Results for thymoquinone

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.

Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Kidney Fibrosis : CK(287) : AC(162)
Pharmacological Actions : Anti-Fibrotic : CK(2594) : AC(1234), Antioxidants : CK(37839) : AC(15955)
Additional Keywords : Anti-Fibrotic, Antioxidants : CK(303) : AC(126), Kidney Fibrosis, thymoquinone

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(259) : AC(97)
Pharmacological Actions : Antineoplastic Agents : CK(2546) : AC(1713), Apoptotic : CK(10616) : AC(8207)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.

Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2061) : AC(526), Thymoquinone : CK(1263) : AC(740)
Diseases : Diabetes: Oxidative Stress : CK(653) : AC(249)
Pharmacological Actions : Antioxidants : CK(37839) : AC(15955), Malondialdehyde Down-regulation : CK(3243) : AC(1066), Pancreato Protective Agents : CK(598) : AC(324), Superoxide Dismutase Up-regulation : CK(2669) : AC(1039)
Additional Keywords : Antioxidants : CK(303) : AC(126), Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy : CK(4204) : AC(1115), Plant Extracts : CK(19977) : AC(7348), thymoquinone

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2061) : AC(526), Thymoquinone : CK(1263) : AC(740)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1376) : AC(665)
Pharmacological Actions : Chemoprotective Agents : CK(4671) : AC(1792)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

These findings strongly suggest that the anti-inflammatory actions of Thymoquinone are caused by suppression of IRAK-linked AP-1/NF-κB pathways.

Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Inflammation : CK(17518) : AC(6064)
Pharmacological Actions : Anti-Inflammatory Agents : CK(44553) : AC(17896), Cyclooxygenase 2 Inhibitors : CK(2438) : AC(1432), Interleukin-1 beta downregulation : CK(6953) : AC(3359), Interleukin-6 Downregulation : CK(10471) : AC(4070), NF-kappaB Inhibitor : CK(6759) : AC(3919), Nitric Oxide Inhibitor : CK(722) : AC(366), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(13080) : AC(5396)
Additional Keywords : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Inflammation : CK(128) : AC(57), Interleukin-1 beta downregulation, thymoquinone

Thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis pathogenesis.

Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Inflammation : CK(17518) : AC(6064), Rheumatoid Arthritis : CK(2567) : AC(627)
Pharmacological Actions : Anti-Inflammatory Agents : CK(44553) : AC(17896), Antiproliferative : CK(11251) : AC(8425), Cyclooxygenase 2 Inhibitors : CK(2438) : AC(1432), Interleukin-1 beta downregulation : CK(6953) : AC(3359), NF-kappaB Inhibitor : CK(6759) : AC(3919), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(13080) : AC(5396)
Additional Keywords : Anti-Inflammatory Agents, Antiproliferative : CK(75) : AC(61), Inflammation : CK(128) : AC(57), rheumatoid arthritis, thymoquinone

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells.

Article Published Date : Sep 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Multiple Myeloma : CK(443) : AC(169)
Pharmacological Actions : Antineoplastic Agents : CK(2546) : AC(1713), Antiproliferative : CK(11251) : AC(8425), Apoptotic : CK(10616) : AC(8207), Chemosensitizer : CK(1785) : AC(1362), Interleukin-6 Downregulation : CK(10471) : AC(4070), STAT3 Inhibitor : CK(325) : AC(217)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, Multiple Myeloma, thymoquinone

Thymoquinone inhibits the migration and invasion of cervical cancer cells.

Article Published Date : Dec 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Cervical Cancer : CK(1027) : AC(639)
Pharmacological Actions : Anti-metastatic : CK(3139) : AC(2387)
Additional Keywords : Anti-metastatic, Cervical Cancer, thymoquinone

Thymoquinone is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Head and Neck Cancer : CK(827) : AC(199)
Pharmacological Actions : Antiproliferative : CK(11251) : AC(8425), Radiosensitizer : CK(407) : AC(276)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Head and Neck Cancer, Radiosensitizer, thymoquinone

Thymoquinone may be considered for topical application alone in the treatment of acute otitis externa.

Article Published Date : Dec 13, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Otitis : CK(25) : AC(5)
Pharmacological Actions : Anti-Bacterial Agents : CK(4596) : AC(2174), Anti-Inflammatory Agents : CK(44553) : AC(17896)
Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis, Superiority of Natural Substances versus Drugs : CK(1952) : AC(410), thymoquinone

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Neurodegenerative Diseases : CK(14026) : AC(4677)
Pharmacological Actions : Antioxidants : CK(37839) : AC(15955), Neuroprotective Agents : CK(22239) : AC(8840), Nrf2 activation : CK(3537) : AC(2013)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(21) : AC(14)

Thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.

Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Drug Toxicity: Methotrexate : CK(224) : AC(111), Lipid Peroxidation : CK(2211) : AC(895), Oxidative Stress : CK(16775) : AC(6661)
Pharmacological Actions : Antioxidants : CK(37839) : AC(15955)
Additional Keywords : Antioxidants : CK(303) : AC(126), Drug Toxicity: Methotrexate, Lipid Peroxidation, oxidative stress, thymoquinone

Treatment by Thymoquinone restores inflammation-induced liver fibrosis.

Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone : CK(1263) : AC(740)
Diseases : Fibrosis: Liver : CK(32) : AC(13), Inflammation : CK(17518) : AC(6064), Lipopolysaccharide-Induced Toxicity : CK(3605) : AC(2105)
Pharmacological Actions : Anti-Inflammatory Agents : CK(44553) : AC(17896)
Additional Keywords : Anti-Inflammatory Agents, Fibrosis: Liver, Inflammation : CK(128) : AC(57), Lipopolysaccharide-Induced Toxicity, thymoquinone

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