Eye Disease: Age-Related

Name	AC	CK
Zinc	8	55
Lutein	14	50
Zeaxanthin	14	42
Saffron	8	37
Vitamin C	6	34
Vitamin E	6	34
Carotenoids	5	32
Omega-3 Fatty Acids	4	23
beta-Carotene	4	23
B-complex	2	20
Curcumin	10	20
Vegetables: All	2	20
Astaxanthin	5	16
Anthocyanins	4	14
Ginkgo biloba	5	14
Goji	4	13
Flavonoids	3	12
Alpha-Lipoic Acid	1	10
Antioxidant formulas	1	10
Coenzyme Q10	1	10
Copper	1	10
Egg	1	10
Fish	1	10
Folic Acid	1	10
Fruit: All	1	10
Glucosamine	1	10
Legumes	1	10
Orange	1	10
Reishi Mushroom	1	10
Vitamin B-12	1	10
Vitamin D	1	10
Turmeric	2	6
Bilberry	3	5
Blueberry	4	5
Curcuminoids	1	5
Delphinidin	1	5
Resveratrol	5	5
Melatonin	4	4
Puerarin	2	4
Celastrol	3	3
Cordyceps Militaris	2	3
Crocetin	2	3
Crocin	2	3
Gotu Kola	2	3
Sulforaphane	3	3
Astragaloside	1	2
Burdock	1	2
Chokeberry	1	2
Fucoidan	2	2
Fucoxanthin	1	2
Kaempferol	1	2
Lactobacillus paracasei	1	2
Paeoniflorin	2	2
Palmitoylethanolamide	1	2
Persimmon	1	2
Piceatannol	2	2
Prunella vulgaris	1	2
Spirulina	1	2
Thymoquinone	2	2
Yerba Mate	1	2
Amla Fruit	1	1
Berberine	1	1
DHA (Docosahexaenoic Acid)	1	1
Ferulic acid	1	1
Fisetin	1	1
Fish Oil	1	1
Genipin	1	1
Hibiscus sabdariffa	1	1
Honokiol	1	1
Luteolin	1	1
Naringenin	1	1
Nobiletin	1	1
Peony	1	1
Phloretin	1	1
Phlorotannins	1	1
Polyphenols	1	1
Quercetin	1	1
Red Wine	1	1
Red Wine Extract	1	1
Shikonin	1	1
Tanshinone IIA	1	1
Wogonin	1	1

Name	AC	CK
Angiotensin-Converting Enzyme (ACE) Inhibitor	1	10
Anticoagulants	1	10
Aspirin	1	10
Statin Drugs	1	10

Name	AC	CK
Dietary Modification: Mediterranean Diet	4	40
Biofeedback	1	10
Photobiomodulation	1	10
Blue Light Blocking	4	9
Exercise	1	2
Sunlight exposure	2	2
Chromotherapeutic Principle	1	1
Sun Gazing (Chromotherapeutic Principle)	1	1

Name	AC	CK
Blue Light (400−495 nm)	18	32
Western Diet	2	20
LED Lighting	1	2

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Pubmed Data : Tohoku J Exp Med. 2016 ;240(3):209-214. PMID: 27840374

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Pubmed Data : Adv Ther. 2019 Sep ;36(9):2493-2505. Epub 2019 Jun 25. PMID: 31243641

Article Published Date : Aug 31, 2019

Study Type : Human Study

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Substances : Reishi Mushroom

Diseases : Macular Degeneration

Pharmacological Actions : Antioxidants

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Pubmed Data : Retina. 2023 Aug 1 ;43(8):1246-1254. PMID: 37027819

Article Published Date : Jul 31, 2023

Study Type : Human Study

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Diseases : Macular Degeneration

Therapeutic Actions : Photobiomodulation

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Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration.May 31, 2017

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Pubmed Data : Acta Ophthalmol. 2017 Jun ;95(4):e270-e277. Epub 2016 Dec 18. PMID: 27989012

