393)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Telomerase Inhibitor : CK(55) : AC(35)
Additional Keywords : Drug Resistant Cancer : CK(9) : AC(9)

Green tea induces programmed cell death in human cancer cells.

Pubmed Data : Oncol Rep. 1998 Mar-Apr;5(2):527-9. PMID: 9468594
Article Published Date : Mar 01, 1998
Authors : H Hibasami, T Komiya, Y Achiwa, K Ohnishi, T Kojima, K Nakanishi, K Akashi, Y Hara
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Green Tea : CK(1976) : AC(562)
Diseases : Stomach Cancer : CK(579) : AC(194)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)

Overexpression of miR-7-1 can highly potentiate efficacy of EGCG for induction of apoptosis in human malignant neuroblastoma cells.

Pubmed Data : Neurochem Res. 2013 Feb ;38(2):420-32. Epub 2012 Nov 30. PMID: 23192662
Article Published Date : Jan 31, 2013
Authors : Mrinmay Chakrabarti, Walden Ai, Naren L Banik, Swapan K Ray
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Polyphenols : CK(931) : AC(335)
Diseases : Neuroblastoma : CK(85) : AC(52)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), MicroRNA modulator : CK(264) : AC(145)
Additional Keywords : Epigenetic Modification : CK(220) : AC(90)

Panaxadiol and Epigallocatechin Gallate have a synergistic apoptotic effect on human colorectal cancer cells.

Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066
Article Published Date : May 08, 2012
Authors : Guang-Jian Du, Chong-Zhi Wang, Lian-Wen Qi, Zhi-Yu Zhang, Tyler Calway, Tong-Chuan He, Wei Du, Chun-Su Yuan
Study Type : Human In Vitro
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Ginseng : CK(473) : AC(133), Green Tea : CK(1976) : AC(562), Panaxadiol : CK(5) : AC(1)
Diseases : Colorectal Cancer : CK(1646) : AC(619)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Chemosensitizer : CK(394) : AC(286)
Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Sulforaphane with EGCG can inhibit both paclitaxel-sensitive and resistant ovarian cancer cells.

Pubmed Data : Exp Cell Res. 2013 Mar 10 ;319(5):697-706. Epub 2013 Jan 16. PMID: 23333498
Article Published Date : Mar 09, 2013
Authors : Huaping Chen, Charles N Landen, Yuanyuan Li, Ronald D Alvarez, Trygve O Tollefsbol
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Sulforaphane : CK(533) : AC(262)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Ovarian Cancer : CK(363) : AC(129)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Bcl-2 protein down-regulation : CK(198) : AC(131), Cell cycle arrest : CK(810) : AC(612), Telomerase Inhibitor : CK(55) : AC(35)
Additional Keywords : Isothiocyanates : CK(108) : AC(34)

The flavonoids apigenin, EGCG and genistein selectively induce programmed cell death in glioblastoma cells.

Pubmed Data : Cancer. 2010 Jan 1;116(1):164-76. PMID: 19894226
Article Published Date : Jan 01, 2010
Authors : Arabinda Das, Naren L Banik, Swapan K Ray
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(158) : AC(101), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Flavonoids : CK(1215) : AC(379), Genistein : CK(515) : AC(228)
Diseases : Glioblastoma : CK(200) : AC(88)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Selective Cytotoxicity : CK(158) : AC(112)

The present study shows the antitumor effects of EGCG are mediated by the inhibition of glycolysis in aerobic glycolytic HCC cells.

Pubmed Data : Sci Rep. 2016 ;6:28479. Epub 2016 Jun 28. PMID: 27349173
Article Published Date : Dec 31, 2015
Authors : Sainan Li, Liwei Wu, Jiao Feng, Jingjing Li, Tong Liu, Rong Zhang, Shizan Xu, Keran Cheng, Yuqing Zhou, Shunfeng Zhou, Rui Kong, Kan Chen, Fan Wang, Yujing Xia, Jie Lu, Yingqun Zhou, Weiqi Dai, Chuanyong Guo
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Cancers: Drug Resistant : CK(352) : AC(223), Liver Cancer : CK(1235) : AC(462)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)

The synergy of flavonoids catechin, quercetin or epigallocatechin gallate with fluconazole demonstrated antifungal activity against fluconazole resistant C. tropicalis in vitro.

Pubmed Data : Antimicrob Agents Chemother. 2014 ;58(3):1468-78. Epub 2013 Dec 23. PMID: 24366745
Article Published Date : Dec 31, 2013
Authors : Cecília Rocha da Silva, João Batista de Andrade Neto, Rosana de Sousa Campos, Narjara Silvestre Figueiredo, Letícia Serpa Sampaio, Hemerson Iury Ferreira Magalhães, Bruno Coêlho Cavalcanti, Danielle Macêdo Gaspar, Geanne Matos de Andrade, Iri Sandro Pampolha Lima, Glauce Socorro de Barros Viana, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles Barbosa Grangeiro, Hélio Vitoriano Nobre Júnior
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(512) : AC(169), EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Quercetin : CK(568) : AC(250)
Diseases : Candida Infection : CK(241) : AC(112), Fungal Infections: Biofilm Formation/Resistance : CK(5) : AC(5)
Pharmacological Actions : Antifungal Agents : CK(234) : AC(146), Antimicrobial : CK(293) : AC(128), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Fluconazole Resistance : CK(2) : AC(1), Natural Substance/Drug Synergy : CK(352) : AC(142)

These results demonstrate that enhanced expression of miR-126 increased the sensitivity of osteosarcoma cells to EGCG through induction of apoptosis.

Pubmed Data : World J Surg Oncol. 2014 ;12:383. Epub 2014 Dec 16. PMID: 25510179
Article Published Date : Dec 31, 2013
Authors : Liangdong Jiang, Cheng Tao, Aiyong He, Xiaojie He
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Osteosarcoma : CK(133) : AC(69)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075), Cell cycle arrest : CK(810) : AC(612)
Additional Keywords : Dose Response : CK(1056) : AC(408)

This study proposes a novel molecular rationale for antitumor activities of green tea in head and neck cancers.

Pubmed Data : Phytomedicine. 2016 Nov 15 ;23(12):1344-1355. Epub 2016 Aug 19. PMID: 27765354
Article Published Date : Nov 14, 2016
Authors : Yoo Seob Shin, Sung Un Kang, Ju Kyeong Park, Yang Eun Kim, Yeon Soo Kim, Seung Joon Baek, Seong-Ho Lee, Chul-Ho Kim
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314)
Diseases : Head and Neck Cancer : CK(165) : AC(44)
Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), MicroRNA modulator : CK(264) : AC(145)

[6]-gingerol and epigallocatechin gallate (EGCG) synergistically induced apoptosis and inhibits the proliferation 1321N1 and LN18 cells.

Pubmed Data : Molecules. 2014 ;19(9):14528-41. Epub 2014 Sep 12. PMID: 25221872
Article Published Date : Dec 31, 2013
Authors : Amirah Abdul Rahman, Suzana Makpol, Rahman Jamal, Roslan Harun, Norfilza Mokhtar, Wan Zurinah Wan Ngah
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1956) : AC(314), Gingerol : CK(53) : AC(31), Tocotrienols : CK(25) : AC(19)
Diseases : Glioma : CK(177) : AC(86)
Pharmacological Actions : Antiproliferative : CK(2546) : AC(1685), Apoptotic : CK(2958) : AC(2075)
Additional Keywords : Natural Substance/Drug Synergy : CK(352) : AC(142)

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