Results for Chemosensitizer

Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells.

Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide : CK(251) : AC(179)
Diseases : Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Autophagy Inhibitors : CK(303) : AC(189), Chemosensitizer : CK(1666) : AC(1277), Chemotherapeutic : CK(4400) : AC(1641)
Additional Keywords : Andrographolidem, Autophagy Inhibitors : CK(8) : AC(6), Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), lung cancer

Chemo-sensitization resulting from fasting may in fact be an effect of enhanced immune surveillance.

Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All : CK(36538) : AC(14432)
Therapeutic Actions : Fasting/Caloric Restriction : CK(820) : AC(176)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Cancer : CK(50) : AC(12), cancer cure, Chemosensitizer, Chemotherapy : CK(45) : AC(8), Fasting

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8002) : AC(3607)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(711) : AC(429)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel : CK(166) : AC(122), CURCUMIN : CK(25) : AC(18)

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Dimethyl trisulfide (DMTS), gastric cancer

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(954) : AC(361), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4305) : AC(1627), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(353) : AC(272), Ehrlich carcinoma, Hesperidin, Sweet Orange

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(785) : AC(322)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Dose Response : CK(1770) : AC(700), Shikonin

Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in liver cancer cells.

Article Published Date : Jan 29, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Liver Cancer : CK(3122) : AC(1644)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Chemosensitizer, Chemotherapeutic Synergy: Oxaliplatin : CK(79) : AC(52), liver cancer, Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Chemosensitizer : CK(1666) : AC(1277), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

Neferine revealed higher toxicity toward paclitaxel and doxorubicin-resistant breast, lung or colon cancer cells.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Breast Cancer : CK(8325) : AC(3056), Cancers: Multi-Drug Resistant : CK(195) : AC(157), Colon Cancer : CK(1921) : AC(1204), Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277), Chemotherapeutic : CK(4400) : AC(1641)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Cancers: Multi-Drug Resistant, Chemosensitizer, Chemotherapeutic, COLON CANCER, Lotus, lung cancer

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3260) : AC(1523)
Diseases : Lung Cancer : CK(3068) : AC(1434), Melanoma : CK(950) : AC(556)
Pharmacological Actions : Anti-metastatic : CK(2882) : AC(2191), Chemoprotective Agents : CK(4305) : AC(1627), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin.

Article Published Date : Jun 22, 2017
Study Type : Animal Study
Additional Links
Substances : Oleuropein : CK(322) : AC(202)
Diseases : Breast Cancer : CK(8325) : AC(3056)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(353) : AC(272), Oleuropein

The combination of centchroman with genistein has selective cytotoxic effect for human breast cancer cell lines.

Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Genistein : CK(945) : AC(434)
Diseases : Breast Cancer : CK(8325) : AC(3056), Breast Cancer: Triple Negative : CK(973) : AC(661)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Chemosensitizer, Genistein, Natural Substance/Drug Synergy : CK(1543) : AC(724), Selective Cytotoxicity : CK(274) : AC(201)

This review describes the role of antioxidants like sulforaphane and curcumin in combatting chemoresistance and chemotherapy-induced oxidative stress through NF-kappaB and HIF-1a inhibition.

Article Published Date : Jun 29, 2019
Study Type : Review
Additional Links
Substances : Broccoli Sprouts : CK(303) : AC(55), Curcumin : CK(8002) : AC(3607), Sulforaphane : CK(1345) : AC(631), Turmeric : CK(10116) : AC(4194)
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects : CK(159) : AC(45), Chemosensitizer : CK(1666) : AC(1277), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(363) : AC(237), NF-kappaB Inhibitor : CK(5977) : AC(3479), Nrf2 activation : CK(3163) : AC(1798)
Additional Keywords : Anti-cancer, Chemoresistance : CK(7) : AC(6), Chemosensitizer, Chemotherapy : CK(45) : AC(8)
Problem Substances : Chemotherapy : CK(459) : AC(79)

Vitamin C and K can sensitize cancer cells to conventional chemotherapy.

Article Published Date : Mar 19, 2018
Study Type : Review
Additional Links
Substances : Vitamin C : CK(6069) : AC(1410), Vitamin K : CK(998) : AC(161)
Diseases : Cancers: All : CK(36538) : AC(14432)
Pharmacological Actions : Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Cancers: All, Chemosensitizer, Vitamin C : CK(48) : AC(13), Vitamin K

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