Article Published Date : May 31, 2017

Study Type : Human Study

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Diseases : Macular Degeneration

Therapeutic Actions : Photobiomodulation

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Photobiomodulation treatment improved clinical and anatomical outcomes in subjects with earlier stages of dry age-related macular degeneration.Aug 08, 2019

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Pubmed Data : Retina. 2019 Aug 9. Epub 2019 Aug 9. PMID: 31404033

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Pubmed Data : Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):e87-97. Epub 2011 Aug 18. PMID: 21668780

Article Published Date : Dec 31, 2011

Study Type : Human In Vitro

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Diseases : Macular Degeneration, Oxidative Stress, Retinal Degeneration: Light-Induced

Therapeutic Actions : Blue Light Blocking

Anti Therapeutic Actions : Blue Light (400−495 nm)

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Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.Aug 29, 2019

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Pubmed Data : Molecules. 2020 Apr 9 ;25(7). Epub 2020 Apr 9. PMID: 32283798

Article Published Date : Apr 08, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Burdock

Diseases : Macular Degeneration

Pharmacological Actions : Anti-Apoptotic

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Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen.Oct 27, 2023

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Pubmed Data : Free Radic Res. 2023 Oct 28:1-14. Epub 2023 Oct 28. PMID: 37897411

Article Published Date : Oct 27, 2023

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C. militaris extract has the potential to prevent or treat light-induced visual dysfunction.Apr 17, 2022

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Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.Sep 30, 2015

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Pubmed Data : Neurobiol Aging. 2015 Oct ;36(10):2869-76. Epub 2015 Jun 15. PMID: 26149919

Article Published Date : Sep 30, 2015

Study Type : Animal Study

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Diseases : Inflammation, Macular Degeneration

Therapeutic Actions : Infrared Light, Photobiomodulation

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Multi-wavelength photobiomodulation ameliorates sodium iodate-induced age-related macular degeneration.Dec 11, 2023

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Pubmed Data : Int J Mol Sci. 2023 Dec 12 ;24(24). Epub 2023 Dec 12. PMID: 38139223

Article Published Date : Dec 11, 2023

Study Type : Animal Study

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Diseases : Macular Degeneration

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina.Dec 31, 2016

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Pubmed Data : PLoS One. 2017 ;12(6):e0178627. Epub 2017 Jun 1. PMID: 28570634

PPARα-dependent effects of palmitoylethanolamide against retinal neovascularization and fibrosis.Jan 08, 2020

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Pubmed Data : Invest Ophthalmol Vis Sci. 2020 04 9 ;61(4):15. PMID: 32298438

Article Published Date : Jan 08, 2020

Study Type : Animal Study

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Substances : Palmitoylethanolamide

Diseases : Macular Degeneration, Retinal Diseases, Retinopathy: Hyperoxia-induced

Pharmacological Actions : Anti-Fibrotic

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Protective effect of Prunella vulgaris var. L extract against blue light induced damages in ARPE-19 cells and mouse retina.Dec 04, 2019

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Pubmed Data : Free Radic Biol Med. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31811921

Pubmed Data : PLoS One. 2013 ;8(2):e57828. Epub 2013 Feb 28. PMID: 23469078

Pubmed Data : Adv Food Nutr Res. 2020 ;93:293-332. Epub 2020 May 4. PMID: 32711865

Article Published Date : Dec 31, 2019

Study Type : Review

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Substances : DHA (Docosahexaenoic Acid), Lutein, Zeaxanthin

Diseases : Macular Degeneration

Pharmacological Actions : Cytoprotective

Additional Keywords : Risk Reduction

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A review, the current human clinical evidence supporting saffron supplementation as a treatment for a range of pathologies and the underlying science supporting its use.Apr 14, 2015

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Pubmed Data : Crit Rev Food Sci Nutr. 2015 Apr 15:0. Epub 2015 Apr 15. PMID: 25875654

