Excitotoxicity

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31 Substances Researched for Excitotoxicity
NameACCKFocus
Curcumin66Locked
Resveratrol35Locked
DHEA (Dehydroepiandrosterone)23Locked
Quercetin23Locked
Apigenin12Locked
Catechin 22Locked
Ginger12Locked
Grape Seed Extract12Locked
Kaempferol12Locked
Nettle12Locked
Saffron12Locked
Safranal12Locked
Schisandra12Locked
Selenium12Locked
St. Johns Wort12Locked
Stilbenes12Locked
Theanine12Locked
Ziziphus spinosa22Locked
Blueberry11Locked
Flavonoids11Locked
Ginkgo biloba11Locked
Ginseng11Locked
Goji11Locked
Green Tea11Locked
Insulin-like Growth Factor (IGF-1)11Locked
Luteolin11Locked
Polyphenols11Locked
Sulforaphane11Locked
Tannic Acid11Locked
Vitamin B-1211Locked
Vitamin B12: methylcobalamin 11Locked
7 Problem Substances Researched for Excitotoxicity
NameACCKFocus
Aspartame313Locked
Monosodium Glutamate (MSG)212Locked
L-glutamic Acid23Locked
Thimerosal 23Locked
Mercury12Locked
Brilliant Blue FCF11Locked
Quinoline Yellow11Locked
3 Therapeutic Actions Researched for Excitotoxicity
NameACCKFocus
Acupuncture12Locked
Exercise: Swimming12Locked
Dietary Modification: Low Carbohydrate/Ketogenic11Locked
1 Problematic Actions Researched for Excitotoxicity
NameACCKFocus
Vaccination: All11Locked

View the Evidence:
36 Abstracts with Excitotoxicity Research

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The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option. Jun 01, 2001

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity , Fibromyalgia
Problem Substances : Aspartame, Monosodium Glutamate (MSG)
[+]

Acupuncture attenuates glutamate level in global ischemia model of rat.Feb 01, 2010

Pubmed Data : Neurol Res. 2010 Feb;32 Suppl 1:79-83. PMID: 20034451
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Cerebral Ischemia, Excitotoxicity
Therapeutic Actions : Acupuncture
[+]

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. Aug 31, 2012

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation , Excitotoxicity , Lipid Peroxidation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]

Ginger root extract has a neuroprotective effect against monosodium glutamate-induced toxicity in male rats. Feb 01, 2009

Pubmed Data : Pak J Biol Sci. 2009 Feb 1;12(3):201-12. PMID: 19579948
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Glutamate induces mitochondrial dynamic imbalance and autophagy activation that can be prevented with selenium.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39382. Epub 2012 Jun 19. PMID: 22724008
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : L-glutamic Acid, Monosodium Glutamate (MSG)
Adverse Pharmacological Actions : Excitotoxic
[+]

Grapeseed exhibits neuroprotective properties against excitotoxicity associated neuronal injury. Jan 01, 2011

Pubmed Data : PLoS One. 2011;6(1):e14575. Epub 2011 Jan 24. PMID: 21283677
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

L-theanine protects against glutamate-induced excitotoxicity in a mouse model.Jul 14, 2010

Pubmed Data : Neuroscience. 2010 Jul 14;168(3):778-86. Epub 2010 Apr 21. PMID: 20416364
Article Published Date : Jul 14, 2010
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Alzheimer's Disease, Excitotoxicity
[+]

Low-intensity swimming maintains normoglycemia, insulin tissue sensitivity, and normal lipid profile in mice programmed to develop metabolic syndrome.Jan 01, 2007

Pubmed Data : Biomed Sci Instrum. 2007;43:272-7. PMID: 21539446
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Excitotoxicity , Hyperlipidemia, Insulin Resistance, Metabolic Syndrome X, MSG Toxicity
Therapeutic Actions : Exercise: Swimming
[+]

Neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEA may protect against mercury-induced neurotoxicity. Oct 21, 2011

Pubmed Data : Neurochem Res. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22015977
Article Published Date : Oct 21, 2011
Study Type : Animal Study
Additional Links
Substances : DHEA (Dehydroepiandrosterone)
Diseases : Excitotoxicity , Mercury Poisoning, Vaccine-induced Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Mercury, Thimerosal
Adverse Pharmacological Actions : Neurotoxic
[+]

Nettle supplementation attenuates excitotoxin-induced brain lesions and memory loss in rats. Dec 12, 2008

Pubmed Data : J Nutr Biochem. 2008 Dec 12. PMID: 19071007
Article Published Date : Dec 12, 2008
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Excitotoxicity , Memory Loss
[+]

