Obsessive-Compulsive Disorder

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39 Substances Researched for Obsessive-Compulsive Disorder
NameACCKFocus
Psilocybin1043Locked
NAC (N-acetyl-L-cysteine)633Locked
Vitamin D424Locked
Vitamin B-12323Locked
Cannabis322Locked
Crocin314Locked
Ashwagandha211Locked
Milk Thistle211Locked
Arginine110Locked
Caffeine110Locked
Cannabinoids 110Locked
Delta-tetrahydrocannabinol (THC)110Locked
Echium amoenum110Locked
Inositol110Locked
Valerian110Locked
Carotenoids24Locked
Probiotics34Locked
Cannabidiol23Locked
Curcumin23Locked
Multivitamin13Locked
Saccharomyces Boulardii13Locked
Saffron23Locked
Bitter Orange12Locked
Cysteine (see N-Acetylcysteine)12Locked
Genistein12Locked
Myo-inositol22Locked
Noni12Locked
Plumbagin12Locked
Psilocybe argentipes12Locked
acetyl-11-keto-beta-boswellic acid12Locked
Ayahuasca11Locked
Bifidobacterium Longum 11Locked
Glycine11Locked
Lactobacillus casei: Shirota11Locked
Lactobacillus helveticus11Locked
Lactobacillus rhamnosus 11Locked
Omega-3 Fatty Acids11Locked
Prebiotics11Locked
Psychedelics:All 11Locked
2 Problem Substances Researched for Obsessive-Compulsive Disorder
NameACCKFocus
Selective Serotonin Reuptake Inhibitors (SSRIs)110Locked
Sodium Fluoride12Locked
10 Therapeutic Actions Researched for Obsessive-Compulsive Disorder
NameACCKFocus
Mindfullness Training220Locked
Yoga220Locked
Binaural Beats110Locked
Electroacupuncture110Locked
Hypnosis110Locked
Kundalini Yoga110Locked
Meditation 110Locked
Vagus Nerve Stimulation110Locked
Dietary Modification: Low Carbohydrate/Ketogenic11Locked
Microbiota Transfer Therapy11Locked

View the Evidence:
82 Abstracts with Obsessive-Compulsive Disorder Research

[+]

A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders.Mar 31, 2008

Pubmed Data : Brain Stimul. 2008 Apr ;1(2):112-21. Epub 2008 Mar 28. PMID: 20633378
Article Published Date : Mar 31, 2008
Study Type : Human Study
Additional Links
Diseases : Anxiety, Obsessive-Compulsive Disorder
Therapeutic Actions : Vagus Nerve Stimulation
Pharmacological Actions : Anti-Anxiety Agents
[+]

A single-dose treatment with Delta(9)-THC is effective and safe in treating tics and obsessive-compulsive disorder in Tourette Syndrome.Sep 24, 2008

Pubmed Data : J Agric Food Chem. 2008 Sep 24;56(18):8601-8. Epub 2008 Aug 30. PMID: 11951146
Article Published Date : Sep 24, 2008
Study Type : Human Study
Additional Links
Substances : Cannabis, Delta-tetrahydrocannabinol (THC)
Diseases : Obsessive-Compulsive Disorder, Tourette Syndrome
[+]

Administration of up to eight doses of psilocybin in a clinical research setting appears to be safe and potentially effective for patients with OCD.Mar 12, 2026

Pubmed Data : J Psychopharmacol. 2026 Mar 13:2698811261424214. Epub 2026 Mar 13. PMID: 41825921
Article Published Date : Mar 12, 2026
Study Type : Human Study
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

Caffeine compares favorably to amphetamine in reducing the symptoms of treatment-resistant obsessive-compulsive disorder.Nov 01, 2009

Pubmed Data : J Clin Psychiatry. 2009 Nov;70(11):1530-5. Epub 2009 Jun 30. PMID: 19573497
Article Published Date : Nov 01, 2009
Study Type : Human Study
Additional Links
Substances : Caffeine
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Natural Substances Versus Drugs
[+]

Cannabis may have therapeutic value in the treatment of Tourette syndrome.Dec 01, 1998