Article Published Date : Apr 14, 2015

Study Type : Review

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Substances : Saffron

Diseases : Alzheimer's Disease, Macular Degeneration, Myocardial Ischemia

Pharmacological Actions : Cardioprotective, Neuroprotective Agents

[+]

Anthocyanin-rich extracts from Hibiscus sabdariffa inhibited angiogenesis in time and concentration-dependent manner.Jan 31, 2017

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Pubmed Data : Int J Sci Eng Res. 2017 Feb ;8(2):299-307. PMID: 28459020

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

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Substances : Anthocyanins, Hibiscus sabdariffa

Diseases : Macular Degeneration

Pharmacological Actions : Angiogenesis Inhibitors

Additional Keywords : Plant Extracts

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Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:1259093. Epub 2022 Sep 30. PMID: 36212977

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Cordyceps Militaris

Diseases : Hydrogen Peroxide Induced Toxicity, Macular Degeneration

Pharmacological Actions : Anti-Apoptotic, Antioxidants

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Crocetin might halt or delay disease progression in age-related macular degeneration.Apr 21, 2020

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Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:8847844. Epub 2021 Mar 3. PMID: 33763175

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Flavonoids

Diseases : Hydrogen Peroxide Induced Toxicity, Macular Degeneration, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation

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Ferulic acid has a therapeutic potential in the prevention and treatment of age-related macular degeneration.Oct 19, 2020

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Honokiol-loaded methoxy poly (ethylene glycol) polycaprolactone micelles for the treatment of age-related macular degeneration.Jul 01, 2021

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Pubmed Data : Assay Drug Dev Technol. 2021 Jul 2. Epub 2021 Jul 2. PMID: 34227879

Article Published Date : Jul 01, 2021

Study Type : In Vitro Study

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Substances : Honokiol

Diseases : Macular Degeneration

Pharmacological Actions : Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Luteoloside mitigates premature age-related macular degeneration.Sep 14, 2024

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Nutraceutical effects of Emblica officinalis in age-related macular degenerationFeb 20, 2019

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Pubmed Data : Arch Pharm Res. 2016 Jan ;39(1):21-32. Epub 2015 Nov 20. PMID: 26589689

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Macular Degeneration

Pharmacological Actions : Anti-Apoptotic

Additional Keywords : Plant Extracts

Anti Therapeutic Actions : Blue Light (400−495 nm)

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Preventive effects against retinal degeneration by Centella asiatica extract.Apr 15, 2021

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Pubmed Data : Molecules. 2020 Nov 27 ;25(23). Epub 2020 Nov 27. PMID: 33260857

Article Published Date : Nov 26, 2020

Study Type : In Vitro Study

Additional Links

Substances : Red Wine Extract

Diseases : Macular Degeneration

Pharmacological Actions : Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Plant Extracts

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Restoring the anti-oxidative capabilities of the retina by increasing intake of lutein and zeaxanthin reduces the likelihood of AMD and cataract.Apr 30, 2011

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Pubmed Data : Med Hypotheses. 2011 May ;76(5):741-4. Epub 2011 Feb 26. PMID: 21354712

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Pubmed Data : Phytomedicine. 2023 Feb ;110:154606. Epub 2022 Dec 15. PMID: 36584606

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Pubmed Data : Bioengineered. 2021 12 ;12(1):7079-7089. PMID: 34982643

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Pubmed Data : Mol Nutr Food Res. 2019 08 ;63(15):e1801049. Epub 2019 Jun 27. PMID: 31148351

Article Published Date : Dec 31, 2018

Study Type : Review

Additional Links

Substances : Zinc

Diseases : Aging, Macular Degeneration, Zinc Deficiency

Pharmacological Actions : Anti-Inflammatory Agents

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Melatonin demonstrates a significant protective effect on the retina delaying macular degeneration.Dec 01, 2005

