Systemic Lupus Erythematosus

Name	AC	CK
Vitamin D	17	146
DHEA (Dehydroepiandrosterone)	4	80
Omega-3 Fatty Acids	5	42
DHA (Docosahexaenoic Acid)	3	32
Indole-3-Carbinol	3	32
EPA (Eicosapentaenoic Acid)	2	30
Fish Oil	4	24
Peony	1	21
Vitamin E	2	21
Vitamin B12	1	20
Lactobacillus delbrueckii Subsp	1	15
Lactobacillus rhamnosus	1	15
Astragalus	2	12
Green Tea	2	12
Polyphenols	2	12
Curcumin	6	11
Apples	1	10
Calcium	1	10
Gentian	1	10
Oranges	1	10
Pine Bark Extract	1	10
Red Wine Extract	1	10
Royal Jelly	1	10
Tea	1	10
Tryptophan	1	10
Paeoniflorin	5	8
Berberine	1	5
Probiotics	3	4
Guduchi	1	3
Melatonin	3	3
Resveratrol	3	3
Antrodia camphorata	1	2
Apigenin	1	2
Ashwagandha	1	2
Bupleurum	1	2
Cordyceps sinensis	1	2
Coumestrol	1	2
Emodin	1	2
Fisetin	1	2
Flavonoids	1	2
Genistein	1	2
Gingerol	1	2
Isoflavones	1	2
Lactobacillus fermentum	1	2
Lactobacillus paracasei	1	2
Lotus	1	2
Mangosteen	1	2
Nigella sativa (aka Black Seed)	1	2
Olive	1	2
Olive Oil	1	2
Reishi Mushroom	1	2
Sophora Flavescens	1	2
Soy	1	2
Sulforaphane	1	2
Turmeric	1	2
Wormwood	1	2
phytoestrogens	1	2
Celastrol	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Naringenin	1	1
Piperine	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Shikonin	1	1

Name	AC	CK
Statin Drugs	2	20
Bisphenol A	1	5
Freund adjuvant	2	4
Pristane	2	4
Atorvastatin	1	3
Gliadin	1	3
Ozempic	1	3
Simvastatin	1	3
Wheat	1	3
Adjuvant	1	2
Aluminum Hydroxide	1	2
Hexadecane	1	2
Mineral Oil	1	2
Squalene	1	2
Squalene, Adjuvant	1	2

Name	AC	CK
Light Therapy	2	11
Sunlight exposure	2	11
Exercise	1	10
Exercise: Aerobic	1	10
Exercise: Resistance Training	1	10
Whole-Body Vibration	1	10
Hyperbaric Treatment	1	3
Microbiota Transfer Therapy	2	2
Fasting/Caloric Restriction	1	1

Name	AC	CK
Vaccination: All	7	47
Vaccination: Hepatitis B	6	36
Vaccination: HPV (Gardasil)	3	7
Vaccination: Tetanus	2	4
Vaccination: COVID-19	1	3
Vaccination: Diphtheria-Pertussis-Tetanus	1	1
Vaccination: Haemophilus Influenzae	1	1
Vaccination: Influenza	1	1
Vaccination: Lyme disease	1	1
Vaccination: Mumps-Measles-Rubella (MMR)	1	1
Vaccination: Rabies	1	1
Vaccination: Rotavirus	1	1
Vaccination: Varicella (Chicken pox)	1	1

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Efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus.Dec 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:932874. Epub 2022 Dec 7. PMID: 36569311

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Appl Physiol (1985). 2014 Sep 15 ;117(6):639-47. Epub 2014 Jul 18. PMID: 25038103

Article Published Date : Sep 14, 2014

Study Type : Human Study

Additional Links

Diseases : Systemic Lupus Erythematosus

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory

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Gentian improves outcome in patients with systemic lupus erythemaatous treated with prednisone. Mar 01, 1989

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Pubmed Data : Zhong Xi Yi Jie He Za Zhi. 1989 Mar;9(3):156-7, 133-4. PMID: 2736700

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lupus Sci Med. 2015 ;2(1):e000064. Epub 2015 Apr 8. PMID: 25893106

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Microbiota

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The decrease of vitamin D level is related to the disease activity of SLE patients.Oct 17, 2021

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Pubmed Data : Beijing Da Xue Xue Bao Yi Xue Ban. 2021 Oct 18 ;53(5):938-941. PMID: 34650298

Article Published Date : Oct 17, 2021

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Systemic Lupus Erythematosus, Vitamin D Deficiency

Additional Keywords : Risk Factors

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These results showed improvements with 3-month royal jelly treatment in regard to the clinical severity score and laboratory markers for the disease.Dec 31, 2015