Pubmed Data : Acta Psychiatr Scand. 1998 Dec;98(6):502-6. PMID: 9879795
Article Published Date : Dec 01, 1998
Study Type : Human Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Obsessive-Compulsive Disorder, Tourette Syndrome
[+]

Crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.Feb 17, 2021

Pubmed Data : Hum Psychopharmacol. 2021 Feb 18:e2780. Epub 2021 Feb 18. PMID: 33599345
Article Published Date : Feb 17, 2021
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Anxiety, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Natural Substances Versus Drugs
[+]

Echium amoenum may have therapeutic value in the treatment of obessive-compulsive disorder.Dec 01, 2006

Pubmed Data : Integr Cancer Ther. 2006 Dec;5(4):362-72. PMID: 19737592
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : Echium amoenum
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Anxiolytic
[+]

Effectiveness of Rajyoga meditation as an adjunct to first-line treatment in patients with obsessive compulsive disorder.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Psychiatry. 2020 ;62(6):684-689. Epub 2020 Dec 12. PMID: 33896974
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Meditation
Additional Keywords : Significant Treatment Outcome
[+]

Electroacupuncture is effective in alleviating obsessive-compulsiver disorder symptoms of treatment-resistant patients. Aug 01, 2009

Pubmed Data : J Nerv Ment Dis. 2009 Aug;197(8):619-22. PMID: 19684500
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Electroacupuncture
[+]

Inositol has value in the treatment of obsessive-compulsive disorder.Sep 01, 1996

Pubmed Data : Am J Psychiatry. 1996 Sep;153(9):1219-21. PMID: 8780431
Article Published Date : Sep 01, 1996
Study Type : Human Study
Additional Links
Substances : Inositol
Diseases : Obsessive-Compulsive Disorder
[+]

Investıgation of vitamin D levels in obsessive-compulsive disorder.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Psychiatry. 2022 Jul-Aug;64(4):349-353. Epub 2022 Jul 13. PMID: 36060722
Article Published Date : Jun 30, 2022
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Obsessive-Compulsive Disorder, Vitamin D Deficiency
Additional Keywords : Increased Risk
[+]

Kundalini yoga shows promise as an add-on option for OCD patients unresponsive to first line therapies.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Psychiatry. 2019 ;10:793. Epub 2019 Nov 11. PMID: 31780963
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Kundalini Yoga
[+]

Kundalini yoga techniques are effective in the treatment of obsessive-compulsive disorder.Dec 01, 1999

Pubmed Data : CNS Spectr. 1999 Dec;4(12):34-47. PMID: 18311106
Article Published Date : Dec 01, 1999
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Yoga
[+]

Milk thistle (Silybum marianum) compares favorably with fluoxetine in the treatment of obsessive-compulsive disorder.Mar 17, 2010

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):362-365. Epub 2009 Dec 24. PMID: 20035818
Article Published Date : Mar 17, 2010
Study Type : Human Study
Additional Links
Substances : Milk Thistle
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Drug: Fluoxetine, Natural Substances Versus Drugs
[+]

Mindfulness training may be an alternative therapy for obsessive-compulsive disorderOct 01, 2008

Pubmed Data : J Nerv Ment Dis. 2008 Oct;196(10):776-9. PMID: 18852623
Article Published Date : Oct 01, 2008
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Mindfullness Training
[+]

Mindfulness-based cognitive therapy was beneficial in patients with obsessive-compulsive disorder.Nov 15, 2018

Pubmed Data : Eur Arch Psychiatry Clin Neurosci. 2018 Nov 16. Epub 2018 Nov 16. PMID: 30446822
Article Published Date : Nov 15, 2018
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Mindfullness Training
[+]

N-acetylcysteine may be a safe and effective option to augment standard treatment in patients with refractory obsessive-compulsive disorder.Nov 30, 2012

Pubmed Data : J Clin Psychopharmacol. 2012 Dec ;32(6):797-803. PMID: 23131885
Article Published Date : Nov 30, 2012
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Obsessive-Compulsive Disorder
[+]

N-acetylcysteine may be therapeutic in treating serotonin reuptake inhibitor refractory obsessive-compulsive disorder.Jan 01, 2008