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Pubmed Data : Ann N Y Acad Sci. 2005 Dec;1057:384-92. PMID: 16399908

Article Published Date : Dec 01, 2005

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Substances : Melatonin

Diseases : Macular Degeneration

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The Following are Sub-Topics of Eye Disease: Age-Related

View the Evidence: 175 Abstracts with Eye Disease: Age-Related Research

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A combination of acetyl-l-carnitine, n-3 fatty acids and coenzyme q10 improves visual functions in early age-related macular degeneraiton.May 01, 2005

A combination of nutrients improves age-related macular degeneration. Feb 01, 2008

A diet low in trans-unsaturated fat and rich in omega-3 fatty acids and olive oil may reduce the risk of age-related macular degeneration.May 01, 2009

Adherence to the Med Diet could have a positive effect on delaying AMD progression in advanced stages.Dec 31, 2022

Alpha-lipoic acid treatment improves vision-related quality of life in patients with dry age-related macular degeneration.Dec 31, 2015

Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration.Dec 01, 2005

Consumption of a western pattern diet may be a risk factor for development of late age-related macular degeneration.Dec 05, 2019

Curcuma-based nutritional supplements and risk of age-related macular degeneration.Oct 23, 2024

Curcumin has therapeutic value in the treatment of recurrent anterior uveitis of different etiologies. Jan 01, 2010

Dietary intake of B vitamins may affect the occurrence of age-related lens opacities. Jun 30, 2015

Effects of Macuprev® supplementation in age-related macular degeneration.Aug 31, 2019

Fast food fed mice showed ocular pathology relevant to various stages of age-related macular degeneration including basal laminar deposits.Nov 16, 2019

Ginkgo biloba shows promise in the treatment of senile macular degeneration.Sep 25, 1986

Glucosamine treatment can decrease the risk of developing dry type age-related macular degeneration.Dec 31, 2020

Goji berry supplementation may be of therapeutic value in macular degeneration. Feb 01, 2011

Greater blueberry intake significantly reduced total age-related macular degeneration.Mar 31, 2024

High adherence to a Mediterranean diet and regular physical activity seem to be protective factors for age-related macular degeneration.Mar 12, 2018

High mediSCORE appears to confer protection against the development of age-related macular degeneration in a Mediterranean population.Sep 13, 2018

Higher adherence to the Mediterranean diet was associated with a 41% reduced risk of incident advanced AMD.Aug 12, 2018

Higher intake of bioavailable lutein and zeaxanthin is associated with a long-term reduced risk of advanced age-related macular degeneration.Oct 07, 2015

Increasing Mediterranean Diet score was associated with reduced odds of neovascular age-related macular degeneration.Nov 04, 2016

LIGHTSITE III provides a prospective, randomized, controlled trial showing improved clinical and anatomical outcomes in intermediate dry AMD following PBM therapy.Feb 29, 2024

Lutein supplementation improves visual function in those with age-related macular degeneration.Apr 01, 2004

Moderate consumption of eggs significantly reduces the risk of developing incident late-stage age-related macular degeneration.Mar 15, 2019

Multiwavelength PBM and support treatment with Valeda as a novel therapy with a unique mechanism of action as a potential treatment for non-exudative AMD.Mar 31, 2023

Multiwavelength photobiomodulation in atrophic age-related macular degeneration.Nov 14, 2024

PBM may provide a valid therapeutic option for large soft drusen and drusenoid pigment epithelial detachment age-related macular degeneration.Jul 31, 2023

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration.May 31, 2017

Photobiomodulation treatment improved clinical and anatomical outcomes in subjects with earlier stages of dry age-related macular degeneration.Aug 08, 2019

Rehabilitation with biofeedback training in age-related macular degeneration for improving distance vision.May 31, 2019

Saffron supplementation improves retinal flicker sensitivity in early AMD.Nov 30, 2010

Saffron therapy for the ongoing treatment of age-related macular degeneration.Mar 12, 2024

