Results for Apoptotic

A comprehensive review on anticancer mechanisms of crocin.

Article Published Date : Jul 02, 2017
Study Type : Review
Additional Links
Substances : Crocin : CK(732) : AC(311)
Diseases : Cancers: All : CK(36538) : AC(14432)
Pharmacological Actions : Anti-metastatic : CK(2882) : AC(2191), Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Chemotherapeutic : CK(4400) : AC(1641), Telomerase Inhibitor : CK(98) : AC(65)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Apoptotic, Cancers: All, Chemotherapeutic, Crocin, Telomerase Inhibitor

A wasabi extract exhibits anti-colon cancer properties through the induction of apoptosis and autophagy.

Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wasabi : CK(47) : AC(23)
Diseases : Colon Cancer : CK(1921) : AC(1204)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Autophagy Up-regulation : CK(839) : AC(560)
Additional Keywords : Apoptotic, Autophagy Up-regulation, COLON CANCER, Plant Extracts : CK(18767) : AC(6786), Wasabi

A water-soluble polysaccharide is able to reduce the number of fat cells and the mass of adipose tissue.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : White Mulberry : CK(156) : AC(66)
Diseases : Obesity : CK(11050) : AC(2679)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Anti-Obesity Agents : CK(5194) : AC(1323), Apoptotic, obesity, Plant Extracts : CK(18767) : AC(6786), Polysaccharides : CK(1330) : AC(750), White Mulberry

Alkaloids from Peganum harmala could be a promising candidate for the therapy of leukemia.

Article Published Date : Nov 02, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Leukemia : CK(2095) : AC(911)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, leukemia, Syrian rue

An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.

Article Published Date : Jan 29, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Litchi : CK(35) : AC(23)
Diseases : Prostate Cancer : CK(2810) : AC(1051)
Pharmacological Actions : Anti-metastatic : CK(2882) : AC(2191), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722), P21 Activation : CK(207) : AC(145)
Additional Keywords : Anti-metastatic, Apoptotic, Cell cycle arrest, Litchi, P21 Activation, Plant Extracts : CK(18767) : AC(6786), prostate cancer

An extract of Lotus may be a powerful agent against colon cancer cells.

Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Colon Cancer : CK(1921) : AC(1204)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Bcl-2 protein down-regulation : CK(714) : AC(530), Bcl-xL down-regulation : CK(41) : AC(30), Cyclooxygenase 2 Inhibitors : CK(2268) : AC(1330), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(950) : AC(592), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1147) : AC(724), NF-kappaB Inhibitor : CK(5977) : AC(3479)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts : CK(18767) : AC(6786)

Anti-cancerous effect of Inonotus taiwanensis polysaccharide extract on human acute monocytic leukemia cells.

Article Published Date : Jan 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms : CK(2674) : AC(1252)
Diseases : Leukemia: Monocytic : CK(38) : AC(18)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Autophagy Inhibitors : CK(303) : AC(189)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Autophagy Inhibitors : CK(8) : AC(6), Leukemia: Monocytic, Medicinal Mushrooms, Polysaccharides : CK(1330) : AC(750)

Apigenin induces the apoptosis of colon cancer cells.

Article Published Date : Mar 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Apigenin : CK(682) : AC(393)
Diseases : Colon Cancer : CK(1921) : AC(1204)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Bcl-xL down-regulation : CK(41) : AC(30)
Additional Keywords : Antiproliferative : CK(75) : AC(61), APIGENIN, Apoptotic, Bcl-xL down-regulation, COLON CANCER

Avocado defensin could induce intrinsic apoptosis in breast cancer cells.

Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Avocado : CK(199) : AC(62)
Diseases : Breast Cancer : CK(8325) : AC(3056)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Caspase-7 Activation : CK(9) : AC(7), Caspase-9 Activation : CK(71) : AC(47)
Additional Keywords : Apoptotic, Avocado, Breast Cancer : CK(113) : AC(34), Caspase-7 Activation, Caspase-9 Activation

Baicalein induces cancer cell apoptosis and cause cell cycle arrest.

Article Published Date : Jul 31, 2016
Study Type : Review
Additional Links
Substances : Baicalein : CK(312) : AC(202)
Diseases : Cancers: All : CK(36538) : AC(14432)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Baicalein, Cancer : CK(50) : AC(12), Cell cycle arrest

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.

Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate : CK(63) : AC(35)
Diseases : Liver Cancer : CK(3122) : AC(1644)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Histone deacetylase inhibitor : CK(117) : AC(83), MicroRNA modulator : CK(1565) : AC(901)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator

Caffeic acid and caffeic acid phenethyl ester induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.

Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Caffeic Acid : CK(136) : AC(87), Caffeic acid phenethyl ester : CK(284) : AC(172)
Diseases : Breast Cancer: Triple Negative : CK(973) : AC(661)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Breast Cancer: Triple Negative, Caffeic Acid, Caffeic acid phenethyl ester, Cell cycle arrest

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.

Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112)
Diseases : Breast Cancer : CK(8325) : AC(3056)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Bcl-2 protein down-regulation : CK(714) : AC(530), Bcl-xL down-regulation : CK(41) : AC(30)
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(113) : AC(34), Carnosic Acid, Synergy with Tamoxifen : CK(33) : AC(27)
Problem Substances : Tamoxifen : CK(401) : AC(68)

Carnosic acid induces apoptosis of hepatocellular carcinoma cells.

Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid : CK(167) : AC(112)
Diseases : Liver Cancer : CK(3122) : AC(1644)
Pharmacological Actions : Antineoplastic Agents : CK(2260) : AC(1491), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Apoptotic, Carnosic Acid, liver cancer

Cinnamon extract from Sanyangxuedai may be effective for treating leukemia.

Article Published Date : Aug 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon : CK(692) : AC(202)
Diseases : Leukemia : CK(2095) : AC(911)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, cinnamon, leukemia, Plant Extracts : CK(18767) : AC(6786)

Combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death.

Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid : CK(254) : AC(178)
Diseases : Carcinoma: Non-Small-Cell Lung : CK(711) : AC(429)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Betulinic acid, Carcinoma: Non-Small-Cell Lung, Natural Substance/Drug Synergy : CK(1543) : AC(724)

Combined use of lower concentrations of jerantinine A and γ-tocotrienol induced potent cytotoxic effects on U87MG cancer cells.

Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(51) : AC(33)
Diseases : Glioblastoma : CK(734) : AC(407)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722), Chemoprotective Agents : CK(4305) : AC(1627), Chemosensitizer : CK(1666) : AC(1277), Chemotherapeutic : CK(4400) : AC(1641), Tumor Suppressor Protein p53 Upregulation : CK(759) : AC(558)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Glioblastoma, Natural Substance/Drug Synergy : CK(1543) : AC(724), Vitamin E: Gamma-tocotrienol

Cucurbitacin E may delay cancer cell growth by apoptosis via upregulation of DR5 gene expression.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E : CK(58) : AC(44)
Diseases : Cervical Cancer : CK(983) : AC(602)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cervical Cancer, Cucurbitacin E, Gene Expression Regulation : CK(1412) : AC(625)

Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.

Article Published Date : Jun 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8012) : AC(3608)
Diseases : Glioma : CK(682) : AC(313)
Pharmacological Actions : Anti-metastatic : CK(2882) : AC(2191), Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Anti-metastatic, Antiproliferative : CK(75) : AC(61), Apoptotic, CURCUMIN : CK(25) : AC(18), Glioma

Curcumin induced leukemic cell apoptosis via an IFIT2-dependent signalling pathways.

Article Published Date : Jan 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8012) : AC(3608)
Diseases : Leukemia : CK(2095) : AC(911)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, CURCUMIN : CK(25) : AC(18), leukemia

Curcumin may serve as a promising anticancer agent by inducing a chronic ER stress mediated cell death and activation of cell cycle arrest.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(8012) : AC(3608)
Diseases : Prostate Cancer : CK(2810) : AC(1051)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, CURCUMIN : CK(25) : AC(18), prostate cancer

Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.

Article Published Date : Mar 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dimethyl trisulfide (DMTS) : CK(14) : AC(8)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Apoptotic, Cell cycle arrest, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Dimethyl trisulfide (DMTS), gastric cancer

Effects of thymol on human gastric adenocarcinoma cells in vitro.

Article Published Date : Feb 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Thymol : CK(149) : AC(104)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, gastric cancer, Thymol

EGCG is effective in decreasing cell viability, apoptosis induction and enhancement of caspase 3 and Fas expression level in jurkat cells.

Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1592) : AC(824)
Diseases : Leukemia: T-cell acute Lymphoblastic : CK(28) : AC(18)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, EGCG (Epigallocatechin gallate), Leukemia: T-cell acute Lymphoblastic

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells.

Article Published Date : Sep 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Antrodia camphorata : CK(52) : AC(33)
Diseases : Colorectal Cancer : CK(4902) : AC(2288)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Antrodia camphorata, Apoptotic, Cell cycle arrest, COLORECTAL CANCER

Extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.

Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Lichens : CK(78) : AC(55)
Diseases : Glioma : CK(682) : AC(313), Liver Cancer : CK(3122) : AC(1644), Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1770) : AC(700), Glioma, Lichens, liver cancer, lung cancer, Parmelia sulcata, Plant Extracts : CK(18767) : AC(6786)

Forced inhibition of PDE1A expression might be a new therapeutic strategy for the management of acute lymphoblastic leukemia.

Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone : CK(1178) : AC(692)
Diseases : Acute lymphoblastic leukemia (ALL) : CK(258) : AC(96)
Pharmacological Actions : Antineoplastic Agents : CK(2260) : AC(1491), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Acute lymphoblastic leukemia (ALL), Antineoplastic Agents : CK(78) : AC(35), Apoptotic, thymoquinone

Fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in thyroid cancer cells.

Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan : CK(866) : AC(451)
Diseases : Thyroid Cancer : CK(489) : AC(162)
Pharmacological Actions : Angiogenesis Inhibitors : CK(725) : AC(482), Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Angiogenesis Inhibitors, Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1770) : AC(700), Fucoidan, Thyroid Cancer

Gallic acid remarkably ameliorated the destabilization of liver tissue architecture caused by N-nitrosodiethylamine.

Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid : CK(341) : AC(212)
Diseases : Liver Cancer : CK(3122) : AC(1644)
Pharmacological Actions : Anti-Inflammatory Agents : CK(39903) : AC(15932), Anticarcinogenic Agents : CK(2152) : AC(1018), Antioxidants : CK(34717) : AC(14562), Apoptotic : CK(9630) : AC(7413), Chemopreventive : CK(6611) : AC(2175)
Additional Keywords : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants : CK(303) : AC(126), Apoptotic, Chemopreventive, Gallic Acid, liver cancer
Problem Substances : N-nitrosodiethylamine : CK(10) : AC(5)

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells.

Article Published Date : Apr 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol : CK(51) : AC(33)
Diseases : Cancers: All : CK(36538) : AC(14432)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Autophagy Up-regulation : CK(839) : AC(560)
Additional Keywords : Apoptotic, Autophagy Up-regulation, Cancers: All, Vitamin E: Gamma-tocotrienol

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.

Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom : CK(650) : AC(349)
Diseases : Breast Cancer : CK(8325) : AC(3056), Skin Cancer : CK(1808) : AC(838)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Apoptotic : CK(9630) : AC(7413), Bcl-2 protein down-regulation : CK(714) : AC(530), Bcl-xL down-regulation : CK(41) : AC(30), Chemopreventive : CK(6611) : AC(2175), Cyclin D1 Down-Regulation : CK(143) : AC(106)
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer : CK(113) : AC(34), Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer

Garcinone E exerts anticancer activities by inducing apoptosis and suppressing migration and invasion in ovarian cancer cells.

Article Published Date : Sep 05, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garcinia Mangostana : CK(22) : AC(13)
Diseases : Ovarian Cancer : CK(1032) : AC(512)
Pharmacological Actions : Anti-metastatic : CK(2882) : AC(2191), Apoptotic : CK(9630) : AC(7413), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(950) : AC(592), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(1147) : AC(724)
Additional Keywords : Anti-metastatic, Apoptotic, Garcinia Mangostana, ovarian cancer

Genistein treatment significantly suppressed proliferation and anchorage-independent growth of the human retinoblastoma cell line Y79 in vitro.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Genistein : CK(945) : AC(434)
Diseases : Retinoblastoma : CK(78) : AC(35)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), MicroRNA modulator : CK(1565) : AC(901)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Genistein, MicroRNA modulator, Retinoblastoma

Harmaline induces cell cycle arrest and apoptosis in SGC-7901 cells.

Article Published Date : Dec 17, 2015
Study Type : Animal Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, gastric cancer, Syrian rue

Harmine might be a potent inducer of apoptosis and autophagy in gastric carcinoma.

Article Published Date : May 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Autophagy Up-regulation : CK(839) : AC(560)
Additional Keywords : Apoptotic, Autophagy Up-regulation, gastric cancer, Syrian rue

Honokiol is a good candidate for further studies as a possible treatment for malignant melanoma.

Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Honokiol : CK(435) : AC(271)
Diseases : Malignant Melanoma : CK(97) : AC(48)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Apoptotic, Cell cycle arrest, Honokiol, Malignant Melanoma

Inhibition of pyruvate kinase M2 markedly reduces chemoresistance of advanced bladder cancer to cisplatin.

Article Published Date : Apr 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin : CK(369) : AC(261)
Diseases : Bladder Cancer : CK(785) : AC(322)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, bladder cancer, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Dose Response : CK(1770) : AC(700), Shikonin

Neferine enhances the antitumor effect of mitomycin-c in hela cells.

