Results for Acetaminophen

Giving the antioxidant NAC during spine surgery was demonstrated to lower patients' postoperative pain and reduce their need for dangerous opioid drugs

A combination of resveratrol and quercetin suppressed glomerular damage and apoptosis induced by acetaminophen in the kidney.

Article Published Date : Feb 02, 2020

Study Type : Animal Study

Additional Links

Substances : Quercetin : CK(1876) : AC(855), Resveratrol : CK(3228) : AC(1513)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Kidney Damage: Drug-Induced : CK(293) : AC(110)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11697) : AC(4806)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A combination strategy of thymoquinone and curcumin might be considered as a potential antidote in combating liver injury induced by acetaminophen.

Article Published Date : Mar 04, 2019

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(7239) : AC(3319), Thymoquinone : CK(1178) : AC(692)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A crude aqueous leafy extract of M. indica possesses hepatoprotective effects.

Article Published Date : Jun 30, 2022

Study Type : Animal Study

Additional Links

Substances : Mango : CK(569) : AC(301)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A methanolic extract of pomegranate peel ameliorated the hepatic damage caused by acetaminophen.

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel : CK(186) : AC(86)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.

Article Published Date : Apr 30, 2014

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A review of the hepatoprotective effect of kaempferol.

Article Published Date : Dec 31, 2022

Study Type : Review

Additional Links

Substances : Kaempferol : CK(354) : AC(229)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage : CK(4109) : AC(1872), Liver Disease : CK(367) : AC(117)

Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen

Click here to view the entire abstract

A. catechu seed extract is a promising agent for protecting liver from acetaminophen induced hepatotoxicity.

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Acacia catechu : CK(20) : AC(13)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Superoxide Dismutase Up-regulation : CK(2383) : AC(928)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages.

Article Published Date : Dec 31, 1999

Study Type : Animal Study

Additional Links

Substances : Burdock : CK(216) : AC(116)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen affects empathy-like behavior in rats.

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Additional Keywords : Conventional Medicine Erodes Empathy : CK(83) : AC(9)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen could cause transient mitochondrial dysfunction that may synergize with other stresses to promote liver damage and steatosis.

Article Published Date : Dec 30, 2015

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285), Mitochondrial Dysfunction : CK(628) : AC(269)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle.

Article Published Date : Dec 13, 2018

Study Type : In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen elevates unbound bilirubin levels by the glucose oxidase-peroxidase method.

Article Published Date : Aug 31, 2021

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Gastrointestinal Diseases : CK(211) : AC(73)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen hepatotoxicity is dominated by necrosis or programmed necrosis and does not involve relevant apoptosis.

Article Published Date : Jun 17, 2018

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Adverse Pharmacological Actions : Necrotic : CK(18) : AC(9)

Click here to view the entire abstract

Acetaminophen is increasingly present in the natural water environment.

Article Published Date : Jul 21, 2019

Study Type : Environmental

Additional Links

Additional Keywords : Environmental Fate of Pharmacueticals : CK(43) : AC(23), Water Pollution

Problem Substances : Acetaminophen, Public Drinking Water : CK(97) : AC(26)

Click here to view the entire abstract

Originally published on www.thevaccinereaction.org by Marco Cáceres

Acetaminophen reduces empathy for other's physical and social pain.

Article Published Date : Apr 30, 2017

Study Type : Review

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Additional Keywords : Conventional Medicine Erodes Empathy : CK(83) : AC(9)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen reduces glutathione in human tissues which is necessary to detoxify residual formaldehyde present in childhood vaccines.

Article Published Date : Aug 01, 2005

Study Type : Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Enzyme Inhibitors : CK(846) : AC(399)

Anti Therapeutic Actions : Vaccination: All : CK(12701) : AC(1349)

Problem Substances : Acetaminophen

Click here to view the entire abstract

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Tryptophan : CK(281) : AC(34)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue.

Article Published Date : Aug 11, 2019

Study Type : Animal Study, Human In Vitro

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Problem Substances : Acetaminophen

Click here to view the entire abstract

Acetaminophen use for fever in children associated with autism spectrum disorder.

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Autism Spectrum Disorders : CK(3722) : AC(571)

Additional Keywords : Endocannabinoid System : CK(157) : AC(56)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products.

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Polyphenols : CK(2736) : AC(1003), Sulforaphane : CK(1344) : AC(630)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen

Click here to view the entire abstract

Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers.

Article Published Date : Nov 30, 1990

Study Type : Human Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Common Cold : CK(859) : AC(124), Rhinovirus Infection : CK(97) : AC(39)

Additional Keywords : Increased Risk : CK(8772) : AC(1121), Viral Shedding

Problem Substances : Acetaminophen, Aspirin : CK(663) : AC(113), Ibuprofen : CK(266) : AC(41), Paracetamol : CK(863) : AC(298)

Adverse Pharmacological Actions : Immunosuppressive : CK(289) : AC(55)

Click here to view the entire abstract

Aged citrus peel (Chenpi) prevents acetaminophen-induced Hepatotoxicity by epigenetically regulating Nrf2 pathway.

