Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Kidney Fibrosis : CK(241) : AC(136)
Pharmacological Actions : Anti-Fibrotic : CK(2165) : AC(1027), Antioxidants : CK(33994) : AC(14222)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(303) : AC(126), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(238) : AC(94)
Pharmacological Actions : Antineoplastic Agents : CK(2221) : AC(1456), Apoptotic : CK(9480) : AC(7298)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1911) : AC(493), Thymoquinone : CK(1178) : AC(692)
Diseases : Diabetes: Oxidative Stress : CK(633) : AC(243)
Pharmacological Actions : Antioxidants : CK(33994) : AC(14222), Malondialdehyde Down-regulation : CK(2974) : AC(968), Pancreato Protective Agents : CK(535) : AC(291), Superoxide Dismutase Up-regulation : CK(2337) : AC(901)
Additional Keywords : Antioxidants : CK(303) : AC(126), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(3963) : AC(1016), Plant Extracts : CK(18617) : AC(6734), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1911) : AC(493), Thymoquinone : CK(1178) : AC(692)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1230) : AC(593)
Pharmacological Actions : Chemoprotective Agents : CK(4093) : AC(1585)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Inflammation : CK(15586) : AC(5304)
Pharmacological Actions : Anti-Inflammatory Agents : CK(38456) : AC(15386), Cyclooxygenase 2 Inhibitors : CK(2174) : AC(1283), Interleukin-1 beta downregulation : CK(5878) : AC(2865), Interleukin-6 Downregulation : CK(9170) : AC(3542), NF-kappaB Inhibitor : CK(5826) : AC(3390), Nitric Oxide Inhibitor : CK(698) : AC(352), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11372) : AC(4686)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Inflammation : CK(15586) : AC(5304), Rheumatoid Arthritis : CK(2286) : AC(552)
Pharmacological Actions : Anti-Inflammatory Agents : CK(38456) : AC(15386), Antiproliferative : CK(9855) : AC(7389), Cyclooxygenase 2 Inhibitors : CK(2174) : AC(1283), Interleukin-1 beta downregulation : CK(5878) : AC(2865), NF-kappaB Inhibitor : CK(5826) : AC(3390), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(11372) : AC(4686)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Inflammation : CK(128) : AC(57), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Multiple Myeloma : CK(414) : AC(159)
Pharmacological Actions : Antineoplastic Agents : CK(2221) : AC(1456), Antiproliferative : CK(9855) : AC(7389), Apoptotic : CK(9480) : AC(7298), Chemosensitizer : CK(1636) : AC(1259), Interleukin-6 Downregulation : CK(9170) : AC(3542), STAT3 Inhibitor : CK(320) : AC(215)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Cervical Cancer : CK(968) : AC(588)
Pharmacological Actions : Anti-metastatic : CK(2843) : AC(2161)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Head and Neck Cancer : CK(667) : AC(174)
Pharmacological Actions : Antiproliferative : CK(9855) : AC(7389), Radiosensitizer : CK(364) : AC(242)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Otitis : CK(25) : AC(5)
Pharmacological Actions : Anti-Bacterial Agents : CK(4120) : AC(1948), Anti-Inflammatory Agents : CK(38456) : AC(15386)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1865) : AC(394), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Neurodegenerative Diseases : CK(12873) : AC(4196)
Pharmacological Actions : Antioxidants : CK(33994) : AC(14222), Neuroprotective Agents : CK(19672) : AC(7790), Nrf2 activation : CK(3111) : AC(1770)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(21) : AC(14)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Drug Toxicity: Methotrexate : CK(192) : AC(99), Lipid Peroxidation : CK(1995) : AC(780), Oxidative Stress : CK(14378) : AC(5533)
Pharmacological Actions : Antioxidants : CK(33994) : AC(14222)
Additional Keywords : Antioxidants : CK(303) : AC(126), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Fibrosis: Liver : CK(32) : AC(13), Inflammation : CK(15586) : AC(5304), Lipopolysaccharide-Induced Toxicity : CK(3153) : AC(1836)
Pharmacological Actions : Anti-Inflammatory Agents : CK(38456) : AC(15386)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(128) : AC(57), Lipopolysaccharide-Induced Toxicity, thymoquinone

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