Hypoxia

Name	AC	CK
Curcumin	10	14
Ginsenosides	10	14
Tanshinone IIA	10	12
Astragaloside	9	11
Garlic	2	11
Oxygen Therapies	2	11
Carnitine	1	10
Puerarin	6	9
Lotus	3	7
Sulforaphane	5	7
Berberine	4	6
DHEA (Dehydroepiandrosterone)	3	6
Astaxanthin	3	5
Green Tea	3	5
Flavonoids	3	4
Melatonin	2	4
Oligosaccharides	2	4
Paeoniflorin	3	4
Resveratrol	3	4
Apigenin	2	3
Fisetin	2	3
Fucoidan	2	3
Genistein	2	3
NAC (N-acetyl-L-cysteine)	2	3
Paeonol	2	3
Quercetin	3	3
Tangeretin	2	3
Vitamin E	2	3
2-Methoxyestradiol	1	2
Alpha-Lipoic Acid	1	2
Apple Polyphenols	1	2
Arginine	1	2
Asiatic Acid	2	2
Capsaicin	1	2
Chocolate	1	2
Citrulline	1	2
Cordyceps sinensis	2	2
Crocin	1	2
Cysteine (see N-Acetylcysteine)	1	2
EGCG (Epigallocatechin gallate)	2	2
Flaxseed	1	2
Formononetin	1	2
Gingerol	2	2
Ginseng (Korean)	2	2
Goji	1	2
Honokiol	1	2
Lactobacillus rhamnosus GG	1	2
Magnesium	1	2
Pomegranate	1	2
Punicalagin	1	2
Purslane	1	2
Red Sage	1	2
Reishi Mushroom	1	2
Safflower	1	2
Sea buckthorn	1	2
Vitamin E: alpha tocopherol	1	2
acetyl-11-keto-beta-boswellic acid	1	2
Angelica	1	1
Barberry	1	1
Beta-Caryophyllene	1	1
Betulinic acid	1	1
Bufalin	1	1
Carnosic Acid	1	1
Catechin	1	1
Chrysin	1	1
Diosgenin	1	1
Elecampane	1	1
Emodin	1	1
Ferulic acid	1	1
Folic Acid	1	1
Galbanic Acid	1	1
Garlic: Aged	1	1
Gastrodin	1	1
Genipin	1	1
Geraniol	1	1
Glutathione	1	1
Gold (nanoparticles)	1	1
Grape Seed Extract	1	1
Huperzine	1	1
Isoliquiritigenin	1	1
Isoquercitrin	1	1
Lentinan	1	1
Licorice	1	1
Lignans	1	1
Ligustrazine	1	1
Lutein	1	1
Luteolin	1	1
Nicotinamide adenine dinucleotide (NADH)	1	1
Nobiletin	1	1
Omega-3 Fatty Acids	1	1
Onion	1	1
Oolong tea	1	1
Parthenolide	1	1
Patchouli	1	1
Persimmon	1	1
Schisandra	1	1
Vitamin K2	1	1

Name	AC	CK	Focus
Aspirin	1	10
Cobalt	1	1

Name	AC	CK
Oxygen Therapy	1	10
Dietary Modification: Caloric Restriction	1	2
Dietary Modification: Low Carbohydrate/Ketogenic	1	2
Electroacupuncture	1	2
Fasting/Caloric Restriction	1	2
Hyperbaric Treatment	1	2

Name	AC	CK
Hypoxia	2	2
Radation Exposure: Low-Dose	1	1
Radiotherapy	1	1

[+]

Docosahexaenoic acid counteracts the hypoxic-induced inflammatory and metabolic alterations.Oct 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Nov 1 ;14(21). Epub 2022 Nov 1. PMID: 36364860

Article Published Date : Oct 31, 2022

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Pubmed Data : J Ethnopharmacol.1998 May;61(1):81-3. PMID: 18545197

Article Published Date : May 01, 1998

Study Type : Human Study

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Substances : Carnitine

Diseases : Athletic Performance, Hypoxia

[+]

Long-term oxygen therapy might offer a new therapeutic approach to improve liver function in patients with cirrhosis with hypoxemia.Feb 01, 2007

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Pubmed Data : J Gastroenterol. 2007 Feb;42(2):176-80. Epub 2007 Mar 12. PMID: 17351808

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Pubmed Data : Proc Natl Acad Sci U S A. 2013 Jul 23 ;110(30):12331-6. Epub 2013 Jul 8. PMID: 23836662

Article Published Date : Jul 22, 2013

Study Type : Human In Vitro

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Diseases : Breast Cancer, Cancer Metastasis, Circadian Dysregulation, Hypoxia

Additional Keywords : Gene Expression, PER2 Protein, Tumor Suppressor Proteins

[+]