Serum 25(OH)D3 levels may have an impact on the neovascular type of age-related macular degeneration.Dec 31, 2019

Short-term results of photobiomodulation using light-emitting diode light of 670 nm in eyes with age-related macular degeneration.Aug 31, 2021

Supplementation with folic acid, pyridoxine, and cyanocobalamin may reduce the risk of age-related macular degeneration.Feb 23, 2009

Supplementation with vitamin C, E, beta-carontene and zinc demonstrates a statistically significant odds reduction for the development of advanced age-related macular degeneration and vision loss. Oct 01, 2001

The carotenoids meso-zeaxanthin, lutein and zeaxanthin augment macular pigmentation. Apr 01, 2010

There is an association between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration.Jun 01, 2000

These findings suggest a protective association between dietary intake of flavonoids and the likelihood of having age-related macular degeneration.Jul 05, 2018

Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) increase the risk of age-related macular degeneration.Jan 01, 2008

Zinc and copper deficiency contributes to age-related macular degeneration. Feb 01, 2009

Zinc supplementation improves cystine levels in patients with age-related macular degeneration. Feb 01, 2007

Zinc supplementation is associated with improved macular function in persons with dry age-related macular degeneration. Jul 01, 2008

Filtering blue light reduces light-induced oxidative stress, senescence and accumulation of extracellular matrix proteins in retinal cells.Dec 31, 2011

Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.Aug 29, 2019

Turmeric extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis retinal cells.Feb 28, 2017

Glabridin attenuates the retinal degeneration.Dec 31, 2019

Protective effect of Ribes nigrum extract against blue light-induced retinal degeneration.Apr 24, 2022

Puerarin suppresses hypoxia-induced vascular endothelial growth factor upregulation in human retinal pigmented epithelial cells.Apr 30, 2022

Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline.Mar 31, 2017

Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.Sep 12, 2023

Arctium lappa could be considered a potentially valuable medicinal food for dry age-related macular degeneration.Apr 08, 2020

Astaxanthin protects human ARPE-19 retinal pigment epithelium cells from blue light-induced phototoxicity by scavenging singlet oxygen.Oct 27, 2023

Astaxanthin protects retinal cells against oxidative damage.May 20, 2010

Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.Dec 31, 2020

Bilberry supplementation may be effective in preventing macular degeneration and cataract. Jan 01, 2005

Blue light induced A2E oxidation in rat eyes.Oct 31, 2010

Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture modelNov 01, 2017

C. militaris extract has the potential to prevent or treat light-induced visual dysfunction.Apr 17, 2022

Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina.May 31, 2020

Crocetin and crocin are potential natural biomedicines for the management of diseases associated with abnormal blood vessel growth.Dec 31, 2020

Curcumin protects retinal cells from light-and oxidant stress-induced cell death, indicating it may have value in age-related macular degeneration (AMD).Mar 01, 2009

Cytoprotective potential of fucoxanthin in oxidative stress-induced age-related macular degeneration.Feb 17, 2021

Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium.Dec 31, 2017

Effects of slit lamp-delivered retinal laser photobiomodulation in a rat model of choroidal neovascularization.Jun 30, 2024

Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells.Jun 30, 2023

Ilex paraguariensis extracts prevent oxidative damage in a mouse model of age-related macular degeneration.Apr 30, 2022

Kaempferol protects against retinal photoreceptor degeneration in a mouse model of light-induced retinal injury.Dec 13, 2022

Melatonin inhibits VEGF-induced endothelial progenitor cell angiogenesis in neovascular age-related macular degeneration.Mar 02, 2023

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.Sep 30, 2015

Multi-wavelength photobiomodulation ameliorates sodium iodate-induced age-related macular degeneration.Dec 11, 2023

Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina.Dec 31, 2016

Eye Disease: Age-Related

View the Evidence:
175 Abstracts with Eye Disease: Age-Related Research