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity. May 01, 2008

Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin, Kaempferol, Quercetin, St. Johns Wort
Diseases : Excitotoxicity
Pharmacological Actions : Excitatory Amino Acid Agonists, Neuroprotective Agents
[+]

Resveratrol has neuroprotective effect on ischemic injury. Feb 01, 2010

Pubmed Data : Neurochem Int. 2010 Feb;56(3):495-500. Epub 2009 Dec 21. PMID: 20026214
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Brain Ischemia, Excitotoxicity , Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Resveratrol may protect against gluatmate associated neurotoxicity. Mar 01, 2010

Pubmed Data : J Neurochem. 2010 Mar;112(6):1477-87. Epub 2009 Dec 28. PMID: 20050970
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Alzheimer's Disease, Excitotoxicity
Pharmacological Actions : Enzyme Inhibitors, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

Safranal, a constituent of Saffron, reduces kainic Acid treatment-induced glutamate and aspartate concentrations in the rat hippocampus. Oct 01, 2008

Pubmed Data : Planta Med. 2008 Oct;74(12):1441-5. Epub 2008 Sep 24. PMID: 18816431
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Saffron, Safranal
Diseases : Excitotoxicity
Pharmacological Actions : Excitatory Amino Acid Agonists
[+]

Schisandra may protect against glutamate-induced toxicity. May 01, 2004

Pubmed Data : J Neurosci Res. 2004 May 1;76(3):397-405. PMID: 15079869
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Schisandra
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.Mar 01, 2006

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity, Excitotoxicity , Neurodevelopmental Disorders
Additional Keywords : Drug-Plant-Vitamin Synergies
Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow
Adverse Pharmacological Actions : Neurotoxic
[+]

Autism spectrum disorders are associated with immunoexcitotoxicity. Jan 01, 2009

Pubmed Data : Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7. PMID: 19161050
Article Published Date : Jan 01, 2009
Study Type : Commentary
Additional Links
Substances : DHEA (Dehydroepiandrosterone)
Diseases : Autism Spectrum Disorders, Excitotoxicity , Inflammation, Mercury Poisoning
Additional Keywords : Diseases that are Linked
[+]

Autism spectrum disorders are associated with vaccination, heavy metal toxicity and excitotoxicity. Nov 01, 2008

Pubmed Data : Altern Ther Health Med. 2008 Nov-Dec;14(6):46-53. PMID: 19043938
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Autism Spectrum Disorders, Excitotoxicity , Vaccine-induced Toxicity
Anti Therapeutic Actions : Vaccination: All
[+]

Blueberry extract may ameliorate glutamate-induced excitotoxicity.Aug 04, 2013

Pubmed Data : J Agric Food Chem. 2013 Aug 5. Epub 2013 Aug 5. PMID: 23875756
Article Published Date : Aug 04, 2013
Study Type : In Vitro Study
Additional Links
Substances : Blueberry
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Curcumin and tannic acid protect against glutamate-induced excitotoxicity. Aug 01, 2006

Pubmed Data : J Pharmacol Exp Ther. 2006 Aug;318(2):476-83. Epub 2006 Apr 27. PMID: 17118359
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Curcumin, Flavonoids, Polyphenols, Tannic Acid
Diseases : Excitotoxicity
Pharmacological Actions : Apoptotic, Neuroprotective Agents
[+]

Curcumin inhibits glutamate-induced excitoxicity in vitro. Apr 01, 2007

Pubmed Data : Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042
Article Published Date : Apr 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Excitotoxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Curcumin protects against glutamate excitotoxicity. May 19, 2008

Pubmed Data : Brain Res. 2008 May 19;1210:84-91. Epub 2008 Apr 16. PMID: 18420184
Article Published Date : May 19, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Excitotoxicity
Pharmacological Actions : Antidepressive Agents, Apoptotic, Enzyme Inhibitors, Neuroprotective Agents
[+]

Curcumin treatment protects rat retinal neurons against excitotoxicity. Dec 01, 2005

Pubmed Data : Exp Brain Res. 2005 Dec;167(4):641-8. Epub 2005 Aug 3. PMID: 16078027
Article Published Date : Dec 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Excitotoxicity
Pharmacological Actions : Apoptotic
[+]

Enhanced neuroprotective effects of Panax ginseng G115 and Ginkgo biloba GK501 combinations in vitro models of excitotoxicity.Nov 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Nov 22 ;20(23). Epub 2019 Nov 22. PMID: 31771121
Article Published Date : Nov 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Ginseng
Diseases : Excitotoxicity , Neurological Conditions
Pharmacological Actions : Neuroprotective Agents
[+]

Excitotoxicity is an important factor in autism. Mar 01, 2009

Pubmed Data : Altern Ther Health Med. 2009 Mar-Apr;15(2):56-60. PMID: 19284184
Article Published Date : Mar 01, 2009
Study Type : Commentary
Additional Links
Diseases : Autism, Excitotoxicity
Additional Keywords : Diseases that are Linked
[+]

