Cancers: Multi-Drug Resistant

Name	AC	CK
Curcumin	31	31
Silibinin	3	15
Quercetin	7	7
Capsaicin	2	6
Achiote	1	5
EGCG (Epigallocatechin gallate)	5	5
Flavonoids	5	5
NAC (N-acetyl-L-cysteine)	1	5
Nobiletin	4	5
Paprika	4	5
Wogonin	1	5
Beta-Elemene	3	4
Carotenoids	3	4
Ginsenosides	2	3
Lycopene	2	3
Resveratrol	3	3
AHCC	1	2
Antrodia camphorata	1	2
Biochanin A	2	2
Bufalin	2	2
Cholesterol	1	2
Chrysin	2	2
Fucoxanthin	2	2
Genistein	2	2
Ginkgo biloba	1	2
Indole-3-Carbinol	1	2
Licorice	2	2
Lotus	2	2
Naringenin	2	2
Polyphenols	2	2
Reishi Mushroom	2	2
Rutin	2	2
Sulforaphane	1	2
Vitamin C	2	2
Zeaxanthin	1	2
beta-Carotene	2	2
Acerola	1	1
Adlay	1	1
Agosterol A	1	1
Antheraxanthin	1	1
Apigenin	1	1
Apple: Golden Delicious	1	1
Arctigenin	1	1
Artesunate	1	1
Asiatic Acid	1	1
Asparagus	1	1
Baicalein	1	1
Barberry	1	1
Bay leaf	1	1
Bee Propolis	1	1
Berberine	1	1
Beta-Caryophyllene	1	1
Betulinic acid	1	1
Birch	1	1
Bisdemethoxycurcumin	1	1
Bryostatin 1	1	1
Burdock	1	1
Caffeic Acid	1	1
Cannabinoids	1	1
Canthaxanthin	1	1
Capsorubin	1	1
Cashew	1	1
Catechols	1	1
Celastrol	1	1
Chokeberry	1	1
Citrus naringin	1	1
Clausena excavata	1	1
Cleistocalyx Operculatus	1	1
Coconut	1	1
Coconut Husk/Fiber	1	1
Crocetin	1	1
Crocin	1	1
Cucurbitacin B	1	1
Cucurbitacin E	1	1
DHA (Docosahexaenoic Acid)	1	1
Daidzein	1	1
EPA (Eicosapentaenoic Acid)	1	1
Ecteinascidin 743	1	1
Ellagic Acid	1	1
Euphorbia	1	1
Farnesiferol A	1	1
Fermented Foods and Beverages	1	1
Ferula Persica	1	1
Ferula Szowitsiana	1	1
Galbanic Acid	1	1
Guggul	1	1
Hedyotis corymbosa	1	1
Hedyotiscone A	1	1
Honey	1	1
Honokiol	1	1
Isoflavones	1	1
Japanese Raisin Tree	1	1
Kaempferol	1	1
Kefir	1	1
Lignans	1	1
Ligustrazine	1	1
Lobelia	1	1
Lutein	1	1
Maca	1	1
Mangosteen	1	1
Mulberry	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Omega-3 Fatty Acids	1	1
Orange	1	1
Paeoniflorin	1	1
Persimmon	1	1
Phloretin	1	1
Psychedelics:All	1	1
Pterostilbene	1	1
Puerarin	1	1
Rosemaric Acid	1	1
Rosemary	1	1
Sakuranetin	1	1
Schisandra	1	1
Sipholane triterpenoids	1	1
Stilbenes	1	1
Tangeretin	1	1
Tannic Acid	1	1
Tetrahydrocurcumin	1	1
Theaflavins	1	1
Thyme	1	1
Thymoquinone	1	1
Tripterygium wilfordii	1	1
Triptolide	1	1
Welwitindolinones	1	1
Xanthones	1	1

Name	AC	CK	Focus
Adrenaline	1	1
Carboplatin	1	1

Name	AC	CK
Chemotherapy	2	2
Radiotherapy	1	1
Stress	1	1
Surgical Procedures	1	1

[+]

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy.Sep 23, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ginseng Res. 2020 Mar ;44(2):247-257. Epub 2018 Nov 8. PMID: 32148406

Article Published Date : Feb 29, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Docetaxel

[+]

Indole-3 carbinol reverses multidrug resistant melanoma in vivo. Feb 01, 1996

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Pubmed Data : Biochem Biophys Res Commun. 2019 Sep 26. Epub 2019 Sep 26. PMID: 31564411

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Rep. 2014 Feb ;31(2):858-66. Epub 2013 Nov 27. PMID: 24284783

Article Published Date : Jan 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts

[+]

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells.Dec 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytomedicine. 2019 Feb 15 ;54:1-8. Epub 2018 Sep 17. PMID: 30668359