Pubmed Data : Digestion. 2008;78(4):224-8. Epub 2009 Jan 13. PMID: 16374600
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Obsessive-Compulsive Disorder, Serotonin Disorders
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Obstinate mental disorders may respond to hypnosis techniques.Jan 01, 2009

Pubmed Data : Am J Psychother. 2009;63(2):133-46. PMID: 19711767
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Depression, Obsessive-Compulsive Disorder
Therapeutic Actions : Hypnosis
[+]

Patients with obessive-compulsive disorder might have folate deficiency, higher homocysteine levels and probable impaired metylation and monoamine metabolism.Oct 01, 2005

Pubmed Data : Psychiatry Clin Neurosci. 2005 Oct;59(5):616-20. PMID: 16194269
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, High Homocysteine, Obsessive-Compulsive Disorder
Additional Keywords : Diseases that are Linked, Methylation
[+]

Patients with OCD had significantly lower levels of ADMA, SDMA, and L-arginine compared with the controls.Dec 31, 2015

Pubmed Data : Turk J Med Sci. 2016 ;46(3):775-82. Epub 2016 Apr 19. PMID: 27513255
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Arginine
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Risk Factors
[+]

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.Oct 31, 2006

Pubmed Data : J Clin Psychiatry. 2006 Nov ;67(11):1735-40. PMID: 17196053
Article Published Date : Oct 31, 2006
Study Type : Human Study
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

Saffron is as effective as fluvoxamine in the treatment of patients with mild to moderate OCD.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Psychiatry. 2017 Jul ;12(3):154-162. PMID: 29062366
Article Published Date : Jun 30, 2017
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Natural Substances Versus Drugs
[+]

Significantly lower levels of vitamin B12 and vitamin D and higher levels of homocysteine were found in people with OCD.Dec 31, 2016

Pubmed Data : Psychiatry Res. 2017 08 ;254:232-237. Epub 2017 Apr 21. PMID: 28477545
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin B-12, Vitamin D
Diseases : Homocysteine: Elevated, Obsessive-Compulsive Disorder, Vitamin B 12 Deficiency, Vitamin D Deficiency
[+]

Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder.Sep 30, 2025

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Compr Psychiatry. 2025 Oct ;142:152619. Epub 2025 Jul 1. PMID: 40618640
Article Published Date : Sep 30, 2025
Study Type : Human Study
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

Some OCD patients might have vitamin B12 deficiency and higher homocysteine levels.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropsychiatr Dis Treat. 2014 ;10:1671-5. Epub 2014 Sep 9. PMID: 25228807
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Homocysteine: Elevated, Obsessive-Compulsive Disorder, Vitamin B 12 Deficiency
[+]

The gut microbiota composition may possibly influence behaviour, as clinically observed in PANS/PANDAS patients.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2018 ;9:675. Epub 2018 Apr 6. PMID: 29686658
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Diseases : Dysbiosis, Inflammation, Obsessive-Compulsive Disorder, Streptococcus Infections
Additional Keywords : Microbiota, Risk Factors
[+]

The present study showed an aberrant microbiome in patients with OCD.Nov 30, 2023

Pubmed Data : Psychiatry Clin Neurosci. 2023 Dec ;77(12):646-652. Epub 2023 Sep 27. PMID: 37646189
Article Published Date : Nov 30, 2023
Study Type : Human Study
Additional Links
Diseases : Dysbiosis, Obsessive-Compulsive Disorder
Additional Keywords : Gut-brain Axis
[+]

The results of this study show that binaural beats can be used as a complementary treatment to reduce the severity of OCD symptoms.Dec 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Neurosci. 2024 ;15(2):233-246. Epub 2024 Mar 1. PMID: 39228455
Article Published Date : Dec 31, 2023
Study Type : Human Study
Additional Links
Diseases : Memory Disorders, Obsessive-Compulsive Disorder
Therapeutic Actions : Binaural Beats
Pharmacological Actions : Neuroprotective Agents
[+]

There may be some initial improvement in OCD symptom severity with NAC treatment. Dec 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Child Adolesc Psychopharmacol. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31800306
Article Published Date : Dec 02, 2019
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Obsessive-Compulsive Disorder
[+]