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Pubmed Data : Food Nutr Res. 2016 ;60:32963. Epub 2016 Nov 24. PMID: 27887663

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Pubmed Data : Semin Arthritis Rheum. 1999 Dec;29(3):131-9. PMID: 10622677

Article Published Date : Dec 01, 1999

Study Type : Human Study

Additional Links

Diseases : Systemic Lupus Erythematosus, Vaccine-induced Toxicity

Anti Therapeutic Actions : Vaccination: All

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Vitamin D can positively modulate endothelial function in patients with stable SLE.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:22341. Epub 2016 Mar 1. PMID: 26930567

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Cardiovascular Disease: Prevention, Systemic Lupus Erythematosus

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Vitamin D deficiency could have a significant impact on cognitive performance in patients with systemic lupus erythematosus.Sep 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Innov Clin Neurosci. 2018 Oct 1 ;15(9-10):25-29. PMID: 30588363

Article Published Date : Sep 30, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Cognitive Decline/Dysfunction, Systemic Lupus Erythematosus, Vitamin D Deficiency

Additional Keywords : Increased Risk

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Vitamin D deficiency is common in juvenile systemic lupus erythematosus.Sep 12, 2020

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Pubmed Data : Lupus. 2020 Sep 13:961203320957721. Epub 2020 Sep 13. PMID: 32924829

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Simvastatin-induced lupus erythematosus has been reported. Sep 01, 1998

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Pubmed Data : South Med J. 1998 Sep ;91(9):873-4. PMID: 9743064

Article Published Date : Sep 01, 1998

Study Type : Human: Case Report

Additional Links

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anticholesteremic Agents

Problem Substances : Simvastatin

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Statin drug induced lupus-like syndrome concomitant with a severe autoimmune hepatitis has been reported. Jan 01, 2003

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Pubmed Data : Lupus. 2003 ;12(5):409-12. PMID: 12765306

Additional Keywords : Phytotherapy

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Antrodia camphorata attenuates the progression of nephritis in systemic lupus erythematosus-prone mice. Sep 02, 2008

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Pubmed Data : Evid Based Complement Alternat Med. 2008 Sep 2. PMID: 18955361

Article Published Date : Sep 02, 2008

Study Type : Animal Study

Additional Links

Substances : Antrodia camphorata

Diseases : Lupus Erythematosus: Systemic, Lupus Nephritis

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Apigenin, a dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation in mice. Jan 01, 2009

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Pubmed Data : Arthritis Res Ther. 2009;11(2):R59. Epub 2009 Apr 30. PMID: 19405952

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Pubmed Data : Chin Med. 2016 ;11:23. Epub 2016 Apr 29. PMID: 27134645

Article Published Date : Dec 31, 2015

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Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus.Jan 11, 2022

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Pubmed Data : BMC Complement Med Ther. 2022 Jan 12 ;22(1):13. Epub 2022 Jan 12. PMID: 35022006

Article Published Date : Jan 11, 2022

Study Type : Animal Study

Additional Links

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Immunomodulatory

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Probiotics prevent hypertension in a murine model of systemic lupus erythematosus.Jul 30, 2021

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Pubmed Data : Nutrients. 2021 Jul 31 ;13(8). Epub 2021 Jul 31. PMID: 34444829

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2022 ;13:805508. Epub 2022 Jan 21. PMID: 35126161

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lupus Sci Med. 2015 ;2(1):e000114. Epub 2015 Sep 8. PMID: 26380101

Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology.Nov 13, 2019

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Pubmed Data : Life Sci. 2019 Nov 14:117063. Epub 2019 Nov 14. PMID: 31734262

Article Published Date : Nov 13, 2019

Study Type : In Vitro Study

Additional Links

Substances : Celastrol

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Naringenin: A flavanone with anti-inflammatory and anti-infective properties.Jul 31, 2023

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Pubmed Data : Mol Med Rep. 2024 Oct ;30(4). Epub 2024 Aug 19. PMID: 39155862

Article Published Date : Sep 30, 2024

Study Type : Review

Additional Links

Substances : Resveratrol

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Immunomodulatory

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Recent advances in shikonin for the treatment of immune-related diseases.Aug 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Immunol. 2019 ;10:2241. Epub 2019 Sep 27. PMID: 31611873

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)

Diseases : Autoimmune Diseases, Diabetes Mellitus: Type 1, Multiple Sclerosis, Rheumatoid Arthritis, Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

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This review provides a general overview of studies describing gut microbiota perturbations in animal models of autoimmune diseases.May 28, 2017

Pubmed Data : Lupus. 2017 Oct ;26(12):1239-1251. Epub 2017 May 8. PMID: 28480786

Article Published Date : Sep 30, 2017

Study Type : In Vitro Study

Additional Links

Diseases : Systemic Lupus Erythematosus

Therapeutic Actions : Light Therapy, Sunlight exposure

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Vaccination may contribute to causing a wide variety of autoimmune disorders. Feb 01, 2010

