Results for Chemoprotective Agents

A short hydration regimen with magnesium supplementation prevents cisplatin-induced nephrotoxicity

Article Published Date : Dec 12, 2016
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(2801) : AC(369)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Magnesium : CK(11) : AC(2)

Combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy.

Article Published Date : Nov 23, 2016
Study Type : Animal Study
Additional Links
Substances : Lycopene : CK(1268) : AC(373), Rosmarinic acid : CK(198) : AC(112)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin : CK(200) : AC(105)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Renoprotective : CK(4736) : AC(2058)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Gentamicin, lycopene, Renoprotective, Rosmarinic acid

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.

Article Published Date : Mar 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin : CK(977) : AC(369), Sweet Orange : CK(48) : AC(17)
Diseases : Ehrlich carcinoma : CK(97) : AC(53)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Chemosensitizer : CK(1709) : AC(1310)
Additional Keywords : Chemoprotective Agents, Chemosensitizer, Chemotherapeutic Synergy: Doxorubicin : CK(362) : AC(281), Ehrlich carcinoma, Hesperidin, Sweet Orange

Folic acid may be a novel therapeutic approach to attenuate doxorubicin induced cardiomyopathy.

Article Published Date : Jun 12, 2017
Study Type : Animal Study
Additional Links
Substances : Folic Acid : CK(1330) : AC(209)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(882) : AC(437)
Pharmacological Actions : Antioxidants : CK(36035) : AC(15062), Cardioprotective : CK(9708) : AC(3036), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Antioxidants : CK(303) : AC(126), Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, folic acid

Ginsenosides Rk2 and Rh3 have kidney protective effects of against cisplatin.

Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2642) : AC(1453)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Renoprotective : CK(4736) : AC(2058)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Ginsenosides Rk3 and Rh4 protect the kidney from cisplatin-induced oxidative injury.

Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides : CK(2642) : AC(1453)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Antioxidants : CK(36035) : AC(15062), Chemoprotective Agents : CK(4441) : AC(1688), Renoprotective : CK(4736) : AC(2058)
Additional Keywords : Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Ginsenosides, Renoprotective

Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility.

Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Honey : CK(1240) : AC(317)
Diseases : Chemotherapy and Radiation Toxicity : CK(2637) : AC(630)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Chemoprotective Agents, Chemotherapy and Radiation Toxicity, Honey : CK(22) : AC(9)

Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers.

Article Published Date : Dec 15, 2017
Study Type : In Vitro Study
Additional Links
Substances : Melatonin : CK(2951) : AC(922)
Diseases : Head and Neck Cancer : CK(823) : AC(195)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Chemotherapeutic : CK(4479) : AC(1661)
Additional Keywords : Chemoprotective Agents, Chemotherapeutic, Head and Neck Cancer, melatonin, Natural Substance/Drug Synergy : CK(1614) : AC(743)

Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin.

Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(882) : AC(437)
Pharmacological Actions : Anti-Inflammatory Agents : CK(41572) : AC(16551), Cardioprotective : CK(9708) : AC(3036), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Lotus

Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy.

Article Published Date : Mar 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Autophagy Up-regulation : CK(867) : AC(579), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Autophagy Up-regulation, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Lotus

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.

Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1925) : AC(498), Thymoquinone : CK(1203) : AC(706)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.

Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed) : CK(1925) : AC(498)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Gastroprotective : CK(1755) : AC(730)
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)

Panax ginseng anthocyanins pre-administration can significantly prevent cisplatin-induced nephrotoxicity.

Article Published Date : Jul 20, 2017
Study Type : Animal Study
Additional Links
Substances : Anthocyanins : CK(1633) : AC(503), Panax Ginseng : CK(94) : AC(45)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Chemoprotective Agents : CK(4441) : AC(1688), Cyclooxygenase 2 Inhibitors : CK(2308) : AC(1353), Nitric Oxide Inhibitor : CK(706) : AC(357)
Additional Keywords : Anthocyanins : CK(11) : AC(9), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Panax Ginseng

Phloretin has an anti-apoptotic effect on cisplatin-induced apoptosis in HEI-OC1 auditory cells.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Phloretin : CK(232) : AC(137)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Anti-Apoptotic : CK(5869) : AC(3319), Chemoprotective Agents : CK(4441) : AC(1688), Heme oxygenase-1 inducer : CK(63) : AC(43)
Additional Keywords : Anti-Apoptotic, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Heme oxygenase-1 inducer, Phloretin

Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma.

Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(3290) : AC(1541)
Diseases : Lung Cancer : CK(3134) : AC(1462), Melanoma : CK(964) : AC(564)
Pharmacological Actions : Anti-metastatic : CK(2929) : AC(2232), Chemoprotective Agents : CK(4441) : AC(1688), Chemosensitizer : CK(1709) : AC(1310)
Additional Keywords : Anti-metastatic, Chemoprotective Agents, Chemosensitizer, lung cancer, melanoma, RESVERATROL

These results highlight the protective effects of tangeretin against cisplatin-induced acute hepatic injury.

Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tangeretin : CK(163) : AC(93)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(1295) : AC(623)
Pharmacological Actions : Anti-Apoptotic : CK(5869) : AC(3319), Anti-Inflammatory Agents : CK(41572) : AC(16551), Antioxidants : CK(36035) : AC(15062), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants : CK(303) : AC(126), Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin

This study suggests the use of neferine for amelioration of doxorubicin -mediated cardiotoxicity.

Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(882) : AC(437)
Pharmacological Actions : Cardioprotective : CK(9708) : AC(3036), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Lotus

Zingiber officinale Roscoe ameliorates anticancer antibiotic doxorubicin-induced acute cardiotoxicity.

Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(1596) : AC(481)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin : CK(882) : AC(437)
Pharmacological Actions : Cardioprotective : CK(9708) : AC(3036), Chemoprotective Agents : CK(4441) : AC(1688)
Additional Keywords : Cardioprotective, Chemoprotective Agents, Chemotherapy-Induced Toxicity: Doxorubicin, Ginger

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