These results confirmed earlier reports of the association between toxoplasmosis and OCD.Dec 15, 2016

Pubmed Data : Eur Psychiatry. 2016 Dec 16 ;40:82-87. Epub 2016 Dec 16. PMID: 27992837
Article Published Date : Dec 15, 2016
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder, Toxoplasma gondii Infection
Additional Keywords : Risk Factors
[+]

These results suggest that Valeriana Officinalis L. has some anti-obsessive and compulsive effects.Oct 10, 2011

Pubmed Data : J Complement Integr Med. 2011 Oct 11 ;8. Epub 2011 Oct 11. PMID: 22718671
Article Published Date : Oct 10, 2011
Study Type : Human Study
Additional Links
Substances : Valerian
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : GABA Modulators
Additional Keywords : Plant Extracts
[+]

This is the first study demonstrating inflammation within the neurocircuitry of OCD.Jul 31, 2017

Pubmed Data : JAMA Psychiatry. 2017 Aug 1 ;74(8):833-840. PMID: 28636705
Article Published Date : Jul 31, 2017
Study Type : Human Study
Additional Links
Diseases : Brain Inflammation , Obsessive-Compulsive Disorder
[+]

This study supports the hypothesis that an association between vitamin D metabolism and PANDAS-related OCD exists.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Noro Psikiyatr Ars. 2016 Mar ;53(1):33-37. Epub 2016 Mar 1. PMID: 28360763
Article Published Date : Feb 29, 2016
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder, Streptococcus infections: Group A , Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

Vitamin B12 deficiency may be linked to obsessive compulsive disorder.Jul 01, 1988

Pubmed Data : Acta Psychiatr Scand. 1988 Jul;78(1):8-10. PMID: 3176999
Article Published Date : Jul 01, 1988
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Obsessive-Compulsive Disorder, Vitamin B 12 Deficiency
[+]

W. somnifera extract may be beneficial as a safe and effective adjunct to SSRIs in the treatment of OCD.Jul 31, 2016

Pubmed Data : Complement Ther Med. 2016 Aug ;27:25-9. Epub 2016 Apr 9. PMID: 27515872
Article Published Date : Jul 31, 2016
Study Type : Human Study
Additional Links
Substances : Ashwagandha
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Plant Extracts
Problem Substances : Selective Serotonin Reuptake Inhibitors (SSRIs)
[+]

Yoga may improve treatment outcomes in patients with obsessive compulsive disorder.Mar 01, 1996

Pubmed Data : Int J Neurosci. 1996 Mar;85(1-2):1-17. PMID: 8727678
Article Published Date : Mar 01, 1996
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Yoga
Additional Keywords : Drug Sparing
[+]

Yoga-based intervention as an adjunct to medication was effective in reducing symptoms in outpatients with OCD over 4 weeks.Jul 13, 2024

Pubmed Data : Asian J Psychiatr. 2024 Jul 14 ;99:104156. Epub 2024 Jul 14. PMID: 39079446
Article Published Date : Jul 13, 2024
Study Type : Human Study
Additional Links
Diseases : Obsessive-Compulsive Disorder
[+]

A case report of vitamin B12 deficiency presenting as obsessive compulsive disorder.Aug 31, 2012

Pubmed Data : Gen Hosp Psychiatry. 2012 Sep-Oct;34(5):578.e7-8. Epub 2012 Jan 9. PMID: 22227032
Article Published Date : Aug 31, 2012
Study Type : Human: Case Report
Additional Links
Substances : Vitamin B-12
Diseases : Obsessive-Compulsive Disorder, Vitamin B 12 Deficiency
[+]

A multinutrient formual demonstrates therapeutic effects in a patient with obsessive compulsive disorder.Aug 01, 2009

Pubmed Data : J Anxiety Disord. 2009 Aug;23(6):836-40. Epub 2009 Mar 9. PMID: 19329277
Article Published Date : Aug 01, 2009
Study Type : Human: Case Report
Additional Links
Substances : Multivitamin
Diseases : Obsessive-Compulsive Disorder
[+]

In this case report an individual successfully used psilocybin to reduce the core symptoms of OCD for several years.Oct 31, 2014

