HPA Axis Dysregulation

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4 Substances Researched for HPA Axis Dysregulation
NameACCKFocus
Estradiol (E(2))12Locked
Magnesium12Locked
Piperine12Locked
Shilajit12Locked
12 Problem Substances Researched for HPA Axis Dysregulation
NameACCKFocus
Corticosteroid110Locked
Dexamethasone110Locked
Letrozole (trade name Femera)110Locked
Prednisone110Locked
Tobacco: Smoking110Locked
Bisphenol A 12Locked
Sucralose (aka Splenda)12Locked
Barley11Locked
Gluten exorphins11Locked
Grains11Locked
Rye11Locked
Wheat11Locked
1 Therapeutic Actions Researched for HPA Axis Dysregulation
NameACCKFocus
Dietary Modification: Mediterranean Diet110Locked

View the Evidence:
14 Abstracts with HPA Axis Dysregulation Research

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Among women with fibromyalgia, pain symptoms early in the day are associated with variations in function of the hypothalamic-pituitary-adrenal axis (e.g. high cortisol). Nov 01, 2005

Pubmed Data : Arthritis Rheum. 2005 Nov;52(11):3660-9. PMID: 16258904
Article Published Date : Nov 01, 2005
Study Type : Human Study
Additional Links
Diseases : Cortisol: High, Fibromyalgia, HPA Axis Dysregulation
Additional Keywords : Diseases that are Linked
[+]

Maternal smoking during pregnancy and infant stress response: Test of a prenatal programming hypothesis.May 28, 2014

Pubmed Data : Psychoneuroendocrinology. 2014 May 29 ;48C:29-40. Epub 2014 May 29. PMID: 24999830
Article Published Date : May 28, 2014
Study Type : Human Study
Additional Links
Diseases : HPA Axis Dysregulation, Periconceptional Origin of Adult Disease, Prenatal Chemical Exposures, Prenatal Nutrition: Health of the Offspring
Additional Keywords : Prenatal Epigenetic Programming, Transgenerational Epigenetic Modification
Problem Substances : Tobacco: Smoking
[+]

Persons with fibromyalgia and rheumatoid arthritis may have a hypothalamic-pituitary-adrenal axis disturbance (e.g. high cortisol). Feb 01, 2000

Pubmed Data : Arthritis Care Res. 2000 Feb;13(1):51-61. PMID: 11094926
Article Published Date : Feb 01, 2000
Study Type : Human Study
Additional Links
Diseases : Cortisol: High, Fibromyalgia, HPA Axis Dysregulation, Rheumatoid Arthritis
Additional Keywords : Diseases that are Linked
[+]

Plasma melatonin pattern are abnormal during cluster headache episodes indicating the involvement of the hypothalmus in this disorder.Apr 01, 2008

Pubmed Data : Funct Neurol. 2008 Apr-Jun;23(2):77-81. PMID: 18671907
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Diseases : HPA Axis Dysregulation, Hypothalmus Disorders: Abnormal Melatonin Secretion
[+]

Systemic corticosteroid use suppresses the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease.Jan 01, 2008

Pubmed Data : BMC Pulm Med. 2008;8:1. Epub 2008 Jan 26. PMID: 18221550
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : COPD, HPA Axis Dysregulation
Problem Substances : Corticosteroid, Dexamethasone, Prednisone
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

The aromatase inhibitor letrozole has endocrine disruptive properties on hypothalamic-pituitary output in normal women.Feb 24, 2011

Pubmed Data : Fertil Steril. 2011 Feb 24. Epub 2011 Feb 24. PMID: 21353673
Article Published Date : Feb 24, 2011
Study Type : Human Study
Additional Links
Diseases : HPA Axis Dysregulation
Problem Substances : Letrozole (trade name Femera)
Adverse Pharmacological Actions : Endocrine Disruptor: Pituitary
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The Mediterranean diet is associated with lower levels of HPA axis disturbance and cortisol. Feb 01, 2007

Pubmed Data : Clin Endocrinol (Oxf). 2007 Feb;66(2):185-91. PMID: 17223986
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Diseases : Cortisol: High, HPA Axis Dysregulation
Therapeutic Actions : Dietary Modification: Mediterranean Diet
[+]

Estradiol reduces cumulative mercury and associated disturbances in the hypothalamus-pituitary axis of ovariectomized rats.Mar 01, 2006

Pubmed Data : Ecotoxicol Environ Saf. 2006 Mar;63(3):488-93. PMID: 16406600
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Substances : Estradiol (E(2))
Diseases : HPA Axis Dysregulation, Mercury Poisoning
[+]

Fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse has a long term adverse effect on the genital tract and hypothalamic-pituitary-gonadal axis in female mice. Jun 01, 2005

Pubmed Data : Biol Reprod. 2005 Jun;72(6):1344-51. Epub 2005 Feb 2. PMID: 15689538
Article Published Date : Jun 01, 2005
Study Type : Animal Study
Additional Links
Diseases : HPA Axis Dysregulation
Problem Substances : Bisphenol A
[+]

Magnesium deficiency induces anxiety and HPA axis dysregulation. Aug 04, 2011

Pubmed Data : Neuropharmacology. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21835188
Article Published Date : Aug 04, 2011
Study Type : Animal Study
Additional Links
Substances : Magnesium
Diseases : HPA Axis Dysregulation, Magnesium Deficiency
[+]

Piperine can relieve depression in rats by modulating the function of HPA axis.Jul 01, 2009

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):667-70. PMID: 19615322
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Depression, HPA Axis Dysregulation
Pharmacological Actions : Antidepressive Agents, Neuroprotective Agents
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Shilajit attenuates behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats.Aug 29, 2012

Pubmed Data : J Ethnopharmacol. 2012 Aug 30 ;143(1):91-9. Epub 2012 Jul 6. PMID: 22771318
Article Published Date : Aug 29, 2012
Study Type : Animal Study
Additional Links
Substances : Shilajit
Diseases : Adrenal Insufficiency , Chronic Fatigue Syndrome, Fatigue, HPA Axis Dysregulation
[+]

Sucralose inhibits thyroid function and metabolism in doses within the range of the human acceptable daily intake. Dec 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879
Article Published Date : Dec 30, 2016
Study Type : Animal Study
Additional Links
Diseases : HPA Axis Dysregulation, Hypothyroidism, Overweight
Additional Keywords : HPA Axis Dysregulation, hypothyroidism, overweight, Splenda, Sucralose
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid, Neurotoxic
[+]

Wheat, rye, and barley proteins may act as aids to carcinogens.Sep 01, 1997

Pubmed Data : Med Hypotheses. 1997 Sep;49(3):285-8. PMID: 9293475
Article Published Date : Sep 01, 1997
Study Type : Commentary
Additional Links
Diseases : Celiac Disease, HPA Axis Dysregulation, Intestinal Permeability , Lymphoma
Problem Substances : Barley, Gluten exorphins, Grains, Rye, Wheat

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