IGF-I prevents glutamate-induced motor neuron programmed cell death.Jan 15, 2009

Pubmed Data : Food Chem Toxicol. 2009 Jan 15. PMID: 15193297
Article Published Date : Jan 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Insulin-like Growth Factor (IGF-1)
Diseases : Amyotrophic Lateral Sclerosis, Excitotoxicity
Pharmacological Actions : Apoptotic, Neuroprotective Agents
[+]

Methylcobalamin protects against glutamate-induced neurotoxicity in retinal cell culture.Apr 01, 1997

Pubmed Data : Invest Ophthalmol Vis Sci. 1997 Apr;38(5):848-54. PMID: 9112980
Article Published Date : Apr 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Vitamin B12: methylcobalamin , Vitamin B-12
Diseases : Excitotoxicity
Pharmacological Actions : Apoptotic, Neuroprotective Agents
[+]

Polysaccharides from wolfberry (goji) antagonizes glutamate excitotoxicity in rat cortical neurons.Dec 01, 1999

Pubmed Data : CNS Spectr. 1999 Dec;4(12):34-47. PMID: 19499323
Article Published Date : Dec 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Goji
Diseases : Alzheimer's Disease, Excitotoxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Resveratrol protects against glutamate-induced neurotoxicity in primary cultured rat cortical cells.Nov 17, 2010

Pubmed Data : Hum Exp Toxicol. 2010 Nov 17. Epub 2010 Nov 17. PMID: 21084527
Article Published Date : Nov 17, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Brain Damage, Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane works synergistically with the drug riluzole to protects against glutamate-mediated motor neuron excitotoxicity.Jan 01, 2010

Pubmed Data : Biol Pharm Bull. 2010;33(9):1477-83. PMID: 20823560
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Drug: Riluzole, Drug-Plant-Vitamin Synergies
[+]

The ketogenic diet may alter brain handling of glutamate, an excitotoxin, through enhanced conversion to glutamine and then to GABA. Nov 01, 2008

Pubmed Data : Epilepsia. 2008 Nov;49 Suppl 8:73-5. PMID: 19049594
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Excitotoxicity
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues Jan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110
Article Published Date : Jan 01, 2012
Study Type : Review
Additional Links
Substances : Curcumin, Green Tea, Luteolin, Quercetin
Diseases : Brain: Microglial Activation, Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : CENTRAL NERVOUS SYSTEM
[+]

The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons. Jan 01, 2010

Pubmed Data : FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Curcumin
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
[+]

The results of this study suggest that ethylmercury is a mitochondrial toxin in human astrocytes. Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol. 2012 ;2012:373678. Epub 2012 Jun 28. PMID: 22811707
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage, Excitotoxicity , Oxidative Stress
Problem Substances : Thimerosal
Adverse Pharmacological Actions : Apoptotic, Excitotoxic
[+]

Ziziphus spinosa protects against excitotoxin induced neuronal damage - Article 1. Nov 01, 2004

Pubmed Data : J Ethnopharmacol. 2004 Nov;95(1):39-45. PMID: 15374605
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Ziziphus spinosa
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents
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Ziziphus spinosa protects against excitotoxin induced neuronal damage - Article 2. Aug 01, 2003

Pubmed Data : Planta Med. 2003 Aug;69(8):692-5. PMID: 14531016
Article Published Date : Aug 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Ziziphus spinosa
Diseases : Excitotoxicity
Pharmacological Actions : Neuroprotective Agents

Copyright: designua / 123RF Stock Photo

Excitotoxicity Related Articles

MSG Hidden in Variety of Foods and Contributing To Illness
Written by Grocery Geek
Despite common perception, the toxic food additive MSG is everywhere - not just in Chinese food! This taste enhancer is actually hidden under dozens of ingredient names in all sorts of processed foods, restaurant foods, beverages, chewing gums, vitamins and supplements. It is added to foods in higher dosages than ever before, and more and more people are experiencing symptoms.
MSG: Delicious Seasoning Or Drug And Poison?
Written by Sayer Ji, Founder
Monosodium glutamate (MSG) is a commonly used "flavor enhancer," and so powerfully so that (arguably) you could spray it on roadkill and it would taste good. This omnipresent ingredient in modern mass market food takes advantage of our biologically hard-wired taste receptors, and makes it very hard to stop eating the foods "seasoned" with this ingredient.
Is Roundup Weedkiller A Brain-Damaging Neurotoxin?
Written by Sayer Ji, Founder
A new study reveals a hitherto unknown mechanism behind how the world's most popular GMO herbicide harms the brain.

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