Pubmed Data : J Psychoactive Drugs. 2014 Nov-Dec;46(5):393-5. PMID: 25364991
Article Published Date : Oct 31, 2014
Study Type : Human: Case Report
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

Long-term amelioration of OCD symptoms in a patient with chronic consumption of psilocybin-containing mushrooms.Mar 31, 2021

Pubmed Data : J Psychoactive Drugs. 2021 Apr-Jun;53(2):146-148. Epub 2020 Nov 22. PMID: 33225874
Article Published Date : Mar 31, 2021
Study Type : Human: Case Report
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Significant Treatment Outcome
[+]

Obsessive-compulsive symptoms may be a manifestation of neuropsychiatric systemic lupus erythematosus.Jan 01, 2008

Pubmed Data : J Formos Med Assoc. 2008 Jan;107(1):68-72. PMID: 18218580
Article Published Date : Jan 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Obsessive-Compulsive Disorder, Systemic Lupus Erythematosus
Additional Keywords : Diseases that are Linked
[+]

Reduction in obsessive compulsive disorder and self-injurious behaviour with saccharomyces boulardii in a child with autism.Nov 30, 2018

Pubmed Data : Integr Med (Encinitas). 2018 Dec ;17(6):38-41. PMID: 31043927
Article Published Date : Nov 30, 2018
Study Type : Human: Case Report
Additional Links
Substances : Saccharomyces Boulardii
Diseases : Autism, Obsessive-Compulsive Disorder
Pharmacological Actions : Antidiarrheals, Gastrointestinal Agents, Immunomodulatory
[+]

Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report.Nov 30, 2022

Pubmed Data : Heliyon. 2022 Dec ;8(12):e12135. Epub 2022 Dec 6. PMID: 36536916
Article Published Date : Nov 30, 2022
Study Type : Human: Case Report
Additional Links
Substances : Psilocybin
Diseases : Neurosis: Obsessive-Compulsive, Obsessive-Compulsive Disorder
[+]

Vitamin D supplementation reduced obsessive-compulsive disorder symptoms associated with streptococcal infection.Jun 30, 2016

Pubmed Data : Pediatr Int. 2016 Jul ;58(7):646-8. Epub 2016 Jul 7. PMID: 27388777
Article Published Date : Jun 30, 2016
Study Type : Human: Case Report
Additional Links
Substances : Vitamin D
Diseases : Obsessive-Compulsive Disorder, Vitamin D Deficiency
[+]

Acetyl-11-keto-beta boswellic acid can serve as an effective basis for developing a novel OCD treatment.Aug 04, 2023

Pubmed Data : Neurotoxicology. 2023 Aug 5 ;98:61-85. Epub 2023 Aug 5. PMID: 37549874
Article Published Date : Aug 04, 2023
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cannabidiol exhibits therapeutic activity in a mouse model of obsessive-compulsive disorder. Feb 01, 2006

Pubmed Data : Platelets. 2006 Feb;17(1):37-41. PMID: 20695034
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Obsessive-Compulsive Disorder
[+]

Crocin potently restores REM sleep deprivation-induced manic- and obsessive-compulsive-like behaviors.May 31, 2024

Pubmed Data : Behav Pharmacol. 2024 Jun 1 ;35(4):239-252. Epub 2024 Mar 29. PMID: 38567447
Article Published Date : May 31, 2024
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin
Diseases : Anxiety, Depression, Obsessive-Compulsive Disorder, Sleep Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin treatment had shown a protective effect in OCD with considerable influence on brain monoamine levels.Jan 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : N Am J Med Sci. 2010 Feb ;2(2):81-6. PMID: 22624119
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Neuroprotective Agents
[+]

Effects of the essential oil from Citrus aurantium L. in experimental anxiety models Mar 05, 2006

Pubmed Data : Life Sci. 2006 Mar 6 ;78(15):1720-5. Epub 2005 Oct 25. PMID: 16253279
Article Published Date : Mar 05, 2006
Study Type : Animal Study
Additional Links
Substances : Bitter Orange
Diseases : Anxiety, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Essential Oils
[+]

Genistein supplementation might be a potential therapeutic line for the management and prevention of diabetes-associated OCD.Mar 20, 2018

Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Mar 21. Epub 2018 Mar 21. PMID: 29561730
Article Published Date : Mar 20, 2018
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Diabetic Complications, Obsessive-Compulsive Disorder
Pharmacological Actions : Neuroprotective Agents
[+]

Multistrain probiotic rescinds quinpirole-induced obsessive-compulsive disorder phenotypes.Oct 04, 2023

Pubmed Data : Pharmacol Biochem Behav. 2023 Oct 5 ;232:173652. Epub 2023 Oct 5. PMID: 37804865
Article Published Date : Oct 04, 2023
Study Type : Animal Study
Additional Links
Substances : Probiotics
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
[+]

Plumbagin alleviates mild traumatic brain injury-induced obsessive-compulsive disorder,Oct 31, 2025

Pubmed Data : Phytother Res. 2025 Nov ;39(11):5282-5301. Epub 2025 Oct 7. PMID: 41057257
Article Published Date : Oct 31, 2025
Study Type : Animal Study
Additional Links
Substances : Plumbagin
Diseases : Obsessive-Compulsive Disorder, Traumatic Brain Injury
Pharmacological Actions : Neuroprotective Agents
[+]

Potential effects of noni fruit extract against obsessive-compulsive disorder.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:993927. Epub 2022 Sep 16. PMID: 36188588
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Noni
Diseases : Obsessive-Compulsive Disorder
[+]

Sodium flouride exposure during pregnancy may interfere with normal development and increase the risk of neurological and psychiatric disorders in adulthood.Jun 01, 2010

Pubmed Data : Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):507-12. PMID: 20712257
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Fluoride Toxicity , Huntington Disease, Obsessive-Compulsive Disorder, Prenatal Chemical Exposures, Schizophrenia, Tourette Syndrome
Problem Substances : Sodium Fluoride
Adverse Pharmacological Actions : Genotoxic, Teratogenic
[+]

The active constituents of C. Sativus L. crocins might play a role in compulsive behaviour.Oct 17, 2012

Pubmed Data : Neurosci Lett. 2012 Oct 18 ;528(1):27-30. Epub 2012 Sep 7. PMID: 22985509
Article Published Date : Oct 17, 2012
Study Type : Animal Study
Additional Links
Substances : Carotenoids, Crocin, Saffron
Diseases : Obsessive-Compulsive Disorder
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The hallucinogenic mushroom psilocybe argentipes reduces their obsessive-compulsive marble-burying behavior of mice.Aug 01, 2009

Pubmed Data : Biosci Biotechnol Biochem. 2009 Aug;73(8):1866-8. Epub 2009 Aug 7. PMID: 19661714
Article Published Date : Aug 01, 2009
Study Type : Animal Study
Additional Links
Substances : Psilocybe argentipes
Diseases : Neurosis: Obsessive-Compulsive, Obsessive-Compulsive Disorder, Scientific Oddities
Additional Keywords : Mad Science
[+]

The results indicated that the induction of locomotor sensitization and compulsive checking was accompanied by changes in several communities of bacteria.Mar 31, 2018

Pubmed Data : Behav Pharmacol. 2018 Apr ;29(2 and 3 - Special Issue):211-224. PMID: 29194070
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis, Obsessive-Compulsive Disorder
Additional Keywords : Microbiota
[+]

These findings suggest that N- acetylcysteine could be a novel OCD treatment.Jul 08, 2018

Pubmed Data : Behav Neurosci. 2018 Jul 9. Epub 2018 Jul 9. PMID: 29985009
Article Published Date : Jul 08, 2018
Study Type : Animal Study
Additional Links
Substances : Cysteine (see N-Acetylcysteine)
Diseases : Obsessive-Compulsive Disorder
[+]

A hypothesis is presented wherein the root cause of OCD is proposed to be a dysfunction of the gut microbiome.Jan 31, 2014

Pubmed Data : Med Hypotheses. 2014 Feb ;82(2):163-6. Epub 2013 Dec 1. PMID: 24332563
Article Published Date : Jan 31, 2014
Study Type : Review
Additional Links
Diseases : Anxiety Disorders, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Gut-brain Axis
[+]

