Folic Acid/Folate Deficiency

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11 Substances Researched for Folic Acid/Folate Deficiency
NameACCKFocus
Folic Acid 1070Locked
Folate1144Locked
Vitamin B-12424Locked
Folate: Dietary322Locked
Fruit: All110Locked
Vitamin B-6110Locked
Whey110Locked
Bifidobacterium12Locked
Bifidobacterium Longum 12Locked
Moringa oleifera12Locked
Durian 11Locked
3 Problem Substances Researched for Folic Acid/Folate Deficiency
NameACCKFocus
Oral Contraceptives120Locked
Arsenic110Locked
Gluten13Locked
1 Therapeutic Actions Researched for Folic Acid/Folate Deficiency
NameACCKFocus
Dietary Modification: Mediterranean Diet110Locked

View the Evidence:
40 Abstracts with Folic Acid/Folate Deficiency Research

[+]

Deficiency of serum folate level was associated with the increased risk of cervical cancer among Asian populations.Aug 28, 2015

Pubmed Data : Arch Gynecol Obstet. 2015 Aug 29. Epub 2015 Aug 29. PMID: 26319154
Article Published Date : Aug 28, 2015
Study Type : Meta Analysis
Additional Links
Diseases : Cervical Cancer, Folic Acid/Folate Deficiency
[+]

Oral contraceptives were found to be associated with a reduction in blood folate levels.Apr 30, 2015

Pubmed Data : J Obstet Gynaecol Can. 2015 May ;37(5):430-8. PMID: 26168104
Article Published Date : Apr 30, 2015
Study Type : Meta Analysis, Review
Additional Links
Diseases : Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
Problem Substances : Oral Contraceptives
[+]

A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.Dec 31, 2011

Pubmed Data : Nutr Cancer. 2012 ;64(4):550-8. Epub 2012 Apr 20. PMID: 22519865
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Folic Acid , Vitamin B-12
Diseases : Cervical Cancer, Folic Acid/Folate Deficiency
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Natural Substance Synergy
[+]

A dietary pattern characterized by low fruit consumption and folate deficiency is associated with LINE-1 hypomethylation and with cancer risk. Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genes Nutr. 2015 Sep ;10(5):480. Epub 2015 Jul 17. PMID: 26183162
Article Published Date : Aug 31, 2015
Study Type : Human Study
Additional Links
Substances : Folate, Fruit: All
Diseases : Folic Acid/Folate Deficiency
Therapeutic Actions : Dietary Modification: Mediterranean Diet
Additional Keywords : DNA Methylation, Hypomethylation, Risk Factors
[+]

Decreased folic acid might possibly be one of the novel risk factors for erectile dysfunction.Nov 02, 2020

Pubmed Data : Andrologia. 2020 Nov 3:e13890. Epub 2020 Nov 3. PMID: 33141950
Article Published Date : Nov 02, 2020
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Deficiency of folate and vitamin B 12 increases oxidative stress in chronic pancreatitis patients.Jan 10, 2022

Pubmed Data : Indian J Gastroenterol. 2022 Jan 11. Epub 2022 Jan 11. PMID: 35015200
Article Published Date : Jan 10, 2022
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Oxidative Stress, Pancreatitis, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
[+]

Environmental arsenic exposure reduces the effectiveness of folic acid supplementation in preventing myelomeningocele.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health. 2015 ;14(1):34. Epub 2015 Apr 10. PMID: 25885259
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Folic Acid/Folate Deficiency, Spina Bifida
Additional Keywords : Inorganic Arsenic
Problem Substances : Arsenic
[+]

Folate, vitamin B-12 and vitamin B-6 intake were inversely associated with the risk of diabetes in US adults.Dec 31, 2020

Pubmed Data : Asia Pac J Clin Nutr. 2021 ;30(1):75-86. PMID: 33787043
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Folate, Vitamin B-12, Vitamin B-6
Diseases : Folic Acid/Folate Deficiency, Prediabetes, Vitamin B 12 Deficiency, Vitamin B Deficiency
Additional Keywords : Risk Factors, Risk Reduction
[+]