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel : CK(159) : AC(62)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage : CK(4109) : AC(1872)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Heme oxygenase-1 up-regulation : CK(1336) : AC(776), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Allicin and omega-3 fatty acids attenuates acetaminophen mediated renal toxicity.

Article Published Date : Jul 11, 2023

Study Type : Animal Study

Additional Links

Substances : Allicin : CK(360) : AC(196), Omega-3 Fatty Acids : CK(5655) : AC(768)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Kidney Damage: Drug-Induced : CK(293) : AC(110)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Renoprotective : CK(4544) : AC(1971)

Problem Substances : Acetaminophen

Click here to view the entire abstract

Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats.

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(2483) : AC(1079), Selenium : CK(1753) : AC(393)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen

Click here to view the entire abstract

Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity.

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Corn Silk : CK(121) : AC(51)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Kidney Damage: Drug-Induced : CK(293) : AC(110), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Renoprotective : CK(4544) : AC(1971)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

An aqueous extract of white clover was protective against the hepatotoxicity induced by acetaminophen.

Article Published Date : Aug 31, 2019

Study Type : Animal Study

Additional Links

Substances : White Clover : CK(11) : AC(7)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

An extract from Mulberry leaf decelerates acetaminophen induced hepatic inflammation.

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Mulberry : CK(546) : AC(274)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

An isoflavonoid from seeds of Lepidium sativum L. has a protective effect on hepatotoxicity induced by paracetamol.

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garden Cress (Lepidium sativum) : CK(65) : AC(32)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen induced liver injury.

Article Published Date : Apr 02, 2019

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury

Article Published Date : Apr 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089), Lipid Peroxidation : CK(2054) : AC(804), Oxidative Stress : CK(14758) : AC(5716)

Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Malondialdehyde Down-regulation : CK(3028) : AC(992)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Anthropogenic contaminants of high concern: Existence in water resources and their adverse effects.

Article Published Date : Nov 09, 2019

Study Type : Environmental

Additional Links

Additional Keywords : Environmental Fate of Pharmacueticals : CK(43) : AC(23), Public Drinking Water : CK(37) : AC(7), Water Pollution

Problem Substances : Acetaminophen, Diclofenac : CK(231) : AC(52), Ibuprofen : CK(266) : AC(41), Naproxen : CK(68) : AC(10), Ofloxacin : CK(4) : AC(2), Pesticides : CK(2401) : AC(488), Ranitidine : CK(14) : AC(3), Triclosan : CK(171) : AC(49)

Click here to view the entire abstract

Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitro.

Article Published Date : Apr 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Poria cocos : CK(213) : AC(117)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats.

Article Published Date : Feb 10, 2020

Study Type : Animal Study

Additional Links

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Anti-Inflammatory Agents : CK(39737) : AC(15858), Hepatoprotective : CK(8989) : AC(3831), Interleukin-1 beta downregulation : CK(6063) : AC(2940)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Apigenin attenuates acetaminophen-induced hepatotoxicity.

Article Published Date : Dec 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apigenin : CK(681) : AC(392)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831), Nrf2 activation : CK(3156) : AC(1794)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Apigenin prevents acetaminophen-induced liver injury by activating the SIRT1 pathway.

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(681) : AC(392)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Autophagy Up-regulation : CK(838) : AC(559), Hepatoprotective : CK(8989) : AC(3831), SIRT1 Activator : CK(382) : AC(190)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Apigenin significantly increases the enzyme antioxidant defence mechanisms in paracetamol-induced hepatotoxicity.

Article Published Date : Mar 01, 2017

Study Type : Animal Study

Additional Links

Substances : Apigenin : CK(681) : AC(392)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Liver Damage: Drug-Induced : CK(651) : AC(285)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Aqueous extracts of C. papaya may be useful in preventing carbon tetrachloride and acetaminophen induced liver toxicities.

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Papaya : CK(309) : AC(124)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362), Chemically-Induced Liver Damage : CK(2304) : AC(1089)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499), Hepatoprotective : CK(8989) : AC(3831)

Additional Keywords : Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Aqueous extracts of Rosa damascene may prevent hepatic damage from acetaminophen induced toxicity in rats.

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Rose : CK(834) : AC(279)

Pharmacological Actions : Antioxidants : CK(34551) : AC(14499)

Additional Keywords : Phytotherapy : CK(4003) : AC(1031), Plant Extracts : CK(18762) : AC(6782)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats.

Article Published Date : Nov 30, 2015

Study Type : Animal Study

Additional Links

Substances : Burdock : CK(216) : AC(116)

Diseases : Acetaminophen (Tylenol) Toxicity : CK(902) : AC(362)

Pharmacological Actions : Hepatoprotective : CK(8989) : AC(3831)

Problem Substances : Acetaminophen, Paracetamol : CK(863) : AC(298)

Click here to view the entire abstract

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In recent years, a narrative has emerged warning the public that herbal supplements may be damaging their livers. Mainstream media headlines such as "6 Supplements, Including Green Tea, Turmeric, Linked to Liver Toxicity" and "Silent Threats: Everyday Herbs and Drugs Linked to Liver Damage" have contributed to a growing sense of fear around herbal products. But how valid are these claims?