A review of nutraceuticals in the treatment of obsessive compulsive disorder.May 31, 2011

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1 ;35(4):887-95. Epub 2011 Feb 23. PMID: 21352883
Article Published Date : May 31, 2011
Study Type : Review
Additional Links
Substances : Glycine, Milk Thistle, Myo-inositol, NAC (N-acetyl-L-cysteine)
Diseases : Obsessive-Compulsive Disorder
[+]

A review of the gut microbiome in obsessive compulsive disorder.Feb 29, 2016

Pubmed Data : Depress Anxiety. 2016 Mar ;33(3):171-8. Epub 2015 Dec 2. PMID: 26629974
Article Published Date : Feb 29, 2016
Study Type : Review
Additional Links
Diseases : Brain Inflammation , Obsessive-Compulsive Disorder
Additional Keywords : Gut-brain Axis
[+]

A review of the supplementation with omega-3 fatty acids in psychiatric disorders.Jul 26, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2016 Jul 27 ;5(8). Epub 2016 Jul 27. PMID: 27472373
Article Published Date : Jul 26, 2016
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Anxiety, Depression, Eating Disorders, Obsessive-Compulsive Disorder, Schizophrenia
[+]

Curcumin is a promising agent for neuropsychiatric disorders.Feb 28, 2017

Pubmed Data : J Psychopharmacol. 2017 Mar ;31(3):287-302. Epub 2017 Jan 30. PMID: 28135888
Article Published Date : Feb 28, 2017
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Autism, Bipolar Disorder, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Autism, bipolar disorder, CURCUMIN, Neuroprotective Agents, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorders (PTSD), Turmeric
[+]

Current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders.Sep 03, 2015

Pubmed Data : Neurotherapeutics. 2015 Sep 4. Epub 2015 Sep 4. PMID: 26341731
Article Published Date : Sep 03, 2015
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Anxiety Disorders, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Anti-Anxiety Agents
[+]

Efficacy and safety of psychedelics for the treatment of mental disorders.Apr 30, 2024

Pubmed Data : Psychiatry Res. 2024 May ;335:115886. Epub 2024 Mar 28. PMID: 38574699
Article Published Date : Apr 30, 2024
Study Type : Review
Additional Links
Substances : Ayahuasca, Psilocybin, Psychedelics:All
Diseases : Anxiety, Borderline Personality Disorder, Depression, Dysmorphophobia, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

Implication of microbiota gut-brain axis in the manifestation of obsessive-compulsive disorder: Preclinical and clinical evidence.Oct 14, 2023

Pubmed Data : Eur J Pharmacol. 2023 Oct 15 ;957:176014. Epub 2023 Aug 22. PMID: 37619786
Article Published Date : Oct 14, 2023
Study Type : Review
Additional Links
Substances : Bifidobacterium Longum , Lactobacillus casei: Shirota, Lactobacillus helveticus, Lactobacillus rhamnosus
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
[+]

Ketogenic diet as a nutritional metabolic intervention for obsessive-compulsive disorder.Dec 24, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Dec 25 ;17(1). Epub 2024 Dec 25. PMID: 39796465
Article Published Date : Dec 24, 2024
Study Type : Review
Additional Links
Diseases : Obsessive-Compulsive Disorder
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Microbial reprogramming in obsessive-compulsive disorders.Jul 25, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Jul 26 ;24(15). Epub 2023 Jul 26. PMID: 37569349
Article Published Date : Jul 25, 2023
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Dysbiosis, Obsessive-Compulsive Disorder
Therapeutic Actions : Microbiota Transfer Therapy
Additional Keywords : Gut-brain Axis
[+]

Myo-inositol may have therapeutic value in obsessive-compulsive disorder. Jan 01, 2002

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan;26(1):21-32. PMID: 11853115
Article Published Date : Jan 01, 2002
Study Type : Review
Additional Links
Substances : Myo-inositol
Diseases : Obsessive-Compulsive Disorder
[+]

N-acetyl cysteine and vitamin D supplementation in treatment resistant obsessive compulsive disorder patients.Jan 16, 2018