Folic acid deficiency should be regarded as an independent risk factor for arteriogenic erectile dysfunction.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Endocrinol (Lausanne). 2023 ;14:1080188. Epub 2023 Jul 24. PMID: 37554765
Article Published Date : Dec 31, 2022
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Folic acid may help with erectile dysfunction.Aug 24, 2015

Pubmed Data : Andrologia. 2015 Aug 25. Epub 2015 Aug 25. PMID: 26302884
Article Published Date : Aug 24, 2015
Study Type : Human Study
Additional Links
Substances : Folic Acid
Diseases : Erectile Dysfunction, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

High plasma homocysteine and low folate levels were observed in the patients with lung cancer compared to control group.Aug 31, 2015

Pubmed Data : Exp Oncol. 2015 Sep ;37(3):218-22. PMID: 26422108
Article Published Date : Aug 31, 2015
Study Type : Human Study
Additional Links
Substances : Folate: Dietary
Diseases : Folic Acid/Folate Deficiency, High Homocysteine, Lung Cancer, Lung Cancer: Prevention
Additional Keywords : Risk Factors
[+]

Indian patients with metabolic syndrome have elevated blood levels of homocysteine and reduced levels of vitamin B12 and folic acid.Jun 30, 2016

Pubmed Data : J Assoc Physicians India. 2016 Jul ;64(7):22-26. PMID: 27759338
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Metabolic Syndrome X, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
[+]

Low levels of serum folate were correlated with an increased severity of laryngeal squamous cell carcinoma.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Dec ;12(6):4510-4514. Epub 2016 Oct 14. PMID: 28105160
Article Published Date : Nov 30, 2016
Study Type : Human In Vitro, Human Study
Additional Links
Substances : Folate: Dietary, Folic Acid
Diseases : Folic Acid/Folate Deficiency, Laryngeal Cancer, Squamous cell carcinoma
Additional Keywords : Risk Factors
[+]

Patients with obessive-compulsive disorder might have folate deficiency, higher homocysteine levels and probable impaired metylation and monoamine metabolism.Oct 01, 2005

Pubmed Data : Psychiatry Clin Neurosci. 2005 Oct;59(5):616-20. PMID: 16194269
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, High Homocysteine, Obsessive-Compulsive Disorder
Additional Keywords : Diseases that are Linked, Methylation
[+]

Plasma folate and vitamin B12 levels could be associated with liver cancer.Jun 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Jun 30 ;17(7). Epub 2016 Aug 30. PMID: 27376276
Article Published Date : Jun 29, 2016
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Liver Cancer, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors
[+]

Serum folate is inversely associated with BP in non-pregnant women of childbearing age with high prevalence of folate deficiency.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0155801. Epub 2016 May 16. PMID: 27182603
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Hypertension
Additional Keywords : Risk Factors
[+]

Serum folate was inversely associated with insulin resistance in U.S. nondiabetic adults.Aug 22, 2017

Pubmed Data : Sci Rep. 2017 Aug 23 ;7(1):9187. Epub 2017 Aug 23. PMID: 28835661
Article Published Date : Aug 22, 2017
Study Type : Human Study
Additional Links
Substances : Folate
Diseases : Folic Acid/Folate Deficiency, Insulin Resistance
Additional Keywords : Risk Factors
[+]

The prevalence of vitamin D, vitamin B12, folate deficiency and low ferritin levels was found to be high among adolescents.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Prog. 2021 Apr-Jun;104(2):368504211007667. PMID: 33821692
Article Published Date : Mar 31, 2021
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Vitamin B 12 Deficiency, Vitamin D Deficiency
Additional Keywords : Risk Factors
[+]

This study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH.Apr 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Apr 2 ;10(4). Epub 2018 Apr 2. PMID: 29614799
Article Published Date : Apr 01, 2018
Study Type : Human Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Nonalcoholic fatty liver disease (NAFLD), Vitamin B 12 Deficiency
Additional Keywords : Increased Risk
[+]

Vitamin D and folic acid are universally deficient in the diets of patients with chronic kidney disease.May 31, 2016

Pubmed Data : Transplant Proc. 2016 Jun ;48(5):1427-30. PMID: 27496421
Article Published Date : May 31, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Kidney Disease (CKD), Folic Acid/Folate Deficiency, Vitamin D Deficiency
[+]