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Pubmed Data : Discov Med. 2010 Feb;9(45):90-7. PMID: 20193633

Article Published Date : Feb 01, 2010

Study Type : Commentary

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Vitamin D exerts important regulatory functions on cells from the innate as well as from the adaptive immune responseDec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2015 ;6:513. Epub 2015 Oct 12. PMID: 26528285

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Vitamin D

Diseases : Systemic Lupus Erythematosus, Vitamin D Deficiency

Pharmacological Actions : Immunomodulatory

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Vitamin E many inhibit initiation of the autoimmune diseases such as scleroderma, discoid lupus erythematosus, porphyria cutanea tarda, several types of vasculitis, and polymyositis.Mar 01, 1978

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Pubmed Data : Cutis. 1978 Mar;21(3):321-5. PMID: 343998

Article Published Date : Mar 01, 1978

Systemic Lupus Erythematosus is a Sub of the following Topic

View the Evidence: 134 Abstracts with Systemic Lupus Erythematosus Research

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Efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus.Dec 31, 2021

Serum homocysteine levels were higher and vitamin B12 levels were lower among individuals with systemic lupus erythematosus.Jul 22, 2020

This study suggests that vaccinations are related to increased risks of systemic lupus erythematosus and rheumatoid arthritis.Jun 30, 2017

Vitamin D supplementation reduced anti-dsDNA positivity on systemic lupus erythematosus and could possibly reduce rheumatoid arthritis recurrence.May 31, 2017

Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile.Feb 29, 2024

Astragalus injection may be a useful approach for enhancing the efficacy of system lupus erythematoosus treatment. May 01, 2006

Combined aerobic and resistance training improves physical and executive functions in women with systemic lupus erythematosus.Mar 02, 2021

Daily consumption of green tea extracts for 12 weeks improves the systemic lupus erythematosus disease activity as well as some aspects of quality of life.Jul 01, 2017

Deficiency of 25(OH)D3, a potentially modifiable risk factor, independently predicted cognitive impairment in SLE patients.Dec 31, 2014

DHEA improves symptoms of systemic lupus erythematosus. Dec 01, 1998

DHEA is well tolerated, clinically beneficial and reduces the need for prednisone in patients with systemic lupus erythematosus. Apr 18, 2007

DHEA is well-tolerated and significantly reduces the number of SLE flares in women with mild-to-moderate systemic lupus erythematosus. Nov 01, 2002

DHEA significantly reduces serum levels of proinflammatory cytokines in women witih systemic lupus erythematosus. Dec 01, 2004

DHEA supplementation improves symptoms in patients with system lupus erythematosus. Sep 01, 1994

Effects of 12-week whole-body vibration exercise on fatigue, functional ability and quality of life in women with systemic lupus erythematosus.Jun 30, 2021

EPA and DHA have therapeutic value in the treatment of systemic lupus erythmeatosus. Mar 01, 1997

EPA and DHA induces prolonged remission of systemic lupus erythematosus without side effects. Sep 01, 1994

Exercise training can attenuate the inflammatory milieu in women with systemic lupus erythematosus.Sep 14, 2014

Gentian improves outcome in patients with systemic lupus erythemaatous treated with prednisone. Mar 01, 1989

Hepatitis B vaccination is associated with a wide range of autoimmune diseases.Feb 01, 2006

Hepatitis B vaccination significantly increases the risk of a wide range of autoimmune diseases.Jun 01, 2005

In patients with systemic lupus erythematosus low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time.Dec 31, 2014

Indole-3 carbinol may be beneficial in the treatment of systemic lupus erythematosus. Jan 01, 2001

Indole-3-carbinol could modulate the gene expression involved in wound healing in systemic lupus erythematosus cases and healthy controls.Jun 30, 2020

Omega-3 Fatty Acids improve symptoms of systemic lupus erythematosus and may improve cardiovascular function.Jun 01, 2008

Omega-3 fish oil reduces the severity of symptoms in patients with systemic lupus erythematosus. Aug 01, 2004

Pcynogenol significantly reduces severity of symptoms in patients with systemic lupus erythematosus. Dec 01, 2001

Proton pump inhibitors induce changes in the gut microbiome composition of systemic lupus erythematosus patients.Apr 26, 2022

Specific changes in vitamin D and calcium homeostasis in SLE patients may be responsible for the severity of symptoms. Aug 30, 2016

Statin drug use is associated with a Lupus-Like syndrome. Aug 23, 2011

Statin-induced lupus has been identified within a nationwide pharmacovigilance database.Feb 14, 2012