Traumatic Brain Injury

Name	AC	CK
Citicoline	3	32
Frankincense	2	20
Flavonoids	3	15
Ginkgo biloba	2	12
Huperzine	2	12
Vinpocetine	2	12
Alpha-Lipoic Acid	2	11
Acetyl-l-carnitine	1	10
Fish Oil	1	10
Folic Acid	1	10
Ginger	1	10
Multivitamin	1	10
NAC (N-acetyl-L-cysteine)	1	10
Hydrogen: Molecular	5	8
Resveratrol	5	8
Thymoquinone	5	7
Ellagic Acid	3	6
Safflower	3	6
Tetrahydrocurcumin	3	6
Caffeic acid phenethyl ester	2	5
Chrysin	3	5
Melatonin	3	5
Aloe Vera	2	4
Astaxanthin	2	4
Berberine	2	4
Cannabidiol	2	4
Nigella sativa (aka Black Seed)	3	4
Oxaloacetate	2	4
Salvia miltiorrhiza	2	4
Sesamin	2	4
Sulforaphane	2	4
Curcumin	2	3
Diosmin	2	3
Ginsenosides	2	3
Phloretin	2	3
Artesunate	1	2
Cannabinoids	1	2
Carvacrol	1	2
Choline	1	2
Cinnamaldehyde	1	2
Coenzyme Q10	1	2
Crocetin	1	2
Crocin	1	2
Endocannabinoids	1	2
Formononetin	2	2
Fucoidan	1	2
Gastrodin	1	2
Genistein	1	2
Honokiol	1	2
Hydrogen Water	1	2
Icariin	1	2
Isoliquiritigenin	1	2
Isothiocyanates	1	2
Lactobacillus Acidophilus	1	2
Lactobacillus reuteri	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Lupeol	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Naringenin	1	2
Nicotinamide Mononucleotide	1	2
Oleocanthal	1	2
Olive Oil	1	2
Paeoniflorin	1	2
Palmitoylethanolamide	1	2
Plumbagin	1	2
Propolis: Bee	1	2
Quercetin	1	2
Royal Jelly	1	2
Saffron	1	2
Shilajit	1	2
Silymarin	1	2
Tangeretin	1	2
Tanshinone IIA	1	2
Tauroursodeoxycholic acid	1	2
Ubiquinol	1	2
Urolithin A	1	2
Ursolic Acid	1	2
Vanillic Acid	1	2
Vitamin C	1	2
Vitamin E: alpha tocopherol	1	2
Wogonin	1	2
magnesium chloride	1	2
Ashwagandha	1	1
Asiatic Acid	1	1
Curcuma Longa	1	1
Glycyrrhizin	1	1
Hesperidin	1	1
Magnesium	1	1
Omega-3 Fatty Acids	1	1
Piperine	1	1
Pterostilbene	1	1
Vitamin C: Intravenous	1	1

Name	AC	CK	Focus
Clopidogrel	1	10
Fluoxetine (trade name Prozac)	1	2

Name	AC	CK
Hyperbaric Treatment	21	134
Yoga	3	40
Acupuncture	5	38
Photobiomodulation	8	28
Electroacupuncture	8	23
Qigong	1	21
Tai Chi	1	21
Meditation	1	20
Mindfullness Training	1	20
Dietary Modification: Low Carbohydrate/Ketogenic	3	13
Acupressure	1	10
Intravascular Laser Blood Irradiation	1	10
Light Therapy	1	10
Light-Emitting Diodes (LEDs) Therapy	1	10
Exercise	1	2
Ultrasound therapy	1	2
Light-Emitting Diode Therapy	1	1
Music	1	1

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Citicoline for traumatic brain injury.Dec 31, 2016

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Pubmed Data : Restor Neurol Neurosci. 2015 ;33(6):943-51. PMID: 26484702

Article Published Date : Dec 31, 2014

Study Type : Human Study

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Diseases : Brain Concussion, Traumatic Brain Injury

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Angiogenesis Inducing Agents, Neuroprotective Agents

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A nutrient combination improves cognitive function in head injuried former NFL players. Jan 01, 2011