Whey protein isolate improves vitamin B12 and folate status in elderly Australians with subclinical deficiency of vitamin B12.Apr 30, 2017

Pubmed Data : Mol Nutr Food Res. 2017 May ;61(5). Epub 2017 Feb 9. PMID: 27981743
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Substances : Whey
Diseases : DNA damage, Folic Acid/Folate Deficiency, Vitamin B 12 Deficiency
[+]

Folic acid deficiency increases sensitivity to DNA damage by glucose and methylglyoxal.Jan 24, 2022

Pubmed Data : Mutagenesis. 2022 Jan 25. Epub 2022 Jan 25. PMID: 35079805
Article Published Date : Jan 24, 2022
Study Type : Human In Vitro
Additional Links
Substances : Folic Acid
Diseases : Diabetes Mellitus: Type 2, DNA damage, Folic Acid/Folate Deficiency
Pharmacological Actions : Genoprotective
[+]

Epilepsy with cerebral calcifications poorly responsive to antiepileptic treatment have been reported significantly improved with folic acid and a gluten-free diet.May 01, 1991

Pubmed Data : Acta Paediatr Scand. 1991 May;80(5):559-62. PMID: 1908173
Article Published Date : May 01, 1991
Study Type : Human: Case Report
Additional Links
Diseases : Celiac Disease, Cerebral Calcifications, Epilepsy, Epilepsy: With Cerebral Calcifications, Folic Acid/Folate Deficiency
Additional Keywords : Diseases that are Linked
Problem Substances : Gluten
[+]

Vitamin deficiencies increased the level of serum homocysteine in this patient. Mar 07, 2016

Pubmed Data : Rinsho Shinkeigaku. 2016 Mar 8 ;56(2):116-9. Epub 2016 Jan 21. PMID: 26797484
Article Published Date : Mar 07, 2016
Study Type : Human: Case Report
Additional Links
Substances : Folate, Vitamin B-12
Diseases : Folic Acid/Folate Deficiency, Homocysteine: Elevated, Thrombosis, Vitamin B 12 Deficiency
[+]

A high methionine, low folate and vitamin B6/B12 containing diet can be associated with memory loss.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2019 Jul ;14(7):1247-1254. PMID: 30804256
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Memory Disorders, Vitamin B 12 Deficiency, Vitamin B Deficiency
Additional Keywords : Epigenetic Modification, Risk Factors
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Ancestral folate promotes neuronal regeneration in serial generations of progeny.Jan 09, 2020

Pubmed Data : Mol Neurobiol. 2020 Jan 10. Epub 2020 Jan 10. PMID: 31919777
Article Published Date : Jan 09, 2020
Study Type : Animal Study
Additional Links
Substances : Folate
Diseases : Folic Acid/Folate Deficiency
Pharmacological Actions : Regenerative
Additional Keywords : DNA Methylation, Nerve Regeneration, Transgenerational Epigenetic Modification, Transgenerational inheritance
[+]

Folate deficiency could induce obesity, glucose and lipid metabolism disorders and subsequent cognitive dysfunction.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(8):e0202910. Epub 2018 Aug 28. PMID: 30153273
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Anxiety, Cognitive Decline/Dysfunction, Diabetes Mellitus: Type 2, Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Folic acid deficiency can enhance Aβ accumulation in APP/PS1 mice brain and decrease amyloid-associated miRNAs expression.Nov 30, 2015

Pubmed Data : J Nutr Biochem. 2015 Dec ;26(12):1502-8. Epub 2015 Aug 8. PMID: 26345540
Article Published Date : Nov 30, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Folic Acid
Diseases : Folic Acid/Folate Deficiency
Additional Keywords : Risk Factors
[+]

Folic acid increases methylation potential and DNMT activity, modifies DNA methylation and ultimately decreases APP, PS1 and Aβ protein levels.Jul 31, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug ;26(8):883-91. Epub 2015 Apr 28. PMID: 25959374
Article Published Date : Jul 31, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Folate, Folic Acid
Diseases : Alzheimer's Disease, Folic Acid/Folate Deficiency
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : DNA Methylation, Epigenetic Modification
[+]

High methionine, low folate and low vitamin B6/B12 diet causes neurodegeneration and subsequent short-term memory loss.Aug 08, 2018

