Results for Shikonin

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(771) : AC(318)
Pharmacological Actions : Antiproliferative : CK(9855) : AC(7389), Apoptotic : CK(9480) : AC(7298), Chemosensitizer : CK(1636) : AC(1259)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(427) : AC(336), Dose Response : CK(1770) : AC(700), Shikonin

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.

Article Published Date : Apr 10, 2017
Study Type : Human In Vitro
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Glioblastoma : CK(703) : AC(390)
Pharmacological Actions : Anti-metastatic : CK(2843) : AC(2161), Antiproliferative : CK(9855) : AC(7389), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(936) : AC(583), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1120) : AC(707)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Chemotherapeutic Synergy: Temozolomide : CK(65) : AC(49), Glioblastoma, Shikonin

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Liver Injury: Ischemia/reperfusion : CK(173) : AC(94)
Pharmacological Actions : Anti-Apoptotic : CK(5418) : AC(3083), Autophagy Inhibitors : CK(299) : AC(186), Hepatoprotective : CK(8852) : AC(3772)
Additional Keywords : Anti-Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Hepatoprotective, Liver Injury: Ischemia/reperfusion, Shikonin

These results indicate that shikonin treatment may prevent the loss of vision associated with diabetic retinopathy.

Article Published Date : Mar 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Diabetic Retinopathy : CK(473) : AC(205)
Pharmacological Actions : Anti-Apoptotic : CK(5418) : AC(3083), Anti-Inflammatory Agents : CK(38654) : AC(15424), Cyclooxygenase 2 Inhibitors : CK(2196) : AC(1287)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Diabetic Retinopathy, Shikonin

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