Results for Nrf2 activation

A leaf extract of Dandelion and its main compound activated nuclear factor erythroid 2-related factor 2 and induced heme oxygenase 1.

Article Published Date : Dec 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Dandelion : CK(262) : AC(134)
Diseases : Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Heme oxygenase-1 inducer : CK(57) : AC(39), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Dandelion, Heme oxygenase-1 inducer, Nrf2 activation, oxidative stress, Plant Extracts : CK(14140) : AC(5210)

Adlay is a potential chemopreventive TCM to block multistage carcinogenesis with anti-initiation, promotion and progression properties.

Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Adlay : CK(1) : AC(1)
Diseases : Cancers: All : CK(28241) : AC(10590)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Antiproliferative : CK(6801) : AC(5032), Chemopreventive : CK(5374) : AC(1717), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Adlay, Antioxidants : CK(303) : AC(126), Antiproliferative : CK(65) : AC(52), Cancers: All, Chemopreventive, Nrf2 activation

Allicin provides protection against arsenic trioxide induced liver injury.

Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Allicin : CK(238) : AC(128)
Diseases : Arsenic Poisoning : CK(243) : AC(91), Oxidative Stress : CK(9437) : AC(3550)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), NF-kappaB Inhibitor : CK(3536) : AC(2098), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Allicin, Antioxidants : CK(303) : AC(126), Arsenic Poisoning, NF-kappaB Inhibitor, Nrf2 activation, oxidative stress
Problem Substances : Arsenic Trioxide : CK(6) : AC(4)

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.

Article Published Date : Apr 04, 2018
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(1010) : AC(437)
Diseases : Diabetic Nephropathy : CK(707) : AC(277), Kidney Fibrosis : CK(121) : AC(68)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Nrf2 activation : CK(1584) : AC(916), Renoprotective : CK(2404) : AC(1075)
Additional Keywords : Antioxidants : CK(303) : AC(126), Astaxanthin, Diabetic Nephropathy, Kidney Fibrosis, Nrf2 activation, Renoprotective

Carnosic acid prevents dextran sulfate sodium-induced acute colitis.

Article Published Date : Sep 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(121) : AC(82)
Diseases : Colitis : CK(840) : AC(406)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Carnosic Acid, Colitis, Nrf2 activation

Fucoxanthin provides neuroprotection in models of traumatic brain injury.

Article Published Date : Apr 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoxanthin : CK(158) : AC(97)
Diseases : Brain Injury: Traumatic : CK(275) : AC(95)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Brain Injury: Traumatic, Fucoxanthin, Neuroprotective Agents, Nrf2 activation

Phloretin has a strong chemopreventive effect against aflatoxin B1.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(177) : AC(101)
Diseases : Liver Damage: Aflatoxin-Induced : CK(72) : AC(30)
Pharmacological Actions : Chemopreventive : CK(5374) : AC(1717), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Chemopreventive, Dose Response : CK(1712) : AC(683), Liver Damage: Aflatoxin-Induced, Nrf2 activation, Phloretin
Problem Substances : Aflatoxin : CK(56) : AC(8)

Piper nigrum might be a promising candidate for the treatment of inflammatory diseases.

Article Published Date : Feb 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Pepper : CK(497) : AC(217)
Diseases : Inflammation : CK(9572) : AC(3089)
Pharmacological Actions : Heme oxygenase-1 inducer : CK(57) : AC(39), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Black Pepper, Heme oxygenase-1 inducer, Inflammation : CK(128) : AC(57), Nrf2 activation

Sulforphane's antioxidant properties make it an effective neuroprotective agent. More studies are needed to determine the exact implications in neurological disease.

Article Published Date : Apr 01, 2019
Study Type : Review
Additional Links
Substances : Sulforaphane : CK(930) : AC(452)
Therapeutic Actions : antioxidant, antioxidants, neuro-protective
Pharmacological Actions : Antioxidant, Antioxidant Effects : CK(15) : AC(4), Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396), NF-E2-Related Factor-2 (Nrf2) Modulator : CK(69) : AC(39), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidant effects, Antioxidant Systems : CK(2) : AC(2), Cruciferous Vegetables, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, Phytotherapy : CK(3062) : AC(812), Sulforaphane

The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Hesperidin : CK(545) : AC(215), Rutin : CK(289) : AC(142)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Heme oxygenase-1 up-regulation : CK(624) : AC(373), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Calcium Carbonate, Gene Expression Regulation : CK(1141) : AC(501), Heme oxygenase-1 up-regulation, Hesperidin, Nrf2 activation, Rutin
Problem Substances : Calcium Carbonate : CK(198) : AC(21)

Thymoquinone protects against cobalt chloride-induced neurotoxicity.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(774) : AC(451)
Diseases : Neurodegenerative Diseases : CK(8689) : AC(2653)
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856), Neuroprotective Agents : CK(10404) : AC(4396), Nrf2 activation : CK(1584) : AC(916)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cobalt, Neurodegenerative diseases, Neuroprotective Agents, Nrf2 activation, thymoquinone
Problem Substances : Cobalt : CK(15) : AC(10)

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