Article Published Date : Feb 14, 2019

Study Type : In Vitro Study

Additional Links

Substances : Celastrol

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Oral Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation

[+]

Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.Oct 31, 2009

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : In Vivo. 2009 Nov-Dec;23(6):959-67. PMID: 20023240

Article Published Date : Oct 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Nordihydroguaiaretic acid (NDGA)

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

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Chokeberry and mulberry leaves were active against the sensitive leukaemic cell line HL60 and retained the in vitro activity against multidrug resistant sublines (HL60/VINC and HL60/DOX).Apr 30, 2008

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Pubmed Data : Phytother Res. 2008 May ;22(5):689-94. PMID: 18350513

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Pubmed Data : Acta Biomater. 2017 Aug 28. Epub 2017 Aug 28. PMID: 28842335

Article Published Date : Aug 27, 2017

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant

Pharmacological Actions : Anti-metastatic, Multidrug Resistance Gene Modulators

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Coconut fiber extract has anti-cancer activity, including against a multi-drug resistant leukemia cell line.Oct 01, 2007

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Pubmed Data : Braz J Med Biol Res. 2007 Oct;40(10):1339-43. Epub 2007 Jul 31. PMID: 17713650

Curcumin down-regulates multidrug-resistance. Jan 18, 2008

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Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):111-8. Epub 2007 Nov 19. PMID: 18006147

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Pubmed Data : Zhong Yao Cai. 2001 Sep;24(9):655-7. PMID: 11799777

Article Published Date : Sep 01, 2001

Study Type : In Vitro Study

Additional Links

Substances : Berberine, Curcumin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Chemosensitizer

Additional Keywords : Drug Synergy

[+]

Curcumin induces programmed cell death in human multidrug-resistant cells.Nov 01, 2002

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Pubmed Data : Ann N Y Acad Sci. 2002 Nov;973:250-4. PMID: 12485871

Article Published Date : Nov 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Multi-Drug Resistant

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

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Pubmed Data : Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):254-8. PMID: 16875558

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Pubmed Data : Ann Hematol. 2010 Apr;89(4):399-404. Epub 2009 Sep 15. PMID: 19756599

Article Published Date : Apr 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Multiple Myeloma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemosensitizer

[+]

Curcumin reverse multidrug resistance of osteosarcoma cells.Jan 01, 2011

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Pubmed Data : Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 21434326

Pubmed Data : Biomed Pharmacother. 2005 Apr;59(3):64-9. PMID: 15795098

Article Published Date : Apr 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Cancers: Multi-Drug Resistant

[+]

EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells.Sep 30, 2017

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Pubmed Data : Pathol Res Pract. 2017 Oct ;213(10):1242-1250. Epub 2017 Sep 12. PMID: 28964574

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Pubmed Data : Eur J Pharmacol. 2019 Jun 5 ;852:231-243. Epub 2019 Apr 5. PMID: 30959046

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Pubmed Data : Xenobiotica. 2012 Feb 21. Epub 2012 Feb 21. PMID: 22352391

Article Published Date : Feb 21, 2012

Study Type : In Vitro Study

Additional Links

Substances : Hedyotis corymbosa, Hedyotiscone A

Diseases : Cancers: Multi-Drug Resistant, Hepatoma: Multidrug Resistant

Pharmacological Actions : Chemosensitizer

[+]

High dose of vitamin C in combination with 5-FU chemotherapy enhances the chemoresponsiveness of cancer cells.Apr 30, 2003

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Pubmed Data : In Vivo. 2003 May-Jun;17(3):289-92. PMID: 12929582

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Pubmed Data : Front Pharmacol. 2017 ;8:238. Epub 2017 May 5. PMID: 28529482

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Pubmed Data : Sci Rep. 2015 ;5:18789. Epub 2015 Dec 22. PMID: 26689156

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: All, Cancers: Multi-Drug Resistant, Colorectal Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Multidrug Resistance Gene Modulators

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Doxorubicin

[+]

Omega-3 fatty acids reduce chemoresistance in multidrug resistant colon cancer cell lines. Nov 12, 2013

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Article Published Date : Nov 12, 2013

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid), Omega-3 Fatty Acids

Diseases : Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Chemosensitizer

[+]

Paeoniflorin modulates multidrug resistance of a human gastric cancer cell line via the inhibition of NF-κB activation.Jan 31, 2012

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Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):888-97. PMID: 15752739

Article Published Date : Apr 15, 2005

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Antineoplastic Agents

Anti Therapeutic Actions : Stress

Problem Substances : Adrenaline

Adverse Pharmacological Actions : Chemoresistance upregulation, Multidrug resistance 1 (p-glycoprotein 1) upregulation

[+]

Pterostilbene and 3'-hydroxypterostilbene are effective in multi-drug resistant leukemia cells.Sep 01, 2000

