Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(782) : AC(320)
Pharmacological Actions : Antiproliferative : CK(10001) : AC(7491), Apoptotic : CK(9585) : AC(7379), Chemosensitizer : CK(1657) : AC(1270)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(430) : AC(339), Dose Response : CK(1770) : AC(700), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Glioblastoma : CK(729) : AC(403)
Pharmacological Actions : Anti-metastatic : CK(2870) : AC(2182), Antiproliferative : CK(10001) : AC(7491), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(944) : AC(588), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1141) : AC(720)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Chemotherapeutic Synergy: Temozolomide : CK(65) : AC(49), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Liver Injury: Ischemia/reperfusion : CK(175) : AC(95)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Autophagy Inhibitors : CK(302) : AC(188), Hepatoprotective : CK(8989) : AC(3831)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Diabetic Retinopathy : CK(483) : AC(211)
Pharmacological Actions : Anti-Apoptotic : CK(5568) : AC(3160), Anti-Inflammatory Agents : CK(39737) : AC(15858), Cyclooxygenase 2 Inhibitors : CK(2264) : AC(1327)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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