2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension.Sep 23, 2018

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Pubmed Data : J Cell Physiol. 2018 Sep 24. Epub 2018 Sep 24. PMID: 30246291

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Pubmed Data : Respir Physiol. 1995 Feb;99(2):283-9. PMID: 7539934

Article Published Date : Feb 01, 1995

Study Type : Animal Study

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Substances : Capsaicin

Diseases : Hypertension, Hypertension: Pulmonary, Hypoxia

[+]

Carthamin yellow protects the heart against ischemia/reperfusion injury.Dec 31, 2018

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Pubmed Data : J Cardiovasc Pharmacol. 2019 09 ;74(3):228-234. PMID: 31356540

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Safflower

Diseases : Hypoxia, Myocardial Infarction, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

[+]

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

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Pubmed Data : Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15 ;305(4):L301-11. Epub 2013 Jun 28. PMID: 23812632

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Pubmed Data : Neurochem Res. 2021 Sep ;46(9):2297-2306. Epub 2021 Jun 4. PMID: 34086144

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Pubmed Data : J Nutr. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31915826

Article Published Date : Jan 07, 2020

Study Type : Animal Study

Additional Links

Substances : Oligosaccharides

Diseases : Hypoxia

Pharmacological Actions : Cytoprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Hyperbaric oxygen enhanced the healing of ischemic anastomoses in rats and improved the postoperative kidney function.Apr 30, 2016

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[+]

Lycopene attenuates hypoxia-induced testicular injury.Dec 31, 2020

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:3471356. Epub 2021 May 8. PMID: 34055003

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Hypoxia

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-2 Downregulation

[+]

Magnesium protects against hypoxia induced hearing loss in rats.Jun 01, 1999

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Pubmed Data : Pediatr Int. 1999 Jun;41(3):277-80. PMID: 12892379

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2013 May-Jun;45(3):258-63. PMID: 23833369

Article Published Date : Apr 30, 2013

Study Type : Animal Study

Additional Links

Substances : Sea buckthorn

Diseases : Hypoxia

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

This study points out the importance of possessing good antioxidant defenses not only after, but mainly prior to the onset of hypoxia.May 31, 2005

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2005 Jun ;15(3):166-73. PMID: 15955464

Article Published Date : May 31, 2005

Study Type : Animal Study

Additional Links

Substances : Green Tea, Vitamin E

Diseases : Hypoxia, Oxidative Stress

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Cardiac Ischemia, Essential Fatty Acids, Hypoxia, Lipid Peroxidation Of Membranes

[+]

"Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia."Apr 30, 2012

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Pubmed Data : Cancer Sci. 2012 May ;103(5):904-12. Epub 2012 Apr 12. PMID: 22380870

Article Published Date : Apr 30, 2012

Study Type : In Vitro Study

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Diseases : Breast Cancer, Hypoxia

[+]

"Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells."Sep 01, 2009

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Pubmed Data : Radiother Oncol. 2009 Sep ;92(3):329-33. Epub 2009 Jul 13. PMID: 19604589

Article Published Date : Sep 01, 2009

Study Type : Review

Additional Links

Substances : Nicotinamide adenine dinucleotide (NADH)

Diseases : Cancers: All, Hypoxia

Pharmacological Actions : Apoptotic

Additional Keywords : Cancer Hypotheses, Tumor Symbiosis, Warburg Effect

[+]

"The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells."Dec 31, 2011

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Pubmed Data : BMC Cancer. 2012 ;12:201. Epub 2012 May 29. PMID: 22642602

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Pubmed Data : IUBMB Life. 2017 09 ;69(9):660-667. Epub 2017 Jul 7. PMID: 28686797

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Asiatic Acid

Diseases : Hypoxia, Myocardial Ischemia

Pharmacological Actions : Cardioprotective, MicroRNA modulator

[+]

Astaxanthin has neuroprotective effects against rat retinal ganglion cell death under various stresses.Dec 31, 2013

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Pubmed Data : Mol Vis. 2014 ;20:1796-805. Epub 2014 Dec 31. PMID: 25593507

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Hypoxia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

[+]

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Pubmed Data : Biomed Pharmacother. 2022 Feb ;146:112500. Epub 2021 Dec 7. PMID: 34891118

Article Published Date : Jan 31, 2022

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin

Diseases : Hypoxia, Lung Cancer

Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

[+]

Chrysin alleviates chronic hypoxia-induced pulmonary hypertension.Oct 31, 2019

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Pubmed Data : J Cardiovasc Pharmacol. 2019 Nov ;74(5):426-435. PMID: 31725079

Article Published Date : Oct 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Chrysin