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Pubmed Data : Indian J Med Res. 2000 Sep;112:73-7. PMID: 15878840

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Pubmed Data : Zhonghua Zhong Liu Za Zhi. 2005 Jun;27(6):326-9. PMID: 16117892

Article Published Date : Jun 01, 2005

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Pubmed Data : J Nat Prod. 2012 Nov 26 ;75(11):1896-902. Epub 2012 Nov 8. PMID: 23137376

Article Published Date : Nov 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Naringenin , Nobiletin , Tangeretin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Taxifolin resensitizes multidrug resistance cancer cells.Nov 21, 2018

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Pubmed Data : Chin J Cancer. 2015 Sep 14 ;34(11):488-95. Epub 2015 Sep 14. PMID: 26370907

Article Published Date : Sep 13, 2015

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Cancers: All, Cancers: Drug Resistant, Cancers: Multi-Drug Resistant

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic

[+]

These data provide a rationale for the use of DIM as a promising radio-sensitizer to MDR cancer cells.Jun 15, 2016

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Pubmed Data : Pharm Biol. 2016 Jun 16:1-5. Epub 2016 Jun 16. PMID: 27307186

Article Published Date : Jun 15, 2016

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant

Pharmacological Actions : Radiosensitizer

[+]

These results suggest bufalin can reverse drug resistance in K562/A02 cells.Apr 06, 2019

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Pubmed Data : Bioorg Med Chem Lett. 2017 Feb 1 ;27(3):447-449. Epub 2016 Dec 20. PMID: 28065566

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Xanthones

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant, Liver Cancer

Pharmacological Actions : Cytotoxic

Additional Keywords : Breast Cancer, Cancers: Multi-Drug Resistant, Cytotoxic, liver cancer, Superiority of Natural Substances versus Drugs, Xanthones

[+]

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma.Jan 27, 2015

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Pubmed Data : World J Gastroenterol. 2015 Jan 28 ;21(4):1148-57. PMID: 25632187

Article Published Date : Jan 27, 2015

Study Type : In Vitro Study

Additional Links

Substances : Horse Chestnut

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Cholangiocarcinoma

Pharmacological Actions : Antiproliferative , Chemosensitizer

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View the Evidence: 154 Abstracts with Cancers: Multi-Drug Resistant Research

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Epstein-Barr virus infection may confer multidrug resistance to breast cancer cells. Sep 20, 1997

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression.Dec 31, 2017

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy.Sep 23, 2022

A variety of carotenoids induce reduce resistance to chemotherapy in multidrug resistant lymphoma and human breast cancer cell lines. Mar 01, 2004

AHCC improves treatment outcome and reduces side effects in anticancer drug treated mice. Jan 01, 2009

Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma. Aug 13, 2008

Berberine reverses breast cancer multidrug resistance.Apr 26, 2021

Cholesterol derived from LDL acts as a chemosensitizer in multidrug resistant lymphoblastic leukemia cells.Oct 01, 2007

Ginkgo biloba exocarp extracts could down regulate drug resistance related gene expression.Sep 30, 2016

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter.Feb 29, 2020

Indole-3 carbinol reverses multidrug resistant melanoma in vivo. Feb 01, 1996

Nobiletin reversed paclitaxel resistance in multi-drug resistance tumors.Nov 25, 2019

Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.Jun 01, 2004

β-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway.Feb 09, 2020

"Cancer Stem Cells and Novel Targets for Antitumor Strategies."Feb 28, 2012

"Evolutionary malignant resistance of cells to damaging factors as common biological defence mechanism in neoplastic development."Sep 01, 2000

Acerola demonstrates cytotoxic potential against tumor cell lines.Mar 01, 2004

Adlay ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin.Jul 31, 2018

Algerian propolis reverses multidrug resistance in resistant human lung adenocarcinoma cells.Dec 31, 2017

Alpha-mangostin has great potential to be further developed into a promising modulator of ABCG2 for reversing multidrug resistance.Jun 21, 2017

Ampelopsin, a compound found within the Japanese Raisin Tree, reverses multidrug resistance in cancer cells. Mar 01, 2009

Apigenin may have a therapeutic role in the treatment of multi-drug resistant cancers. Sep 10, 2009

Application of curcumin and its derivatives in tumor multidrug resistance.Sep 30, 2020

Arctigenin enhances the sensitivity of cisplatin resistant colorectal cancer cell by activating autophagy.Sep 25, 2019

Artesunate and bufalin may have value in treating multi-drug resistant human leukemia cells. Mar 01, 2002

Asiatic acid sensitizes multidrug-resistant human lung adenocarcinoma A549/DDP cells.Dec 31, 2017

Baicalein might provide a potential therapeutic strategy for overcoming multidrug resistance.Nov 19, 2016