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Pubmed Data : J Psychoactive Drugs. 2011 Jan-Mar;43(1):1-5. PMID: 21615001

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Pubmed Data : Chin J Integr Med. 2022 May 4. Epub 2022 May 4. PMID: 35508860

Article Published Date : May 03, 2022

Study Type : Human Study

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Diseases : Traumatic Brain Injury

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Gastroprotective

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Effect of a Boswellia and ginger mixture on the memory dysfunction of the mild traumatic brain injury patients.Dec 31, 2021

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Pubmed Data : Bull Emerg Trauma. 2022 ;10(4):157-164. PMID: 36568722

Article Published Date : Dec 31, 2021

Study Type : Human Study

Additional Links

Substances : Frankincense, Ginger

Diseases : Traumatic Brain Injury

Pharmacological Actions : Neuroprotective Agents

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Effects of intravascular photobiomodulation on cognitive impairment and crossed cerebellar diaschisis in patients with traumatic brain injury.Apr 19, 2023

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Pubmed Data : Lasers Med Sci. 2023 Apr 20 ;38(1):108. Epub 2023 Apr 20. PMID: 37076743

Article Published Date : Apr 19, 2023

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Pubmed Data : J Clin Med. 2022 Dec 14 ;11(24). Epub 2022 Dec 14. PMID: 36556017

Article Published Date : Dec 13, 2022

Study Type : Human Study

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Substances : Folic Acid

Diseases : Pneumonia, Traumatic Brain Injury

Pharmacological Actions : Prophylactic Agents

Additional Keywords : Risk Reduction

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From dawn to dusk-mimicking natural daylight exposure improves circadian rhythm entrainment in patients with severe brain injury.Jul 10, 2022

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Pubmed Data : Acupunct Med. 2006 Sep ;24(3):129-33. PMID: 17013360

Article Published Date : Aug 31, 2006

Study Type : Human: Case Report

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Diseases : Central Pain Syndrome, Fractures: Bone, Traumatic Brain Injury

Therapeutic Actions : Acupuncture

Pharmacological Actions : Analgesics

Additional Keywords : Significant Treatment Outcome

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Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury.Jan 09, 2020

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Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Isothiocyanates

Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation

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Aloe vera leaf extract reduced BBB permeability and improved neurological results after traumatic brain injury.Dec 31, 2023

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Pubmed Data : Oxid Med Cell Longev. 2024 ;2024:5586814. Epub 2024 Jul 15. PMID: 39040520

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Pubmed Data : Polymers (Basel). 2025 Jul 9 ;17(14). Epub 2025 Jul 9. PMID: 40732779

Article Published Date : Jul 08, 2025

Study Type : Animal Study

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Substances : Safflower, Salvia miltiorrhiza

Diseases : Traumatic Brain Injury

Pharmacological Actions : Angiogenesis Inducing Agents, Anti-Inflammatory Agents

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Combined phloretin and hPRP therapy is superior to either treatment alone in protecting the brain against TBD.Dec 31, 2023

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Pubmed Data : Biomedicine (Taipei). 2024 ;14(3):23-30. Epub 2024 Sep 1. PMID: 39386181

Article Published Date : Dec 31, 2023

Study Type : Animal Study

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Substances : Mucuna pruriens (aka Velvet Beans)

Diseases : Depression, Traumatic Brain Injury

Pharmacological Actions : Antidepressive Agents

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Effects of caffeic acid phenethyl ester in reducing cerebral edema.Aug 31, 2020

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Ginkgolide A attenuated apoptosis via inhibition of oxidative stress in mice with traumatic brain injury.Jan 29, 2024

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Pubmed Data : Neuroreport. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28953090

Article Published Date : Sep 24, 2017

Study Type : Animal Study

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Diseases : Traumatic Brain Injury

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Neuroprotective Agents

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Hyperbaric oxygen therapy treatment improves the cumulative tissue damage in juvenile brain following repetitive mild traumatic brain injury.Sep 30, 2016

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Pubmed Data : Med Gas Res. 2016 Oct-Dec;6(4):187-193. Epub 2016 Dec 30. PMID: 28217290