Diseases : Hypoxia, Pulmonary Hypertension

Pharmacological Actions : Antihypertensive Agents

[+]

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2016 Nov 23. Epub 2016 Nov 23. PMID: 27889433

Article Published Date : Nov 22, 2016

Study Type : In Vitro Study

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Substances : Curcumin

Diseases : Hypoxia, Spinal Cord Injuries

[+]

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Pubmed Data : Minerva Med. 2017 Nov 7. Epub 2017 Nov 7. PMID: 29115797

Article Published Date : Nov 06, 2017

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Hypoxia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Epigallocatechin-3-gallate protects cardiomyocytes from hypoxia-reoxygenation damage via raising autophagy related 4C expression.Oct 25, 2021

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Pubmed Data : Fitoterapia. 2015 Mar ;101:1-11. Epub 2014 Dec 13. PMID: 25510323

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Pubmed Data : Stem Cells. 2008 Jul ;26(7):1818-30. Epub 2008 May 8. PMID: 18467664

Article Published Date : Jun 30, 2008

Pubmed Data : Am J Gastroenterol. 1985 Sep;80(9):678-81. PMID: 15073105

Article Published Date : Sep 01, 1985

Study Type : In Vitro Study

Additional Links

Substances : Oxygen Therapies

Diseases : Hypoxia, Pancreatic Cancer

[+]

Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1.May 31, 2018

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Pubmed Data : Int J Oncol. 2018 Jun ;52(6):2119-2129. Epub 2018 Mar 23. PMID: 29620169

Article Published Date : May 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Lutein

Diseases : Breast Cancer, Hypoxia, Oxidative Stress

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemopreventive

[+]

Mangiferin inhibits hypoxia/reoxygenation-induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway.Oct 31, 2021

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Pubmed Data : Eur J Pharmacol. 2019 Apr 2. Epub 2019 Apr 2. PMID: 30951715

Article Published Date : Apr 01, 2019

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Hypoxia, Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Onion extrract atttenuates ischemia/hypoxia-induced programmed cell death in cardiomyocytes. Jun 01, 2009

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Pubmed Data : Eur J Nutr. 2009 Jun;48(4):235-42. Epub 2009 Feb 21. PMID: 19234663

[+]

Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons.May 31, 2007

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Pubmed Data : Planta Med. 2007 Jun ;73(7):650-4. Epub 2007 Jun 22. PMID: 17583824

Article Published Date : May 31, 2007

Study Type : In Vitro Study

Additional Links

Substances : Gastrodin

Diseases : Brain Ischemia, Hypoxia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Protective effects of Myrica rubra flavonoids against hypoxia/reoxygenation-induced cardiomyocyte injury.Apr 30, 2019

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Jan;35(1):94-8. PMID: 20349725

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View the Evidence: 210 Abstracts with Hypoxia Research

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Docosahexaenoic acid counteracts the hypoxic-induced inflammatory and metabolic alterations.Oct 31, 2022

Garlic may increase oxygenation and improve dyspnea in children with hepatopulmonary syndrome.Apr 21, 2006

Investigating the impact of silymarin on liver oxidative injury.Feb 29, 2020

L-carnitine appears to reduce hypoxic stress through enhancing oxygen consumption in subjects performing resistance exercise. May 01, 1998

Long-term oxygen therapy might offer a new therapeutic approach to improve liver function in patients with cirrhosis with hypoxemia.Feb 01, 2007

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.May 01, 1999

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

This finding was corroborated by clinical observation that PER2 down-regulation was associated with poor prognosis in breast cancer patients. Jul 22, 2013

2-Methoxyestradiol attenuates chronic-intermittent-hypoxia-induced pulmonary hypertension.Sep 23, 2018

7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage.May 14, 2021

Acteoside presents protective effects on cerebral ischemia/reperfusion injury.May 31, 2021

Alpha lipoic acid improves endothelial function and oxidative stress in mice exposed to chronic intermittent hypoxia.May 11, 2019

Antenatal pomegranate juice rescues hypoxia-induced fetal growth restriction in pregnant mice.May 31, 2018

Antifatigue and antihypoxia activities of oligosaccharides and polysaccharides.Jun 30, 2020

Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury.May 31, 2016

Apigenin is a bioflavonoid that inhibits hypoxia-activated pathways linked to cancer progression in human prostate cancerSep 01, 2008

Apple polyphenol relieves hypoxia-induced pulmonary arterial hypertension.Oct 31, 2018

Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.Apr 18, 2020

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Berberine attenuates hypoxia-induced pulmonary arterial hypertension.Feb 19, 2019

Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke modelsDec 05, 2008

Caloric restriction enhances cell adaptation to hypoxia.Apr 01, 2010

Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension.Feb 01, 1995

Carthamin yellow protects the heart against ischemia/reperfusion injury.Dec 31, 2018

Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure.Dec 31, 2019

Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.Aug 01, 2006

Curcumin has a neuroprotective effect in hypoxia ischemia brain tissue injury. Apr 01, 2009

Curcumin prevents chronic intermittent hypoxia-induced myocardial injury. Dec 31, 2019

Curcumin prevents hyperoxia-induced neonatal lung injury long-term, suggesting its potential usefulness in preventing bronchopulmonary dysplasia.Aug 14, 2013

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension.Aug 05, 2003

Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats.Mar 01, 1997

Dehydroepiandrosterone upregulates inhibits hypoxic pulmonary hypertension.Jun 01, 2007

Dl-3-n-butylphthalide attenuates spinal cord injury.Aug 31, 2021

Electroacupuncture protects against hypoxia-induced pulmonary hypertension.May 01, 2010

Fisetin alleviates hypoxia and reoxygenation injury in rat hepatocytes.Jun 30, 2017

Fucoidan suppresses hypoxia-induced lymphangiogenesis and lymphatic metastasis in mouse hepatocarcinoma.Jun 02, 2015

Genistein prevents hypoxia-induced cognitive dysfunctions by ameliorating oxidative stress and inflammation in the hippocampus.Mar 18, 2021

Ginsenoside Rb1 ameliorates autophagy of hypoxia cardiomyocytes.Jul 17, 2018

Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury.Aug 31, 2009

Green tea polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. May 15, 2008

Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury.Dec 31, 2017

Human milk oligosaccharides activate epidermal growth factor receptor and protect against hypoxia-induced injuries.Jan 07, 2020

Hyperbaric oxygen enhanced the healing of ischemic anastomoses in rats and improved the postoperative kidney function.Apr 30, 2016

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of dietary obese mice.Oct 01, 2007

L-arginine ameliorates hypoxic pulmonary hypertension.Jun 01, 2009

L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets.Sep 01, 2009

Luteolin ameliorates hypoxia-induced pulmonary hypertension.Aug 31, 2022

Lycium barbarum polysaccharides protects H9c2 cells from hypoxia-induced injury.Jan 31, 2019

Lycopene attenuates hypoxia-induced testicular injury.Dec 31, 2020

Magnesium protects against hypoxia induced hearing loss in rats.Jun 01, 1999

Markers of hypoxia and oxidative stress in aging volunteers ingesting lycosomal formulation of dark chocolate containing astaxanthin.Dec 31, 2017

Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo.Oct 06, 2015

N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia.May 27, 2005

N-acetylcysteine is capable of attenuating lipid metabolism alterations and abnormal body weight gain in the chronic intermittent hypoxia model.Jul 02, 2018

Oral administration of flaxseed can be useful for prevention from the detrimental effects of hypoxia on rat testes structure and sperm parameters.May 31, 2018

Oral pretreatment with MAK exerts moderate but significant protective effects against H/I-induced brain infarction and neurological deficits in type 2 diabetic mice.Dec 31, 2014

Paeoniflorin ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension.Dec 31, 2019

Paeoniflorin could be a novel strategy for hypoxia-induced brain injury.Jun 10, 2021

Paeonol represents a potential novel therapeutic approach for the treatment of pulmonary hypertension.Sep 04, 2018

Pre-treatment with astaxanthin has a protective effect and is a safe therapeutic treatment for ischemia-reperfusion injury.Dec 31, 2016

Protective effect of Lactobacillus rhamnosus GG and its supernatant against myocardial dysfunction in obesity. Dec 31, 2018

Protective effects of rutin and chlorogenic acid against antihypoxic conditions.Aug 31, 2021

Puerarin could prevent lung and cerebrum injury of rats exposed to hypobaric hypoxia.Sep 15, 2016

Puerarin has the therapeutic effect on the pulmonary hypertension and accompanying pulmonary fibrosis.May 31, 2018

Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy.Sep 27, 2019

Punicalagin prevents hypoxic pulmonary hypertension in rats. Dec 31, 2015

Purslane (P. olecracea) has an anti-hypoxic activity in mice. Jul 15, 2009

Red sage extract may have therapeutic activity in reducing hypoxia-induced pulmonary hypertension.May 01, 2003

Reduction of hyperoxic acute lung injury in mice by formononetin.Dec 31, 2020

Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.Aug 10, 2019

Sesamol alleviates chronic intermittent hypoxia-induced cognitive deficits via inhibiting oxidative stress and inflammation in rats.Jan 12, 2021

Sinomenine attenuates chronic intermittent hypoxia-induced lung injury.Mar 16, 2018

Hypoxia

View the Evidence:
210 Abstracts with Hypoxia Research