Article Published Date : Mar 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Cervical Cancer : CK(983) : AC(602)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, Cervical Cancer, Chemotherapeutic Synergy: Mitomycin C : CK(8) : AC(7), Lotus

Neferine reduces the cisplatin dose requirement in cancer chemotherapy.

Article Published Date : Feb 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus : CK(398) : AC(258)
Diseases : Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Chemosensitizer : CK(1666) : AC(1277), Vascular Endothelial Growth Factor Inhibitors : CK(611) : AC(335)
Additional Keywords : Apoptotic, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin : CK(433) : AC(341), Lotus, lung cancer, Vascular Endothelial Growth Factor Inhibitors

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.

Article Published Date : Apr 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Lichens : CK(78) : AC(55)
Diseases : Breast Cancer : CK(8325) : AC(3056), Breast Cancer: Triple Negative : CK(973) : AC(661)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Caspase-3 Activation : CK(137) : AC(90)
Additional Keywords : Apoptotic, Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Caspase-3 Activation, Dose Response : CK(1770) : AC(700), Lichens

Peganum harmala's extract decreases the growth rate of the cancer cell line through inducing apoptosis.

Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Syrian rue : CK(84) : AC(51)
Diseases : Breast Cancer : CK(8325) : AC(3056), Breast Cancer: Triple Negative : CK(973) : AC(661)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Apoptotic, Breast Cancer : CK(113) : AC(34), Breast Cancer: Triple Negative, Syrian rue

Piperine is a promising candidate for targeting G-quadruplex DNA.

Article Published Date : Dec 19, 2016
Study Type : In Vitro Study
Additional Links
Substances : Piperine : CK(636) : AC(265)
Diseases : Lung Cancer : CK(3068) : AC(1434)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, lung cancer, Piperine

Polysaccharide from Pleurotus nebrodensis induces apoptosis via a mitochondrial pathway in HepG2 cells.

Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pleurotus nebrodensis : CK(9) : AC(6)
Diseases : DNA damage : CK(2305) : AC(845)
Pharmacological Actions : Antineoplastic Agents : CK(2260) : AC(1491), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antineoplastic Agents : CK(78) : AC(35), Apoptotic, DNA damage, Pleurotus nebrodensis, Polysaccharides : CK(1330) : AC(750)

Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis in human colorectal cancer SW620 cells.

Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Quercetin : CK(1885) : AC(863), Toona sinensis : CK(40) : AC(25)
Diseases : Colorectal Cancer : CK(4902) : AC(2288)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, COLORECTAL CANCER, QUERCETIN, Toona sinensis

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.

Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot : CK(37) : AC(13)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Apoptotic : CK(9630) : AC(7413), Caspase-3 Activation : CK(137) : AC(90), Chemosensitizer : CK(1666) : AC(1277)
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.

Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane : CK(1345) : AC(631)
Diseases : Glioblastoma : CK(734) : AC(407)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cancer Stem Cells : CK(501) : AC(365), glioblastoma (GBM), Sulforaphane

Tangeretin may be a therapeutic agent for glioblastoma treatment.

Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Tangeretin : CK(163) : AC(93)
Diseases : Glioblastoma : CK(734) : AC(407)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Glioblastoma, Tangeretin

Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.

Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Polyphenols : CK(2762) : AC(1009)
Diseases : Gallbladder Cancer : CK(115) : AC(37)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413), Cell cycle arrest : CK(2128) : AC(1722)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Cell cycle arrest, Gallbladder Cancer, POLYPHENOLS : CK(16) : AC(5)

These findings indicate that mangiferin effectively inhibits cell growth and induces apoptosis of gastric cancer cells.

Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin : CK(376) : AC(223)
Diseases : Gastric Cancer : CK(1626) : AC(731)
Pharmacological Actions : Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Antiproliferative : CK(75) : AC(61), Apoptotic, Dose Response : CK(1770) : AC(700), gastric cancer, Mangiferin

These results indicate a chemopreventive potential of in vitro fermented hazelnuts.

Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages : CK(3367) : AC(829), Hazelnut : CK(100) : AC(23)
Diseases : Colon Cancer : CK(1921) : AC(1204), DNA damage : CK(2305) : AC(845)
Pharmacological Actions : Anticarcinogenic Agents : CK(2152) : AC(1018), Antineoplastic Agents : CK(2260) : AC(1491), Antiproliferative : CK(10073) : AC(7536), Apoptotic : CK(9630) : AC(7413)
Additional Keywords : Anticarcinogenic Agents, Antineoplastic Agents : CK(78) : AC(35), Antiproliferative : CK(75) : AC(61), Apoptotic, COLON CANCER, DNA damage, Fermented Foods and Beverages, Hazelnut

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