Article Published Date : Sep 30, 2016

Study Type : Animal Study

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Diseases : Traumatic Brain Injury

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Neuroprotective Agents

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Hyperbaric oxygen therapy treatment may ameliorate TBI-induced depression-like behaviour in rats by attenuating neuro-inflammation.Jan 04, 2017

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Pubmed Data : World Neurosurg. 2017 Jan 5. Epub 2017 Jan 5. PMID: 28065873

Article Published Date : Jan 04, 2017

Study Type : Animal Study

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Diseases : Brain Inflammation , Traumatic Brain Injury

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury.Dec 31, 2019

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Pubmed Data : Brain Res Bull. 2021 Oct ;175:246-253. Epub 2021 Jul 31. PMID: 34343642

Article Published Date : Sep 30, 2021

Study Type : Animal Study

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Substances : Flavonoids

Diseases : Traumatic Brain Injury

Therapeutic Actions : Ultrasound therapy

Pharmacological Actions : Neuroprotective Agents

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Pubmed Data : J Neurosci Rural Pract. 2013 Jul ;4(3):292-7. PMID: 24250162

Article Published Date : Jun 30, 2013

Study Type : Animal Study

Additional Links

Substances : Vitamin C, Vitamin E: alpha tocopherol

Diseases : Brain: Oxidative Stress, Traumatic Brain Injury

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents

Additional Keywords : Significant Treatment Outcome

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Propolis may protect brain cell from apoptosis after injury by maintaining Hsp70 expression in addition to antioxidant and anti-inflammatory.Sep 14, 2019

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Pubmed Data : Mol Med Rep. 2018 Mar 28. Epub 2018 Mar 28. PMID: 29620218

Article Published Date : Mar 27, 2018

Study Type : Animal Study

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Substances : Quercetin

Diseases : Traumatic Brain Injury

Pharmacological Actions : Neuroprotective Agents

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Resveratrol attenuates autophagy and inflammation after traumatic brain injury.Dec 31, 2021

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Pubmed Data : Folia Neuropathol. 2022 ;60(2):153-164. PMID: 35950468

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Brain Inflammation , Traumatic Brain Injury

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

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Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562

Article Published Date : Nov 15, 2005

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Brain Edema, Traumatic Brain Injury

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Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

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Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205

Article Published Date : Oct 18, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain Injury: Traumatic, Traumatic Brain Injury

Pharmacological Actions : Antioxidants, Neuroprotective Agents

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Tanshinone IIA alleviates traumatic brain Injury by reducing ischemia‒reperfusion.Dec 31, 2023

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Pubmed Data : Mediators Inflamm. 2024 ;2024:7459054. Epub 2024 Mar 21. PMID: 38549714

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Traumatic Brain Injury

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : MicroRNA-124

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Tauroursodeoxycholic acid may attenuate early brain injury via Akt pathway activation.Dec 31, 2016

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Pubmed Data : Front Neurol. 2024 ;15:1450134. Epub 2024 Oct 9. PMID: 39445195

Article Published Date : Dec 31, 2023

Study Type : Review

Additional Links

Diseases : Brain Concussion, Fibromyalgia, Post-Traumatic Stress Disorders (PTSD), Traumatic Brain Injury

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Neuromodulatory, Neuroprotective Agents

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Hyperbaric oxygen therapy has been demonstrated to have neuroprotective effects without increased oxygen toxicity in experimental TBI models.Mar 31, 2016

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Pubmed Data : PM R. 2010 Dec ;2(12 Suppl 2):S292-305. PMID: 21172691

Article Published Date : Dec 01, 2010

Study Type : Review

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Diseases : Brain Damage, Head Injuries, Traumatic Brain Injury

Therapeutic Actions : Photobiomodulation

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Magnesium and nerve injury: Mechanisms and applications.Aug 12, 2025

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Pubmed Data : Neural Regen Res. 2025 Aug 13. Epub 2025 Aug 13. PMID: 40808387

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Pubmed Data : PLoS One. 2022 ;17(3):e0264533. Epub 2022 Mar 3. PMID: 35239693