Pubmed Data : Curr Pharm Des. 2018 04 17. Epub 2018 Apr 17. PMID: 29663874
Article Published Date : Jan 16, 2018
Study Type : Review
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Vitamin D
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Neuroprotective Agents
[+]

N-acetylcysteine for obsessive-compulsive and related disorders in children and adolescents.Nov 15, 2022

Pubmed Data : Ann Pharmacother. 2022 Nov 16:10600280221138092. Epub 2022 Nov 16. PMID: 36384314
Article Published Date : Nov 15, 2022
Study Type : Review
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Obsessive-Compulsive Disorder
[+]

Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders.Sep 29, 2015

Pubmed Data : Psychiatry Res. 2015 Sep 30 ;229(1-2):37-48. Epub 2015 Jun 6. PMID: 26296951
Article Published Date : Sep 29, 2015
Study Type : Review
Additional Links
Diseases : Anxiety, Brain Inflammation , Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorders (PTSD)
[+]

New horizons for the study of saffron and its active ingredients in the management of neurological and psychiatric disorders.Feb 28, 2024

Pubmed Data : Phytother Res. 2024 Feb 29. Epub 2024 Feb 29. PMID: 38424688
Article Published Date : Feb 28, 2024
Study Type : Review
Additional Links
Substances : Saffron
Diseases : Anxiety, Attention Deficit Disorder with Hyperactivity, Depression, Obsessive-Compulsive Disorder, Sleep Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Psilocybin appears as a valuable treatment for OCD.Jul 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Rep. 2024 Aug 1. Epub 2024 Aug 1. PMID: 39088105
Article Published Date : Jul 31, 2024
Study Type : Review
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

Psilocybin for the treatment of obsessive-compulsive disorders. Nov 16, 2021

Pubmed Data : Curr Top Behav Neurosci. 2021 Nov 17. Epub 2021 Nov 17. PMID: 34784024
Article Published Date : Nov 16, 2021
Study Type : Review
Additional Links
Substances : Psilocybin
Diseases : Obsessive-Compulsive Disorder
[+]

The clinical outcomes of gut-brain axis (GBA) microbiota influence on psychiatric disorders.Jan 31, 2023

Pubmed Data : Iran J Microbiol. 2023 Feb ;15(1):1-9. PMID: 37069911
Article Published Date : Jan 31, 2023
Study Type : Review
Additional Links
Diseases : Autism, Obsessive-Compulsive Disorder, Psychiatric Disorders, Schizophrenia
Additional Keywords : Gut-brain Axis
[+]

The gut-brain axis and the microbiome in anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder.Feb 21, 2023

Pubmed Data : Curr Neuropharmacol. 2023 Feb 22. Epub 2023 Feb 22. PMID: 36815632
Article Published Date : Feb 21, 2023
Study Type : Review
Additional Links
Substances : Prebiotics, Probiotics
Diseases : Anxiety, Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorders (PTSD)
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
[+]

This narrative review delves into the most recent findings and provides a comprehensive overview of the current understanding of ashwagandha's potential uses.Mar 23, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2023 Mar 24 ;15(4). Epub 2023 Mar 24. PMID: 37111543
Article Published Date : Mar 23, 2023
Study Type : Review
Additional Links
Substances : Ashwagandha
Diseases : Alzheimer's Disease, Cancers: All, Candida Albicans, Inflammation, Obsessive-Compulsive Disorder
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antimicrobial, Cardioprotective, Neuroprotective Agents
[+]

What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Porto Biomed J. 2021 Jan-Feb;6(1):e128. Epub 2021 Feb 11. PMID: 33884324
Article Published Date : Dec 31, 2020
Study Type : Review
Additional Links
Substances : Psilocybin
Diseases : Depression, Obsessive-Compulsive Disorder, Substance Abuse
Pharmacological Actions : Antidepressive Agents
[+]

[Orthorexia--a new diagnosis?].Apr 30, 2012

Pubmed Data : Psychiatr Pol. 2012 May-Jun;46(3):441-50. PMID: 23045897
Article Published Date : Apr 30, 2012
Study Type : Review
Additional Links
Diseases : Obsessive-Compulsive Disorder, Orthorexia
Additional Keywords : Health Food

Copyright: lightwise / 123RF Stock Photo

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