Beta-carotene may be considered as a chemo-sensitizer and regarded as an adjuvant therapy in multidrug resistance cancer treatment.Mar 14, 2016

Beta-caryophyllene could be used as chemosensitizing agents for doxorubicin chemotherapy and to re-sensitize cancer-resistant cells.Dec 31, 2016

Beta-elemene potentiates the cytotoxic effects of various antineoplastic drugs in cell lines overexpressing the ABCB1 transporter.Jan 31, 2014

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells.Dec 31, 2017

Bisdemethoxycurcumin is able to sensitize cisplatin-resistant NSCLC cells to chemotherapeutic agents.Jul 03, 2017

Cannabinoids reduce multidrug resistance in a human T lymphoblastoid leukaemia cell line.Apr 14, 2006

Carotenoids extracted from red paprika, Valencia orange and Golden delicious apple exhibit anti-H. pylori and anti-multidrug resistance activity.Aug 01, 2005

Cashew contains an anticancer catechol with activity against multidrug resistant cancer cell lines.Apr 21, 2009

Celastrol induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway.Feb 14, 2019

Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.Oct 31, 2009

Chokeberry and mulberry leaves were active against the sensitive leukaemic cell line HL60 and retained the in vitro activity against multidrug resistant sublines (HL60/VINC and HL60/DOX).Apr 30, 2008

Clausena excavata exhibits anti-Hepatitis B virus activity and cytotoxicity against multi-drug resistant cancer cells. Aug 15, 2009

Cleistocalyx operculatus contains a compound which reverses multi-drug resistance in human liver cancer cells.May 17, 2011

Co-administration of natural compounds and chemotherapeutic drugs could be an effective strategy to overcome tumor multidrug resistance.Mar 19, 2020

Co-delivery of paclitaxel and honokiol suppressed multidrug resistance and metastasis of breast cancer.Aug 27, 2017

Coconut fiber extract has anti-cancer activity, including against a multi-drug resistant leukemia cell line.Oct 01, 2007

Combination therapy with EGCG and doxorubicin in the micelle core could protect the cardiomyocytes from DOX-mediated cardiotoxicity.Dec 31, 2015

Comparative analysis of proteomic of curcumin reversing multidrug resistance in HCT-8/VCR cells.Dec 31, 2021

Compounds found within Schisandra reverses multidrug resistance of cancer cells. Nov 01, 2008

Crocetin could quench drug resistance through modulation of MRP transporters in the drug resistant human ovarian cancer cells.Oct 31, 2018

Cucurbitaceae B reversed multidrug resistance and down-regulated CIP2A expression in MCF-7/Adriamycin (MCF-7/Adr) cells.Jul 31, 2016

Curcumin appears to have value in multi-drug chemoresistance.Feb 02, 2010

Curcumin can reverse the multi-drug resistance of a human gastric carcinoma cell line. Aug 01, 2005

Curcumin contributes to overcoming multidrug resistance in human non-small cell lung carcinoma cell lines.Jul 01, 2008

Curcumin down-regulates multidrug-resistance. Jan 18, 2008

Curcumin exhibits chemosensitizing properties against multidrug resistance in rat liver cells.Jan 01, 1998

Curcumin has antiproliferative effects against human breast tumor cell lines.Jun 01, 1997

Curcumin has chemosensitizing activity in multidrug resistant tumor cell lines. Sep 01, 2001

Curcumin induces programmed cell death in human multidrug-resistant cells.Nov 01, 2002

Curcumin inhibit the growth of hormone-independent and multi-drug resistant breast cancer cells. Feb 01, 2009

Curcumin inhibits multi drug resistance associated protein (MRP1) in retinoblastoma cells.Jan 01, 2012

Curcumin inhibits multi-drug resistance gene expression in human leukemic cells.Oct 01, 2006

Curcumin inhibits multi-drug resistant pancreatic cancer. Nov 30, 2010

Curcumin may act as a chemosensitizer in multi-drug resistant cancer. Sep 01, 2010

Curcumin may act as a chemosensitizing agent in multidrug resistant cancer cells. Aug 15, 2002

Curcumin may act as a chemosensitizing agent. Jan 01, 2007

Curcumin may be used as a chemosensitizer to make the retinoblastoma cells more sensitive to the effects of chemotherapy.Oct 01, 2009

Curcumin participates in reversing multi-drug resistance in cancer cells.Apr 01, 2006

Curcumin promotes programmed cell death in multidrug-resistant human lung cancer cells.Aug 13, 2010

Curcumin reduces multi-drug resistance in uterine cancer cells.Oct 01, 2008

Curcumin reverse multi-drug resistance in multiple myeloma cells.Apr 01, 2010

Cancers: Multi-Drug Resistant

View the Evidence:
154 Abstracts with Cancers: Multi-Drug Resistant Research