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Diseases : Traumatic Brain Injury

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Piperine attenuates TBI-induced seizures via inhibiting cytokine-activated reactive astrogliosis.Dec 31, 2019

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View the Evidence: 181 Abstracts with Traumatic Brain Injury Research

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Citicoline for traumatic brain injury.Dec 31, 2016

Effects of tai chi and Qigong on cognition in neurological disorders.Jun 11, 2022

Acupuncture can be an effective treatment for patients unconscious following traumatic brain injury.Feb 20, 2020

Patients undergoing hyperbaric therapy achieved significant improvement in the GCS and GOS with a lower overall mortality.Apr 30, 2016

Therapeutic effects of meditation, yoga, and mindfulness-based interventions for chronic symptoms of mild traumatic brain injury.Nov 01, 2020

HBOT may induce cerebral angiogenesis, which improves perfusion to the chronic damage brain tissue even months to years after the injury.Dec 31, 2014

A nutrient combination improves cognitive function in head injuried former NFL players. Jan 01, 2011

Acupuncture treatment increased the cortico spinal tract activity of patients with chronic chronic disorders of consciousness after severe TBI.Oct 31, 2016

Boswellia serrata extract shows cognitive benefits.Apr 05, 2022

Both NBH and HBOT can effectively improve cognitive outcome for patients with mild TBI.Sep 14, 2023

Citicoline in severe traumatic brain injury: indications for improved outcome.Dec 31, 2017

Early adjuvant HBOT is also associated with significantly improved GOS-E at 3 months postinjury compared to standard of care alone.Feb 28, 2025

Early electroacupuncture can improve gastrointestinal function and clinical prognosis in patients with traumatic brain injury complicated by gastrointestinal injury.May 03, 2022

Effect of a Boswellia and ginger mixture on the memory dysfunction of the mild traumatic brain injury patients.Dec 31, 2021

Effects of intravascular photobiomodulation on cognitive impairment and crossed cerebellar diaschisis in patients with traumatic brain injury.Apr 19, 2023

Effects of self-administered acupressure on fatigue following traumatic brain injury.Mar 22, 2023

Feasibility of yoga to improve symptoms in individuals with severe, chronic traumatic brain injury.Jan 07, 2021

Folic acid treatment in TBI patients has the potential for preventing and treating hospital acquired pneumonia.Dec 13, 2022

From dawn to dusk-mimicking natural daylight exposure improves circadian rhythm entrainment in patients with severe brain injury.Jul 10, 2022

HBO2 relative to sham improved some measures of sleep quality.Oct 31, 2018

HBOT can induce neuroplasticity leading to repair of chronically impaired brain functions and improved quality of life in mTBI patients.Dec 31, 2012

HBOT was significantly effective for veterans with mild to moderate traumatic brain injury with persistent post-concussion syndrome and PTSD.Jun 30, 2017

Hyperbaric oxygen for post-concussive symptoms in United States military service members.Dec 31, 2017

Hyperbaric oxygen therapy can improve pain symptoms, quality of life, emotional and social function of patients suffering from fibromyalgia triggered by TBI.Dec 31, 2022

Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients.Dec 31, 2016

Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome.Dec 31, 2019

Hyperbaric oxygen therapy in children with brain injury.Dec 31, 2024

Increased circulating stem cells and better cognitive performance was seen in traumatic brain injury subjects following hyperbaric oxygen therapy.Apr 30, 2017

Oligopin supplementation in traumatic brain injury patients in ICU reduced inflammation and improved the clinical status.Aug 31, 2021

This pilot study shows that ketogenic diet is feasible in the management of traumatic brain injury patients.Jan 31, 2022

This potentially suggests a neuroprotective and anti-inflammatory effect from the acute administration of LLLT in individuals with moderate TBI.Sep 08, 2025

Transcranial LED treatment improved sleep and led to fewer post-traumatic stress disorder symptoms.May 31, 2014

Transcranial photobiomodulation improves cognitive function, post-concussion, and PTSD symptoms in mild traumatic brain injury.Jun 08, 2025