Pubmed Data : Metab Brain Dis. 2018 Aug 9. Epub 2018 Aug 9. PMID: 30094804
Article Published Date : Aug 08, 2018
Study Type : Animal Study
Additional Links
Diseases : Folic Acid/Folate Deficiency, Hypermethioninemia, Memory Loss, Neurodegenerative Diseases, Vitamin B 12 Deficiency, Vitamin B Deficiency
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M. oleifera based food can be used as a significant source of folate. Dec 31, 2015

Pubmed Data : J Food Sci Technol. 2016 Jan ;53(1):511-20. Epub 2015 Sep 7. PMID: 26787970
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Folate: Dietary, Moringa oleifera
Diseases : Folic Acid/Folate Deficiency
[+]

These findings suggest the utility of human-residential bifidobacteria from the perspective of potential folate delivery to the host.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Microbiota Food Health. 2015 ;34(4):87-93. Epub 2015 Aug 5. PMID: 26594608
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bifidobacterium, Bifidobacterium Longum , Folate
Diseases : Folic Acid/Folate Deficiency
[+]

This data provides rationales for the consideration of folate supplement as a metastasis preventive measure.Apr 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27119349
Article Published Date : Apr 21, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Folate
Diseases : Cancer Metastasis, Folic Acid/Folate Deficiency, Glioma, Liver Cancer, Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Cancer Stem Cells, Increased Risk
[+]

Folate deficiency-triggered redox pathways confering drug resistance in hepatocellular carcinoma.Jun 26, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26327128
Article Published Date : Jun 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Folate
Diseases : Folic Acid/Folate Deficiency, Liver Cancer, Oxidative Stress
Additional Keywords : Multidrug Resistance, Supplementation
[+]

In the current review, an attempt has been made to discuss the neurotoxic effects of homocysteine in the pathogenesis of depression.Aug 26, 2015

Pubmed Data : Fundam Clin Pharmacol. 2015 Aug 27. Epub 2015 Aug 27. PMID: 26376956
Article Published Date : Aug 26, 2015
Study Type : Review
Additional Links
Diseases : Depression, Folic Acid/Folate Deficiency, High Homocysteine
Additional Keywords : Risk Factors
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Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures.Aug 21, 2017

Pubmed Data : Int J Cancer. 2017 Aug 22. Epub 2017 Aug 22. PMID: 28833104
Article Published Date : Aug 21, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Colorectal Cancer, Folic Acid/Folate Deficiency
Additional Keywords : Cancer Stem Cells
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Maternal folic acid supplementation before and during pregnancy seems to confer protection against the risk of childhood leukaemia in the offspring.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genes Nutr. 2017 ;12:14. Epub 2017 Jun 2. PMID: 28588742
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Folic Acid
Diseases : Folic Acid/Folate Deficiency, Leukemia
Pharmacological Actions : Chemopreventive
Additional Keywords : Chemopreventive, folic acid, Folic Acid/Folate Deficiency, leukemia, Risk Reduction
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The relationship between folate, vitamin B12 and gestational diabetes mellitus.Aug 31, 2021

Pubmed Data : J Family Reprod Health. 2021 Sep ;15(3):141-149. PMID: 34721605
Article Published Date : Aug 31, 2021
Study Type : Review
Additional Links
Substances : Folate, Vitamin B-12
Diseases : Folic Acid/Folate Deficiency, Gestational Diabetes, Vitamin B 12 Deficiency
Pharmacological Actions : Antioxidants
Additional Keywords : Risk Factors
[+]

The tropical fruit durian can be considered as a very rich dietary source of natural folates.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2018 ;5:114. Epub 2018 Nov 28. PMID: 30547032
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Durian , Folate
Diseases : Folic Acid/Folate Deficiency
[+]

This review summarizes the basic pathophysiology of vitamin B12 and folate deficiency and neuropsychiatric symptoms.Mar 31, 2016

Pubmed Data : Brain Nerve. 2016 Apr ;68(4):407-20. PMID: 27056859
Article Published Date : Mar 31, 2016
Study Type : Review
Additional Links
Diseases : Cognitive Decline/Dysfunction, Dementia, Folic Acid/Folate Deficiency, Vitamin B 12 Deficiency
Additional Keywords : Risk Factors

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