Results for Chemotherapy-Induced Toxicity: Cisplatin

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(3094) : AC(403)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Chemoprotective Agents : CK(4587) : AC(1758)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(11) : AC(2)

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2649) : AC(1457)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Chemoprotective Agents : CK(4587) : AC(1758), Renoprotective : CK(4944) : AC(2149)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2649) : AC(1457)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Antioxidants : CK(37417) : AC(15721), Chemoprotective Agents : CK(4587) : AC(1758), Renoprotective : CK(4944) : AC(2149)
Additional Keywords : Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(454) : AC(291)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Autophagy Up-regulation : CK(926) : AC(610), Chemoprotective Agents : CK(4587) : AC(1758)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2061) : AC(526), Thymoquinone : CK(1256) : AC(736)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Chemoprotective Agents : CK(4587) : AC(1758)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(2061) : AC(526)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Chemoprotective Agents : CK(4587) : AC(1758), Gastroprotective : CK(1817) : AC(762)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1679) : AC(530), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Chemoprotective Agents : CK(4587) : AC(1758), Cyclooxygenase 2 Inhibitors : CK(2397) : AC(1406), Nitric Oxide Inhibitor : CK(721) : AC(365)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(275) : AC(165)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Anti-Apoptotic : CK(6278) : AC(3556), Chemoprotective Agents : CK(4587) : AC(1758), Heme oxygenase-1 inducer : CK(63) : AC(43)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Tangeretin not only enhanced cisplatin’s cytotoxic actions in Hep3B and HCT-116 human cancer cells but could protect against its harmful effects.

Article Published Date : Oct 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin : CK(206) : AC(114)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648), Inflammation : CK(17298) : AC(5965), Lipid Peroxidation : CK(2184) : AC(878), Oxidative Stress : CK(16515) : AC(6515)
Pharmacological Actions : Anti-Inflammatory Agents : CK(43672) : AC(17511), Antioxidants : CK(37417) : AC(15721), Chemoprotective Agents : CK(4587) : AC(1758), Interleukin-10 upregulation : CK(1458) : AC(492), NF-kappaB Inhibitor : CK(6610) : AC(3839), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(12808) : AC(5273)
Additional Keywords : Chemotherapeutic Synergy: Cisplatin : CK(457) : AC(363), Chemotherapy-Induced Toxicity: Cisplatin, Inflammation : CK(128) : AC(57), Lipid Peroxidation, oxidative stress, Tangeretin

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(206) : AC(114)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1345) : AC(648)
Pharmacological Actions : Anti-Apoptotic : CK(6278) : AC(3556), Anti-Inflammatory Agents : CK(43672) : AC(17511), Antioxidants : CK(37417) : AC(15721), Chemoprotective Agents : CK(4587) : AC(1758)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

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